Reviewed, UniProtKB/Swiss-Prot Q15773 (MLF2_HUMAN)

Names and origin

Protein names

Recommended name:
    Myeloid leukemia factor 2
Alternative name(s):
    Myelodysplasia-myeloid leukemia factor 2

Gene names

Name:

MLF2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Tissue specificity	Ubiquitously expressed.
Sequence similarities	Belongs to the MLF family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	defense response Ref.1 Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW focal adhesion Inferred from direct assay. Source: HPA nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABCD3	P28288	1	EBI-1051875,EBI-80992
AIFM1	O95831	1	EBI-1051875,EBI-356440
BAG2	O95816	1	EBI-1051875,EBI-355275
CIAO1	O76071	1	EBI-1051875,EBI-725145
FAM96B	Q9Y3D0	1	EBI-1051875,EBI-744045
MMS19	Q96T76	1	EBI-1051875,EBI-1044169
PMVK	Q15126	1	EBI-1051875,EBI-1055562
RGS20	O76081	1	EBI-1051875,EBI-1052678

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Myeloid leukemia factor 2		PRO_0000220754
Amino acid modifications
	Modified residue	144	1	Phosphoserine
	Modified residue	152	1	Phosphoserine
	Modified residue	238	1	Phosphoserine
Natural variations
	Natural variant	80	1	F → C in a colorectal cancer sample; somatic mutation.		VAR_036429

Sequences

	Sequence		Length	Mass (Da)
	Q15773-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EB1DC52AD1767715	FASTA	248	28,147
	10 20 30 40 50 60 MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG TRPASRRMQQ 70 80 90 100 110 120 AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ TFSSSTVISY SNTGDGAPKV 130 140 150 160 170 180 YQETSEMRSA PGGIRETRRT VRDSDSGLEQ MSIGHHIRDR AHILQRSRNH RTGDQEERQD 190 200 210 220 230 240 YINLDESEAA AFDDEWRRET SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS RQSRRYDW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2)." Kuefer M.U., Look A.T., Williams D.C., Valentine V., Naeve C.W., Behm F.G., Mullersman J.E., Yoneda-Kato N., Montgomery K., Kucherlapati R., Morris S.W. Genomics 35:392-396(1996) [PubMed: 8661158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	Yu W., Gibbs R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Placenta.
[4]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-152 AND SER-238, MASS SPECTROMETRY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, MASS SPECTROMETRY.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-80.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U57342 mRNA. Translation: AAB08988.1. AF070539 mRNA. Translation: AAC28632.1. BC000898 mRNA. Translation: AAH00898.1. BC002340 mRNA. Translation: AAH02340.1.
RefSeq	NP_005430.1.
UniGene	Hs.524214
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15773.
PTM databases
PhosphoSite	Q15773.
Genome annotation databases
Ensembl	ENSG00000089693. Homo sapiens. [Contig view]
GeneID	8079.
KEGG	hsa:8079.
Organism-specific databases
HGNC	HGNC:7126. MLF2.
HPA	HPA010811. HPA010859.
MIM	601401. gene.
PharmGKB	PA30844.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q15773.
HOVERGEN	Q15773.
Gene expression databases
ArrayExpress	Q15773.
CleanEx	HS_MLF2.
GermOnline	ENSG00000089693. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
LinkHub	Q15773.
NextBio	30693.
SOURCE	Search...

Entry information

Entry name

MLF2_HUMAN

Accession

Primary (citable) accession number: Q15773

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)