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Q15758

- AAAT_HUMAN

UniProt

Q15758 - AAAT_HUMAN

Protein

Neutral amino acid transporter B(0)

Gene

SLC1A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (20 Jun 2002)
      Previous versions | rss
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    Functioni

    Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).4 Publications

    GO - Molecular functioni

    1. L-glutamine transmembrane transporter activity Source: BHF-UCL
    2. L-serine transmembrane transporter activity Source: Ensembl
    3. neutral amino acid transmembrane transporter activity Source: ProtInc
    4. protein binding Source: UniProtKB
    5. receptor activity Source: ProtInc
    6. sodium:dicarboxylate symporter activity Source: InterPro
    7. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. extracellular amino acid transport Source: Ensembl
    3. glutamine transport Source: BHF-UCL
    4. ion transport Source: Reactome
    5. neutral amino acid transport Source: ProtInc
    6. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Receptor

    Keywords - Biological processi

    Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.23.3.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neutral amino acid transporter B(0)
    Short name:
    ATB(0)
    Alternative name(s):
    Baboon M7 virus receptor
    RD114/simian type D retrovirus receptor
    Sodium-dependent neutral amino acid transporter type 2
    Solute carrier family 1 member 5
    Gene namesi
    Name:SLC1A5
    Synonyms:ASCT2, M7V1, RDR, RDRC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10943. SLC1A5.

    Subcellular locationi

    Cell membrane Curated; Multi-pass membrane protein Curated. Melanosome
    Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi apparatus Source: HPA
    3. integral component of plasma membrane Source: ProtInc
    4. melanosome Source: UniProtKB-SubCell
    5. membrane Source: UniProtKB
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35830.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Neutral amino acid transporter B(0)PRO_0000202082Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)1 Publication
    Modified residuei493 – 4931Phosphoserine1 Publication
    Modified residuei503 – 5031Phosphoserine1 Publication
    Modified residuei535 – 5351Phosphoserine4 Publications

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ15758.
    PaxDbiQ15758.
    PeptideAtlasiQ15758.
    PRIDEiQ15758.

    PTM databases

    PhosphoSiteiQ15758.

    Expressioni

    Tissue specificityi

    Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

    Gene expression databases

    ArrayExpressiQ15758.
    BgeeiQ15758.
    CleanExiHS_SLC1A5.
    GenevestigatoriQ15758.

    Organism-specific databases

    HPAiHPA035239.
    HPA035240.

    Interactioni

    Subunit structurei

    Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization.1 Publication

    Protein-protein interaction databases

    BioGridi112401. 16 interactions.
    IntActiQ15758. 6 interactions.
    MINTiMINT-5001314.
    STRINGi9606.ENSP00000303623.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15758.
    SMRiQ15758. Positions 59-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini154 – 22471ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei426 – 44621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1301.
    HOVERGENiHBG000080.
    InParanoidiQ15758.
    KOiK05616.
    OMAiLVRNIFP.
    OrthoDBiEOG7RV9G2.
    PhylomeDBiQ15758.
    TreeFamiTF315206.

    Family and domain databases

    Gene3Di1.10.3860.10. 1 hit.
    InterProiIPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11958. PTHR11958. 1 hit.
    PfamiPF00375. SDF. 1 hit.
    [Graphical view]
    PRINTSiPR00173. EDTRNSPORT.
    SUPFAMiSSF118215. SSF118215. 1 hit.
    PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. Align

    Note: A number of isoforms are produced by alternative initiation. Isoforms start at multiple alternative CUG and GUG codons.1 Publication

    Isoform 1 (identifier: Q15758-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR    50
    ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL 100
    RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA 150
    LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA 200
    FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP 250
    EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA 300
    RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT 350
    SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF 400
    IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV 450
    DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ 500
    VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M 541
    Length:541
    Mass (Da):56,598
    Last modified:June 20, 2002 - v2
    Checksum:iAD61C789CCFFE934
    GO
    Isoform 2 (identifier: Q15758-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-203: MVADPPRDSK...SNLVSAAFRS → M

    Note: No experimental confirmation available.

    Show »
    Length:339
    Mass (Da):36,636
    Checksum:iCFF2D2673EDD4FC9
    GO
    Isoform 3 (identifier: Q15758-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-228: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:313
    Mass (Da):33,710
    Checksum:iA2CF681DC2A2F24E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 247TANGGLA → PPTGAWQ in AAC50629. (PubMed:8702519)Curated
    Sequence conflicti44 – 441Q → L in AAC50629. (PubMed:8702519)Curated
    Sequence conflicti84 – 874ERLS → GALE in AAC50629. (PubMed:8702519)Curated
    Sequence conflicti341 – 3411V → A in BAH14917. (PubMed:14702039)Curated
    Sequence conflicti453 – 4531I → V in AAD09812. (PubMed:10051606)Curated
    Sequence conflicti460 – 4601D → G in AAD09812. (PubMed:10051606)Curated
    Sequence conflicti463 – 4631V → A in AAD09812. (PubMed:10051606)Curated
    Sequence conflicti508 – 5081D → G in AAD09812. (PubMed:10051606)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171P → A.
    Corresponds to variant rs3027956 [ dbSNP | Ensembl ].
    VAR_020439
    Natural varianti512 – 5121V → L.2 Publications
    Corresponds to variant rs3027961 [ dbSNP | Ensembl ].
    VAR_013517

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 228228Missing in isoform 3. 1 PublicationVSP_046851Add
    BLAST
    Alternative sequencei1 – 203203MVADP…AAFRS → M in isoform 2. 1 PublicationVSP_046354Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53347 mRNA. Translation: AAC50629.1.
    AF102826 mRNA. Translation: AAD09812.1.
    AF105423 mRNA. Translation: AAD27806.1.
    GQ919058 mRNA. Translation: ACX53626.1.
    AK292690 mRNA. Translation: BAF85379.1.
    AK299137 mRNA. Translation: BAG61189.1.
    AK301661 mRNA. Translation: BAG63136.1.
    AK316546 mRNA. Translation: BAH14917.1.
    AC008622 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57446.1.
    BC000062 mRNA. Translation: AAH00062.1.
    AF334818 mRNA. Translation: AAK77026.1.
    CCDSiCCDS12692.1. [Q15758-1]
    CCDS46125.1. [Q15758-2]
    CCDS46126.1. [Q15758-3]
    RefSeqiNP_001138616.1. NM_001145144.1. [Q15758-3]
    NP_001138617.1. NM_001145145.1. [Q15758-2]
    NP_005619.1. NM_005628.2. [Q15758-1]
    UniGeneiHs.631582.

    Genome annotation databases

    EnsembliENST00000412532; ENSP00000397924; ENSG00000105281. [Q15758-3]
    ENST00000434726; ENSP00000406532; ENSG00000105281. [Q15758-2]
    ENST00000542575; ENSP00000444408; ENSG00000105281. [Q15758-1]
    GeneIDi6510.
    KEGGihsa:6510.
    UCSCiuc002pfr.3. human. [Q15758-1]

    Polymorphism databases

    DMDMi21542389.

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53347 mRNA. Translation: AAC50629.1 .
    AF102826 mRNA. Translation: AAD09812.1 .
    AF105423 mRNA. Translation: AAD27806.1 .
    GQ919058 mRNA. Translation: ACX53626.1 .
    AK292690 mRNA. Translation: BAF85379.1 .
    AK299137 mRNA. Translation: BAG61189.1 .
    AK301661 mRNA. Translation: BAG63136.1 .
    AK316546 mRNA. Translation: BAH14917.1 .
    AC008622 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57446.1 .
    BC000062 mRNA. Translation: AAH00062.1 .
    AF334818 mRNA. Translation: AAK77026.1 .
    CCDSi CCDS12692.1. [Q15758-1 ]
    CCDS46125.1. [Q15758-2 ]
    CCDS46126.1. [Q15758-3 ]
    RefSeqi NP_001138616.1. NM_001145144.1. [Q15758-3 ]
    NP_001138617.1. NM_001145145.1. [Q15758-2 ]
    NP_005619.1. NM_005628.2. [Q15758-1 ]
    UniGenei Hs.631582.

    3D structure databases

    ProteinModelPortali Q15758.
    SMRi Q15758. Positions 59-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112401. 16 interactions.
    IntActi Q15758. 6 interactions.
    MINTi MINT-5001314.
    STRINGi 9606.ENSP00000303623.

    Chemistry

    DrugBanki DB00174. L-Asparagine.
    DB00130. L-Glutamine.
    GuidetoPHARMACOLOGYi 874.

    Protein family/group databases

    TCDBi 2.A.23.3.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

    PTM databases

    PhosphoSitei Q15758.

    Polymorphism databases

    DMDMi 21542389.

    Proteomic databases

    MaxQBi Q15758.
    PaxDbi Q15758.
    PeptideAtlasi Q15758.
    PRIDEi Q15758.

    Protocols and materials databases

    DNASUi 6510.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412532 ; ENSP00000397924 ; ENSG00000105281 . [Q15758-3 ]
    ENST00000434726 ; ENSP00000406532 ; ENSG00000105281 . [Q15758-2 ]
    ENST00000542575 ; ENSP00000444408 ; ENSG00000105281 . [Q15758-1 ]
    GeneIDi 6510.
    KEGGi hsa:6510.
    UCSCi uc002pfr.3. human. [Q15758-1 ]

    Organism-specific databases

    CTDi 6510.
    GeneCardsi GC19M047278.
    H-InvDB HIX0015262.
    HGNCi HGNC:10943. SLC1A5.
    HPAi HPA035239.
    HPA035240.
    MIMi 109190. gene.
    neXtProti NX_Q15758.
    PharmGKBi PA35830.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1301.
    HOVERGENi HBG000080.
    InParanoidi Q15758.
    KOi K05616.
    OMAi LVRNIFP.
    OrthoDBi EOG7RV9G2.
    PhylomeDBi Q15758.
    TreeFami TF315206.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    ChiTaRSi SLC1A5. human.
    GeneWikii SLC1A5.
    GenomeRNAii 6510.
    NextBioi 25315.
    PROi Q15758.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15758.
    Bgeei Q15758.
    CleanExi HS_SLC1A5.
    Genevestigatori Q15758.

    Family and domain databases

    Gene3Di 1.10.3860.10. 1 hit.
    InterProi IPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11958. PTHR11958. 1 hit.
    Pfami PF00375. SDF. 1 hit.
    [Graphical view ]
    PRINTSi PR00173. EDTRNSPORT.
    SUPFAMi SSF118215. SSF118215. 1 hit.
    PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line."
      Kekuda R., Prasad P.D., Fei Y.-J., Torres-Zamorano V., Sinha S., Yang-Feng T.L., Leibach F.H., Ganapathy V.
      J. Biol. Chem. 271:18657-18661(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Choriocarcinoma.
    2. "The RD114/simian type D retrovirus receptor is a neutral amino acid transporter."
      Rasko J.E.J., Battini J.L., Gottschalk R.J., Mazo I., Miller A.D.
      Proc. Natl. Acad. Sci. U.S.A. 96:2129-2134(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A VIRAL RECEPTOR.
    3. "A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses."
      Tailor C.S., Nouri A., Zhao Y., Takeuchi Y., Kabat D.
      J. Virol. 73:4470-4474(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A VIRAL RECEPTOR.
    4. "Cloning of ASCT2 cDNA from MCF-7 cells and its expression in B16 cells."
      Ouyang D.-Y., Xu L.-H., He X.-H., Zha Q.-B., Guo H., Gao Q., Zhang Y.-T.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT LEU-512.
      Tissue: Esophagus and Thymus.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    9. "Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons."
      Tailor C.S., Marin M., Nouri A., Kavanaugh M.P., Kabat D.
      J. Biol. Chem. 276:27221-27230(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-541 (ISOFORM 1), ALTERNATIVE INITIATION.
    10. "An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor."
      Blond J.-L., Lavillette D., Cheynet V., Bouton O., Oriol G., Chapel-Fernandes S., Mandrand B., Mallet F., Cosset F.-L.
      J. Virol. 74:3321-3329(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212.
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503 AND SER-535, VARIANT [LARGE SCALE ANALYSIS] LEU-512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "A novel human endogenous retroviral protein inhibits cell-cell fusion."
      Sugimoto J., Sugimoto M., Bernstein H., Jinno Y., Schust D.
      Sci. Rep. 3:1462-1462(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ERVH48-1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAAAT_HUMAN
    AccessioniPrimary (citable) accession number: Q15758
    Secondary accession number(s): A8K9H5
    , B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q96RL9, Q9BWQ3, Q9UNP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3