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Q15758 (AAAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neutral amino acid transporter B(0)

Short name=ATB(0)
Alternative name(s):
Baboon M7 virus receptor
RD114/simian type D retrovirus receptor
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene names
Name:SLC1A5
Synonyms:ASCT2, M7V1, RDR, RDRC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. Ref.2 Ref.3

Subcellular location

Membrane; Multi-pass membrane protein Probable. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.11

Tissue specificity

Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Sequence similarities

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. [View classification]

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative initiation
Alternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionHost cell receptor for virus entry
Receptor
   PTMAcetylation
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processamino acid transport

Traceable author statement. Source: Reactome

extracellular amino acid transport

Inferred from electronic annotation. Source: Ensembl

glutamine transport

Traceable author statement PubMed 21757002. Source: BHF-UCL

ion transport

Traceable author statement. Source: Reactome

neutral amino acid transport

Traceable author statement Ref.2. Source: ProtInc

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentGolgi apparatus

Inferred from direct assay. Source: HPA

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

melanosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Inferred from direct assay. Source: HPA

   Molecular_functionL-glutamine transmembrane transporter activity

Traceable author statement PubMed 21757002. Source: BHF-UCL

L-serine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

neutral amino acid transmembrane transporter activity

Traceable author statement Ref.2. Source: ProtInc

receptor activity

Traceable author statement Ref.2. Source: ProtInc

sodium:dicarboxylate symporter activity

Inferred from electronic annotation. Source: InterPro

virus receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]

Note: A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.
Isoform 1 (identifier: Q15758-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q15758-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: MVADPPRDSK...SNLVSAAFRS → M
Note: No experimental confirmation available.
Isoform 3 (identifier: Q15758-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 541541Neutral amino acid transporter B(0)
PRO_0000202082

Regions

Topological domain1 – 5252Cytoplasmic Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane133 – 15321Helical; Potential
Topological domain154 – 22471Extracellular Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane266 – 28621Helical; Potential
Transmembrane306 – 32621Helical; Potential
Transmembrane336 – 35621Helical; Potential
Transmembrane377 – 39721Helical; Potential
Transmembrane399 – 41921Helical; Potential
Transmembrane426 – 44621Helical; Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.13 Ref.19
Modified residue4931Phosphoserine Ref.18
Modified residue5031Phosphoserine Ref.15
Modified residue5351Phosphoserine Ref.10 Ref.12 Ref.15 Ref.16
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Ref.14

Natural variations

Alternative sequence1 – 228228Missing in isoform 3.
VSP_046851
Alternative sequence1 – 203203MVADP…AAFRS → M in isoform 2.
VSP_046354
Natural variant171P → A.
Corresponds to variant rs3027956 [ dbSNP | Ensembl ].
VAR_020439
Natural variant5121V → L. Ref.5 Ref.15
Corresponds to variant rs3027961 [ dbSNP | Ensembl ].
VAR_013517

Experimental info

Sequence conflict18 – 247TANGGLA → PPTGAWQ in AAC50629. Ref.1
Sequence conflict441Q → L in AAC50629. Ref.1
Sequence conflict84 – 874ERLS → GALE in AAC50629. Ref.1
Sequence conflict3411V → A in BAH14917. Ref.5
Sequence conflict4531I → V in AAD09812. Ref.2
Sequence conflict4601D → G in AAD09812. Ref.2
Sequence conflict4631V → A in AAD09812. Ref.2
Sequence conflict5081D → G in AAD09812. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 20, 2002. Version 2.
Checksum: AD61C789CCFFE934

FASTA54156,598
        10         20         30         40         50         60 
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR ANLLVLLTVV 

        70         80         90        100        110        120 
AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL RMIILPLVVC SLIGGAASLD 

       130        140        150        160        170        180 
PGALGRLGAW ALLFFLVTTL LASALGVGLA LALQPGAASA AINASVGAAG SAENAPSKEV 

       190        200        210        220        230        240 
LDSFLDLARN IFPSNLVSAA FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV 

       250        260        270        280        290        300 
FGVALRKLGP EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA 

       310        320        330        340        350        360 
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT SSSSATLPLM 

       370        380        390        400        410        420 
MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF IAQLSQQSLD FVKIITILVT 

       430        440        450        460        470        480 
ATASSVGAAG IPAGGVLTLA IILEAVNLPV DHISLILAVD WLVDRSCTVL NVEGDALGAG 

       490        500        510        520        530        540 
LLQNYVDRTE SRSTEPELIQ VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV 


M 

« Hide

Isoform 2 [UniParc].

Checksum: CFF2D2673EDD4FC9
Show »

FASTA33936,636
Isoform 3 [UniParc].

