SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q15751

- HERC1_HUMAN

UniProt

Q15751 - HERC1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable E3 ubiquitin-protein ligase HERC1

Gene
HERC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.3 Publications

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei4811 – 48111Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ARF guanyl-nucleotide exchange factor activity Source: ProtInc
  2. ligase activity Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: InterPro

GO - Biological processi

  1. cerebellar Purkinje cell differentiation Source: Ensembl
  2. negative regulation of autophagy Source: Ensembl
  3. neuromuscular process controlling balance Source: Ensembl
  4. neuron projection development Source: Ensembl
  5. regulation of GTPase activity Source: GOC
  6. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Ligase

Keywords - Biological processi

Transport, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ15751.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC1 (EC:6.3.2.-)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 1
p532
p619
Gene namesi
Name:HERC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:4867. HERC1.

Subcellular locationi

Membrane; Peripheral membrane protein. Cytoplasmcytosol. Golgi apparatus
Note: Recruited onto actin-rich surface protrusions.3 Publications

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. cytosol Source: UniProtKB-SubCell
  3. Golgi apparatus Source: ProtInc
  4. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48614861Probable E3 ubiquitin-protein ligase HERC1PRO_0000328871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1491 – 14911Phosphoserine1 Publication
Modified residuei1517 – 15171Phosphoserine1 Publication
Modified residuei1521 – 15211Phosphoserine3 Publications
Modified residuei2701 – 27011Phosphothreonine3 Publications
Modified residuei2706 – 27061Phosphoserine1 Publication
Modified residuei2710 – 27101Phosphoserine1 Publication
Modified residuei4857 – 48571Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15751.
PaxDbiQ15751.
PRIDEiQ15751.

PTM databases

PhosphoSiteiQ15751.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ15751.
BgeeiQ15751.
CleanExiHS_HERC1.
GenevestigatoriQ15751.

Organism-specific databases

HPAiHPA049749.

Interactioni

Subunit structurei

Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A.5 Publications

Protein-protein interaction databases

BioGridi114439. 14 interactions.
IntActiQ15751. 6 interactions.
MINTiMINT-8330052.
STRINGi9606.ENSP00000390158.

Structurei

Secondary structure

1
4861
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3999 – 40046
Helixi4011 – 40133
Beta strandi4015 – 40228
Helixi4024 – 40263
Beta strandi4029 – 40346
Beta strandi4036 – 40438
Beta strandi4048 – 40525
Helixi4055 – 40573
Beta strandi4060 – 40634
Beta strandi4067 – 40726
Helixi4074 – 40763
Beta strandi4081 – 40866
Beta strandi4093 – 40986
Beta strandi4103 – 41075
Helixi4110 – 41123
Beta strandi4116 – 41183
Beta strandi4122 – 41276
Helixi4129 – 41313
Beta strandi4136 – 41416
Beta strandi4143 – 41508
Beta strandi4155 – 41595
Helixi4162 – 41643
Beta strandi4168 – 41703
Beta strandi4174 – 41796
Helixi4181 – 41833
Beta strandi4188 – 41936
Beta strandi4195 – 42028
Beta strandi4208 – 42125
Helixi4215 – 42173
Beta strandi4221 – 42233
Beta strandi4227 – 42326
Helixi4234 – 42363
Beta strandi4237 – 42393
Beta strandi4241 – 42466
Beta strandi4248 – 42558
Beta strandi4260 – 42645
Helixi4266 – 42683
Helixi4273 – 42786
Helixi4286 – 42883
Beta strandi4293 – 42986
Beta strandi4300 – 43078
Beta strandi4312 – 43165
Beta strandi4325 – 43273
Beta strandi4331 – 43366
Helixi4338 – 43403
Beta strandi4347 – 43504
Beta strandi4352 – 43587

