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Q15758

- AAAT_HUMAN

UniProt

Q15758 - AAAT_HUMAN

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Protein

Neutral amino acid transporter B(0)

Gene

SLC1A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).4 Publications

GO - Molecular functioni

  1. L-glutamine transmembrane transporter activity Source: BHF-UCL
  2. L-serine transmembrane transporter activity Source: Ensembl
  3. neutral amino acid transmembrane transporter activity Source: ProtInc
  4. receptor activity Source: ProtInc
  5. sodium:dicarboxylate symporter activity Source: InterPro
  6. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. extracellular amino acid transport Source: Ensembl
  3. glutamine transport Source: BHF-UCL
  4. ion transport Source: Reactome
  5. neutral amino acid transport Source: ProtInc
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.23.3.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
Baboon M7 virus receptor
RD114/simian type D retrovirus receptor
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene namesi
Name:SLC1A5
Synonyms:ASCT2, M7V1, RDR, RDRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10943. SLC1A5.

Subcellular locationi

Cell membrane Curated; Multi-pass membrane protein Curated. Melanosome
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi apparatus Source: HPA
  3. integral component of plasma membrane Source: ProtInc
  4. membrane Source: UniProtKB
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Neutral amino acid transporter B(0)PRO_0000202082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)1 Publication
Modified residuei493 – 4931Phosphoserine1 Publication
Modified residuei503 – 5031Phosphoserine1 Publication
Modified residuei535 – 5351Phosphoserine4 Publications

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ15758.
PaxDbiQ15758.
PeptideAtlasiQ15758.
PRIDEiQ15758.

PTM databases

PhosphoSiteiQ15758.

Expressioni

Tissue specificityi

Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Gene expression databases

BgeeiQ15758.
CleanExiHS_SLC1A5.
ExpressionAtlasiQ15758. baseline and differential.
GenevestigatoriQ15758.

Organism-specific databases

HPAiHPA035239.
HPA035240.

Interactioni

Subunit structurei

Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization.1 Publication

Protein-protein interaction databases

BioGridi112401. 16 interactions.
IntActiQ15758. 6 interactions.
MINTiMINT-5001314.
STRINGi9606.ENSP00000303623.

Structurei

3D structure databases

ProteinModelPortaliQ15758.
SMRiQ15758. Positions 59-482.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini154 – 22471ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Transmembranei426 – 44621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1301.
GeneTreeiENSGT00760000119117.
HOVERGENiHBG000080.
InParanoidiQ15758.
KOiK05616.
OMAiLVRNIFP.
OrthoDBiEOG7RV9G2.
PhylomeDBiQ15758.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. Align

Note: A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.1 Publication

Isoform 1 (identifier: Q15758-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR
60 70 80 90 100
ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL
110 120 130 140 150
RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA
160 170 180 190 200
LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA
210 220 230 240 250
FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP
260 270 280 290 300
EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA
310 320 330 340 350
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT
360 370 380 390 400
SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF
410 420 430 440 450
IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV
460 470 480 490 500
DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ
510 520 530 540
VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M
Length:541
Mass (Da):56,598
Last modified:June 20, 2002 - v2
Checksum:iAD61C789CCFFE934
GO
Isoform 2 (identifier: Q15758-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: MVADPPRDSK...SNLVSAAFRS → M

Note: No experimental confirmation available.

Show »
Length:339
Mass (Da):36,636
Checksum:iCFF2D2673EDD4FC9
GO
Isoform 3 (identifier: Q15758-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.

