Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q15751 (HERC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable E3 ubiquitin-protein ligase HERC1

EC=6.3.2.-
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 1
p532
p619
Gene names
Name:HERC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4861 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ref.1 Ref.5 Ref.8

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A. Ref.1 Ref.5 Ref.6 Ref.8 Ref.10

Subcellular location

Membrane; Peripheral membrane protein. Cytoplasmcytosol. Golgi apparatus. Note: Recruited onto actin-rich surface protrusions. Ref.1 Ref.6 Ref.7

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Contains 1 B30.2/SPRY domain.

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.

Contains 14 RCC1 repeats.

Contains 11 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 48614861Probable E3 ubiquitin-protein ligase HERC1
PRO_0000328871

Regions

Repeat371 – 42050RCC1 1
Repeat421 – 47555RCC1 2
Repeat441 – 48343WD 1
Repeat476 – 52853RCC1 3
Repeat506 – 54540WD 2
Repeat529 – 57850RCC1 4
Repeat580 – 63152RCC1 5
Repeat633 – 68250RCC1 6
Repeat660 – 69940WD 3
Repeat683 – 73553RCC1 7
Domain2002 – 2193192B30.2/SPRY
Repeat3426 – 346540WD 4
Repeat3484 – 352239WD 5
Repeat3524 – 357249WD 6
Repeat3580 – 361940WD 7
Repeat3624 – 366340WD 8
Repeat3667 – 371347WD 9
Repeat3745 – 378440WD 10
Repeat3996 – 404449RCC1 8
Repeat4046 – 409954RCC1 9
Repeat4101 – 415151RCC1 10
Repeat4153 – 420351RCC1 11
Repeat4205 – 425652RCC1 12
Repeat4258 – 430851RCC1 13
Repeat4287 – 432539WD 11
Repeat4310 – 436051RCC1 14
Domain4501 – 4848348HECT
Compositional bias1349 – 137830Glu-rich

Sites

Active site48111Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue14911Phosphoserine Ref.17
Modified residue15171Phosphoserine Ref.13
Modified residue15211Phosphoserine Ref.11 Ref.13 Ref.14
Modified residue27011Phosphothreonine Ref.12 Ref.13 Ref.14
Modified residue27061Phosphoserine Ref.13
Modified residue27101Phosphoserine Ref.13
Modified residue48571Phosphoserine Ref.15

Natural variations

Natural variant10881L → F.
Corresponds to variant rs1063423 [ dbSNP | Ensembl ].
VAR_042556
Natural variant12781L → F.
Corresponds to variant rs3764187 [ dbSNP | Ensembl ].
VAR_042557
Natural variant14111G → V.
Corresponds to variant rs36089909 [ dbSNP | Ensembl ].
VAR_042558
Natural variant14471H → N.
Corresponds to variant rs7162519 [ dbSNP | Ensembl ].
VAR_042559
Natural variant15721S → A.
Corresponds to variant rs16947363 [ dbSNP | Ensembl ].
VAR_042560
Natural variant16961G → A. Ref.1
Corresponds to variant rs2255243 [ dbSNP | Ensembl ].
VAR_042561
Natural variant19951T → A.
Corresponds to variant rs2228512 [ dbSNP | Ensembl ].
VAR_042562
Natural variant22201I → V. Ref.1
Corresponds to variant rs2228510 [ dbSNP | Ensembl ].
VAR_042563
Natural variant28161A → T.
Corresponds to variant rs35122568 [ dbSNP | Ensembl ].
VAR_042564
Natural variant31521S → F.
Corresponds to variant rs2228513 [ dbSNP | Ensembl ].
VAR_042565
Natural variant35171G → R.
Corresponds to variant rs7182782 [ dbSNP | Ensembl ].
VAR_042566
Natural variant37221E → D. Ref.1
Corresponds to variant rs2229749 [ dbSNP | Ensembl ].
VAR_042567
Natural variant43941I → V.
Corresponds to variant rs2228516 [ dbSNP | Ensembl ].
VAR_057122

Experimental info

Sequence conflict15321R → Q in AAD12586. Ref.1

Secondary structure

.............................................................................................. 4861
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q15751 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 31B2C1A1430B9622

FASTA4,861532,228
        10         20         30         40         50         60 
MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP 

        70         80         90        100        110        120 
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 

       130        140        150        160        170        180 
YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP 

       190        200        210        220        230        240 
VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD 

       250        260        270        280        290        300 
TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVHT MEKGKLLSSQ EGMISFDCFM 

       310        320        330        340        350        360 
TILMQMRRSL GSSADRSQWR EPTRTSDGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI 

       370        380        390        400        410        420 
QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVIST 

       430        440        450        460        470        480 
DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF 

       490        500        510        520        530        540 
SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF 

       550        560        570        580        590        600 
GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN 

       610        620        630        640        650        660 
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE 

       670        680        690        700        710        720 
ELAATRIVDV SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI 

       730        740        750        760        770        780 
QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP 

       790        800        810        820        830        840 
FPSSREHHSF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE 

       850        860        870        880        890        900 
VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA 

       910        920        930        940        950        960 
SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR NLGFYTDQAF 

       970        980        990       1000       1010       1020 
GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNISENSS SVALLHKHLQ 

      1030       1040       1050       1060       1070       1080 
LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP 

      1090       1100       1110       1120       1130       1140 
LLSYLLDLLP PLDCLNRLLP AADLLEDQEL QWPLHGGPEL IDPAGLPLPQ PAQSWVWLVD 

      1150       1160       1170       1180       1190       1200 
LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA 

      1210       1220       1230       1240       1250       1260 
LSGNEEQKPF DYKLRPEIAV YVDLALGCSK EPARSLWISM QDYAVSKDWD SATLSNESLL 

      1270       1280       1290       1300       1310       1320 
DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KHLSEVYRCV YKVRSRLLAC KNLELIQTRS 

      1330       1340       1350       1360       1370       1380 
SSRDRWISEN QDSADVDPQE HSFTRTIDEE AEMEEQAERD REEGHPEPED EEEEREHEVM 

      1390       1400       1410       1420       1430       1440 
TAGKIFQCFL SAREVARSRD RDRMNSGAGS GARADDPPPQ SQQERRVSTD LPEGQDVYTA 

      1450       1460       1470       1480       1490       1500 
ACNSVIHRCA LLILGVSPVI DELQKRREEG QLQQPSTSAS EGGGLMTRSE SLTAESRLVH 

      1510       1520       1530       1540       1550       1560 
TSPNYRLIKS RSESDLSQPE SDEEGYALSG RRNVDLDLAA SHRKRGPMHS QLESLSDSWA 

      1570       1580       1590       1600       1610       1620 
RLKHSRDWLC NSSYSFESDF DLTKSLGVHT LIENVVSFVS GDVGNAPGFK EPEESMSTSP 

      1630       1640       1650       1660       1670       1680 
QASIIAMEQQ QLRAELRLEA LHQILVLLSG MEEKGSISLA GSRLSSGFQS STLLTSVRLQ 

      1690       1700       1710       1720       1730       1740 
FLAGCFGLGT VGHTGGKGES GRLHHYQDGI RAAKRNIQIE IQVAVHKIYQ QLSATLERAL 

      1750       1760       1770       1780       1790       1800 
QANKHHIEAQ QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP 

      1810       1820       1830       1840       1850       1860 
KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK NLLSQTGVLH 

      1870       1880       1890       1900       1910       1920 
MASFGEGEQE DGEEEEKKVD SSGETEKKDF RAALRKQHAA ELHLGDFLVF LRRVVSSKAI 

      1930       1940       1950       1960       1970       1980 
QSKMASPKWT EVLLNIASQK CSSGIPLVGN LRTRLLALHV LEAVLPACES GVEDDQMAQI 

      1990       2000       2010       2020       2030       2040 
VERLFSLLSD CMWETPIAQA KHAIQIKEKE QEIKLQKQGE LEEEDENLPI QEVSFDPEKA 

      2050       2060       2070       2080       2090       2100 
QCCLVENGQI LTHGSGGKGY GLASTGVTSG CYQWKFYIVK ENRGNEGTCV GVSRWPVHDF 

      2110       2120       2130       2140       2150       2160 
NHRTTSDMWL YRAYSGNLYH NGEQTLTLSS FTQGDFITCV LDMEARTISF GKNGEEPKLA 

      2170       2180       2190       2200       2210       2220 
FEDVDAAELY PCVMFYSSNP GEKVKICDMQ MRGTPRDLLP GDPICSPVAA VLAEATIQLI 

      2230       2240       2250       2260       2270       2280 
RILHRTDRWT YCINKKMMER LHKIKICIKE SGQKLKKSRS VQSREENEMR EEKESKEEEK 

      2290       2300       2310       2320       2330       2340 
GKHTRHGLAD LSELQLRTLC IEVWPVLAVI GGVDAGLRVG GRCVHKQTGR HATLLGVVKE 

      2350       2360       2370       2380       2390       2400 
GSTSAKVQWD EAEITISFPT FWSPSDTPLY NLEPCEPLPF DVARFRGLTA SVLLDLTYLT 

      2410       2420       2430       2440       2450       2460 
GVHEDMGKQS TKRHEKKHRH ESEEKGDVEQ KPESESALDM RTGLTSDDVK SQSTTSSKSE 

      2470       2480       2490       2500       2510       2520 
NEIASFSLDP TLPSVESQHQ ITEGKRKNHE HMSKNHDVAQ SEIRAVQLSY LYLGAMKSLS 

      2530       2540       2550       2560       2570       2580 
ALLGCSKYAE LLLIPKVLAE NGHNSDCASS PVVHEDVEMR AALQFLMRHM VKRAVMRSPI 

      2590       2600       2610       2620       2630       2640 
KRALGLADLE RAQAMIYKLV VHGLLEDQFG GKIKQEIDQQ AEESDPAQQA QTPVTTSPSA 

      2650       2660       2670       2680       2690       2700 
SSTTSFMSSS LEDTTTATTP VTDTETVPAS ESPGVMPLSL LRQMFSSYPT TTVLPTRRAQ 

      2710       2720       2730       2740       2750       2760 
TPPISSLPTS PSDEVGRRQS LTSPDSQSAR PANRTALSDP SSRLSTSPPP PAIAVPLLEM 

      2770       2780       2790       2800       2810       2820 
GFSLRQIAKA MEATGARGEA DAQNITVLAM WMIEHPGHED EEEPQSGSTA DSRPGAAVLG 

      2830       2840       2850       2860       2870       2880 
SGGKSNDPCY LQSPGDIPSA DAAEMEEGFS ESPDNLDHTE NAASGSGPSA RGRSAVTRRH 

      2890       2900       2910       2920       2930       2940 
KFDLAARTLL ARAAGLYRSV QAHRNQSRRE GISLQQDPGA LYDFNLDEEL EIDLDDEAME 

      2950       2960       2970       2980       2990       3000 
AMFGQDLTSD NDILGMWIPE VLDWPTWHVC ESEDREEVVV CELCECSVVS FNQHMKRNHP 

      3010       3020       3030       3040       3050       3060 
GCGRSANRQG YRSNGSYVDG WFGGECGSGN PYYLLCGTCR EKYLAMKTKS KSTSSERYKG 

      3070       3080       3090       3100       3110       3120 
QAPDLIGKQD SVYEEDWDML DVDEDEKLTG EEEFELLAGP LGLNDRRIVP EPVQFPDSDP 

      3130       3140       3150       3160       3170       3180 
LGASVAMVTA TNSMEETLMQ IGCHGSVEKS SSGRITLGEQ AAALANPHDR VVALRRVTAA 

      3190       3200       3210       3220       3230       3240 
AQVLLARTMV MRALSLLSVS GSSCSLAAGL ESLGLTDIRT LVRLMCLAAA GRAGLSTSPS 

      3250       3260       3270       3280       3290       3300 
AMASTSERSR GGHSKANKPI SCLAYLSTAV GCLASNAPSA AKLLVQLCTQ NLISAATGVN 

      3310       3320       3330       3340       3350       3360 
LTTVDDSIQR KFLPSFLRGI AEENKLVTSP NFVVTQALVA LLADKGAKLR PNYDKSEVEK 

      3370       3380       3390       3400       3410       3420 
KGPLELANAL AACCLSSRLS SQHRQWAAQQ LVRTLAAHDR DNQTTLQTLA DMGGDLRKCS 

      3430       3440       3450       3460       3470       3480 
FIKLEAHQNR VMTCVWCNKK GLLATSGNDG TIRVWNVTKK QYSLQQTCVF NRLEGDAEES 

      3490       3500       3510       3520       3530       3540 
LGSPSDPSFS PVSWSISGKY LAGALEKMVN IWQVNGGKGL VDIQPHWVSA LAWPEEGPAT 

