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Protein

Probable G-protein coupled receptor 19

Gene

GPR19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 19
Alternative name(s):
GPR-NGA
Gene namesi
Name:GPR19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4473. GPR19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 69ExtracellularSequence analysisAdd BLAST69
Transmembranei70 – 90Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini91 – 102CytoplasmicSequence analysisAdd BLAST12
Transmembranei103 – 123Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini124 – 143ExtracellularSequence analysisAdd BLAST20
Transmembranei144 – 161Helical; Name=3Sequence analysisAdd BLAST18
Topological domaini162 – 182CytoplasmicSequence analysisAdd BLAST21
Transmembranei183 – 203Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini204 – 221ExtracellularSequence analysisAdd BLAST18
Transmembranei222 – 242Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini243 – 277CytoplasmicSequence analysisAdd BLAST35
Transmembranei278 – 298Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini299 – 309ExtracellularSequence analysisAdd BLAST11
Transmembranei310 – 325Helical; Name=7Sequence analysisAdd BLAST16
Topological domaini326 – 415CytoplasmicSequence analysisAdd BLAST90

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2842.
OpenTargetsiENSG00000183150.
PharmGKBiPA28861.

Polymorphism and mutation databases

BioMutaiGPR19.
DMDMi322510031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695381 – 415Probable G-protein coupled receptor 19Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi138 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15760.
PaxDbiQ15760.
PeptideAtlasiQ15760.
PRIDEiQ15760.

PTM databases

iPTMnetiQ15760.
PhosphoSitePlusiQ15760.

Expressioni

Tissue specificityi

Abundant expression in the brain.

Gene expression databases

BgeeiENSG00000183150.
CleanExiHS_GPR19.
ExpressionAtlasiQ15760. baseline and differential.
GenevisibleiQ15760. HS.

Organism-specific databases

HPAiHPA013955.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333744.

Structurei

3D structure databases

ProteinModelPortaliQ15760.
SMRiQ15760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiQ15760.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ15760.
TreeFamiTF331630.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM
60 70 80 90 100
SNQTDLHYVL KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT
110 120 130 140 150
NYFVVSMACA DLLISVASTP FVLLQFTTGR WTLGSATCKV VRYFQYLTPG
160 170 180 190 200
VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KKMIAASWVF DAGFVTPVLF
210 220 230 240 250
FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII LFYQKVIKYI
260 270 280 290 300
WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP
310 320 330 340 350
HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM
360 370 380 390 400
KCYRSNAYTI TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK
410
KLAWPINSNP PNTFV
Length:415
Mass (Da):47,687
Last modified:February 8, 2011 - v2
Checksum:iD5DF78C1BFA401FD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024256189V → I.2 PublicationsCorresponds to variant rs4763862dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64871 Genomic DNA. Translation: AAB49751.1.
U55312 Genomic DNA. Translation: AAB00316.1.
AC008115 Genomic DNA. No translation available.
CCDSiCCDS8652.1.
PIRiS74237.
RefSeqiNP_006134.1. NM_006143.2.
XP_011518927.1. XM_011520625.2.
XP_016874705.1. XM_017019216.1.
UniGeneiHs.657862.

Genome annotation databases

EnsembliENST00000332427; ENSP00000333744; ENSG00000183150.
ENST00000540510; ENSP00000441832; ENSG00000183150.
GeneIDi2842.
KEGGihsa:2842.
UCSCiuc001raq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64871 Genomic DNA. Translation: AAB49751.1.
U55312 Genomic DNA. Translation: AAB00316.1.
AC008115 Genomic DNA. No translation available.
CCDSiCCDS8652.1.
PIRiS74237.
RefSeqiNP_006134.1. NM_006143.2.
XP_011518927.1. XM_011520625.2.
XP_016874705.1. XM_017019216.1.
UniGeneiHs.657862.

3D structure databases

ProteinModelPortaliQ15760.
SMRiQ15760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333744.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15760.
PhosphoSitePlusiQ15760.

Polymorphism and mutation databases

BioMutaiGPR19.
DMDMi322510031.

Proteomic databases

EPDiQ15760.
PaxDbiQ15760.
PeptideAtlasiQ15760.
PRIDEiQ15760.

Protocols and materials databases

DNASUi2842.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332427; ENSP00000333744; ENSG00000183150.
ENST00000540510; ENSP00000441832; ENSG00000183150.
GeneIDi2842.
KEGGihsa:2842.
UCSCiuc001raq.2. human.

Organism-specific databases

CTDi2842.
DisGeNETi2842.
GeneCardsiGPR19.
HGNCiHGNC:4473. GPR19.
HPAiHPA013955.
MIMi602927. gene.
neXtProtiNX_Q15760.
OpenTargetsiENSG00000183150.
PharmGKBiPA28861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiQ15760.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ15760.
TreeFamiTF331630.

Enzyme and pathway databases

BioCyciZFISH:G66-33330-MONOMER.

Miscellaneous databases

ChiTaRSiGPR19. human.
GeneWikiiGPR19.
GenomeRNAii2842.
PROiQ15760.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183150.
CleanExiHS_GPR19.
ExpressionAtlasiQ15760. baseline and differential.
GenevisibleiQ15760. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR19_HUMAN
AccessioniPrimary (citable) accession number: Q15760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.