Q15760 (GPR19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 19

Alternative name(s):
GPR-NGA

Gene names

Name:

GPR19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Abundant expression in the brain.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	Probable G-protein coupled receptor 19		PRO_0000069538
Regions
	Topological domain	1 – 69	69	Extracellular Potential
	Transmembrane	70 – 90	21	Helical; Name=1; Potential
	Topological domain	91 – 102	12	Cytoplasmic Potential
	Transmembrane	103 – 123	21	Helical; Name=2; Potential
	Topological domain	124 – 143	20	Extracellular Potential
	Transmembrane	144 – 161	18	Helical; Name=3; Potential
	Topological domain	162 – 182	21	Cytoplasmic Potential
	Transmembrane	183 – 203	21	Helical; Name=4; Potential
	Topological domain	204 – 221	18	Extracellular Potential
	Transmembrane	222 – 242	21	Helical; Name=5; Potential
	Topological domain	243 – 277	35	Cytoplasmic Potential
	Transmembrane	278 – 298	21	Helical; Name=6; Potential
	Topological domain	299 – 309	11	Extracellular Potential
	Transmembrane	310 – 325	16	Helical; Name=7; Potential
	Topological domain	326 – 415	90	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
	Disulfide bond	138 ↔ 210		By similarity
Natural variations
	Natural variant	189	1	V → I. Ref.1 Ref.2 Corresponds to variant rs4763862 [ dbSNP | Ensembl ].		VAR_024256

Sequences

	Sequence		Length	Mass (Da)
	Q15760 [UniParc]. Last modified February 8, 2011. Version 2. Checksum: D5DF78C1BFA401FD	FASTA	415	47,687
	10 20 30 40 50 60 MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM SNQTDLHYVL 70 80 90 100 110 120 KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP 130 140 150 160 170 180 FVLLQFTTGR WTLGSATCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA 190 200 210 220 230 240 KKMIAASWVF DAGFVTPVLF FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII 250 260 270 280 290 300 LFYQKVIKYI WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP 310 320 330 340 350 360 HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI 370 380 390 400 410 TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK KLAWPINSNP PNTFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain." O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R. FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
[2]	"A G protein-coupled receptor expressed in NG108-15 and AtT-20 cells." Bonner T.I., Matsuda L.A. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U64871 Genomic DNA. Translation: AAB49751.1. U55312 Genomic DNA. Translation: AAB00316.1. AC008115 Genomic DNA. No translation available.
IPI	IPI00019489.
PIR	S74237.
RefSeq	NP_006134.1. NM_006143.2.
UniGene	Hs.657862.
3D structure databases
ProteinModelPortal	Q15760.
SMR	Q15760. Positions 64-342.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000333744.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q15760.
Polymorphism databases
DMDM	2495036.
Proteomic databases
PaxDb	Q15760.
PRIDE	Q15760.
Protocols and materials databases
DNASU	2842.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332427; ENSP00000333744; ENSG00000183150. ENST00000540510; ENSP00000441832; ENSG00000183150.
GeneID	2842.
KEGG	hsa:2842.
UCSC	uc001rar.3. human.
Organism-specific databases
CTD	2842.
GeneCards	GC12M012813.
HGNC	HGNC:4473. GPR19.
HPA	HPA013955.
MIM	602927. gene.
neXtProt	NX_Q15760.
PharmGKB	PA28861.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG318116.
HOGENOM	HOG000112786.
HOVERGEN	HBG051799.
InParanoid	Q15760.
KO	K04316.
OMA	QLWHPHE.
OrthoDB	EOG4SJ5F4.
PhylomeDB	Q15760.
Gene expression databases
ArrayExpress	Q15760.
Bgee	Q15760.
CleanEx	HS_GPR19.
Genevestigator	Q15760.
GermOnline	ENSG00000183150. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPR19. human.
GenomeRNAi	2842.
NextBio	11211.
SOURCE	Search...

Entry information

Entry name

GPR19_HUMAN

Accession

Primary (citable) accession number: Q15760

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.