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Q15762

- CD226_HUMAN

UniProt

Q15762 - CD226_HUMAN

Protein

CD226 antigen

Gene

CD226

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.1 Publication

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. integrin binding Source: BHF-UCL
    3. protein binding Source: IntAct
    4. protein kinase binding Source: BHF-UCL

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. cell recognition Source: BHF-UCL
    3. cytokine production Source: Ensembl
    4. positive regulation of Fc receptor mediated stimulatory signaling pathway Source: BHF-UCL
    5. positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
    6. positive regulation of mast cell activation Source: BHF-UCL
    7. positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
    8. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
    9. regulation of immune response Source: Reactome
    10. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD226 antigen
    Alternative name(s):
    DNAX accessory molecule 1
    Short name:
    DNAM-1
    CD_antigen: CD226
    Gene namesi
    Name:CD226
    Synonyms:DNAM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:16961. CD226.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. external side of plasma membrane Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. membrane raft Source: BHF-UCL
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134911130.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 336318CD226 antigenPRO_0000014665Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi37 ↔ 108PROSITE-ProRule annotation
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 222PROSITE-ProRule annotation
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Modified residuei322 – 3221Phosphotyrosine3 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ15762.
    PRIDEiQ15762.

    PTM databases

    PhosphoSiteiQ15762.

    Expressioni

    Tissue specificityi

    Expressed by peripheral blood T-lymphocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ15762.
    BgeeiQ15762.
    CleanExiHS_CD226.
    GenevestigatoriQ15762.

    Organism-specific databases

    HPAiHPA015715.

    Interactioni

    Subunit structurei

    Interacts with PVR and PVRL2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PVRL2Q926922EBI-4314442,EBI-718419

    Protein-protein interaction databases

    BioGridi115908. 5 interactions.
    IntActiQ15762. 2 interactions.
    STRINGi9606.ENSP00000280200.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15762.
    SMRiQ15762. Positions 24-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 254236ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini276 – 33661CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 126108Ig-like C2-type 1Add
    BLAST
    Domaini135 – 239105Ig-like C2-type 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi277 – 2848Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41580.
    HOGENOMiHOG000059567.
    HOVERGENiHBG050849.
    InParanoidiQ15762.
    KOiK06567.
    OMAiEDIYVNY.
    PhylomeDBiQ15762.
    TreeFamiTF336260.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q15762-1 [UniParc]FASTAAdd to Basket

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    MDYPTLLLAL LHVYRALCEE VLWHTSVPFA ENMSLECVYP SMGILTQVEW    50
    FKIGTQQDSI AIFSPTHGMV IRKPYAERVY FLNSTMASNN MTLFFRNASE 100
    DDVGYYSCSL YTYPQGTWQK VIQVVQSDSF EAAVPSNSHI VSEPGKNVTL 150
    TCQPQMTWPV QAVRWEKIQP RQIDLLTYCN LVHGRNFTSK FPRQIVSNCS 200
    HGRWSVIVIP DVTVSDSGLY RCYLQASAGE NETFVMRLTV AEGKTDNQYT 250
    LFVAGGTVLL LLFVISITTI IVIFLNRRRR RERRDLFTES WDTQKAPNNY 300
    RSPISTSQPT NQSMDDTRED IYVNYPTFSR RPKTRV 336
    Length:336
    Mass (Da):38,614
    Last modified:January 11, 2011 - v2
    Checksum:i5379182CC4695097
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti307 – 3071S → G.4 Publications
    Corresponds to variant rs763361 [ dbSNP | Ensembl ].
    VAR_018632

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56102 mRNA. Translation: AAC50560.1.
    AJ537553 mRNA. Translation: CAD61184.1.
    AK313199 mRNA. Translation: BAG36015.1.
    AC011930 Genomic DNA. No translation available.
    AC090231 Genomic DNA. No translation available.
    AC091137 Genomic DNA. No translation available.
    CH471117 Genomic DNA. Translation: EAW66515.1.
    BC074787 mRNA. Translation: AAH74787.1.
    CCDSiCCDS11997.1.
    RefSeqiNP_006557.2. NM_006566.2.
    XP_005266699.1. XM_005266642.1.
    XP_006722436.1. XM_006722373.1.
    UniGeneiHs.660130.

    Genome annotation databases

    EnsembliENST00000280200; ENSP00000280200; ENSG00000150637.
    ENST00000582621; ENSP00000461947; ENSG00000150637.
    GeneIDi10666.
    KEGGihsa:10666.
    UCSCiuc002lkm.4. human.

    Polymorphism databases

    DMDMi317373338.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56102 mRNA. Translation: AAC50560.1 .
    AJ537553 mRNA. Translation: CAD61184.1 .
    AK313199 mRNA. Translation: BAG36015.1 .
    AC011930 Genomic DNA. No translation available.
    AC090231 Genomic DNA. No translation available.
    AC091137 Genomic DNA. No translation available.
    CH471117 Genomic DNA. Translation: EAW66515.1 .
    BC074787 mRNA. Translation: AAH74787.1 .
    CCDSi CCDS11997.1.
    RefSeqi NP_006557.2. NM_006566.2.
    XP_005266699.1. XM_005266642.1.
    XP_006722436.1. XM_006722373.1.
    UniGenei Hs.660130.

    3D structure databases

    ProteinModelPortali Q15762.
    SMRi Q15762. Positions 24-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115908. 5 interactions.
    IntActi Q15762. 2 interactions.
    STRINGi 9606.ENSP00000280200.

    PTM databases

    PhosphoSitei Q15762.

    Polymorphism databases

    DMDMi 317373338.

    Proteomic databases

    PaxDbi Q15762.
    PRIDEi Q15762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280200 ; ENSP00000280200 ; ENSG00000150637 .
    ENST00000582621 ; ENSP00000461947 ; ENSG00000150637 .
    GeneIDi 10666.
    KEGGi hsa:10666.
    UCSCi uc002lkm.4. human.

    Organism-specific databases

    CTDi 10666.
    GeneCardsi GC18M067528.
    H-InvDB HIX0039717.
    HGNCi HGNC:16961. CD226.
    HPAi HPA015715.
    MIMi 605397. gene.
    neXtProti NX_Q15762.
    PharmGKBi PA134911130.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41580.
    HOGENOMi HOG000059567.
    HOVERGENi HBG050849.
    InParanoidi Q15762.
    KOi K06567.
    OMAi EDIYVNY.
    PhylomeDBi Q15762.
    TreeFami TF336260.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    GeneWikii CD226.
    GenomeRNAii 10666.
    NextBioi 40559.
    PROi Q15762.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15762.
    Bgeei Q15762.
    CleanExi HS_CD226.
    Genevestigatori Q15762.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes."
      Shibuya A., Campbell D., Hannum C., Yssel H., Franz-Bacon K., McClanahan T., Kitamura T., Nicholl J., Sutherland G.R., Lanier L.L., Phillips J.H.
      Immunity 4:573-581(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-39; 54-72; 204-221 AND 285-294, FUNCTION, PHOSPHORYLATION, GLYCOSYLATION, TISSUE SPECIFICITY, VARIANT GLY-307.
    2. "Receptor involved in the NK cell triggering."
      Biassoni R.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-307.
      Tissue: Natural killer cell.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-307.
      Tissue: Brain.
    7. "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)."
      Tahara-Hanaoka S., Shibuya K., Onoda Y., Zhang H., Yamazaki S., Miyamoto A., Honda S., Lanier L.L., Shibuya A.
      Int. Immunol. 16:533-538(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PVR AND PVRL2.
    8. "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."
      Pende D., Bottino C., Castriconi R., Cantoni C., Marcenaro S., Rivera P., Spaggiari G.M., Dondero A., Carnemolla B., Reymond N., Mingari M.C., Lopez M., Moretta L., Moretta A.
      Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PVR AND PVRL2.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-322, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-322, VARIANT [LARGE SCALE ANALYSIS] GLY-307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCD226_HUMAN
    AccessioniPrimary (citable) accession number: Q15762
    Secondary accession number(s): B2R818
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3