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4O2WX-ray2.00A/B/C/D3975-4360[»]
ProteinModelPortaliQ15751.
SMRiQ15751. Positions 372-735, 3423-3727, 3735-3805, 3996-4360, 4489-4834.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati371 – 42050RCC1 1Add
BLAST
Repeati421 – 47555RCC1 2Add
BLAST
Repeati441 – 48343WD 1Add
BLAST
Repeati476 – 52853RCC1 3Add
BLAST
Repeati506 – 54540WD 2Add
BLAST
Repeati529 – 57850RCC1 4Add
BLAST
Repeati580 – 63152RCC1 5Add
BLAST
Repeati633 – 68250RCC1 6Add
BLAST
Repeati660 – 69940WD 3Add
BLAST
Repeati683 – 73553RCC1 7Add
BLAST
Domaini2002 – 2193192B30.2/SPRYAdd
BLAST
Repeati3426 – 346540WD 4Add
BLAST
Repeati3484 – 352239WD 5Add
BLAST
Repeati3524 – 357249WD 6Add
BLAST
Repeati3580 – 361940WD 7Add
BLAST
Repeati3624 – 366340WD 8Add
BLAST
Repeati3667 – 371347WD 9Add
BLAST
Repeati3745 – 378440WD 10Add
BLAST
Repeati3996 – 404449RCC1 8Add
BLAST
Repeati4046 – 409954RCC1 9Add
BLAST
Repeati4101 – 415151RCC1 10Add
BLAST
Repeati4153 – 420351RCC1 11Add
BLAST
Repeati4205 – 425652RCC1 12Add
BLAST
Repeati4258 – 430851RCC1 13Add
BLAST
Repeati4287 – 432539WD 11Add
BLAST
Repeati4310 – 436051RCC1 14Add
BLAST
Domaini4501 – 4848348HECTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1349 – 137830Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.
Contains 14 RCC1 repeats.
Contains 11 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG5021.
HOGENOMiHOG000168589.
HOVERGENiHBG053919.
InParanoidiQ15751.
KOiK10594.
OMAiPIAQAKH.
OrthoDBiEOG70KGNN.
PhylomeDBiQ15751.
TreeFamiTF106426.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
2.130.10.30. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR000569. HECT.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00415. RCC1. 12 hits.
PF00622. SPRY. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00119. HECTc. 1 hit.
SM00449. SPRY. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF50985. SSF50985. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50237. HECT. 1 hit.
PS00626. RCC1_2. 4 hits.
PS50012. RCC1_3. 14 hits.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15751-1 [UniParc]FASTAAdd to Basket

« Hide

MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL     50
PQQVLCLKGP QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA 100
GALRKRLLVL QRVFYALSNK YHDKGKVKQQ QHSPESSSGS ADVHSVSERP 150
RSSTDALIEM GVRTGLSLLF ALLRQSWMMP VSGPGLSLCN DVIHTAIEVV 200
SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD TLGRRLASEL 250
LLGLAAQRGS LRYLLEWIEM ALGASAVVHT MEKGKLLSSQ EGMISFDCFM 300
TILMQMRRSL GSSADRSQWR EPTRTSDGLC SLYEAALCLF EEVCRMASDY 350
SRTCASPDSI QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP 400
SFSDAQTIEA GQYCTFVIST DGSVRACGKG SYGRLGLGDS NNQSTLKKLT 450
FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF SWGDGDYGKL GHGNSSTQKY 500
PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF GRLGHGDSNS 550
RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN 600
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE 650
ATALRPKLIE ELAATRIVDV SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG 700
NSTGPITKPK KVSGLDGIAI QQISAGTSHS LAWTALPRDR QVVAWHRPYC 750
VDLEESTFSH LRSFLERYCD KINSEIPPLP FPSSREHHSF LKLCLKLLSN 800
HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE VVIETLSVGA 850
TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA 900
SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR 950
NLGFYTDQAF GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC 1000
HINNISENSS SVALLHKHLQ LLLPHATDIY SRSANLLKES PWNGSVGEKL 1050
RDVIYVSAAG SMLCQIVNSL LLLPVSVARP LLSYLLDLLP PLDCLNRLLP 1100
AADLLEDQEL QWPLHGGPEL IDPAGLPLPQ PAQSWVWLVD LERTIALLIG 1150
RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA 1200
LSGNEEQKPF DYKLRPEIAV YVDLALGCSK EPARSLWISM QDYAVSKDWD 1250
SATLSNESLL DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KHLSEVYRCV 1300
YKVRSRLLAC KNLELIQTRS SSRDRWISEN QDSADVDPQE HSFTRTIDEE 1350
AEMEEQAERD REEGHPEPED EEEEREHEVM TAGKIFQCFL SAREVARSRD 1400
RDRMNSGAGS GARADDPPPQ SQQERRVSTD LPEGQDVYTA ACNSVIHRCA 1450
LLILGVSPVI DELQKRREEG QLQQPSTSAS EGGGLMTRSE SLTAESRLVH 1500
TSPNYRLIKS RSESDLSQPE SDEEGYALSG RRNVDLDLAA SHRKRGPMHS 1550
QLESLSDSWA RLKHSRDWLC NSSYSFESDF DLTKSLGVHT LIENVVSFVS 1600
GDVGNAPGFK EPEESMSTSP QASIIAMEQQ QLRAELRLEA LHQILVLLSG 1650
MEEKGSISLA GSRLSSGFQS STLLTSVRLQ FLAGCFGLGT VGHTGGKGES 1700
GRLHHYQDGI RAAKRNIQIE IQVAVHKIYQ QLSATLERAL QANKHHIEAQ 1750
QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP 1800
KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK 1850
NLLSQTGVLH MASFGEGEQE DGEEEEKKVD SSGETEKKDF RAALRKQHAA 1900
ELHLGDFLVF LRRVVSSKAI QSKMASPKWT EVLLNIASQK CSSGIPLVGN 1950
LRTRLLALHV LEAVLPACES GVEDDQMAQI VERLFSLLSD CMWETPIAQA 2000
KHAIQIKEKE QEIKLQKQGE LEEEDENLPI QEVSFDPEKA QCCLVENGQI 2050
LTHGSGGKGY GLASTGVTSG CYQWKFYIVK ENRGNEGTCV GVSRWPVHDF 2100
NHRTTSDMWL YRAYSGNLYH NGEQTLTLSS FTQGDFITCV LDMEARTISF 2150
GKNGEEPKLA FEDVDAAELY PCVMFYSSNP GEKVKICDMQ MRGTPRDLLP 2200
GDPICSPVAA VLAEATIQLI RILHRTDRWT YCINKKMMER LHKIKICIKE 2250
SGQKLKKSRS VQSREENEMR EEKESKEEEK GKHTRHGLAD LSELQLRTLC 2300
IEVWPVLAVI GGVDAGLRVG GRCVHKQTGR HATLLGVVKE GSTSAKVQWD 2350
EAEITISFPT FWSPSDTPLY NLEPCEPLPF DVARFRGLTA SVLLDLTYLT 2400
GVHEDMGKQS TKRHEKKHRH ESEEKGDVEQ KPESESALDM RTGLTSDDVK 2450
SQSTTSSKSE NEIASFSLDP TLPSVESQHQ ITEGKRKNHE HMSKNHDVAQ 2500
SEIRAVQLSY LYLGAMKSLS ALLGCSKYAE LLLIPKVLAE NGHNSDCASS 2550
PVVHEDVEMR AALQFLMRHM VKRAVMRSPI KRALGLADLE RAQAMIYKLV 2600
VHGLLEDQFG GKIKQEIDQQ AEESDPAQQA QTPVTTSPSA SSTTSFMSSS 2650
LEDTTTATTP VTDTETVPAS ESPGVMPLSL LRQMFSSYPT TTVLPTRRAQ 2700
TPPISSLPTS PSDEVGRRQS LTSPDSQSAR PANRTALSDP SSRLSTSPPP 2750
PAIAVPLLEM GFSLRQIAKA MEATGARGEA DAQNITVLAM WMIEHPGHED 2800
EEEPQSGSTA DSRPGAAVLG SGGKSNDPCY LQSPGDIPSA DAAEMEEGFS 2850
ESPDNLDHTE NAASGSGPSA RGRSAVTRRH KFDLAARTLL ARAAGLYRSV 2900
QAHRNQSRRE GISLQQDPGA LYDFNLDEEL EIDLDDEAME AMFGQDLTSD 2950
NDILGMWIPE VLDWPTWHVC ESEDREEVVV CELCECSVVS FNQHMKRNHP 3000
GCGRSANRQG YRSNGSYVDG WFGGECGSGN PYYLLCGTCR EKYLAMKTKS 3050
KSTSSERYKG QAPDLIGKQD SVYEEDWDML DVDEDEKLTG EEEFELLAGP 3100
LGLNDRRIVP EPVQFPDSDP LGASVAMVTA TNSMEETLMQ IGCHGSVEKS 3150
SSGRITLGEQ AAALANPHDR VVALRRVTAA AQVLLARTMV MRALSLLSVS 3200
GSSCSLAAGL ESLGLTDIRT LVRLMCLAAA GRAGLSTSPS AMASTSERSR 3250
GGHSKANKPI SCLAYLSTAV GCLASNAPSA AKLLVQLCTQ NLISAATGVN 3300
LTTVDDSIQR KFLPSFLRGI AEENKLVTSP NFVVTQALVA LLADKGAKLR 3350
PNYDKSEVEK KGPLELANAL AACCLSSRLS SQHRQWAAQQ LVRTLAAHDR 3400
DNQTTLQTLA DMGGDLRKCS FIKLEAHQNR VMTCVWCNKK GLLATSGNDG 3450
TIRVWNVTKK QYSLQQTCVF NRLEGDAEES LGSPSDPSFS PVSWSISGKY 3500
LAGALEKMVN IWQVNGGKGL VDIQPHWVSA LAWPEEGPAT AWSGESPELL 3550
LVGRMDGSLG LIEVVDVSTM HRRELEHCYR KDVSVTCIAW FSEDRPFAVG 3600
YFDGKLLLGT KEPLEKGGIV LIDAHKDTLI SMKWDPTGHI LMTCAKEDSV 3650
KLWGSISGCW CCLHSLCHPS IVNGIAWCRL PGKGSKLQLL MATGCQSGLV 3700
CVWRIPQDTT QTNVTSAEGW WEQESNCQDG YRKSSGAKCV YQLRGHITPV 3750
RTVAFSSDGL ALVSGGLGGL MNIWSLRDGS VLQTVVIGSG AIQTTVWIPE 3800
VGVAACSNRS KDVLVVNCTA EWAAANHVLA TCRTALKQQG VLGLNMAPCM 3850
RAFLERLPMM LQEQYAYEKP HVVCGDQLVH SPYMQCLASL AVGLHLDQLL 3900
CNPPVPPHHQ NCLPDPASWN PNEWAWLECF STTIKAAEAL TNGAQFPESF 3950
TVPDLEPVPE DELVFLMDNS KWINGMDEQI MSWATSRPED WHLGGKCDVY 4000
