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Q15761 (NPY5R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide Y receptor type 5

Short name=NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name=NPYY5-R
Short name=Y5 receptor
Gene names
Name:NPY5R
Synonyms:NPYR5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Brain; hypothalamus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAC50623.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

cardiac left ventricle morphogenesis

Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL

eating behavior

Inferred from electronic annotation. Source: Ensembl

generation of ovulation cycle rhythm

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Traceable author statement Ref.1. Source: GOC

outflow tract morphogenesis

Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL

positive regulation of acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionneuropeptide Y receptor activity

Traceable author statement Ref.1. Source: ProtInc

pancreatic polypeptide receptor activity

Inferred from electronic annotation. Source: Ensembl

peptide YY receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Neuropeptide Y receptor type 5
PRO_0000069939

Regions

Topological domain1 – 4242Extracellular Potential
Transmembrane43 – 6321Helical; Name=1; Potential
Topological domain64 – 7714Cytoplasmic Potential
Transmembrane78 – 9821Helical; Name=2; Potential
Topological domain99 – 11719Extracellular Potential
Transmembrane118 – 13821Helical; Name=3; Potential
Topological domain139 – 15618Cytoplasmic Potential
Transmembrane157 – 17721Helical; Name=4; Potential
Topological domain178 – 20831Extracellular Potential
Transmembrane209 – 22921Helical; Name=5; Potential
Topological domain230 – 369140Cytoplasmic Potential
Transmembrane370 – 39021Helical; Name=6; Potential
Topological domain391 – 40717Extracellular Potential
Transmembrane408 – 42821Helical; Name=7; Potential
Topological domain429 – 44517Cytoplasmic Potential

Amino acid modifications

Lipidation4421S-palmitoyl cysteine Potential
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 198 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q15761 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: A2B0F3169DBA66BE

FASTA44550,727
        10         20         30         40         50         60 
MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL 

        70         80         90        100        110        120 
LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL 

       130        140        150        160        170        180 
QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL 

       190        200        210        220        230        240 
VELQETFGSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC 

       250        260        270        280        290        300 
GLSNKENRLE ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP 

       310        320        330        340        350        360 
ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL RVKRSVTRIK 

       370        380        390        400        410        420 
KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL 

       430        440 
NPILYGFLNN GIKADLVSLI HCLHM 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior."
Hu Y., Bloomquist B.T., Cornfield L.J., Decarr L.B., Flores-Riveros J.R., Friedman L., Jiang P., Lewis-Higgins L., Sadlowski Y., Schaefer J., Velazquez N., McCaleb M.L.
J. Biol. Chem. 271:26315-26319(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A receptor subtype involved in neuropeptide-Y-induced food intake."
Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L.
Nature 382:168-171(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[3]"Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation."
Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J.
Genomics 41:315-319(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Isolation of complete coding sequence for neuropeptide Y receptor Y5 (NPY5R)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66275 mRNA. Translation: AAC50741.1.
U56079 mRNA. Translation: AAC50623.1. Different initiation.
U94320 mRNA. Translation: AAC51295.1.
AY322538 Genomic DNA. Translation: AAP84351.1.
AC079238 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04839.1.
BC042416 mRNA. Translation: AAH42416.1.
CCDSCCDS3804.1.
RefSeqNP_006165.1. NM_006174.2.
XP_005263093.1. XM_005263036.1.
XP_005263094.1. XM_005263037.1.
XP_005263095.1. XM_005263038.1.
XP_005263096.1. XM_005263039.1.
UniGeneHs.519058.
Hs.598503.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HE6model-@1-445[»]
ProteinModelPortalQ15761.
SMRQ15761. Positions 40-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110949. 2 interactions.
IntActQ15761. 3 interactions.
STRING9606.ENSP00000339377.

Chemistry

BindingDBQ15761.
ChEMBLCHEMBL4561.
GuidetoPHARMACOLOGY308.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM215274093.

Proteomic databases

PaxDbQ15761.
PRIDEQ15761.

Protocols and materials databases

DNASU4889.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338566; ENSP00000339377; ENSG00000164129.
ENST00000506953; ENSP00000423474; ENSG00000164129.
ENST00000515560; ENSP00000423917; ENSG00000164129.
GeneID4889.
KEGGhsa:4889.
UCSCuc003iqn.3. human.

Organism-specific databases

CTD4889.
GeneCardsGC04P164265.
HGNCHGNC:7958. NPY5R.
HPAHPA013790.
MIM602001. gene.
neXtProtNX_Q15761.
PharmGKBPA31742.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256822.
HOGENOMHOG000294210.
HOVERGENHBG052662.
InParanoidQ15761.
KOK04207.
OMAIKADLMS.
OrthoDBEOG7S7SDH.
PhylomeDBQ15761.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ15761.
CleanExHS_NPY5R.
GenevestigatorQ15761.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuropeptide_Y_receptor_Y5.
GenomeRNAi4889.
NextBio18821.
PROQ15761.
SOURCESearch...

Entry information

Entry nameNPY5R_HUMAN
AccessionPrimary (citable) accession number: Q15761
Secondary accession number(s): Q6GTR7, Q92916
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries