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Protein

Probable G-protein coupled receptor 19

Gene

GPR19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 19
Alternative name(s):
GPR-NGA
Gene namesi
Name:GPR19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4473. GPR19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969ExtracellularSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini91 – 10212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini124 – 14320ExtracellularSequence AnalysisAdd
BLAST
Transmembranei144 – 16118Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini162 – 18221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini204 – 22118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini243 – 27735CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini299 – 30911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 32516Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini326 – 41590CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Probable G-protein coupled receptor 19PRO_0000069538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi138 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15760.
PRIDEiQ15760.

PTM databases

PhosphoSiteiQ15760.

Expressioni

Tissue specificityi

Abundant expression in the brain.

Gene expression databases

BgeeiQ15760.
CleanExiHS_GPR19.
ExpressionAtlasiQ15760. baseline and differential.
GenevestigatoriQ15760.

Organism-specific databases

HPAiHPA013955.

Interactioni

Protein-protein interaction databases

BioGridi109101. 1 interaction.
STRINGi9606.ENSP00000333744.

Structurei

3D structure databases

ProteinModelPortaliQ15760.
SMRiQ15760. Positions 57-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318116.
GeneTreeiENSGT00780000121924.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiQ15760.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG7SXW36.
PhylomeDBiQ15760.
TreeFamiTF331630.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15760-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM
60 70 80 90 100
SNQTDLHYVL KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT
110 120 130 140 150
NYFVVSMACA DLLISVASTP FVLLQFTTGR WTLGSATCKV VRYFQYLTPG
160 170 180 190 200
VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KKMIAASWVF DAGFVTPVLF
210 220 230 240 250
FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII LFYQKVIKYI
260 270 280 290 300
WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP
310 320 330 340 350
HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM
360 370 380 390 400
KCYRSNAYTI TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK
410
KLAWPINSNP PNTFV
Length:415
Mass (Da):47,687
Last modified:February 8, 2011 - v2
Checksum:iD5DF78C1BFA401FD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891V → I.2 Publications
Corresponds to variant rs4763862 [ dbSNP | Ensembl ].
VAR_024256

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64871 Genomic DNA. Translation: AAB49751.1.
U55312 Genomic DNA. Translation: AAB00316.1.
AC008115 Genomic DNA. No translation available.
CCDSiCCDS8652.1.
PIRiS74237.
RefSeqiNP_006134.1. NM_006143.2.
UniGeneiHs.657862.

Genome annotation databases

EnsembliENST00000332427; ENSP00000333744; ENSG00000183150.
ENST00000540510; ENSP00000441832; ENSG00000183150.
GeneIDi2842.
KEGGihsa:2842.
UCSCiuc001rar.3. human.

Polymorphism databases

DMDMi322510031.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64871 Genomic DNA. Translation: AAB49751.1.
U55312 Genomic DNA. Translation: AAB00316.1.
AC008115 Genomic DNA. No translation available.
CCDSiCCDS8652.1.
PIRiS74237.
RefSeqiNP_006134.1. NM_006143.2.
UniGeneiHs.657862.

3D structure databases

ProteinModelPortaliQ15760.
SMRiQ15760. Positions 57-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109101. 1 interaction.
STRINGi9606.ENSP00000333744.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ15760.

Polymorphism databases

DMDMi322510031.

Proteomic databases

PaxDbiQ15760.
PRIDEiQ15760.

Protocols and materials databases

DNASUi2842.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332427; ENSP00000333744; ENSG00000183150.
ENST00000540510; ENSP00000441832; ENSG00000183150.
GeneIDi2842.
KEGGihsa:2842.
UCSCiuc001rar.3. human.

Organism-specific databases

CTDi2842.
GeneCardsiGC12M012813.
HGNCiHGNC:4473. GPR19.
HPAiHPA013955.
MIMi602927. gene.
neXtProtiNX_Q15760.
PharmGKBiPA28861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG318116.
GeneTreeiENSGT00780000121924.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiQ15760.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG7SXW36.
PhylomeDBiQ15760.
TreeFamiTF331630.

Miscellaneous databases

ChiTaRSiGPR19. human.
GeneWikiiGPR19.
GenomeRNAii2842.
NextBioi11211.
PROiQ15760.
SOURCEiSearch...

Gene expression databases

BgeeiQ15760.
CleanExiHS_GPR19.
ExpressionAtlasiQ15760. baseline and differential.
GenevestigatoriQ15760.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain."
    O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.
    FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
  2. "A G protein-coupled receptor expressed in NG108-15 and AtT-20 cells."
    Bonner T.I., Matsuda L.A.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGPR19_HUMAN
AccessioniPrimary (citable) accession number: Q15760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.