      3550       3560       3570       3580       3590       3600 
AWSGESPELL LVGRMDGSLG LIEVVDVSTM HRRELEHCYR KDVSVTCIAW FSEDRPFAVG 

      3610       3620       3630       3640       3650       3660 
YFDGKLLLGT KEPLEKGGIV LIDAHKDTLI SMKWDPTGHI LMTCAKEDSV KLWGSISGCW 

      3670       3680       3690       3700       3710       3720 
CCLHSLCHPS IVNGIAWCRL PGKGSKLQLL MATGCQSGLV CVWRIPQDTT QTNVTSAEGW 

      3730       3740       3750       3760       3770       3780 
WEQESNCQDG YRKSSGAKCV YQLRGHITPV RTVAFSSDGL ALVSGGLGGL MNIWSLRDGS 

      3790       3800       3810       3820       3830       3840 
VLQTVVIGSG AIQTTVWIPE VGVAACSNRS KDVLVVNCTA EWAAANHVLA TCRTALKQQG 

      3850       3860       3870       3880       3890       3900 
VLGLNMAPCM RAFLERLPMM LQEQYAYEKP HVVCGDQLVH SPYMQCLASL AVGLHLDQLL 

      3910       3920       3930       3940       3950       3960 
CNPPVPPHHQ NCLPDPASWN PNEWAWLECF STTIKAAEAL TNGAQFPESF TVPDLEPVPE 

      3970       3980       3990       4000       4010       4020 
DELVFLMDNS KWINGMDEQI MSWATSRPED WHLGGKCDVY LWGAGRHGQL AEAGRNVMVP 

      4030       4040       4050       4060       4070       4080 
AAAPSFSQAQ QVICGQNCTF VIQANGTVLA CGEGSYGRLG QGNSDDLHVL TVISALQGFV 

      4090       4100       4110       4120       4130       4140 
VTQLVTSCGS DGHSMALTES GEVFSWGDGD YGKLGHGNSD RQRRPRQIEA LQGEEVVQMS 

      4150       4160       4170       4180       4190       4200 
CGFKHSAVVT SDGKLFTFGN GDYGRLGLGN TSNKKLPERV TALEGYQIGQ VACGLNHTLA 

      4210       4220       4230       4240       4250       4260 
VSADGSMVWA FGDGDYGKLG LGNSTAKSSP QKIDVLCGIG IKKVACGTQF SVALTKDGHV 

      4270       4280       4290       4300       4310       4320 
YTFGQDRLIG LPEGRARNHN RPQQIPVLAG VIIEDVAVGA EHTLALASNG DVYAWGSNSE 

      4330       4340       4350       4360       4370       4380 
GQLGLGHTNH VREPTLVTGL QGKNVRQISA GRCHSAAWTA PPVPPRAPGV SVPLQLGLPD 

      4390       4400       4410       4420       4430       4440 
TVPPQYGALR EVSIHTVRAR LRLLYHFSDL MYSSWRLLNL SPNNQNSTSH YNAGTWGIVQ 

      4450       4460       4470       4480       4490       4500 
GQLRPLLAPR VYTLPMVRSI GKTMVQGKNY GPQITVKRIS TRGRKCKPIF VQIARQVVKL 

      4510       4520       4530       4540       4550       4560 
NASDLRLPSR AWKVKLVGEG ADDAGGVFDD TITEMCQELE TGIVDLLIPS PNATAEVGYN 

      4570       4580       4590       4600       4610       4620 
RDRFLFNPSA CLDEHLMQFK FLGILMGVAI RTKKPLDLHL APLVWKQLCC VPLTLEDLEE 

      4630       4640       4650       4660       4670       4680 
VDLLYVQTLN SILHIEDSGI TEESFHEMIP LDSFVGQSAD GKMVPIIPGG NSIPLTFSNR 

      4690       4700       4710       4720       4730       4740 
KEYVERAIEY RLHEMDRQVA AVREGMSWIV PVPLLSLLTA KQLEQMVCGM PEISVEVLKK 

      4750       4760       4770       4780       4790       4800 
VVRYREVDEQ HQLVQWFWHT LEEFSNEERV LFMRFVSGRS RLPANTADIS QRFQIMKVDR 

      4810       4820       4830       4840       4850       4860 
PYDSLPTSQT CFFQLRLPPY SSQLVMAERL RYAINNCRSI DMDNYMLSRN VDNAEGSDTD 


Y 

« Hide

References

« Hide 'large scale' references
[1]"p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins."
Rosa J.L., Casaroli-Marano R.P., Buckler A.J., Vilaro S., Barbacid M.
EMBO J. 15:4262-4273(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH ARF1, VARIANTS ALA-1696; VAL-2220 AND ASP-3722.
[2]Erratum
Rosa J.L., Casaroli-Marano R.P., Buckler A.J., Vilaro S., Barbacid M.
EMBO J. 15:5738-5738(1996)
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4211-4861.
Tissue: Liver.
[5]"A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70."
Rosa J.L., Barbacid M.
Oncogene 15:1-6(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CLTC.
[6]"Interaction between HERC1 and M2-type pyruvate kinase."
Garcia-Gonzalo F.R., Cruz C., Munoz P., Mazurek S., Eigenbrodt E., Ventura F., Bartrons R., Rosa J.L.
FEBS Lett. 539:78-84(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PKM.
[7]"The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells."
Garcia-Gonzalo F.R., Munoz P., Gonzalez E., Casaroli-Marano R.P., Vilaro S., Bartrons R., Ventura F., Rosa J.L.
FEBS Lett. 559:77-83(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins."
Garcia-Gonzalo F.R., Bartrons R., Ventura F., Rosa J.L.
FEBS Lett. 579:343-348(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ARF6.
[9]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase."
Chong-Kopera H., Inoki K., Li Y., Zhu T., Garcia-Gonzalo F.R., Rosa J.L., Guan K.-L.
J. Biol. Chem. 281:8313-8316(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TSC2.
[11]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[12]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2701, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1517; SER-1521; THR-2701; SER-2706 AND SER-2710, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1521 AND THR-2701, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[15]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4857, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U50078 mRNA. Translation: AAD12586.1.
AC073167 Genomic DNA. No translation available.
AC118274 Genomic DNA. No translation available.
BC040929 mRNA. Translation: AAH40929.1.
PIRS71752.
RefSeqNP_003913.3. NM_003922.3.
XP_005254799.1. XM_005254742.2.
XP_005254800.1. XM_005254743.2.
UniGeneHs.210385.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4O2WX-ray2.00A/B/C/D3975-4360[»]
ProteinModelPortalQ15751.
SMRQ15751. Positions 374-735, 3423-3727, 3999-4359, 4455-4835.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114439. 14 interactions.
IntActQ15751. 6 interactions.
MINTMINT-8330052.
STRING9606.ENSP00000390158.

PTM databases

PhosphoSiteQ15751.

Polymorphism databases

DMDM296434522.

Proteomic databases

PaxDbQ15751.
PRIDEQ15751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000443617; ENSP00000390158; ENSG00000103657.
GeneID8925.
KEGGhsa:8925.
UCSCuc002amp.3. human.

Organism-specific databases

CTD8925.
GeneCardsGC15M063900.
HGNCHGNC:4867. HERC1.
HPAHPA049749.
MIM605109. gene.
neXtProtNX_Q15751.
PharmGKBPA29242.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5021.
HOGENOMHOG000168589.
HOVERGENHBG053919.
InParanoidQ15751.
KOK10594.
OMAPIAQAKH.
OrthoDBEOG70KGNN.
PhylomeDBQ15751.
TreeFamTF106426.

Enzyme and pathway databases

SignaLinkQ15751.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ15751.
BgeeQ15751.
CleanExHS_HERC1.
GenevestigatorQ15751.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
2.130.10.30. 2 hits.
InterProIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR000569. HECT.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00632. HECT. 1 hit.
PF00415. RCC1. 12 hits.
PF00622. SPRY. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSPR00633. RCCNDNSATION.
SMARTSM00119. HECTc. 1 hit.
SM00449. SPRY. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF50985. SSF50985. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50237. HECT. 1 hit.
PS00626. RCC1_2. 4 hits.
PS50012. RCC1_3. 14 hits.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHERC1.
GenomeRNAi8925.
NextBio33556.
PROQ15751.
SOURCESearch...

Entry information

Entry nameHERC1_HUMAN
AccessionPrimary (citable) accession number: Q15751
Secondary accession number(s): Q8IW65
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM