Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q15750 (TAB1_HUMAN)

Last modified February 9, 2010. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
Alternative name(s):
    TGF-beta-activated kinase 1-binding protein 1
      Short name=TAK1-binding protein 1
Gene names
Name: MAP3K7IP1
Synonyms: TAB1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Subunit structure

Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling.

Tissue specificity

Ubiquitous.

Sequence similarities

Contains 1 PP2C-like domain.

Hide | Top

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processactivation of MAPKKK activity Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentcytosol

Inferred from Experiment. Source: Reactome

   Molecular functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
PRO_0000057797

Regions

Domain64 – 368305PP2C-like
Compositional bias452 – 4576Poly-Ser

Amino acid modifications

Modified residue71Phosphoserine Ref.6 Ref.7
Modified residue3781Phosphoserine Ref.9

Natural variations

Natural variant2241D → E: dbSNP rs17001096.
VAR_039271

Experimental info

Mutagenesis2131D → A: Loss of interaction with XIAP. Ref.11
Mutagenesis2161F → A: Loss of interaction with XIAP. Ref.11

Secondary structure

1 .......................................................... 504
Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q15750-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A45743288718983A

FASTA50454,644
        10         20         30         40         50         60 
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN 

        70         80         90        100        110        120 
NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES 

       130        140        150        160        170        180 
IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV 

       190        200        210        220        230        240 
ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST 

       250        260        270        280        290        300 
RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 

       310        320        330        340        350        360 
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL 

       370        380        390        400        410        420 
LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG 

       430        440        450        460        470        480 
AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP 

       490        500 
YVDFAEFYRL WSVDHGEQSV VTAP

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction."
Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., Irie K., Nishida E., Matsumoto K.
Science 272:1179-1182(1996) [PubMed: 8638164] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MAP3K7.
Tissue: Brain.
[2]NHLBI resequencing and genotyping service (RS&G)
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed: 10591208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS.
[5]"The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."
Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z., Matsumoto K.
Nature 398:252-256(1999) [PubMed: 10094049] [Abstract]
Cited for: INTERACTION WITH TRAF6 AND MAP3K7.
[6]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, MASS SPECTROMETRY.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, MASS SPECTROMETRY.
[8]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, MASS SPECTROMETRY.
Tissue: T-cell.
[10]"TAK1-binding protein 1 is a pseudophosphatase."
Conner S.H., Kular G., Peggie M., Shepherd S., Schuettelkopf A.W., Cohen P., Van Aalten D.M.F.
Biochem. J. 399:427-434(2006) [PubMed: 16879102] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1-401.
[11]"XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization."
Lu M., Lin S.-C., Huang Y., Kang Y.J., Rich R., Lo Y.-C., Myszka D., Han J., Wu H.
Mol. Cell 26:689-702(2007) [PubMed: 17560374] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 1-370 IN COMPLEX WITH XIAP, MUTAGENESIS OF ASP-213 AND PHE-216.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U49928 mRNA. Translation: AAC12660.1.
DQ314876 Genomic DNA. Translation: ABC40735.1.
Z83845 Genomic DNA. Translation: CAB55304.1.
BC050554 mRNA. Translation: AAH50554.1.
IPIIPI00019459.
RefSeqNP_006107.1.
NP_705717.1.
UniGeneHs.507681

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2J4OX-ray2.25A1-401[»]
2POMX-ray2.27A1-370[»]
2POPX-ray3.10A/C1-370[»]
SMRQ15750. Positions 468-496.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-27524N.
IntActQ15750. 31 interactions.
STRINGQ15750.

PTM databases

PhosphoSiteQ15750.

Proteomic databases

PRIDEQ15750.

Genome annotation databases

EnsemblENST00000216160; ENSP00000216160; ENSG00000100324; Homo sapiens. [Genome view]
GeneID10454.
KEGGhsa:10454.
UCSCuc003axt.1. human.

Organism-specific databases

CTD10454.
GeneCardsGC22P038120.
HGNCHGNC:18157. MAP3K7IP1.
MIM602615. gene.
PharmGKBPA30604.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG07714.
HOVERGENQ15750.
InParanoidQ15750.
OMAEHTEADV.
PhylomeDBQ15750.

Enzyme and pathway databases

Pathway_Interaction_DBbmppathway. BMP receptor signaling.
il1pathway. IL1-mediated signaling events.
wnt_calcium_pathway. Noncanonical Wnt signaling pathway.
p38_mkk3_6pathway. p38 MAPK signaling pathway.
ps1pathway. Presenilin action in Notch and Wnt signaling.
p38alphabetapathway. Regulation of p38-alpha and p38-beta.
tgfbrpathway. TGF-beta receptor signaling.
tnfpathway. TNF receptor signaling pathway.
ReactomeREACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpressQ15750.
BgeeQ15750.
CleanExHS_MAP3K7IP1.
GenevestigatorQ15750.
GermOnlineENSG00000100324. Homo sapiens.

Family and domain databases

InterProIPR015655. PP2C.
IPR001932. PP2C-related.
IPR014045. PP2C_N.
[Graphical view]
Gene3DG3DSA:3.60.40.10. PP2C-related. 1 hit.
PANTHERPTHR13832. PP2C. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio39627.
SOURCESearch...

Hide | Top

Entry information

Entry nameTAB1_HUMAN
AccessionPrimary (citable) accession number: Q15750
Secondary accession number(s): Q2PP09
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top

Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents