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Q15761

- NPY5R_HUMAN

UniProt

Q15761 - NPY5R_HUMAN

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Protein
Neuropeptide Y receptor type 5
Gene
NPY5R, NPYR5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

GO - Molecular functioni

  1. neuropeptide Y receptor activity Source: ProtInc
  2. pancreatic polypeptide receptor activity Source: Ensembl
  3. peptide YY receptor activity Source: Ensembl

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. cardiac left ventricle morphogenesis Source: BHF-UCL
  3. eating behavior Source: Ensembl
  4. generation of ovulation cycle rhythm Source: Ensembl
  5. negative regulation of apoptotic process Source: Ensembl
  6. negative regulation of glutamate secretion Source: Ensembl
  7. negative regulation of synaptic transmission, GABAergic Source: Ensembl
  8. neuropeptide signaling pathway Source: GOC
  9. outflow tract morphogenesis Source: BHF-UCL
  10. positive regulation of acute inflammatory response Source: Ensembl
  11. positive regulation of smooth muscle cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 5
Short name:
NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name:
NPYY5-R
Short name:
Y5 receptor
Gene namesi
Name:NPY5R
Synonyms:NPYR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7958. NPY5R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Extracellular Reviewed prediction
Add
BLAST
Transmembranei43 – 6321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini64 – 7714Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini99 – 11719Extracellular Reviewed prediction
Add
BLAST
Transmembranei118 – 13821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini139 – 15618Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini178 – 20831Extracellular Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini230 – 369140Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei370 – 39021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini391 – 40717Extracellular Reviewed prediction
Add
BLAST
Transmembranei408 – 42821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini429 – 44517Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Neuropeptide Y receptor type 5
PRO_0000069939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi17 – 171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi114 ↔ 198 By similarity
Lipidationi442 – 4421S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ15761.
PRIDEiQ15761.

Expressioni

Tissue specificityi

Brain; hypothalamus.

Gene expression databases

BgeeiQ15761.
CleanExiHS_NPY5R.
GenevestigatoriQ15761.

Organism-specific databases

HPAiHPA013790.

Interactioni

Protein-protein interaction databases

BioGridi110949. 2 interactions.
IntActiQ15761. 3 interactions.
STRINGi9606.ENSP00000339377.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HE6model-@1-445[»]
ProteinModelPortaliQ15761.
SMRiQ15761. Positions 40-238.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256822.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiQ15761.
KOiK04207.
OMAiIKADLMS.
OrthoDBiEOG7S7SDH.
PhylomeDBiQ15761.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15761-1 [UniParc]FASTAAdd to Basket

« Hide

MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF    50
VSLLGFMGNL LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT 100
SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN 150
LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFGSA LLSSRYLCVE 200
SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENRLE 250
ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP 300
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL 350
RVKRSVTRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN 400
RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLVSLI HCLHM 445
Length:445
Mass (Da):50,727
Last modified:November 25, 2008 - v2
Checksum:iA2B0F3169DBA66BE
GO

Sequence cautioni

The sequence AAC50623.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66275 mRNA. Translation: AAC50741.1.
U56079 mRNA. Translation: AAC50623.1. Different initiation.
U94320 mRNA. Translation: AAC51295.1.
AY322538 Genomic DNA. Translation: AAP84351.1.
AC079238 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04839.1.
BC042416 mRNA. Translation: AAH42416.1.
CCDSiCCDS3804.1.
RefSeqiNP_006165.1. NM_006174.2.
XP_005263093.1. XM_005263036.1.
XP_005263094.1. XM_005263037.1.
XP_005263095.1. XM_005263038.1.
XP_005263096.1. XM_005263039.1.
UniGeneiHs.519058.
Hs.598503.

Genome annotation databases

EnsembliENST00000338566; ENSP00000339377; ENSG00000164129.
ENST00000506953; ENSP00000423474; ENSG00000164129.
ENST00000515560; ENSP00000423917; ENSG00000164129.
GeneIDi4889.
KEGGihsa:4889.
UCSCiuc003iqn.3. human.

Polymorphism databases

DMDMi215274093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66275 mRNA. Translation: AAC50741.1 .
U56079 mRNA. Translation: AAC50623.1 . Different initiation.
U94320 mRNA. Translation: AAC51295.1 .
AY322538 Genomic DNA. Translation: AAP84351.1 .
AC079238 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04839.1 .
BC042416 mRNA. Translation: AAH42416.1 .
CCDSi CCDS3804.1.
RefSeqi NP_006165.1. NM_006174.2.
XP_005263093.1. XM_005263036.1.
XP_005263094.1. XM_005263037.1.
XP_005263095.1. XM_005263038.1.
XP_005263096.1. XM_005263039.1.
UniGenei Hs.519058.
Hs.598503.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HE6 model - @ 1-445 [» ]
ProteinModelPortali Q15761.
SMRi Q15761. Positions 40-238.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110949. 2 interactions.
IntActi Q15761. 3 interactions.
STRINGi 9606.ENSP00000339377.

Chemistry

BindingDBi Q15761.
ChEMBLi CHEMBL4561.
GuidetoPHARMACOLOGYi 308.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 215274093.

Proteomic databases

PaxDbi Q15761.
PRIDEi Q15761.

Protocols and materials databases

DNASUi 4889.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338566 ; ENSP00000339377 ; ENSG00000164129 .
ENST00000506953 ; ENSP00000423474 ; ENSG00000164129 .
ENST00000515560 ; ENSP00000423917 ; ENSG00000164129 .
GeneIDi 4889.
KEGGi hsa:4889.
UCSCi uc003iqn.3. human.

Organism-specific databases

CTDi 4889.
GeneCardsi GC04P164265.
HGNCi HGNC:7958. NPY5R.
HPAi HPA013790.
MIMi 602001. gene.
neXtProti NX_Q15761.
PharmGKBi PA31742.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256822.
HOGENOMi HOG000294210.
HOVERGENi HBG052662.
InParanoidi Q15761.
KOi K04207.
OMAi IKADLMS.
OrthoDBi EOG7S7SDH.
PhylomeDBi Q15761.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Neuropeptide_Y_receptor_Y5.
GenomeRNAii 4889.
NextBioi 18821.
PROi Q15761.
SOURCEi Search...

Gene expression databases

Bgeei Q15761.
CleanExi HS_NPY5R.
Genevestigatori Q15761.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  3. "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation."
    Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J.
    Genomics 41:315-319(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation of complete coding sequence for neuropeptide Y receptor Y5 (NPY5R)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNPY5R_HUMAN
AccessioniPrimary (citable) accession number: Q15761
Secondary accession number(s): Q6GTR7, Q92916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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