ID   GPR19_HUMAN             Reviewed;         415 AA.
AC   Q15760;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 2.
DT   24-JAN-2024, entry version 173.
DE   RecName: Full=Probable G-protein coupled receptor 19;
DE   AltName: Full=GPR-NGA;
GN   Name=GPR19;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-189.
RX   PubMed=8830667; DOI=10.1016/0014-5793(96)00901-5;
RA   O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M.,
RA   Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.;
RT   "A novel gene codes for a putative G protein-coupled receptor with an
RT   abundant expression in brain.";
RL   FEBS Lett. 394:325-329(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-189.
RA   Bonner T.I., Matsuda L.A.;
RT   "A G protein-coupled receptor expressed in NG108-15 and AtT-20 cells.";
RL   Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Abundant expression in the brain.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U64871; AAB49751.1; -; Genomic_DNA.
DR   EMBL; U55312; AAB00316.1; -; Genomic_DNA.
DR   EMBL; AC008115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS8652.1; -.
DR   PIR; S74237; S74237.
DR   RefSeq; NP_006134.1; NM_006143.2.
DR   RefSeq; XP_011518927.1; XM_011520625.2.
DR   RefSeq; XP_016874705.1; XM_017019216.1.
DR   AlphaFoldDB; Q15760; -.
DR   SMR; Q15760; -.
DR   BioGRID; 109101; 1.
DR   STRING; 9606.ENSP00000498976; -.
DR   ChEMBL; CHEMBL4523870; -.
DR   GuidetoPHARMACOLOGY; 90; -.
DR   GlyCosmos; Q15760; 2 sites, No reported glycans.
DR   GlyGen; Q15760; 2 sites.
DR   iPTMnet; Q15760; -.
DR   PhosphoSitePlus; Q15760; -.
DR   BioMuta; GPR19; -.
DR   DMDM; 322510031; -.
DR   MassIVE; Q15760; -.
DR   PaxDb; 9606-ENSP00000441832; -.
DR   PeptideAtlas; Q15760; -.
DR   ProteomicsDB; 60746; -.
DR   Antibodypedia; 2961; 192 antibodies from 30 providers.
DR   DNASU; 2842; -.
DR   Ensembl; ENST00000332427.6; ENSP00000333744.2; ENSG00000183150.8.
DR   Ensembl; ENST00000540510.1; ENSP00000441832.1; ENSG00000183150.8.
DR   Ensembl; ENST00000651487.1; ENSP00000498976.1; ENSG00000183150.8.
DR   GeneID; 2842; -.
DR   KEGG; hsa:2842; -.
DR   MANE-Select; ENST00000651487.1; ENSP00000498976.1; NM_006143.3; NP_006134.2.
DR   UCSC; uc001raq.2; human.
DR   AGR; HGNC:4473; -.
DR   CTD; 2842; -.
DR   DisGeNET; 2842; -.
DR   GeneCards; GPR19; -.
DR   HGNC; HGNC:4473; GPR19.
DR   HPA; ENSG00000183150; Tissue enhanced (brain, pituitary gland, testis).
DR   MIM; 602927; gene.
DR   neXtProt; NX_Q15760; -.
DR   OpenTargets; ENSG00000183150; -.
DR   PharmGKB; PA28861; -.
DR   VEuPathDB; HostDB:ENSG00000183150; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000160365; -.
DR   HOGENOM; CLU_009579_20_0_1; -.
DR   InParanoid; Q15760; -.
DR   OMA; QLWHPRE; -.
DR   OrthoDB; 2911431at2759; -.
DR   PhylomeDB; Q15760; -.
DR   TreeFam; TF331630; -.
DR   PathwayCommons; Q15760; -.
DR   SignaLink; Q15760; -.
DR   BioGRID-ORCS; 2842; 7 hits in 1140 CRISPR screens.
DR   ChiTaRS; GPR19; human.
DR   GeneWiki; GPR19; -.
DR   GenomeRNAi; 2842; -.
DR   Pharos; Q15760; Tdark.
DR   PRO; PR:Q15760; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q15760; Protein.
DR   Bgee; ENSG00000183150; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 118 other cell types or tissues.
DR   ExpressionAtlas; Q15760; baseline and differential.
DR   GO; GO:0005929; C:cilium; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd15008; 7tmA_GPR19; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR047829; GPR19_7tmA.
DR   PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24243:SF224; G-PROTEIN COUPLED RECEPTOR 19-RELATED; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q15760; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..415
FT                   /note="Probable G-protein coupled receptor 19"
FT                   /id="PRO_0000069538"
FT   TOPO_DOM        1..69
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..143
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..161
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..182
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..221
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        243..277
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..325
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..415
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        25
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        138..210
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         189
FT                   /note="V -> I (in dbSNP:rs4763862)"
FT                   /evidence="ECO:0000269|PubMed:8830667, ECO:0000269|Ref.2"
FT                   /id="VAR_024256"
SQ   SEQUENCE   415 AA;  47687 MW;  D5DF78C1BFA401FD CRC64;
     MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM SNQTDLHYVL
     KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP
     FVLLQFTTGR WTLGSATCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA
     KKMIAASWVF DAGFVTPVLF FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII
     LFYQKVIKYI WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP
     HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI
     TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK KLAWPINSNP PNTFV
//