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Q15762

- CD226_HUMAN

UniProt

Q15762 - CD226_HUMAN

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Protein

CD226 antigen

Gene

CD226

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.1 Publication

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. integrin binding Source: BHF-UCL
  3. protein kinase binding Source: BHF-UCL

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. cell recognition Source: BHF-UCL
  3. cytokine production Source: Ensembl
  4. positive regulation of Fc receptor mediated stimulatory signaling pathway Source: BHF-UCL
  5. positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
  6. positive regulation of mast cell activation Source: BHF-UCL
  7. positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
  8. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
  9. regulation of immune response Source: Reactome
  10. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD226 antigen
Alternative name(s):
DNAX accessory molecule 1
Short name:
DNAM-1
CD_antigen: CD226
Gene namesi
Name:CD226
Synonyms:DNAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:16961. CD226.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. external side of plasma membrane Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. membrane raft Source: BHF-UCL
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 336318CD226 antigenPRO_0000014665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi37 ↔ 108PROSITE-ProRule annotation
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 222PROSITE-ProRule annotation
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Modified residuei322 – 3221Phosphotyrosine2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15762.
PRIDEiQ15762.

PTM databases

PhosphoSiteiQ15762.

Expressioni

Tissue specificityi

Expressed by peripheral blood T-lymphocytes.1 Publication

Gene expression databases

BgeeiQ15762.
CleanExiHS_CD226.
ExpressionAtlasiQ15762. baseline and differential.
GenevestigatoriQ15762.

Organism-specific databases

HPAiHPA015715.

Interactioni

Subunit structurei

Interacts with PVR and PVRL2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PVRL2Q926922EBI-4314442,EBI-718419

Protein-protein interaction databases

BioGridi115908. 5 interactions.
IntActiQ15762. 2 interactions.
STRINGi9606.ENSP00000280200.

Structurei

3D structure databases

ProteinModelPortaliQ15762.
SMRiQ15762. Positions 24-243.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 254236ExtracellularSequence AnalysisAdd
BLAST
Topological domaini276 – 33661CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 126108Ig-like C2-type 1Add
BLAST
Domaini135 – 239105Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi277 – 2848Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41580.
GeneTreeiENSGT00500000044993.
HOGENOMiHOG000059567.
HOVERGENiHBG050849.
InParanoidiQ15762.
KOiK06567.
OMAiEDIYVNY.
PhylomeDBiQ15762.
TreeFamiTF336260.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15762-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYPTLLLAL LHVYRALCEE VLWHTSVPFA ENMSLECVYP SMGILTQVEW
60 70 80 90 100
FKIGTQQDSI AIFSPTHGMV IRKPYAERVY FLNSTMASNN MTLFFRNASE
110 120 130 140 150
DDVGYYSCSL YTYPQGTWQK VIQVVQSDSF EAAVPSNSHI VSEPGKNVTL
160 170 180 190 200
TCQPQMTWPV QAVRWEKIQP RQIDLLTYCN LVHGRNFTSK FPRQIVSNCS
210 220 230 240 250
HGRWSVIVIP DVTVSDSGLY RCYLQASAGE NETFVMRLTV AEGKTDNQYT
260 270 280 290 300
LFVAGGTVLL LLFVISITTI IVIFLNRRRR RERRDLFTES WDTQKAPNNY
310 320 330
RSPISTSQPT NQSMDDTRED IYVNYPTFSR RPKTRV
Length:336
Mass (Da):38,614
Last modified:January 11, 2011 - v2
Checksum:i5379182CC4695097
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti307 – 3071S → G.4 Publications
Corresponds to variant rs763361 [ dbSNP | Ensembl ].
VAR_018632

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56102 mRNA. Translation: AAC50560.1.
AJ537553 mRNA. Translation: CAD61184.1.
AK313199 mRNA. Translation: BAG36015.1.
AC011930 Genomic DNA. No translation available.
AC090231 Genomic DNA. No translation available.
AC091137 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66515.1.
BC074787 mRNA. Translation: AAH74787.1.
CCDSiCCDS11997.1.
RefSeqiNP_006557.2. NM_006566.2.
XP_005266699.1. XM_005266642.1.
XP_006722436.1. XM_006722373.1.
UniGeneiHs.660130.

