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Protein

Neuropeptide Y receptor type 5

Gene

NPY5R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

GO - Molecular functioni

  1. neuropeptide Y receptor activity Source: ProtInc
  2. pancreatic polypeptide receptor activity Source: Ensembl
  3. peptide YY receptor activity Source: Ensembl

GO - Biological processi

  1. cardiac left ventricle morphogenesis Source: BHF-UCL
  2. eating behavior Source: Ensembl
  3. generation of ovulation cycle rhythm Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. negative regulation of apoptotic process Source: Ensembl
  6. negative regulation of glutamate secretion Source: Ensembl
  7. negative regulation of synaptic transmission, GABAergic Source: Ensembl
  8. neuropeptide signaling pathway Source: GOC
  9. outflow tract morphogenesis Source: BHF-UCL
  10. positive regulation of acute inflammatory response Source: Ensembl
  11. positive regulation of smooth muscle cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 5
Short name:
NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name:
NPYY5-R
Short name:
Y5 receptor
Gene namesi
Name:NPY5R
Synonyms:NPYR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7958. NPY5R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7714CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini99 – 11719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 15618CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini230 – 369140CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei370 – 39021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini391 – 40717ExtracellularSequence AnalysisAdd
BLAST
Transmembranei408 – 42821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini429 – 44517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Neuropeptide Y receptor type 5PRO_0000069939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 198PROSITE-ProRule annotation
Lipidationi442 – 4421S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ15761.
PRIDEiQ15761.

Expressioni

Tissue specificityi

Brain; hypothalamus.

Gene expression databases

BgeeiQ15761.
CleanExiHS_NPY5R.
GenevestigatoriQ15761.

Organism-specific databases

HPAiHPA013790.

Interactioni

Protein-protein interaction databases

BioGridi110949. 2 interactions.
IntActiQ15761. 3 interactions.
STRINGi9606.ENSP00000339377.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HE6model-@1-445[»]
ProteinModelPortaliQ15761.
SMRiQ15761. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256822.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiQ15761.
KOiK04207.
OMAiSDVHEMR.
OrthoDBiEOG7S7SDH.
PhylomeDBiQ15761.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15761-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF
60 70 80 90 100
VSLLGFMGNL LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT
110 120 130 140 150
SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN
160 170 180 190 200
LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFGSA LLSSRYLCVE
210 220 230 240 250
SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENRLE
260 270 280 290 300
ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP
310 320 330 340 350
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL
360 370 380 390 400
RVKRSVTRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN
410 420 430 440
RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLVSLI HCLHM
Length:445
Mass (Da):50,727
Last modified:November 25, 2008 - v2
Checksum:iA2B0F3169DBA66BE
GO

Sequence cautioni

The sequence AAC50623.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66275 mRNA. Translation: AAC50741.1.
U56079 mRNA. Translation: AAC50623.1. Different initiation.
U94320 mRNA. Translation: AAC51295.1.
AY322538 Genomic DNA. Translation: AAP84351.1.
AC079238 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04839.1.
BC042416 mRNA. Translation: AAH42416.1.
CCDSiCCDS3804.1.
RefSeqiNP_006165.1. NM_006174.2.
XP_005263093.1. XM_005263036.1.
XP_005263094.1. XM_005263037.1.
XP_005263095.1. XM_005263038.1.
XP_005263096.1. XM_005263039.1.
UniGeneiHs.519058.
Hs.598503.

Genome annotation databases

EnsembliENST00000338566; ENSP00000339377; ENSG00000164129.
ENST00000506953; ENSP00000423474; ENSG00000164129.
ENST00000515560; ENSP00000423917; ENSG00000164129.
GeneIDi4889.
KEGGihsa:4889.
UCSCiuc003iqn.3. human.

Polymorphism databases

DMDMi215274093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66275 mRNA. Translation: AAC50741.1.
U56079 mRNA. Translation: AAC50623.1. Different initiation.
U94320 mRNA. Translation: AAC51295.1.
AY322538 Genomic DNA. Translation: AAP84351.1.
AC079238 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04839.1.
BC042416 mRNA. Translation: AAH42416.1.
CCDSiCCDS3804.1.
RefSeqiNP_006165.1. NM_006174.2.
XP_005263093.1. XM_005263036.1.
XP_005263094.1. XM_005263037.1.
XP_005263095.1. XM_005263038.1.
XP_005263096.1. XM_005263039.1.
UniGeneiHs.519058.
Hs.598503.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HE6model-@1-445[»]
ProteinModelPortaliQ15761.
SMRiQ15761. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110949. 2 interactions.
IntActiQ15761. 3 interactions.
STRINGi9606.ENSP00000339377.

Chemistry

BindingDBiQ15761.
ChEMBLiCHEMBL4561.
GuidetoPHARMACOLOGYi308.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi215274093.

Proteomic databases

PaxDbiQ15761.
PRIDEiQ15761.

Protocols and materials databases

DNASUi4889.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338566; ENSP00000339377; ENSG00000164129.
ENST00000506953; ENSP00000423474; ENSG00000164129.
ENST00000515560; ENSP00000423917; ENSG00000164129.
GeneIDi4889.
KEGGihsa:4889.
UCSCiuc003iqn.3. human.

Organism-specific databases

CTDi4889.
GeneCardsiGC04P164265.
HGNCiHGNC:7958. NPY5R.
HPAiHPA013790.
MIMi602001. gene.
neXtProtiNX_Q15761.
PharmGKBiPA31742.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256822.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiQ15761.
KOiK04207.
OMAiSDVHEMR.
OrthoDBiEOG7S7SDH.
PhylomeDBiQ15761.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiNeuropeptide_Y_receptor_Y5.
GenomeRNAii4889.
NextBioi18821.
PROiQ15761.
SOURCEiSearch...

Gene expression databases

BgeeiQ15761.
CleanExiHS_NPY5R.
GenevestigatoriQ15761.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  3. "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation."
    Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J.
    Genomics 41:315-319(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation of complete coding sequence for neuropeptide Y receptor Y5 (NPY5R)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNPY5R_HUMAN
AccessioniPrimary (citable) accession number: Q15761
Secondary accession number(s): Q6GTR7, Q92916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: January 7, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.