Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myeloid leukemia factor 2

Gene

MLF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • defense response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid leukemia factor 2
Alternative name(s):
Myelodysplasia-myeloid leukemia factor 2
Gene namesi
Name:MLF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:7126. MLF2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30844.

Polymorphism and mutation databases

BioMutaiMLF2.
DMDMi17368482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Myeloid leukemia factor 2PRO_0000220754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171PhosphoserineCombined sources
Modified residuei238 – 2381PhosphoserineCombined sources
Modified residuei240 – 2401PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15773.
PaxDbiQ15773.
PeptideAtlasiQ15773.
PRIDEiQ15773.

PTM databases

iPTMnetiQ15773.
PhosphoSiteiQ15773.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiQ15773.
CleanExiHS_MLF2.
ExpressionAtlasiQ15773. baseline and differential.
GenevisibleiQ15773. HS.

Organism-specific databases

HPAiHPA010811.
HPA010859.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJB6O751903EBI-1051875,EBI-1053164

Protein-protein interaction databases

BioGridi113752. 42 interactions.
IntActiQ15773. 22 interactions.
STRINGi9606.ENSP00000203630.

Structurei

3D structure databases

ProteinModelPortaliQ15773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MLF family.Curated

Phylogenomic databases

eggNOGiKOG4049. Eukaryota.
ENOG4111J7M. LUCA.
HOGENOMiHOG000045671.
HOVERGENiHBG019060.
InParanoidiQ15773.
OMAiAHRQQMR.
OrthoDBiEOG7H1JN6.
PhylomeDBiQ15773.
TreeFamiTF317561.

Family and domain databases

InterProiIPR019376. Myeloid_leukemia_factor.
[Graphical view]
PfamiPF10248. Mlf1IP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRFMRDVEP EDPMFLMDPF AIHRQHMSRM LSGGFGYSPF LSITDGNMPG
60 70 80 90 100
TRPASRRMQQ AGAVSPFGML GMSGGFMDMF GMMNDMIGNM EHMTAGGNCQ
110 120 130 140 150
TFSSSTVISY SNTGDGAPKV YQETSEMRSA PGGIRETRRT VRDSDSGLEQ
160 170 180 190 200
MSIGHHIRDR AHILQRSRNH RTGDQEERQD YINLDESEAA AFDDEWRRET
210 220 230 240
SRFRQQRPLE FRRLESSGAG GRRAEGPPRL AIQGPEDSPS RQSRRYDW
Length:248
Mass (Da):28,147
Last modified:November 1, 1996 - v1
Checksum:iEB1DC52AD1767715
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801F → C in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036429

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57342 mRNA. Translation: AAB08988.1.
AF070539 mRNA. Translation: AAC28632.1.
BC000898 mRNA. Translation: AAH00898.1.
BC002340 mRNA. Translation: AAH02340.1.
CCDSiCCDS8559.1.
RefSeqiNP_005430.1. NM_005439.2.
UniGeneiHs.524214.

Genome annotation databases

EnsembliENST00000203630; ENSP00000203630; ENSG00000089693.
ENST00000435120; ENSP00000403941; ENSG00000089693.
ENST00000539187; ENSP00000446317; ENSG00000089693.
ENST00000542154; ENSP00000438671; ENSG00000089693.
GeneIDi8079.
KEGGihsa:8079.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57342 mRNA. Translation: AAB08988.1.
AF070539 mRNA. Translation: AAC28632.1.
BC000898 mRNA. Translation: AAH00898.1.
BC002340 mRNA. Translation: AAH02340.1.
CCDSiCCDS8559.1.
RefSeqiNP_005430.1. NM_005439.2.
UniGeneiHs.524214.

3D structure databases

ProteinModelPortaliQ15773.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113752. 42 interactions.
IntActiQ15773. 22 interactions.
STRINGi9606.ENSP00000203630.

PTM databases

iPTMnetiQ15773.
PhosphoSiteiQ15773.

Polymorphism and mutation databases

BioMutaiMLF2.
DMDMi17368482.

Proteomic databases

EPDiQ15773.
PaxDbiQ15773.
PeptideAtlasiQ15773.
PRIDEiQ15773.

Protocols and materials databases

DNASUi8079.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000203630; ENSP00000203630; ENSG00000089693.
ENST00000435120; ENSP00000403941; ENSG00000089693.
ENST00000539187; ENSP00000446317; ENSG00000089693.
ENST00000542154; ENSP00000438671; ENSG00000089693.
GeneIDi8079.
KEGGihsa:8079.

Organism-specific databases

CTDi8079.
GeneCardsiMLF2.
HGNCiHGNC:7126. MLF2.
HPAiHPA010811.
HPA010859.
MIMi601401. gene.
neXtProtiNX_Q15773.
PharmGKBiPA30844.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4049. Eukaryota.
ENOG4111J7M. LUCA.
HOGENOMiHOG000045671.
HOVERGENiHBG019060.
InParanoidiQ15773.
OMAiAHRQQMR.
OrthoDBiEOG7H1JN6.
PhylomeDBiQ15773.
TreeFamiTF317561.

Miscellaneous databases

ChiTaRSiMLF2. human.
GenomeRNAii8079.
PROiQ15773.
SOURCEiSearch...

Gene expression databases

BgeeiQ15773.
CleanExiHS_MLF2.
ExpressionAtlasiQ15773. baseline and differential.
GenevisibleiQ15773. HS.

Family and domain databases

InterProiIPR019376. Myeloid_leukemia_factor.
[Graphical view]
PfamiPF10248. Mlf1IP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2)."
    Kuefer M.U., Look A.T., Williams D.C., Valentine V., Naeve C.W., Behm F.G., Mullersman J.E., Yoneda-Kato N., Montgomery K., Kucherlapati R., Morris S.W.
    Genomics 35:392-396(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Yu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238 AND SER-240, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238 AND SER-240, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  14. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-80.

Entry informationi

Entry nameiMLF2_HUMAN
AccessioniPrimary (citable) accession number: Q15773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.