Genome annotation databases

EnsembliENST00000280200; ENSP00000280200; ENSG00000150637.
ENST00000582621; ENSP00000461947; ENSG00000150637.
GeneIDi10666.
KEGGihsa:10666.
UCSCiuc002lkm.4. human.

Polymorphism databases

DMDMi317373338.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56102 mRNA. Translation: AAC50560.1 .
AJ537553 mRNA. Translation: CAD61184.1 .
AK313199 mRNA. Translation: BAG36015.1 .
AC011930 Genomic DNA. No translation available.
AC090231 Genomic DNA. No translation available.
AC091137 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66515.1 .
BC074787 mRNA. Translation: AAH74787.1 .
CCDSi CCDS11997.1.
RefSeqi NP_006557.2. NM_006566.2.
XP_005266699.1. XM_005266642.1.
XP_006722436.1. XM_006722373.1.
UniGenei Hs.660130.

3D structure databases

ProteinModelPortali Q15762.
SMRi Q15762. Positions 24-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115908. 5 interactions.
IntActi Q15762. 2 interactions.
STRINGi 9606.ENSP00000280200.

PTM databases

PhosphoSitei Q15762.

Polymorphism databases

DMDMi 317373338.

Proteomic databases

PaxDbi Q15762.
PRIDEi Q15762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280200 ; ENSP00000280200 ; ENSG00000150637 .
ENST00000582621 ; ENSP00000461947 ; ENSG00000150637 .
GeneIDi 10666.
KEGGi hsa:10666.
UCSCi uc002lkm.4. human.

Organism-specific databases

CTDi 10666.
GeneCardsi GC18M067528.
H-InvDB HIX0039717.
HGNCi HGNC:16961. CD226.
HPAi HPA015715.
MIMi 605397. gene.
neXtProti NX_Q15762.
PharmGKBi PA134911130.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41580.
GeneTreei ENSGT00500000044993.
HOGENOMi HOG000059567.
HOVERGENi HBG050849.
InParanoidi Q15762.
KOi K06567.
OMAi EDIYVNY.
PhylomeDBi Q15762.
TreeFami TF336260.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikii CD226.
GenomeRNAii 10666.
NextBioi 40559.
PROi Q15762.
SOURCEi Search...

Gene expression databases

Bgeei Q15762.
CleanExi HS_CD226.
ExpressionAtlasi Q15762. baseline and differential.
Genevestigatori Q15762.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes."
    Shibuya A., Campbell D., Hannum C., Yssel H., Franz-Bacon K., McClanahan T., Kitamura T., Nicholl J., Sutherland G.R., Lanier L.L., Phillips J.H.
    Immunity 4:573-581(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-39; 54-72; 204-221 AND 285-294, FUNCTION, PHOSPHORYLATION, GLYCOSYLATION, TISSUE SPECIFICITY, VARIANT GLY-307.
  2. "Receptor involved in the NK cell triggering."
    Biassoni R.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-307.
    Tissue: Natural killer cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-307.
    Tissue: Brain.
  7. "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)."
    Tahara-Hanaoka S., Shibuya K., Onoda Y., Zhang H., Yamazaki S., Miyamoto A., Honda S., Lanier L.L., Shibuya A.
    Int. Immunol. 16:533-538(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PVR AND PVRL2.
  8. "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."
    Pende D., Bottino C., Castriconi R., Cantoni C., Marcenaro S., Rivera P., Spaggiari G.M., Dondero A., Carnemolla B., Reymond N., Mingari M.C., Lopez M., Moretta L., Moretta A.
    Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PVR AND PVRL2.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-322, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-322, VARIANT [LARGE SCALE ANALYSIS] GLY-307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCD226_HUMAN
AccessioniPrimary (citable) accession number: Q15762
Secondary accession number(s): B2R818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3