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Q15751

- HERC1_HUMAN

UniProt

Q15751 - HERC1_HUMAN

Protein

Probable E3 ubiquitin-protein ligase HERC1

Gene

HERC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.3 Publications

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei4811 – 48111Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. ARF guanyl-nucleotide exchange factor activity Source: ProtInc
    2. ligase activity Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: InterPro

    GO - Biological processi

    1. cerebellar Purkinje cell differentiation Source: Ensembl
    2. negative regulation of autophagy Source: Ensembl
    3. neuromuscular process controlling balance Source: Ensembl
    4. neuron projection development Source: Ensembl
    5. positive regulation of GTPase activity Source: GOC
    6. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor, Ligase

    Keywords - Biological processi

    Transport, Ubl conjugation pathway

    Enzyme and pathway databases

    SignaLinkiQ15751.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable E3 ubiquitin-protein ligase HERC1 (EC:6.3.2.-)
    Alternative name(s):
    HECT domain and RCC1-like domain-containing protein 1
    p532
    p619
    Gene namesi
    Name:HERC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:4867. HERC1.

    Subcellular locationi

    Membrane; Peripheral membrane protein. Cytoplasmcytosol. Golgi apparatus
    Note: Recruited onto actin-rich surface protrusions.

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. cytosol Source: UniProtKB-SubCell
    3. Golgi apparatus Source: ProtInc
    4. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29242.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 48614861Probable E3 ubiquitin-protein ligase HERC1PRO_0000328871Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1491 – 14911Phosphoserine1 Publication
    Modified residuei1517 – 15171Phosphoserine1 Publication
    Modified residuei1521 – 15211Phosphoserine3 Publications
    Modified residuei2701 – 27011Phosphothreonine3 Publications
    Modified residuei2706 – 27061Phosphoserine1 Publication
    Modified residuei2710 – 27101Phosphoserine1 Publication
    Modified residuei4857 – 48571Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15751.
    PaxDbiQ15751.
    PRIDEiQ15751.

    PTM databases

    PhosphoSiteiQ15751.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ15751.
    BgeeiQ15751.
    CleanExiHS_HERC1.
    GenevestigatoriQ15751.

    Organism-specific databases

    HPAiHPA049749.

    Interactioni

    Subunit structurei

    Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A.5 Publications

    Protein-protein interaction databases

    BioGridi114439. 14 interactions.
    IntActiQ15751. 6 interactions.
    MINTiMINT-8330052.
    STRINGi9606.ENSP00000390158.

    Structurei

    Secondary structure

    1
    4861
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3999 – 40046
    Helixi4011 – 40133
    Beta strandi4015 – 40228
    Helixi4024 – 40263
    Beta strandi4029 – 40346
    Beta strandi4036 – 40438
    Beta strandi4048 – 40525
    Helixi4055 – 40573
    Beta strandi4060 – 40634
    Beta strandi4067 – 40726
    Helixi4074 – 40763
    Beta strandi4081 – 40866
    Beta strandi4093 – 40986
    Beta strandi4103 – 41075
    Helixi4110 – 41123
    Beta strandi4116 – 41183
    Beta strandi4122 – 41276
    Helixi4129 – 41313
    Beta strandi4136 – 41416
    Beta strandi4143 – 41508
    Beta strandi4155 – 41595
    Helixi4162 – 41643
    Beta strandi4168 – 41703
    Beta strandi4174 – 41796
    Helixi4181 – 41833
    Beta strandi4188 – 41936
    Beta strandi4195 – 42028
    Beta strandi4208 – 42125
    Helixi4215 – 42173
    Beta strandi4221 – 42233
    Beta strandi4227 – 42326
    Helixi4234 – 42363
    Beta strandi4237 – 42393
    Beta strandi4241 – 42466
    Beta strandi4248 – 42558
    Beta strandi4260 – 42645
    Helixi4266 – 42683
    Helixi4273 – 42786
    Helixi4286 – 42883
    Beta strandi4293 – 42986
    Beta strandi4300 – 43078
    Beta strandi4312 – 43165
    Beta strandi4325 – 43273
    Beta strandi4331 – 43366
    Helixi4338 – 43403
    Beta strandi4347 – 43504
    Beta strandi4352 – 43587

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4O2WX-ray2.00A/B/C/D3975-4360[»]
    ProteinModelPortaliQ15751.
    SMRiQ15751. Positions 372-735, 3423-3727, 3735-3805, 3996-4360, 4489-4834.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati371 – 42050RCC1 1Add
    BLAST
    Repeati421 – 47555RCC1 2Add
    BLAST
    Repeati441 – 48343WD 1Add
    BLAST
    Repeati476 – 52853RCC1 3Add
    BLAST
    Repeati506 – 54540WD 2Add
    BLAST
    Repeati529 – 57850RCC1 4Add
    BLAST
    Repeati580 – 63152RCC1 5Add
    BLAST
    Repeati633 – 68250RCC1 6Add
    BLAST
    Repeati660 – 69940WD 3Add
    BLAST
    Repeati683 – 73553RCC1 7Add
    BLAST
    Domaini2002 – 2193192B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST
    Repeati3426 – 346540WD 4Add
    BLAST
    Repeati3484 – 352239WD 5Add
    BLAST
    Repeati3524 – 357249WD 6Add
    BLAST
    Repeati3580 – 361940WD 7Add
    BLAST
    Repeati3624 – 366340WD 8Add
    BLAST
    Repeati3667 – 371347WD 9Add
    BLAST
    Repeati3745 – 378440WD 10Add
    BLAST
    Repeati3996 – 404449RCC1 8Add
    BLAST
    Repeati4046 – 409954RCC1 9Add
    BLAST
    Repeati4101 – 415151RCC1 10Add
    BLAST
    Repeati4153 – 420351RCC1 11Add
    BLAST
    Repeati4205 – 425652RCC1 12Add
    BLAST
    Repeati4258 – 430851RCC1 13Add
    BLAST
    Repeati4287 – 432539WD 11Add
    BLAST
    Repeati4310 – 436051RCC1 14Add
    BLAST
    Domaini4501 – 4848348HECTPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1349 – 137830Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
    Contains 14 RCC1 repeats.PROSITE-ProRule annotation
    Contains 11 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG5021.
    HOGENOMiHOG000168589.
    HOVERGENiHBG053919.
    InParanoidiQ15751.
    KOiK10594.
    OMAiPIAQAKH.
    OrthoDBiEOG70KGNN.
    PhylomeDBiQ15751.
    TreeFamiTF106426.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    2.130.10.30. 2 hits.
    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000569. HECT.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00632. HECT. 1 hit.
    PF00415. RCC1. 12 hits.
    PF00622. SPRY. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view]
    PRINTSiPR00633. RCCNDNSATION.
    SMARTiSM00119. HECTc. 1 hit.
    SM00449. SPRY. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF50978. SSF50978. 2 hits.
    SSF50985. SSF50985. 2 hits.
    SSF56204. SSF56204. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50237. HECT. 1 hit.
    PS00626. RCC1_2. 4 hits.
    PS50012. RCC1_3. 14 hits.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15751-1 [UniParc]FASTAAdd to Basket

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    MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL     50
    PQQVLCLKGP QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA 100
    GALRKRLLVL QRVFYALSNK YHDKGKVKQQ QHSPESSSGS ADVHSVSERP 150
    RSSTDALIEM GVRTGLSLLF ALLRQSWMMP VSGPGLSLCN DVIHTAIEVV 200
    SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD TLGRRLASEL 250
    LLGLAAQRGS LRYLLEWIEM ALGASAVVHT MEKGKLLSSQ EGMISFDCFM 300
    TILMQMRRSL GSSADRSQWR EPTRTSDGLC SLYEAALCLF EEVCRMASDY 350
    SRTCASPDSI QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP 400
    SFSDAQTIEA GQYCTFVIST DGSVRACGKG SYGRLGLGDS NNQSTLKKLT 450
    FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF SWGDGDYGKL GHGNSSTQKY 500
    PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF GRLGHGDSNS 550
    RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN 600
    RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE 650
    ATALRPKLIE ELAATRIVDV SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG 700
    NSTGPITKPK KVSGLDGIAI QQISAGTSHS LAWTALPRDR QVVAWHRPYC 750
    VDLEESTFSH LRSFLERYCD KINSEIPPLP FPSSREHHSF LKLCLKLLSN 800
    HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE VVIETLSVGA 850
    TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA 900
    SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR 950
    NLGFYTDQAF GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC 1000
    HINNISENSS SVALLHKHLQ LLLPHATDIY SRSANLLKES PWNGSVGEKL 1050
    RDVIYVSAAG SMLCQIVNSL LLLPVSVARP LLSYLLDLLP PLDCLNRLLP 1100
    AADLLEDQEL QWPLHGGPEL IDPAGLPLPQ PAQSWVWLVD LERTIALLIG 1150
    RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA 1200
    LSGNEEQKPF DYKLRPEIAV YVDLALGCSK EPARSLWISM QDYAVSKDWD 1250
    SATLSNESLL DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KHLSEVYRCV 1300
    YKVRSRLLAC KNLELIQTRS SSRDRWISEN QDSADVDPQE HSFTRTIDEE 1350
    AEMEEQAERD REEGHPEPED EEEEREHEVM TAGKIFQCFL SAREVARSRD 1400
    RDRMNSGAGS GARADDPPPQ SQQERRVSTD LPEGQDVYTA ACNSVIHRCA 1450
    LLILGVSPVI DELQKRREEG QLQQPSTSAS EGGGLMTRSE SLTAESRLVH 1500
    TSPNYRLIKS RSESDLSQPE SDEEGYALSG RRNVDLDLAA SHRKRGPMHS 1550
    QLESLSDSWA RLKHSRDWLC NSSYSFESDF DLTKSLGVHT LIENVVSFVS 1600
    GDVGNAPGFK EPEESMSTSP QASIIAMEQQ QLRAELRLEA LHQILVLLSG 1650
    MEEKGSISLA GSRLSSGFQS STLLTSVRLQ FLAGCFGLGT VGHTGGKGES 1700
    GRLHHYQDGI RAAKRNIQIE IQVAVHKIYQ QLSATLERAL QANKHHIEAQ 1750
    QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP 1800
    KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK 1850
    NLLSQTGVLH MASFGEGEQE DGEEEEKKVD SSGETEKKDF RAALRKQHAA 1900
    ELHLGDFLVF LRRVVSSKAI QSKMASPKWT EVLLNIASQK CSSGIPLVGN 1950
    LRTRLLALHV LEAVLPACES GVEDDQMAQI VERLFSLLSD CMWETPIAQA 2000
    KHAIQIKEKE QEIKLQKQGE LEEEDENLPI QEVSFDPEKA QCCLVENGQI 2050
    LTHGSGGKGY GLASTGVTSG CYQWKFYIVK ENRGNEGTCV GVSRWPVHDF 2100
    NHRTTSDMWL YRAYSGNLYH NGEQTLTLSS FTQGDFITCV LDMEARTISF 2150
    GKNGEEPKLA FEDVDAAELY PCVMFYSSNP GEKVKICDMQ MRGTPRDLLP 2200
    GDPICSPVAA VLAEATIQLI RILHRTDRWT YCINKKMMER LHKIKICIKE 2250
    SGQKLKKSRS VQSREENEMR EEKESKEEEK GKHTRHGLAD LSELQLRTLC 2300
    IEVWPVLAVI GGVDAGLRVG GRCVHKQTGR HATLLGVVKE GSTSAKVQWD 2350
    EAEITISFPT FWSPSDTPLY NLEPCEPLPF DVARFRGLTA SVLLDLTYLT 2400
    GVHEDMGKQS TKRHEKKHRH ESEEKGDVEQ KPESESALDM RTGLTSDDVK 2450
    SQSTTSSKSE NEIASFSLDP TLPSVESQHQ ITEGKRKNHE HMSKNHDVAQ 2500
    SEIRAVQLSY LYLGAMKSLS ALLGCSKYAE LLLIPKVLAE NGHNSDCASS 2550
    PVVHEDVEMR AALQFLMRHM VKRAVMRSPI KRALGLADLE RAQAMIYKLV 2600
    VHGLLEDQFG GKIKQEIDQQ AEESDPAQQA QTPVTTSPSA SSTTSFMSSS 2650
    LEDTTTATTP VTDTETVPAS ESPGVMPLSL LRQMFSSYPT TTVLPTRRAQ 2700
    TPPISSLPTS PSDEVGRRQS LTSPDSQSAR PANRTALSDP SSRLSTSPPP 2750
    PAIAVPLLEM GFSLRQIAKA MEATGARGEA DAQNITVLAM WMIEHPGHED 2800
    EEEPQSGSTA DSRPGAAVLG SGGKSNDPCY LQSPGDIPSA DAAEMEEGFS 2850
    ESPDNLDHTE NAASGSGPSA RGRSAVTRRH KFDLAARTLL ARAAGLYRSV 2900
    QAHRNQSRRE GISLQQDPGA LYDFNLDEEL EIDLDDEAME AMFGQDLTSD 2950
    NDILGMWIPE VLDWPTWHVC ESEDREEVVV CELCECSVVS FNQHMKRNHP 3000
    GCGRSANRQG YRSNGSYVDG WFGGECGSGN PYYLLCGTCR EKYLAMKTKS 3050
    KSTSSERYKG QAPDLIGKQD SVYEEDWDML DVDEDEKLTG EEEFELLAGP 3100
    LGLNDRRIVP EPVQFPDSDP LGASVAMVTA TNSMEETLMQ IGCHGSVEKS 3150
    SSGRITLGEQ AAALANPHDR VVALRRVTAA AQVLLARTMV MRALSLLSVS 3200
    GSSCSLAAGL ESLGLTDIRT LVRLMCLAAA GRAGLSTSPS AMASTSERSR 3250
    GGHSKANKPI SCLAYLSTAV GCLASNAPSA AKLLVQLCTQ NLISAATGVN 3300
    LTTVDDSIQR KFLPSFLRGI AEENKLVTSP NFVVTQALVA LLADKGAKLR 3350
    PNYDKSEVEK KGPLELANAL AACCLSSRLS SQHRQWAAQQ LVRTLAAHDR 3400
    DNQTTLQTLA DMGGDLRKCS FIKLEAHQNR VMTCVWCNKK GLLATSGNDG 3450
    TIRVWNVTKK QYSLQQTCVF NRLEGDAEES LGSPSDPSFS PVSWSISGKY 3500
    LAGALEKMVN IWQVNGGKGL VDIQPHWVSA LAWPEEGPAT AWSGESPELL 3550
    LVGRMDGSLG LIEVVDVSTM HRRELEHCYR KDVSVTCIAW FSEDRPFAVG 3600
    YFDGKLLLGT KEPLEKGGIV LIDAHKDTLI SMKWDPTGHI LMTCAKEDSV 3650
    KLWGSISGCW CCLHSLCHPS IVNGIAWCRL PGKGSKLQLL MATGCQSGLV 3700
    CVWRIPQDTT QTNVTSAEGW WEQESNCQDG YRKSSGAKCV YQLRGHITPV 3750
    RTVAFSSDGL ALVSGGLGGL MNIWSLRDGS VLQTVVIGSG AIQTTVWIPE 3800
    VGVAACSNRS KDVLVVNCTA EWAAANHVLA TCRTALKQQG VLGLNMAPCM 3850
    RAFLERLPMM LQEQYAYEKP HVVCGDQLVH SPYMQCLASL AVGLHLDQLL 3900
    CNPPVPPHHQ NCLPDPASWN PNEWAWLECF STTIKAAEAL TNGAQFPESF 3950
    TVPDLEPVPE DELVFLMDNS KWINGMDEQI MSWATSRPED WHLGGKCDVY 4000
    LWGAGRHGQL AEAGRNVMVP AAAPSFSQAQ QVICGQNCTF VIQANGTVLA 4050
    CGEGSYGRLG QGNSDDLHVL TVISALQGFV VTQLVTSCGS DGHSMALTES 4100
    GEVFSWGDGD YGKLGHGNSD RQRRPRQIEA LQGEEVVQMS CGFKHSAVVT 4150
    SDGKLFTFGN GDYGRLGLGN TSNKKLPERV TALEGYQIGQ VACGLNHTLA 4200
    VSADGSMVWA FGDGDYGKLG LGNSTAKSSP QKIDVLCGIG IKKVACGTQF 4250
    SVALTKDGHV YTFGQDRLIG LPEGRARNHN RPQQIPVLAG VIIEDVAVGA 4300
    EHTLALASNG DVYAWGSNSE GQLGLGHTNH VREPTLVTGL QGKNVRQISA 4350
    GRCHSAAWTA PPVPPRAPGV SVPLQLGLPD TVPPQYGALR EVSIHTVRAR 4400
    LRLLYHFSDL MYSSWRLLNL SPNNQNSTSH YNAGTWGIVQ GQLRPLLAPR 4450
    VYTLPMVRSI GKTMVQGKNY GPQITVKRIS TRGRKCKPIF VQIARQVVKL 4500
    NASDLRLPSR AWKVKLVGEG ADDAGGVFDD TITEMCQELE TGIVDLLIPS 4550
    PNATAEVGYN RDRFLFNPSA CLDEHLMQFK FLGILMGVAI RTKKPLDLHL 4600
    APLVWKQLCC VPLTLEDLEE VDLLYVQTLN SILHIEDSGI TEESFHEMIP 4650
    LDSFVGQSAD GKMVPIIPGG NSIPLTFSNR KEYVERAIEY RLHEMDRQVA 4700
    AVREGMSWIV PVPLLSLLTA KQLEQMVCGM PEISVEVLKK VVRYREVDEQ 4750
    HQLVQWFWHT LEEFSNEERV LFMRFVSGRS RLPANTADIS QRFQIMKVDR 4800
    PYDSLPTSQT CFFQLRLPPY SSQLVMAERL RYAINNCRSI DMDNYMLSRN 4850
    VDNAEGSDTD Y 4861
    Length:4,861
    Mass (Da):532,228
    Last modified:May 18, 2010 - v2
    Checksum:i31B2C1A1430B9622
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1532 – 15321R → Q in AAD12586. (PubMed:8861955)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1088 – 10881L → F.
    Corresponds to variant rs1063423 [ dbSNP | Ensembl ].
    VAR_042556
    Natural varianti1278 – 12781L → F.
    Corresponds to variant rs3764187 [ dbSNP | Ensembl ].
    VAR_042557
    Natural varianti1411 – 14111G → V.
    Corresponds to variant rs36089909 [ dbSNP | Ensembl ].
    VAR_042558
    Natural varianti1447 – 14471H → N.
    Corresponds to variant rs7162519 [ dbSNP | Ensembl ].
    VAR_042559
    Natural varianti1572 – 15721S → A.
    Corresponds to variant rs16947363 [ dbSNP | Ensembl ].
    VAR_042560
    Natural varianti1696 – 16961G → A.1 Publication
    Corresponds to variant rs2255243 [ dbSNP | Ensembl ].
    VAR_042561
    Natural varianti1995 – 19951T → A.
    Corresponds to variant rs2228512 [ dbSNP | Ensembl ].
    VAR_042562
    Natural varianti2220 – 22201I → V.1 Publication
    Corresponds to variant rs2228510 [ dbSNP | Ensembl ].
    VAR_042563
    Natural varianti2816 – 28161A → T.
    Corresponds to variant rs35122568 [ dbSNP | Ensembl ].
    VAR_042564
    Natural varianti3152 – 31521S → F.
    Corresponds to variant rs2228513 [ dbSNP | Ensembl ].
    VAR_042565
    Natural varianti3517 – 35171G → R.
    Corresponds to variant rs7182782 [ dbSNP | Ensembl ].
    VAR_042566
    Natural varianti3722 – 37221E → D.1 Publication
    Corresponds to variant rs2229749 [ dbSNP | Ensembl ].
    VAR_042567
    Natural varianti4394 – 43941I → V.
    Corresponds to variant rs2228516 [ dbSNP | Ensembl ].
    VAR_057122

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50078 mRNA. Translation: AAD12586.1.
    AC073167 Genomic DNA. No translation available.
    AC118274 Genomic DNA. No translation available.
    BC040929 mRNA. Translation: AAH40929.1.
    CCDSiCCDS45277.1.
    PIRiS71752.
    RefSeqiNP_003913.3. NM_003922.3.
    XP_005254799.1. XM_005254742.2.
    XP_005254800.1. XM_005254743.2.
    UniGeneiHs.210385.

    Genome annotation databases

    EnsembliENST00000443617; ENSP00000390158; ENSG00000103657.
    GeneIDi8925.
    KEGGihsa:8925.
    UCSCiuc002amp.3. human.

    Polymorphism databases

    DMDMi296434522.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50078 mRNA. Translation: AAD12586.1 .
    AC073167 Genomic DNA. No translation available.
    AC118274 Genomic DNA. No translation available.
    BC040929 mRNA. Translation: AAH40929.1 .
    CCDSi CCDS45277.1.
    PIRi S71752.
    RefSeqi NP_003913.3. NM_003922.3.
    XP_005254799.1. XM_005254742.2.
    XP_005254800.1. XM_005254743.2.
    UniGenei Hs.210385.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4O2W X-ray 2.00 A/B/C/D 3975-4360 [» ]
    ProteinModelPortali Q15751.
    SMRi Q15751. Positions 372-735, 3423-3727, 3735-3805, 3996-4360, 4489-4834.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114439. 14 interactions.
    IntActi Q15751. 6 interactions.
    MINTi MINT-8330052.
    STRINGi 9606.ENSP00000390158.

    PTM databases

    PhosphoSitei Q15751.

    Polymorphism databases

    DMDMi 296434522.

    Proteomic databases

    MaxQBi Q15751.
    PaxDbi Q15751.
    PRIDEi Q15751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000443617 ; ENSP00000390158 ; ENSG00000103657 .
    GeneIDi 8925.
    KEGGi hsa:8925.
    UCSCi uc002amp.3. human.

    Organism-specific databases

    CTDi 8925.
    GeneCardsi GC15M063900.
    HGNCi HGNC:4867. HERC1.
    HPAi HPA049749.
    MIMi 605109. gene.
    neXtProti NX_Q15751.
    PharmGKBi PA29242.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5021.
    HOGENOMi HOG000168589.
    HOVERGENi HBG053919.
    InParanoidi Q15751.
    KOi K10594.
    OMAi PIAQAKH.
    OrthoDBi EOG70KGNN.
    PhylomeDBi Q15751.
    TreeFami TF106426.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    SignaLinki Q15751.

    Miscellaneous databases

    GeneWikii HERC1.
    GenomeRNAii 8925.
    NextBioi 33556.
    PROi Q15751.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15751.
    Bgeei Q15751.
    CleanExi HS_HERC1.
    Genevestigatori Q15751.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    2.130.10.30. 2 hits.
    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000569. HECT.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00632. HECT. 1 hit.
    PF00415. RCC1. 12 hits.
    PF00622. SPRY. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view ]
    PRINTSi PR00633. RCCNDNSATION.
    SMARTi SM00119. HECTc. 1 hit.
    SM00449. SPRY. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF50978. SSF50978. 2 hits.
    SSF50985. SSF50985. 2 hits.
    SSF56204. SSF56204. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50237. HECT. 1 hit.
    PS00626. RCC1_2. 4 hits.
    PS50012. RCC1_3. 14 hits.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins."
      Rosa J.L., Casaroli-Marano R.P., Buckler A.J., Vilaro S., Barbacid M.
      EMBO J. 15:4262-4273(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH ARF1, VARIANTS ALA-1696; VAL-2220 AND ASP-3722.
    2. Erratum
      Rosa J.L., Casaroli-Marano R.P., Buckler A.J., Vilaro S., Barbacid M.
      EMBO J. 15:5738-5738(1996)
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4211-4861.
      Tissue: Liver.
    5. "A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70."
      Rosa J.L., Barbacid M.
      Oncogene 15:1-6(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CLTC.
    6. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PKM.
    7. "The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells."
      Garcia-Gonzalo F.R., Munoz P., Gonzalez E., Casaroli-Marano R.P., Vilaro S., Bartrons R., Ventura F., Rosa J.L.
      FEBS Lett. 559:77-83(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins."
      Garcia-Gonzalo F.R., Bartrons R., Ventura F., Rosa J.L.
      FEBS Lett. 579:343-348(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ARF6.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase."
      Chong-Kopera H., Inoki K., Li Y., Zhu T., Garcia-Gonzalo F.R., Rosa J.L., Guan K.-L.
      J. Biol. Chem. 281:8313-8316(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TSC2.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2701, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1517; SER-1521; THR-2701; SER-2706 AND SER-2710, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1521 AND THR-2701, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4857, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHERC1_HUMAN
    AccessioniPrimary (citable) accession number: Q15751
    Secondary accession number(s): Q8IW65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3