Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neutral amino acid transporter B(0)

Gene

SLC1A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).4 Publications

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: Reactome
  • L-glutamine transmembrane transporter activity Source: BHF-UCL
  • neutral amino acid transmembrane transporter activity Source: ProtInc
  • receptor activity Source: ProtInc
  • symporter activity Source: UniProtKB-KW
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  • amino acid transport Source: Reactome
  • glutamine transport Source: BHF-UCL
  • neutral amino acid transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.23.3.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
Baboon M7 virus receptor
RD114/simian type D retrovirus receptor
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene namesi
Name:SLC1A5
Synonyms:ASCT2, M7V1, RDR, RDRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10943. SLC1A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Topological domaini154 – 22471ExtracellularSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence analysisAdd
BLAST
Transmembranei426 – 44621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: HPA
  • integral component of plasma membrane Source: ProtInc
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35830.

Chemistry

DrugBankiDB00174. L-Asparagine.
DB00130. L-Glutamine.
GuidetoPHARMACOLOGYi874.

Polymorphism and mutation databases

BioMutaiSLC1A5.
DMDMi21542389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Neutral amino acid transporter B(0)PRO_0000202082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)1 Publication
Modified residuei493 – 4931PhosphoserineCombined sources
Modified residuei494 – 4941PhosphothreonineCombined sources
Modified residuei503 – 5031PhosphoserineCombined sources
Modified residuei503 – 5031Phosphoserine; in variant Leu-512Combined sources
Modified residuei535 – 5351PhosphoserineCombined sources
Modified residuei539 – 5391PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15758.
MaxQBiQ15758.
PaxDbiQ15758.
PeptideAtlasiQ15758.
PRIDEiQ15758.

PTM databases

iPTMnetiQ15758.
PhosphoSiteiQ15758.
SwissPalmiQ15758.

Expressioni

Tissue specificityi

Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

Gene expression databases

BgeeiENSG00000105281.
CleanExiHS_SLC1A5.
ExpressionAtlasiQ15758. baseline and differential.
GenevisibleiQ15758. HS.

Organism-specific databases

HPAiHPA035239.
HPA035240.

Interactioni

Subunit structurei

Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF5Q999424EBI-356576,EBI-348482

Protein-protein interaction databases

BioGridi112401. 60 interactions.
IntActiQ15758. 37 interactions.
MINTiMINT-5001314.
STRINGi9606.ENSP00000444408.

Structurei

3D structure databases

ProteinModelPortaliQ15758.
SMRiQ15758. Positions 59-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiQ15758.
KOiK05616.
OMAiGTDQDGM.
OrthoDBiEOG091G0UCE.
PhylomeDBiQ15758.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Note: A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.1 Publication
Isoform 1 (identifier: Q15758-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR
60 70 80 90 100
ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL
110 120 130 140 150
RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA
160 170 180 190 200
LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA
210 220 230 240 250
FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP
260 270 280 290 300
EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA
310 320 330 340 350
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT
360 370 380 390 400
SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF
410 420 430 440 450
IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV
460 470 480 490 500
DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ
510 520 530 540
VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M
Length:541
Mass (Da):56,598
Last modified:June 20, 2002 - v2
Checksum:iAD61C789CCFFE934
GO
Isoform 2 (identifier: Q15758-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: MVADPPRDSK...SNLVSAAFRS → M

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):36,636
Checksum:iCFF2D2673EDD4FC9
GO
Isoform 3 (identifier: Q15758-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):33,710
Checksum:iA2CF681DC2A2F24E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 247TANGGLA → PPTGAWQ in AAC50629 (PubMed:8702519).Curated
Sequence conflicti44 – 441Q → L in AAC50629 (PubMed:8702519).Curated
Sequence conflicti84 – 874ERLS → GALE in AAC50629 (PubMed:8702519).Curated
Sequence conflicti341 – 3411V → A in BAH14917 (PubMed:14702039).Curated
Sequence conflicti453 – 4531I → V in AAD09812 (PubMed:10051606).Curated
Sequence conflicti460 – 4601D → G in AAD09812 (PubMed:10051606).Curated
Sequence conflicti463 – 4631V → A in AAD09812 (PubMed:10051606).Curated
Sequence conflicti508 – 5081D → G in AAD09812 (PubMed:10051606).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171P → A.
Corresponds to variant rs3027956 [ dbSNP | Ensembl ].
VAR_020439
Natural varianti512 – 5121V → L.Combined sources1 Publication
Corresponds to variant rs3027961 [ dbSNP | Ensembl ].
VAR_013517

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 228228Missing in isoform 3. 1 PublicationVSP_046851Add
BLAST
Alternative sequencei1 – 203203MVADP…AAFRS → M in isoform 2. 1 PublicationVSP_046354Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53347 mRNA. Translation: AAC50629.1.
AF102826 mRNA. Translation: AAD09812.1.
AF105423 mRNA. Translation: AAD27806.1.
GQ919058 mRNA. Translation: ACX53626.1.
AK292690 mRNA. Translation: BAF85379.1.
AK299137 mRNA. Translation: BAG61189.1.
AK301661 mRNA. Translation: BAG63136.1.
AK316546 mRNA. Translation: BAH14917.1.
AC008622 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57446.1.
BC000062 mRNA. Translation: AAH00062.1.
AF334818 mRNA. Translation: AAK77026.1.
CCDSiCCDS12692.1. [Q15758-1]
CCDS46125.1. [Q15758-2]
CCDS46126.1. [Q15758-3]
RefSeqiNP_001138616.1. NM_001145144.1. [Q15758-3]
NP_001138617.1. NM_001145145.1. [Q15758-2]
NP_005619.1. NM_005628.2. [Q15758-1]
UniGeneiHs.631582.

Genome annotation databases

EnsembliENST00000412532; ENSP00000397924; ENSG00000105281. [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281. [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281. [Q15758-1]
GeneIDi6510.
KEGGihsa:6510.
UCSCiuc002pfr.4. human. [Q15758-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53347 mRNA. Translation: AAC50629.1.
AF102826 mRNA. Translation: AAD09812.1.
AF105423 mRNA. Translation: AAD27806.1.
GQ919058 mRNA. Translation: ACX53626.1.
AK292690 mRNA. Translation: BAF85379.1.
AK299137 mRNA. Translation: BAG61189.1.
AK301661 mRNA. Translation: BAG63136.1.
AK316546 mRNA. Translation: BAH14917.1.
AC008622 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57446.1.
BC000062 mRNA. Translation: AAH00062.1.
AF334818 mRNA. Translation: AAK77026.1.
CCDSiCCDS12692.1. [Q15758-1]
CCDS46125.1. [Q15758-2]
CCDS46126.1. [Q15758-3]
RefSeqiNP_001138616.1. NM_001145144.1. [Q15758-3]
NP_001138617.1. NM_001145145.1. [Q15758-2]
NP_005619.1. NM_005628.2. [Q15758-1]
UniGeneiHs.631582.

3D structure databases

ProteinModelPortaliQ15758.
SMRiQ15758. Positions 59-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112401. 60 interactions.
IntActiQ15758. 37 interactions.
MINTiMINT-5001314.
STRINGi9606.ENSP00000444408.

Chemistry

DrugBankiDB00174. L-Asparagine.
DB00130. L-Glutamine.
GuidetoPHARMACOLOGYi874.

Protein family/group databases

TCDBi2.A.23.3.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

iPTMnetiQ15758.
PhosphoSiteiQ15758.
SwissPalmiQ15758.

Polymorphism and mutation databases

BioMutaiSLC1A5.
DMDMi21542389.

Proteomic databases

EPDiQ15758.
MaxQBiQ15758.
PaxDbiQ15758.
PeptideAtlasiQ15758.
PRIDEiQ15758.

Protocols and materials databases

DNASUi6510.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412532; ENSP00000397924; ENSG00000105281. [Q15758-3]
ENST00000434726; ENSP00000406532; ENSG00000105281. [Q15758-2]
ENST00000542575; ENSP00000444408; ENSG00000105281. [Q15758-1]
GeneIDi6510.
KEGGihsa:6510.
UCSCiuc002pfr.4. human. [Q15758-1]

Organism-specific databases

CTDi6510.
GeneCardsiSLC1A5.
H-InvDBHIX0015262.
HGNCiHGNC:10943. SLC1A5.
HPAiHPA035239.
HPA035240.
MIMi109190. gene.
neXtProtiNX_Q15758.
PharmGKBiPA35830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiQ15758.
KOiK05616.
OMAiGTDQDGM.
OrthoDBiEOG091G0UCE.
PhylomeDBiQ15758.
TreeFamiTF315206.

Enzyme and pathway databases

ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSLC1A5. human.
GeneWikiiSLC1A5.
GenomeRNAii6510.
PROiQ15758.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105281.
CleanExiHS_SLC1A5.
ExpressionAtlasiQ15758. baseline and differential.
GenevisibleiQ15758. HS.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAAT_HUMAN
AccessioniPrimary (citable) accession number: Q15758
Secondary accession number(s): A8K9H5
, B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q96RL9, Q9BWQ3, Q9UNP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2002
Last modified: September 7, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.