Show »
Length:313
Mass (Da):33,710
Checksum:iA2CF681DC2A2F24E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 247TANGGLA → PPTGAWQ in AAC50629. (PubMed:8702519)Curated
Sequence conflicti44 – 441Q → L in AAC50629. (PubMed:8702519)Curated
Sequence conflicti84 – 874ERLS → GALE in AAC50629. (PubMed:8702519)Curated
Sequence conflicti341 – 3411V → A in BAH14917. (PubMed:14702039)Curated
Sequence conflicti453 – 4531I → V in AAD09812. (PubMed:10051606)Curated
Sequence conflicti460 – 4601D → G in AAD09812. (PubMed:10051606)Curated
Sequence conflicti463 – 4631V → A in AAD09812. (PubMed:10051606)Curated
Sequence conflicti508 – 5081D → G in AAD09812. (PubMed:10051606)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171P → A.
Corresponds to variant rs3027956 [ dbSNP | Ensembl ].
VAR_020439
Natural varianti512 – 5121V → L.2 Publications
Corresponds to variant rs3027961 [ dbSNP | Ensembl ].
VAR_013517

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 228228Missing in isoform 3. 1 PublicationVSP_046851Add
BLAST
Alternative sequencei1 – 203203MVADP…AAFRS → M in isoform 2. 1 PublicationVSP_046354Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53347 mRNA. Translation: AAC50629.1.
AF102826 mRNA. Translation: AAD09812.1.
AF105423 mRNA. Translation: AAD27806.1.
GQ919058 mRNA. Translation: ACX53626.1.
AK292690 mRNA. Translation: BAF85379.1.
AK299137 mRNA. Translation: BAG61189.1.
AK301661 mRNA. Translation: BAG63136.1.
AK316546 mRNA. Translation: BAH14917.1.
AC008622 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57446.1.
BC000062 mRNA. Translation: AAH00062.1.
AF334818 mRNA. Translation: AAK77026.1.
CCDSiCCDS12692.1. [Q15758-1]
CCDS46125.1. [Q15758-2]
CCDS46126.1. [Q15758-3]
RefSeqiNP_001138616.1. NM_001145144.1. [Q15758-3]
NP_001138617.1. NM_001145145.1. [Q15758-2]
NP_005619.1. NM_005628.2. [Q15758-1]
UniGeneiHs.631582.

Genome annotation databases

EnsembliENST00000412532; ENSP00000397924; ENSG00000105281. [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281. [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281. [Q15758-1]
GeneIDi6510.
KEGGihsa:6510.
UCSCiuc002pfr.3. human. [Q15758-1]

Polymorphism databases

DMDMi21542389.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53347 mRNA. Translation: AAC50629.1 .
AF102826 mRNA. Translation: AAD09812.1 .
AF105423 mRNA. Translation: AAD27806.1 .
GQ919058 mRNA. Translation: ACX53626.1 .
AK292690 mRNA. Translation: BAF85379.1 .
AK299137 mRNA. Translation: BAG61189.1 .
AK301661 mRNA. Translation: BAG63136.1 .
AK316546 mRNA. Translation: BAH14917.1 .
AC008622 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57446.1 .
BC000062 mRNA. Translation: AAH00062.1 .
AF334818 mRNA. Translation: AAK77026.1 .
CCDSi CCDS12692.1. [Q15758-1 ]
CCDS46125.1. [Q15758-2 ]
CCDS46126.1. [Q15758-3 ]
RefSeqi NP_001138616.1. NM_001145144.1. [Q15758-3 ]
NP_001138617.1. NM_001145145.1. [Q15758-2 ]
NP_005619.1. NM_005628.2. [Q15758-1 ]
UniGenei Hs.631582.

3D structure databases

ProteinModelPortali Q15758.
SMRi Q15758. Positions 59-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112401. 16 interactions.
IntActi Q15758. 6 interactions.
MINTi MINT-5001314.
STRINGi 9606.ENSP00000303623.

Chemistry

DrugBanki DB00174. L-Asparagine.
DB00130. L-Glutamine.
GuidetoPHARMACOLOGYi 874.

Protein family/group databases

TCDBi 2.A.23.3.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

PhosphoSitei Q15758.

Polymorphism databases

DMDMi 21542389.

Proteomic databases

MaxQBi Q15758.
PaxDbi Q15758.
PeptideAtlasi Q15758.
PRIDEi Q15758.