LWGAGRHGQL AEAGRNVMVP AAAPSFSQAQ QVICGQNCTF VIQANGTVLA 4050
CGEGSYGRLG QGNSDDLHVL TVISALQGFV VTQLVTSCGS DGHSMALTES 4100
GEVFSWGDGD YGKLGHGNSD RQRRPRQIEA LQGEEVVQMS CGFKHSAVVT 4150
SDGKLFTFGN GDYGRLGLGN TSNKKLPERV TALEGYQIGQ VACGLNHTLA 4200
VSADGSMVWA FGDGDYGKLG LGNSTAKSSP QKIDVLCGIG IKKVACGTQF 4250
SVALTKDGHV YTFGQDRLIG LPEGRARNHN RPQQIPVLAG VIIEDVAVGA 4300
EHTLALASNG DVYAWGSNSE GQLGLGHTNH VREPTLVTGL QGKNVRQISA 4350
GRCHSAAWTA PPVPPRAPGV SVPLQLGLPD TVPPQYGALR EVSIHTVRAR 4400
LRLLYHFSDL MYSSWRLLNL SPNNQNSTSH YNAGTWGIVQ GQLRPLLAPR 4450
VYTLPMVRSI GKTMVQGKNY GPQITVKRIS TRGRKCKPIF VQIARQVVKL 4500
NASDLRLPSR AWKVKLVGEG ADDAGGVFDD TITEMCQELE TGIVDLLIPS 4550
PNATAEVGYN RDRFLFNPSA CLDEHLMQFK FLGILMGVAI RTKKPLDLHL 4600
APLVWKQLCC VPLTLEDLEE VDLLYVQTLN SILHIEDSGI TEESFHEMIP 4650
LDSFVGQSAD GKMVPIIPGG NSIPLTFSNR KEYVERAIEY RLHEMDRQVA 4700
AVREGMSWIV PVPLLSLLTA KQLEQMVCGM PEISVEVLKK VVRYREVDEQ 4750
HQLVQWFWHT LEEFSNEERV LFMRFVSGRS RLPANTADIS QRFQIMKVDR 4800
PYDSLPTSQT CFFQLRLPPY SSQLVMAERL RYAINNCRSI DMDNYMLSRN 4850
VDNAEGSDTD Y 4861
Length:4,861
Mass (Da):532,228
Last modified:May 18, 2010 - v2
Checksum:i31B2C1A1430B9622
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1088 – 10881L → F.
Corresponds to variant rs1063423 [ dbSNP | Ensembl ].
VAR_042556
Natural varianti1278 – 12781L → F.
Corresponds to variant rs3764187 [ dbSNP | Ensembl ].
VAR_042557
Natural varianti1411 – 14111G → V.
Corresponds to variant rs36089909 [ dbSNP | Ensembl ].
VAR_042558
Natural varianti1447 – 14471H → N.
Corresponds to variant rs7162519 [ dbSNP | Ensembl ].
VAR_042559
Natural varianti1572 – 15721S → A.
Corresponds to variant rs16947363 [ dbSNP | Ensembl ].
VAR_042560
Natural varianti1696 – 16961G → A.1 Publication
Corresponds to variant rs2255243 [ dbSNP | Ensembl ].
VAR_042561
Natural varianti1995 – 19951T → A.
Corresponds to variant rs2228512 [ dbSNP | Ensembl ].
VAR_042562
Natural varianti2220 – 22201I → V.1 Publication
Corresponds to variant rs2228510 [ dbSNP | Ensembl ].
VAR_042563
Natural varianti2816 – 28161A → T.
Corresponds to variant rs35122568 [ dbSNP | Ensembl ].
VAR_042564
Natural varianti3152 – 31521S → F.
Corresponds to variant rs2228513 [ dbSNP | Ensembl ].
VAR_042565
Natural varianti3517 – 35171G → R.
Corresponds to variant rs7182782 [ dbSNP | Ensembl ].
VAR_042566
Natural varianti3722 – 37221E → D.1 Publication
Corresponds to variant rs2229749 [ dbSNP | Ensembl ].
VAR_042567
Natural varianti4394 – 43941I → V.
Corresponds to variant rs2228516 [ dbSNP | Ensembl ].
VAR_057122

