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Protein

CD226 antigen

Gene

CD226

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • integrin binding Source: BHF-UCL
  • protein homodimerization activity Source: GO_Central
  • protein kinase binding Source: BHF-UCL
  • receptor activity Source: GO_Central

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell recognition Source: BHF-UCL
  • cytokine production Source: Ensembl
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
  • positive regulation of Fc receptor mediated stimulatory signaling pathway Source: BHF-UCL
  • positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
  • positive regulation of interferon-gamma production Source: Ensembl
  • positive regulation of mast cell activation Source: BHF-UCL
  • positive regulation of natural killer cell cytokine production Source: Ensembl
  • positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
  • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
  • regulation of immune response Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150637-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD226 antigen
Alternative name(s):
DNAX accessory molecule 1
Short name:
DNAM-1
CD_antigen: CD226
Gene namesi
Name:CD226
Synonyms:DNAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:16961. CD226.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 254ExtracellularSequence analysisAdd BLAST236
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 336CytoplasmicSequence analysisAdd BLAST61

GO - Cellular componenti

  • cell-cell adherens junction Source: GO_Central
  • cell surface Source: BHF-UCL
  • external side of plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane raft Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10666.
OpenTargetsiENSG00000150637.
PharmGKBiPA134911130.

Polymorphism and mutation databases

BioMutaiCD226.
DMDMi317373338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001466519 – 336CD226 antigenAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi37 ↔ 108PROSITE-ProRule annotation
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi152 ↔ 222PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Modified residuei322PhosphotyrosineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15762.
PeptideAtlasiQ15762.
PRIDEiQ15762.

PTM databases

iPTMnetiQ15762.
PhosphoSitePlusiQ15762.

Expressioni

Tissue specificityi

Expressed by peripheral blood T-lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000150637.
CleanExiHS_CD226.
ExpressionAtlasiQ15762. baseline and differential.
GenevisibleiQ15762. HS.

Organism-specific databases

HPAiHPA015715.

Interactioni

Subunit structurei

Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NECTIN2Q926922EBI-4314442,EBI-718419
TIGITQ495A14EBI-4314442,EBI-4314807

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • integrin binding Source: BHF-UCL
  • protein homodimerization activity Source: GO_Central
  • protein kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi115908. 4 interactors.
IntActiQ15762. 3 interactors.
STRINGi9606.ENSP00000280200.

Structurei

3D structure databases

ProteinModelPortaliQ15762.
SMRiQ15762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 126Ig-like C2-type 1Add BLAST108
Domaini135 – 239Ig-like C2-type 2Add BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 284Poly-Arg8

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXC. Eukaryota.
ENOG41129MS. LUCA.
GeneTreeiENSGT00500000044993.
HOGENOMiHOG000059567.
HOVERGENiHBG050849.
InParanoidiQ15762.
KOiK06567.
OMAiYVNYPTF.
OrthoDBiEOG091G0823.
PhylomeDBiQ15762.
TreeFamiTF336260.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYPTLLLAL LHVYRALCEE VLWHTSVPFA ENMSLECVYP SMGILTQVEW
60 70 80 90 100
FKIGTQQDSI AIFSPTHGMV IRKPYAERVY FLNSTMASNN MTLFFRNASE
110 120 130 140 150
DDVGYYSCSL YTYPQGTWQK VIQVVQSDSF EAAVPSNSHI VSEPGKNVTL
160 170 180 190 200
TCQPQMTWPV QAVRWEKIQP RQIDLLTYCN LVHGRNFTSK FPRQIVSNCS
210 220 230 240 250
HGRWSVIVIP DVTVSDSGLY RCYLQASAGE NETFVMRLTV AEGKTDNQYT
260 270 280 290 300
LFVAGGTVLL LLFVISITTI IVIFLNRRRR RERRDLFTES WDTQKAPNNY
310 320 330
RSPISTSQPT NQSMDDTRED IYVNYPTFSR RPKTRV
Length:336
Mass (Da):38,614
Last modified:January 11, 2011 - v2
Checksum:i5379182CC4695097
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018632307S → G.Combined sources3 PublicationsCorresponds to variant rs763361dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56102 mRNA. Translation: AAC50560.1.
AJ537553 mRNA. Translation: CAD61184.1.
AK313199 mRNA. Translation: BAG36015.1.
AC011930 Genomic DNA. No translation available.
AC090231 Genomic DNA. No translation available.
AC091137 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66515.1.
BC074787 mRNA. Translation: AAH74787.1.
CCDSiCCDS11997.1.
RefSeqiNP_001290547.1. NM_001303618.1.
NP_006557.2. NM_006566.3.
XP_005266699.1. XM_005266642.3.
UniGeneiHs.660130.

Genome annotation databases

EnsembliENST00000280200; ENSP00000280200; ENSG00000150637.
ENST00000582621; ENSP00000461947; ENSG00000150637.
GeneIDi10666.
KEGGihsa:10666.
UCSCiuc002lkm.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56102 mRNA. Translation: AAC50560.1.
AJ537553 mRNA. Translation: CAD61184.1.
AK313199 mRNA. Translation: BAG36015.1.
AC011930 Genomic DNA. No translation available.
AC090231 Genomic DNA. No translation available.
AC091137 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66515.1.
BC074787 mRNA. Translation: AAH74787.1.
CCDSiCCDS11997.1.
RefSeqiNP_001290547.1. NM_001303618.1.
NP_006557.2. NM_006566.3.
XP_005266699.1. XM_005266642.3.
UniGeneiHs.660130.

3D structure databases

ProteinModelPortaliQ15762.
SMRiQ15762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115908. 4 interactors.
IntActiQ15762. 3 interactors.
STRINGi9606.ENSP00000280200.

PTM databases

iPTMnetiQ15762.
PhosphoSitePlusiQ15762.

Polymorphism and mutation databases

BioMutaiCD226.
DMDMi317373338.

Proteomic databases

PaxDbiQ15762.
PeptideAtlasiQ15762.
PRIDEiQ15762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280200; ENSP00000280200; ENSG00000150637.
ENST00000582621; ENSP00000461947; ENSG00000150637.
GeneIDi10666.
KEGGihsa:10666.
UCSCiuc002lkm.6. human.

Organism-specific databases

CTDi10666.
DisGeNETi10666.
GeneCardsiCD226.
H-InvDBHIX0039717.
HGNCiHGNC:16961. CD226.
HPAiHPA015715.
MIMi605397. gene.
neXtProtiNX_Q15762.
OpenTargetsiENSG00000150637.
PharmGKBiPA134911130.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDXC. Eukaryota.
ENOG41129MS. LUCA.
GeneTreeiENSGT00500000044993.
HOGENOMiHOG000059567.
HOVERGENiHBG050849.
InParanoidiQ15762.
KOiK06567.
OMAiYVNYPTF.
OrthoDBiEOG091G0823.
PhylomeDBiQ15762.
TreeFamiTF336260.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150637-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiCD226.
GenomeRNAii10666.
PROiQ15762.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150637.
CleanExiHS_CD226.
ExpressionAtlasiQ15762. baseline and differential.
GenevisibleiQ15762. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD226_HUMAN
AccessioniPrimary (citable) accession number: Q15762
Secondary accession number(s): B2R818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.