Protocols and materials databases

DNASUi 6510.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412532 ; ENSP00000397924 ; ENSG00000105281 . [Q15758-3 ]
ENST00000434726 ; ENSP00000406532 ; ENSG00000105281 . [Q15758-2 ]
ENST00000542575 ; ENSP00000444408 ; ENSG00000105281 . [Q15758-1 ]
GeneIDi 6510.
KEGGi hsa:6510.
UCSCi uc002pfr.3. human. [Q15758-1 ]

Organism-specific databases

CTDi 6510.
GeneCardsi GC19M047278.
H-InvDB HIX0015262.
HGNCi HGNC:10943. SLC1A5.
HPAi HPA035239.
HPA035240.
MIMi 109190. gene.
neXtProti NX_Q15758.
PharmGKBi PA35830.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1301.
GeneTreei ENSGT00760000119117.
HOVERGENi HBG000080.
InParanoidi Q15758.
KOi K05616.
OMAi LVRNIFP.
OrthoDBi EOG7RV9G2.
PhylomeDBi Q15758.
TreeFami TF315206.

Enzyme and pathway databases

Reactomei REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSi SLC1A5. human.
GeneWikii SLC1A5.
GenomeRNAii 6510.
NextBioi 25315.
PROi Q15758.
SOURCEi Search...

Gene expression databases

Bgeei Q15758.
CleanExi HS_SLC1A5.
ExpressionAtlasi Q15758. baseline and differential.
Genevestigatori Q15758.

Family and domain databases

Gene3Di 1.10.3860.10. 1 hit.
InterProi IPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view ]
PANTHERi PTHR11958. PTHR11958. 1 hit.
Pfami PF00375. SDF. 1 hit.
[Graphical view ]
PRINTSi PR00173. EDTRNSPORT.
SUPFAMi SSF118215. SSF118215. 1 hit.
PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line."
    Kekuda R., Prasad P.D., Fei Y.-J., Torres-Zamorano V., Sinha S., Yang-Feng T.L., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 271:18657-18661(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Choriocarcinoma.
  2. "The RD114/simian type D retrovirus receptor is a neutral amino acid transporter."
    Rasko J.E.J., Battini J.L., Gottschalk R.J., Mazo I., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:2129-2134(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A VIRAL RECEPTOR.
  3. "A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses."
    Tailor C.S., Nouri A., Zhao Y., Takeuchi Y., Kabat D.
    J. Virol. 73:4470-4474(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A VIRAL RECEPTOR.
  4. "Cloning of ASCT2 cDNA from MCF-7 cells and its expression in B16 cells."
    Ouyang D.-Y., Xu L.-H., He X.-H., Zha Q.-B., Guo H., Gao Q., Zhang Y.-T.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT LEU-512.
    Tissue: Esophagus and Thymus.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  9. "Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons."
    Tailor C.S., Marin M., Nouri A., Kavanaugh M.P., Kabat D.
    J. Biol. Chem. 276:27221-27230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-541 (ISOFORM 1), ALTERNATIVE INITIATION.
  10. "An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor."
    Blond J.-L., Lavillette D., Cheynet V., Bouton O., Oriol G., Chapel-Fernandes S., Mandrand B., Mallet F., Cosset F.-L.
    J. Virol. 74:3321-3329(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212.
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503 AND SER-535, VARIANT [LARGE SCALE ANALYSIS] LEU-512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "A novel human endogenous retroviral protein inhibits cell-cell fusion."
    Sugimoto J., Sugimoto M., Bernstein H., Jinno Y., Schust D.
    Sci. Rep. 3:1462-1462(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ERVH48-1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAAAT_HUMAN
AccessioniPrimary (citable) accession number: Q15758
Secondary accession number(s): A8K9H5
, B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q96RL9, Q9BWQ3, Q9UNP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2002
Last modified: October 29, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3