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1532 – 15321R → Q in AAD12586. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U50078 mRNA. Translation: AAD12586.1.
AC073167 Genomic DNA. No translation available.
AC118274 Genomic DNA. No translation available.
BC040929 mRNA. Translation: AAH40929.1.
CCDSiCCDS45277.1.
PIRiS71752.
RefSeqiNP_003913.3. NM_003922.3.
XP_005254799.1. XM_005254742.2.
XP_005254800.1. XM_005254743.2.
UniGeneiHs.210385.

Genome annotation databases

EnsembliENST00000443617; ENSP00000390158; ENSG00000103657.
GeneIDi8925.
KEGGihsa:8925.
UCSCiuc002amp.3. human.

Polymorphism databases

DMDMi296434522.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U50078 mRNA. Translation: AAD12586.1 .
AC073167 Genomic DNA. No translation available.
AC118274 Genomic DNA. No translation available.
BC040929 mRNA. Translation: AAH40929.1 .
CCDSi CCDS45277.1.
PIRi S71752.
RefSeqi NP_003913.3. NM_003922.3.
XP_005254799.1. XM_005254742.2.
XP_005254800.1. XM_005254743.2.
UniGenei Hs.210385.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4O2W X-ray 2.00 A/B/C/D 3975-4360 [» ]
ProteinModelPortali Q15751.
SMRi Q15751. Positions 372-735, 3423-3727, 3735-3805, 3996-4360, 4489-4834.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114439. 14 interactions.
IntActi Q15751. 6 interactions.
MINTi MINT-8330052.
STRINGi 9606.ENSP00000390158.

PTM databases

PhosphoSitei Q15751.

Polymorphism databases

DMDMi 296434522.

Proteomic databases

MaxQBi Q15751.
PaxDbi Q15751.
PRIDEi Q15751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000443617 ; ENSP00000390158 ; ENSG00000103657 .
GeneIDi 8925.
KEGGi hsa:8925.
UCSCi uc002amp.3. human.

Organism-specific databases

CTDi 8925.
GeneCardsi GC15M063900.
HGNCi HGNC:4867. HERC1.
HPAi HPA049749.
MIMi 605109. gene.
neXtProti NX_Q15751.
PharmGKBi PA29242.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5021.
HOGENOMi HOG000168589.
HOVERGENi HBG053919.
InParanoidi Q15751.
KOi K10594.
OMAi PIAQAKH.
OrthoDBi EOG70KGNN.
PhylomeDBi Q15751.
TreeFami TF106426.

Enzyme and pathway databases

UniPathwayi UPA00143 .
SignaLinki Q15751.

Miscellaneous databases

GeneWikii HERC1.
GenomeRNAii 8925.
NextBioi 33556.
PROi Q15751.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15751.
Bgeei Q15751.
CleanExi HS_HERC1.
Genevestigatori Q15751.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
2.130.10.30. 2 hits.
InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR000569. HECT.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00632. HECT. 1 hit.
PF00415. RCC1. 12 hits.
PF00622. SPRY. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00119. HECTc. 1 hit.
SM00449. SPRY. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF50985. SSF50985. 2 hits.
SSF56204. SSF56204. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50237. HECT. 1 hit.
PS00626. RCC1_2. 4 hits.
PS50012. RCC1_3. 14 hits.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins."
    Rosa J.L., Casaroli-Marano R.P., Buckler A.J., Vilaro S., Barbacid M.
    EMBO J. 15:4262-4273(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH ARF1, VARIANTS ALA-1696; VAL-2220 AND ASP-3722.
  2. Erratum
    Rosa J.L., Casaroli-Marano R.P., Buckler A.J., Vilaro S., Barbacid M.
    EMBO J. 15:5738-5738(1996)
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4211-4861.
    Tissue: Liver.
  5. "A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70."
    Rosa J.L., Barbacid M.
    Oncogene 15:1-6(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CLTC.
  6. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PKM.
  7. "The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells."
    Garcia-Gonzalo F.R., Munoz P., Gonzalez E., Casaroli-Marano R.P., Vilaro S., Bartrons R., Ventura F., Rosa J.L.
    FEBS Lett. 559:77-83(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins."
    Garcia-Gonzalo F.R., Bartrons R., Ventura F., Rosa J.L.
    FEBS Lett. 579:343-348(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARF6.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase."
    Chong-Kopera H., Inoki K., Li Y., Zhu T., Garcia-Gonzalo F.R., Rosa J.L., Guan K.-L.
    J. Biol. Chem. 281:8313-8316(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TSC2.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2701, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1517; SER-1521; THR-2701; SER-2706 AND SER-2710, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1521 AND THR-2701, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4857, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHERC1_HUMAN
AccessioniPrimary (citable) accession number: Q15751
Secondary accession number(s): Q8IW65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi