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Q15761

- NPY5R_HUMAN

UniProt

Q15761 - NPY5R_HUMAN

Protein

Neuropeptide Y receptor type 5

Gene

NPY5R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

    GO - Molecular functioni

    1. neuropeptide Y receptor activity Source: ProtInc
    2. pancreatic polypeptide receptor activity Source: Ensembl
    3. peptide YY receptor activity Source: Ensembl

    GO - Biological processi

    1. cardiac left ventricle morphogenesis Source: BHF-UCL
    2. eating behavior Source: Ensembl
    3. generation of ovulation cycle rhythm Source: Ensembl
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. negative regulation of apoptotic process Source: Ensembl
    6. negative regulation of glutamate secretion Source: Ensembl
    7. negative regulation of synaptic transmission, GABAergic Source: Ensembl
    8. neuropeptide signaling pathway Source: GOC
    9. outflow tract morphogenesis Source: BHF-UCL
    10. positive regulation of acute inflammatory response Source: Ensembl
    11. positive regulation of smooth muscle cell proliferation Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide Y receptor type 5
    Short name:
    NPY5-R
    Alternative name(s):
    NPY-Y5 receptor
    Short name:
    NPYY5-R
    Short name:
    Y5 receptor
    Gene namesi
    Name:NPY5R
    Synonyms:NPYR5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7958. NPY5R.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31742.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Neuropeptide Y receptor type 5PRO_0000069939Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 198PROSITE-ProRule annotation
    Lipidationi442 – 4421S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ15761.
    PRIDEiQ15761.

    Expressioni

    Tissue specificityi

    Brain; hypothalamus.

    Gene expression databases

    BgeeiQ15761.
    CleanExiHS_NPY5R.
    GenevestigatoriQ15761.

    Organism-specific databases

    HPAiHPA013790.

    Interactioni

    Protein-protein interaction databases

    BioGridi110949. 2 interactions.
    IntActiQ15761. 3 interactions.
    STRINGi9606.ENSP00000339377.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HE6model-@1-445[»]
    ProteinModelPortaliQ15761.
    SMRiQ15761. Positions 40-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 369140CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini391 – 40717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini429 – 44517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256822.
    HOGENOMiHOG000294210.
    HOVERGENiHBG052662.
    InParanoidiQ15761.
    KOiK04207.
    OMAiIKADLMS.
    OrthoDBiEOG7S7SDH.
    PhylomeDBiQ15761.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000393. NPY5_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01016. NRPEPTIDEY5R.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF    50
    VSLLGFMGNL LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT 100
    SVLLDQWMFG KVMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN 150
    LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELQETFGSA LLSSRYLCVE 200
    SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSNKENRLE 250
    ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP 300
    ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL 350
    RVKRSVTRIK KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN 400
    RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLVSLI HCLHM 445
    Length:445
    Mass (Da):50,727
    Last modified:November 25, 2008 - v2
    Checksum:iA2B0F3169DBA66BE
    GO

    Sequence cautioni

    The sequence AAC50623.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66275 mRNA. Translation: AAC50741.1.
    U56079 mRNA. Translation: AAC50623.1. Different initiation.
    U94320 mRNA. Translation: AAC51295.1.
    AY322538 Genomic DNA. Translation: AAP84351.1.
    AC079238 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX04839.1.
    BC042416 mRNA. Translation: AAH42416.1.
    CCDSiCCDS3804.1.
    RefSeqiNP_006165.1. NM_006174.2.
    XP_005263093.1. XM_005263036.1.
    XP_005263094.1. XM_005263037.1.
    XP_005263095.1. XM_005263038.1.
    XP_005263096.1. XM_005263039.1.
    UniGeneiHs.519058.
    Hs.598503.

    Genome annotation databases

    EnsembliENST00000338566; ENSP00000339377; ENSG00000164129.
    ENST00000506953; ENSP00000423474; ENSG00000164129.
    ENST00000515560; ENSP00000423917; ENSG00000164129.
    GeneIDi4889.
    KEGGihsa:4889.
    UCSCiuc003iqn.3. human.

    Polymorphism databases

    DMDMi215274093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66275 mRNA. Translation: AAC50741.1 .
    U56079 mRNA. Translation: AAC50623.1 . Different initiation.
    U94320 mRNA. Translation: AAC51295.1 .
    AY322538 Genomic DNA. Translation: AAP84351.1 .
    AC079238 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX04839.1 .
    BC042416 mRNA. Translation: AAH42416.1 .
    CCDSi CCDS3804.1.
    RefSeqi NP_006165.1. NM_006174.2.
    XP_005263093.1. XM_005263036.1.
    XP_005263094.1. XM_005263037.1.
    XP_005263095.1. XM_005263038.1.
    XP_005263096.1. XM_005263039.1.
    UniGenei Hs.519058.
    Hs.598503.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HE6 model - @ 1-445 [» ]
    ProteinModelPortali Q15761.
    SMRi Q15761. Positions 40-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110949. 2 interactions.
    IntActi Q15761. 3 interactions.
    STRINGi 9606.ENSP00000339377.

    Chemistry

    BindingDBi Q15761.
    ChEMBLi CHEMBL4561.
    GuidetoPHARMACOLOGYi 308.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 215274093.

    Proteomic databases

    PaxDbi Q15761.
    PRIDEi Q15761.

    Protocols and materials databases

    DNASUi 4889.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338566 ; ENSP00000339377 ; ENSG00000164129 .
    ENST00000506953 ; ENSP00000423474 ; ENSG00000164129 .
    ENST00000515560 ; ENSP00000423917 ; ENSG00000164129 .
    GeneIDi 4889.
    KEGGi hsa:4889.
    UCSCi uc003iqn.3. human.

    Organism-specific databases

    CTDi 4889.
    GeneCardsi GC04P164265.
    HGNCi HGNC:7958. NPY5R.
    HPAi HPA013790.
    MIMi 602001. gene.
    neXtProti NX_Q15761.
    PharmGKBi PA31742.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256822.
    HOGENOMi HOG000294210.
    HOVERGENi HBG052662.
    InParanoidi Q15761.
    KOi K04207.
    OMAi IKADLMS.
    OrthoDBi EOG7S7SDH.
    PhylomeDBi Q15761.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Neuropeptide_Y_receptor_Y5.
    GenomeRNAii 4889.
    NextBioi 18821.
    PROi Q15761.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15761.
    CleanExi HS_NPY5R.
    Genevestigatori Q15761.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000393. NPY5_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01016. NRPEPTIDEY5R.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    3. "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation."
      Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J.
      Genomics 41:315-319(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Isolation of complete coding sequence for neuropeptide Y receptor Y5 (NPY5R)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNPY5R_HUMAN
    AccessioniPrimary (citable) accession number: Q15761
    Secondary accession number(s): Q6GTR7, Q92916
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3