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Q15760

- GPR19_HUMAN

UniProt

Q15760 - GPR19_HUMAN

Protein

Probable G-protein coupled receptor 19

Gene

GPR19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 19
    Alternative name(s):
    GPR-NGA
    Gene namesi
    Name:GPR19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4473. GPR19.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28861.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Probable G-protein coupled receptor 19PRO_0000069538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi138 ↔ 210PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ15760.
    PRIDEiQ15760.

    PTM databases

    PhosphoSiteiQ15760.

    Expressioni

    Tissue specificityi

    Abundant expression in the brain.

    Gene expression databases

    ArrayExpressiQ15760.
    BgeeiQ15760.
    CleanExiHS_GPR19.
    GenevestigatoriQ15760.

    Organism-specific databases

    HPAiHPA013955.

    Interactioni

    Protein-protein interaction databases

    BioGridi109101. 1 interaction.
    STRINGi9606.ENSP00000333744.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15760.
    SMRiQ15760. Positions 64-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6969ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini91 – 10212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 18221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini204 – 22118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 27735CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini299 – 30911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 41590CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16118Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 32516Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318116.
    HOGENOMiHOG000112786.
    HOVERGENiHBG051799.
    InParanoidiQ15760.
    KOiK04316.
    OMAiQLWHPHE.
    OrthoDBiEOG7SXW36.
    PhylomeDBiQ15760.
    TreeFamiTF331630.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15760-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM    50
    SNQTDLHYVL KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT 100
    NYFVVSMACA DLLISVASTP FVLLQFTTGR WTLGSATCKV VRYFQYLTPG 150
    VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KKMIAASWVF DAGFVTPVLF 200
    FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII LFYQKVIKYI 250
    WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP 300
    HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM 350
    KCYRSNAYTI TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK 400
    KLAWPINSNP PNTFV 415
    Length:415
    Mass (Da):47,687
    Last modified:February 8, 2011 - v2
    Checksum:iD5DF78C1BFA401FD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti189 – 1891V → I.2 Publications
    Corresponds to variant rs4763862 [ dbSNP | Ensembl ].
    VAR_024256

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64871 Genomic DNA. Translation: AAB49751.1.
    U55312 Genomic DNA. Translation: AAB00316.1.
    AC008115 Genomic DNA. No translation available.
    CCDSiCCDS8652.1.
    PIRiS74237.
    RefSeqiNP_006134.1. NM_006143.2.
    UniGeneiHs.657862.

    Genome annotation databases

    EnsembliENST00000332427; ENSP00000333744; ENSG00000183150.
    ENST00000540510; ENSP00000441832; ENSG00000183150.
    GeneIDi2842.
    KEGGihsa:2842.
    UCSCiuc001rar.3. human.

    Polymorphism databases

    DMDMi322510031.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64871 Genomic DNA. Translation: AAB49751.1 .
    U55312 Genomic DNA. Translation: AAB00316.1 .
    AC008115 Genomic DNA. No translation available.
    CCDSi CCDS8652.1.
    PIRi S74237.
    RefSeqi NP_006134.1. NM_006143.2.
    UniGenei Hs.657862.

    3D structure databases

    ProteinModelPortali Q15760.
    SMRi Q15760. Positions 64-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109101. 1 interaction.
    STRINGi 9606.ENSP00000333744.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q15760.

    Polymorphism databases

    DMDMi 322510031.

    Proteomic databases

    PaxDbi Q15760.
    PRIDEi Q15760.

    Protocols and materials databases

    DNASUi 2842.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332427 ; ENSP00000333744 ; ENSG00000183150 .
    ENST00000540510 ; ENSP00000441832 ; ENSG00000183150 .
    GeneIDi 2842.
    KEGGi hsa:2842.
    UCSCi uc001rar.3. human.

    Organism-specific databases

    CTDi 2842.
    GeneCardsi GC12M012813.
    HGNCi HGNC:4473. GPR19.
    HPAi HPA013955.
    MIMi 602927. gene.
    neXtProti NX_Q15760.
    PharmGKBi PA28861.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318116.
    HOGENOMi HOG000112786.
    HOVERGENi HBG051799.
    InParanoidi Q15760.
    KOi K04316.
    OMAi QLWHPHE.
    OrthoDBi EOG7SXW36.
    PhylomeDBi Q15760.
    TreeFami TF331630.

    Miscellaneous databases

    ChiTaRSi GPR19. human.
    GeneWikii GPR19.
    GenomeRNAii 2842.
    NextBioi 11211.
    PROi Q15760.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15760.
    Bgeei Q15760.
    CleanExi HS_GPR19.
    Genevestigatori Q15760.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain."
      O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.
      FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
    2. "A G protein-coupled receptor expressed in NG108-15 and AtT-20 cells."
      Bonner T.I., Matsuda L.A.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-189.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGPR19_HUMAN
    AccessioniPrimary (citable) accession number: Q15760
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3