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Protein

Ras-related protein Rab-30

Gene

RAB30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTP8
Nucleotide bindingi64 – 68GTP5
Nucleotide bindingi122 – 125GTP4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • Golgi organization Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137502-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-30
Gene namesi
Name:RAB30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9770. RAB30.

Subcellular locationi

GO - Cellular componenti

  • cis-Golgi network Source: UniProtKB
  • cytoplasm Source: HPA
  • Golgi cisterna Source: UniProtKB
  • Golgi membrane Source: Reactome
  • Golgi stack Source: ProtInc
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137502.
PharmGKBiPA34121.

Polymorphism and mutation databases

DMDMi38258937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212301 – 200Ras-related protein Rab-30Add BLAST200
PropeptideiPRO_0000370826201 – 203Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi199S-geranylgeranyl cysteineBy similarity1
Modified residuei200Cysteine methyl esterSequence analysis1
Lipidationi200S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ15771.
MaxQBiQ15771.
PaxDbiQ15771.
PeptideAtlasiQ15771.
PRIDEiQ15771.

PTM databases

iPTMnetiQ15771.
PhosphoSitePlusiQ15771.

Expressioni

Gene expression databases

BgeeiENSG00000137502.
CleanExiHS_RAB30.
ExpressionAtlasiQ15771. baseline and differential.
GenevisibleiQ15771. HS.

Organism-specific databases

HPAiHPA051208.
HPA054514.

Interactioni

Protein-protein interaction databases

BioGridi118132. 25 interactors.
DIPiDIP-60519N.
IntActiQ15771. 2 interactors.
STRINGi9606.ENSP00000260056.

Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 17Combined sources11
Helixi22 – 31Combined sources10
Beta strandi43 – 53Combined sources11
Beta strandi56 – 65Combined sources10
Helixi69 – 71Combined sources3
Helixi72 – 75Combined sources4
Helixi76 – 78Combined sources3
Beta strandi83 – 90Combined sources8
Helixi94 – 98Combined sources5
Helixi100 – 110Combined sources11
Beta strandi116 – 122Combined sources7
Helixi124 – 129Combined sources6
Helixi134 – 144Combined sources11
Beta strandi148 – 150Combined sources3
Turni153 – 155Combined sources3
Helixi159 – 174Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EW1X-ray2.00A2-184[»]
ProteinModelPortaliQ15771.
SMRiQ15771.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15771.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0095. Eukaryota.
ENOG410XRPC. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ15771.
KOiK07917.
OMAiFAEAQSM.
OrthoDBiEOG091G0HS5.
PhylomeDBiQ15771.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA TIGVDFMIKT
60 70 80 90 100
VEINGEKVKL QIWDTAGQER FRSITQSYYR SANALILTYD ITCEESFRCL
110 120 130 140 150
PEWLREIEQY ASNKVITVLV GNKIDLAERR EVSQQRAEEF SEAQDMYYLE
160 170 180 190 200
TSAKESDNVE KLFLDLACRL ISEARQNTLV NNVSSPLPGE GKSISYLTCC

NFN
Length:203
Mass (Da):23,058
Last modified:October 31, 2003 - v2
Checksum:i935E56DBD48DD7C2
GO
Isoform 2 (identifier: Q15771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-164: VGNKIDLAER...ESDNVEKLFL → ATRLTWLKGE...LIMWRNSSLT
     165-203: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,994
Checksum:i17BE813BEC1CD455
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45D → G in AAC50774 (PubMed:8863739).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055833120 – 164VGNKI…EKLFL → ATRLTWLKGERFPSSELKNS QKLRTCIIWRPQPRNLIMWR NSSLT in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_055834165 – 203Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57092 mRNA. Translation: AAC50774.1.
AF498956 mRNA. Translation: AAM21104.1.
CR542106 mRNA. Translation: CAG46903.1.
BX641138 mRNA. Translation: CAE46061.1.
AP000893 Genomic DNA. No translation available.
AP001767 Genomic DNA. No translation available.
BC014213 mRNA. Translation: AAH14213.1.
CCDSiCCDS8264.1. [Q15771-1]
PIRiJC4962.
RefSeqiNP_001272988.1. NM_001286059.1. [Q15771-1]
NP_001272989.1. NM_001286060.1. [Q15771-1]
NP_001272990.1. NM_001286061.1. [Q15771-1]
NP_055303.2. NM_014488.4. [Q15771-1]
UniGeneiHs.40758.
Hs.594773.

Genome annotation databases

EnsembliENST00000260056; ENSP00000260056; ENSG00000137502. [Q15771-1]
ENST00000527633; ENSP00000435089; ENSG00000137502. [Q15771-1]
ENST00000533486; ENSP00000435189; ENSG00000137502. [Q15771-1]
ENST00000534141; ENSP00000434974; ENSG00000137502. [Q15771-2]
ENST00000612684; ENSP00000478702; ENSG00000137502. [Q15771-1]
GeneIDi27314.
KEGGihsa:27314.
UCSCiuc001ozu.5. human. [Q15771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57092 mRNA. Translation: AAC50774.1.
AF498956 mRNA. Translation: AAM21104.1.
CR542106 mRNA. Translation: CAG46903.1.
BX641138 mRNA. Translation: CAE46061.1.
AP000893 Genomic DNA. No translation available.
AP001767 Genomic DNA. No translation available.
BC014213 mRNA. Translation: AAH14213.1.
CCDSiCCDS8264.1. [Q15771-1]
PIRiJC4962.
RefSeqiNP_001272988.1. NM_001286059.1. [Q15771-1]
NP_001272989.1. NM_001286060.1. [Q15771-1]
NP_001272990.1. NM_001286061.1. [Q15771-1]
NP_055303.2. NM_014488.4. [Q15771-1]
UniGeneiHs.40758.
Hs.594773.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EW1X-ray2.00A2-184[»]
ProteinModelPortaliQ15771.
SMRiQ15771.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118132. 25 interactors.
DIPiDIP-60519N.
IntActiQ15771. 2 interactors.
STRINGi9606.ENSP00000260056.

PTM databases

iPTMnetiQ15771.
PhosphoSitePlusiQ15771.

Polymorphism and mutation databases

DMDMi38258937.

Proteomic databases

EPDiQ15771.
MaxQBiQ15771.
PaxDbiQ15771.
PeptideAtlasiQ15771.
PRIDEiQ15771.

Protocols and materials databases

DNASUi27314.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260056; ENSP00000260056; ENSG00000137502. [Q15771-1]
ENST00000527633; ENSP00000435089; ENSG00000137502. [Q15771-1]
ENST00000533486; ENSP00000435189; ENSG00000137502. [Q15771-1]
ENST00000534141; ENSP00000434974; ENSG00000137502. [Q15771-2]
ENST00000612684; ENSP00000478702; ENSG00000137502. [Q15771-1]
GeneIDi27314.
KEGGihsa:27314.
UCSCiuc001ozu.5. human. [Q15771-1]

Organism-specific databases

CTDi27314.
GeneCardsiRAB30.
HGNCiHGNC:9770. RAB30.
HPAiHPA051208.
HPA054514.
MIMi605693. gene.
neXtProtiNX_Q15771.
OpenTargetsiENSG00000137502.
PharmGKBiPA34121.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0095. Eukaryota.
ENOG410XRPC. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ15771.
KOiK07917.
OMAiFAEAQSM.
OrthoDBiEOG091G0HS5.
PhylomeDBiQ15771.
TreeFamiTF300097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137502-MONOMER.
ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Miscellaneous databases

EvolutionaryTraceiQ15771.
GenomeRNAii27314.
PROiQ15771.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137502.
CleanExiHS_RAB30.
ExpressionAtlasiQ15771. baseline and differential.
GenevisibleiQ15771. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB30_HUMAN
AccessioniPrimary (citable) accession number: Q15771
Secondary accession number(s): Q6FGK1, Q6MZH2, Q96CI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 31, 2003
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.