Q15761 (NPY5R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide Y receptor type 5
Short name=NPY5-R

Alternative name(s):
NPY-Y5 receptor
Short name=NPYY5-R
Short name=Y5 receptor

Gene names

Name:	NPY5R
Synonyms:	NPYR5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Brain; hypothalamus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAC50623.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac left ventricle morphogenesis Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL eating behavior Inferred from electronic annotation. Source: Compara generation of ovulation cycle rhythm Inferred from electronic annotation. Source: Compara negative regulation of glutamate secretion Inferred from electronic annotation. Source: Compara negative regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL positive regulation of acute inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	neuropeptide Y receptor activity Traceable author statement Ref.1. Source: ProtInc pancreatic polypeptide receptor activity Inferred from electronic annotation. Source: Compara peptide YY receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Neuropeptide Y receptor type 5		PRO_0000069939
Regions
	Topological domain	1 – 42	42	Extracellular Potential
	Transmembrane	43 – 63	21	Helical; Name=1; Potential
	Topological domain	64 – 77	14	Cytoplasmic Potential
	Transmembrane	78 – 98	21	Helical; Name=2; Potential
	Topological domain	99 – 117	19	Extracellular Potential
	Transmembrane	118 – 138	21	Helical; Name=3; Potential
	Topological domain	139 – 156	18	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Helical; Name=4; Potential
	Topological domain	178 – 208	31	Extracellular Potential
	Transmembrane	209 – 229	21	Helical; Name=5; Potential
	Topological domain	230 – 369	140	Cytoplasmic Potential
	Transmembrane	370 – 390	21	Helical; Name=6; Potential
	Topological domain	391 – 407	17	Extracellular Potential
	Transmembrane	408 – 428	21	Helical; Name=7; Potential
	Topological domain	429 – 445	17	Cytoplasmic Potential
Amino acid modifications
	Lipidation	442	1	S-palmitoyl cysteine Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Disulfide bond	114 ↔ 198		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q15761 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: A2B0F3169DBA66BE	FASTA	445	50,727
	10 20 30 40 50 60 MDLELDEYYN KTLATENNTA ATRNSDFPVW DDYKSSVDDL QYFLIGLYTF VSLLGFMGNL 70 80 90 100 110 120 LILMALMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT SVLLDQWMFG KVMCHIMPFL 130 140 150 160 170 180 QCVSVLVSTL ILISIAIVRY HMIKHPISNN LTANHGYFLI ATVWTLGFAI CSPLPVFHSL 190 200 210 220 230 240 VELQETFGSA LLSSRYLCVE SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC 250 260 270 280 290 300 GLSNKENRLE ENEMINLTLH PSKKSGPQVK LSGSHKWSYS FIKKHRRRYS KKTACVLPAP 310 320 330 340 350 360 ERPSQENHSR ILPENFGSVR SQLSSSSKFI PGVPTCFEIK PEENSDVHEL RVKRSVTRIK 370 380 390 400 410 420 KRSRSVFYRL TILILVFAVS WMPLHLFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL 430 440 NPILYGFLNN GIKADLVSLI HCLHM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior." Hu Y., Bloomquist B.T., Cornfield L.J., Decarr L.B., Flores-Riveros J.R., Friedman L., Jiang P., Lewis-Higgins L., Sadlowski Y., Schaefer J., Velazquez N., McCaleb M.L. J. Biol. Chem. 271:26315-26319(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A receptor subtype involved in neuropeptide-Y-induced food intake." Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L. Nature 382:168-171(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.
[3]	"Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation." Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J. Genomics 41:315-319(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Isolation of complete coding sequence for neuropeptide Y receptor Y5 (NPY5R)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U66275 mRNA. Translation: AAC50741.1.
U56079 mRNA. Translation: AAC50623.1. Different initiation.
U94320 mRNA. Translation: AAC51295.1.
AY322538 Genomic DNA. Translation: AAP84351.1.
AC079238 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04839.1.
BC042416 mRNA. Translation: AAH42416.1.

IPI

IPI00019491.

RefSeq

NP_006165.1. NM_006174.2.

UniGene

Hs.519058.
Hs.598503.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HE6	model	-	@	1-445	[»]

ProteinModelPortal

Q15761.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15761. 3 interactions.

STRING

9606.ENSP00000339377.

Protein family/group databases

GPCRDB

Search...

Polymorphism databases

DMDM

215274093.

Proteomic databases

PaxDb

Q15761.

PRIDE

Q15761.

Protocols and materials databases

DNASU

4889.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000338566; ENSP00000339377; ENSG00000164129.
ENST00000506953; ENSP00000423474; ENSG00000164129.
ENST00000515560; ENSP00000423917; ENSG00000164129.

GeneID

4889.

KEGG

hsa:4889.

UCSC

uc003iqn.3. human.

Organism-specific databases

CTD

4889.

GeneCards

GC04P164265.

HGNC

HGNC:7958. NPY5R.

HPA

HPA013790.

MIM

602001. gene.

neXtProt

NX_Q15761.

PharmGKB

PA31742.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG256822.

HOGENOM

HOG000294210.

HOVERGEN

HBG052662.

InParanoid

Q15761.

KO

K04207.

OMA

IKADLMS.

OrthoDB

EOG4Q2DFD.

PhylomeDB

Q15761.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

Q15761.

CleanEx

HS_NPY5R.

Genevestigator

Q15761.

GermOnline

ENSG00000164129. Homo sapiens.

Family and domain databases

InterPro

IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q15761.

ChEMBL

CHEMBL4561.

GenomeRNAi

4889.

NextBio

18821.

SOURCE

Search...

Entry information

Entry name

NPY5R_HUMAN

Accession

Primary (citable) accession number: Q15761
Secondary accession number(s): Q6GTR7, Q92916

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.