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Protein

Ephrin-B3

Gene

EFNB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).By similarity
(Microbial infection) Acts as a receptor for nipah virus and hendra virus.2 Publications

GO - Molecular functioni

  • ephrin receptor binding Source: MGI
  • protein tyrosine kinase activity Source: Reactome
  • transmembrane-ephrin receptor activity Source: ProtInc
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  • adult walking behavior Source: Ensembl
  • axon choice point recognition Source: Ensembl
  • axon guidance Source: GO_Central
  • cell-cell signaling Source: ProtInc
  • ephrin receptor signaling pathway Source: MGI
  • negative regulation of axonogenesis Source: ARUK-UCL
  • nervous system development Source: ProtInc
  • T cell costimulation Source: Ensembl

Keywordsi

Molecular functionDevelopmental protein, Host cell receptor for virus entry, Receptor
Biological processDifferentiation, Host-virus interaction, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928664 Ephrin signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
SignaLinkiQ15768
SIGNORiQ15768

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-B3
Alternative name(s):
EPH-related receptor transmembrane ligand ELK-L3
EPH-related receptor tyrosine kinase ligand 8
Short name:
LERK-8
Gene namesi
Name:EFNB3
Synonyms:EPLG8, LERK8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108947.4
HGNCiHGNC:3228 EFNB3
MIMi602297 gene
neXtProtiNX_Q15768

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 226ExtracellularSequence analysisAdd BLAST199
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 340CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi124 – 125LW → YM: Complete loss of Nipah protein G binding. 1 Publication2

Organism-specific databases

DisGeNETi1949
OpenTargetsiENSG00000108947
PharmGKBiPA27663

Polymorphism and mutation databases

BioMutaiEFNB3
DMDMi2494367

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000839528 – 340Ephrin-B3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 104PROSITE-ProRule annotation
Disulfide bondi92 ↔ 156PROSITE-ProRule annotation
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei271Omega-N-methylarginineBy similarity1
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ15768
PaxDbiQ15768
PeptideAtlasiQ15768
PRIDEiQ15768

PTM databases

iPTMnetiQ15768
PhosphoSitePlusiQ15768

Miscellaneous databases

PMAP-CutDBiQ15768

Expressioni

Tissue specificityi

Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.

Gene expression databases

BgeeiENSG00000108947
CleanExiHS_EFNB3
GenevisibleiQ15768 HS

Organism-specific databases

HPAiHPA001623

Interactioni

Subunit structurei

Interacts with GRIP1 and GRIP2.1 Publication
(Microbial infection) Interacts with nipah virus and hendra virus glycoprotein (PubMed:16477309, PubMed:17376907).2 Publications

GO - Molecular functioni

  • ephrin receptor binding Source: MGI

Protein-protein interaction databases

BioGridi108269, 40 interactors
DIPiDIP-59196N
IntActiQ15768, 9 interactors
STRINGi9606.ENSP00000226091

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BKFX-ray4.65C/D27-169[»]
ProteinModelPortaliQ15768
SMRiQ15768
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 167Ephrin RBDPROSITE-ProRule annotationAdd BLAST140

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi338 – 340PDZ-bindingSequence analysis3

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000005839
HOGENOMiHOG000220931
HOVERGENiHBG051448
InParanoidiQ15768
KOiK05463
OMAiSSPSYEF
OrthoDBiEOG091G0BPC
PhylomeDBiQ15768

Family and domain databases

Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL
60 70 80 90 100
YPQIGDRLDL LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL
110 120 130 140 150
LLTCDRPDLD LRFTIKFQEY SPNLWGHEFR SHHDYYIIAT SDGTREGLES
160 170 180 190 200
LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP VSEMPMERDR GAAHSLEPGK
210 220 230 240 250
ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL GVAGAGGAMC
260 270 280 290 300
WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG
310 320 330 340
GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV
Length:340
Mass (Da):35,835
Last modified:November 1, 1996 - v1
Checksum:iEDFF2A23C2FDE79F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002356166R → Q. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57001 mRNA Translation: AAB05170.1
U66406 mRNA Translation: AAC51203.1
U62775 mRNA Translation: AAC50707.1
AK314841 mRNA Translation: BAG37359.1
CH471108 Genomic DNA Translation: EAW90133.1
CH471108 Genomic DNA Translation: EAW90135.1
BC022499 mRNA Translation: AAH22499.1
BC042944 mRNA Translation: AAH42944.1
CCDSiCCDS11120.1
RefSeqiNP_001397.1, NM_001406.3
UniGeneiHs.26988

Genome annotation databases

EnsembliENST00000226091; ENSP00000226091; ENSG00000108947
GeneIDi1949
KEGGihsa:1949
UCSCiuc002gis.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEFNB3_HUMAN
AccessioniPrimary (citable) accession number: Q15768
Secondary accession number(s): B2RBW2
, D3DTQ6, O00680, Q8TBH7, Q92875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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