Checksum: A2CF681DC2A2F24E
Show »

FASTA31333,710

References

« Hide 'large scale' references
[1]"Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line."
Kekuda R., Prasad P.D., Fei Y.-J., Torres-Zamorano V., Sinha S., Yang-Feng T.L., Leibach F.H., Ganapathy V.
J. Biol. Chem. 271:18657-18661(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Choriocarcinoma.
[2]"The RD114/simian type D retrovirus receptor is a neutral amino acid transporter."
Rasko J.E.J., Battini J.L., Gottschalk R.J., Mazo I., Miller A.D.
Proc. Natl. Acad. Sci. U.S.A. 96:2129-2134(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A VIRAL RECEPTOR.
[3]"A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses."
Tailor C.S., Nouri A., Zhao Y., Takeuchi Y., Kabat D.
J. Virol. 73:4470-4474(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A VIRAL RECEPTOR.
[4]"Cloning of ASCT2 cDNA from MCF-7 cells and its expression in B16 cells."
Ouyang D.-Y., Xu L.-H., He X.-H., Zha Q.-B., Guo H., Gao Q., Zhang Y.-T.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT LEU-512.
Tissue: Esophagus and Thymus.
[6]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[9]"Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons."
Tailor C.S., Marin M., Nouri A., Kavanaugh M.P., Kabat D.
J. Biol. Chem. 276:27221-27230(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-541 (ISOFORM 1), ALTERNATIVE INITIATION.
[10]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F.
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Melanoma.
[12]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212.
Tissue: Leukemic T-cell.
[15]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503 AND SER-535, VARIANT [LARGE SCALE ANALYSIS] LEU-512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[16]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[17]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53347 mRNA. Translation: AAC50629.1.
AF102826 mRNA. Translation: AAD09812.1.
AF105423 mRNA. Translation: AAD27806.1.
GQ919058 mRNA. Translation: ACX53626.1.
AK292690 mRNA. Translation: BAF85379.1.
AK299137 mRNA. Translation: BAG61189.1.
AK301661 mRNA. Translation: BAG63136.1.
AK316546 mRNA. Translation: BAH14917.1.
AC008622 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57446.1.
BC000062 mRNA. Translation: AAH00062.1.
AF334818 mRNA. Translation: AAK77026.1.
CCDSCCDS12692.1. [Q15758-1]
CCDS46125.1. [Q15758-2]
CCDS46126.1. [Q15758-3]
RefSeqNP_001138616.1. NM_001145144.1. [Q15758-3]
NP_001138617.1. NM_001145145.1. [Q15758-2]
NP_005619.1. NM_005628.2. [Q15758-1]
UniGeneHs.631582.

3D structure databases

ProteinModelPortalQ15758.
SMRQ15758. Positions 59-482.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112401. 15 interactions.
IntActQ15758. 6 interactions.
MINTMINT-5001314.
STRING9606.ENSP00000303623.

Chemistry

DrugBankDB00174. L-Asparagine.
DB00130. L-Glutamine.
GuidetoPHARMACOLOGY874.

Protein family/group databases

TCDB2.A.23.3.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

PhosphoSiteQ15758.

Polymorphism databases

DMDM21542389.

Proteomic databases

MaxQBQ15758.
PaxDbQ15758.
PeptideAtlasQ15758.
PRIDEQ15758.

Protocols and materials databases

DNASU6510.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000412532; ENSP00000397924; ENSG00000105281. [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281. [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281. [Q15758-1]
GeneID6510.
KEGGhsa:6510.
UCSCuc002pfr.3. human. [Q15758-1]

Organism-specific databases

CTD6510.
GeneCardsGC19M047278.
H-InvDBHIX0015262.
HGNCHGNC:10943. SLC1A5.
HPAHPA035239.
HPA035240.
MIM109190. gene.
neXtProtNX_Q15758.
PharmGKBPA35830.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1301.
HOVERGENHBG000080.
InParanoidQ15758.
KOK05616.
OMALVRNIFP.
OrthoDBEOG7RV9G2.
PhylomeDBQ15758.
TreeFamTF315206.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

ArrayExpressQ15758.
BgeeQ15758.
CleanExHS_SLC1A5.
GenevestigatorQ15758.

Family and domain databases

Gene3D1.10.3860.10. 1 hit.
InterProIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERPTHR11958. PTHR11958. 1 hit.
PfamPF00375. SDF. 1 hit.
[Graphical view]
PRINTSPR00173. EDTRNSPORT.
SUPFAMSSF118215. SSF118215. 1 hit.
PROSITEPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC1A5. human.
GeneWikiSLC1A5.
GenomeRNAi6510.
NextBio25315.
PROQ15758.
SOURCESearch...

Entry information

Entry nameAAAT_HUMAN
AccessionPrimary (citable) accession number: Q15758
Secondary accession number(s): A8K9H5 expand/collapse secondary AC list , B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q96RL9, Q9BWQ3, Q9UNP2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2002
Last modified: July 9, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM