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Q15760 (GPR19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 19
Alternative name(s):
GPR-NGA
Gene names
Name:GPR19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Abundant expression in the brain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionG-protein coupled receptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Probable G-protein coupled receptor 19
PRO_0000069538

Regions

Topological domain1 – 6969Extracellular Potential
Transmembrane70 – 9021Helical; Name=1; Potential
Topological domain91 – 10212Cytoplasmic Potential
Transmembrane103 – 12321Helical; Name=2; Potential
Topological domain124 – 14320Extracellular Potential
Transmembrane144 – 16118Helical; Name=3; Potential
Topological domain162 – 18221Cytoplasmic Potential
Transmembrane183 – 20321Helical; Name=4; Potential
Topological domain204 – 22118Extracellular Potential
Transmembrane222 – 24221Helical; Name=5; Potential
Topological domain243 – 27735Cytoplasmic Potential
Transmembrane278 – 29821Helical; Name=6; Potential
Topological domain299 – 30911Extracellular Potential
Transmembrane310 – 32516Helical; Name=7; Potential
Topological domain326 – 41590Cytoplasmic Potential

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Disulfide bond138 ↔ 210 By similarity

Natural variations

Natural variant1891V → I. Ref.1 Ref.2
Corresponds to variant rs4763862 [ dbSNP | Ensembl ].
VAR_024256

Sequences

Sequence LengthMass (Da)Tools
Q15760 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: D5DF78C1BFA401FD

FASTA41547,687
        10         20         30         40         50         60 
MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM SNQTDLHYVL 

        70         80         90        100        110        120 
KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP 

       130        140        150        160        170        180 
FVLLQFTTGR WTLGSATCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA 

       190        200        210        220        230        240 
KKMIAASWVF DAGFVTPVLF FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII 

       250        260        270        280        290        300 
LFYQKVIKYI WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP 

       310        320        330        340        350        360 
HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI 

       370        380        390        400        410 
TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK KLAWPINSNP PNTFV 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain."
O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.
FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
[2]"A G protein-coupled receptor expressed in NG108-15 and AtT-20 cells."
Bonner T.I., Matsuda L.A.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
[3]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U64871 Genomic DNA. Translation: AAB49751.1.
U55312 Genomic DNA. Translation: AAB00316.1.
AC008115 Genomic DNA. No translation available.
PIRS74237.
RefSeqNP_006134.1. NM_006143.2.
UniGeneHs.657862.

3D structure databases

ProteinModelPortalQ15760.
SMRQ15760. Positions 57-367.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109101. 1 interaction.
STRING9606.ENSP00000333744.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ15760.

Polymorphism databases

DMDM322510031.

Proteomic databases

PaxDbQ15760.
PRIDEQ15760.

Protocols and materials databases

DNASU2842.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332427; ENSP00000333744; ENSG00000183150.
ENST00000540510; ENSP00000441832; ENSG00000183150.
GeneID2842.
KEGGhsa:2842.
UCSCuc001rar.3. human.

Organism-specific databases

CTD2842.
GeneCardsGC12M012813.
HGNCHGNC:4473. GPR19.
HPAHPA013955.
MIM602927. gene.
neXtProtNX_Q15760.
PharmGKBPA28861.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318116.
HOGENOMHOG000112786.
HOVERGENHBG051799.
InParanoidQ15760.
KOK04316.
OMAQLWHPHE.
OrthoDBEOG7SXW36.
PhylomeDBQ15760.
TreeFamTF331630.

Gene expression databases

ArrayExpressQ15760.
BgeeQ15760.
CleanExHS_GPR19.
GenevestigatorQ15760.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR19. human.
GeneWikiGPR19.
GenomeRNAi2842.
NextBio11211.
PROQ15760.
SOURCESearch...

Entry information

Entry nameGPR19_HUMAN
AccessionPrimary (citable) accession number: Q15760
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries