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Q15750

- TAB1_HUMAN

UniProt

Q15750 - TAB1_HUMAN

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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene
TAB1, MAP3K7IP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.1 Publication

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. enzyme activator activity Source: ProtInc
  3. kinase activator activity Source: Ensembl
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: Reactome
  2. activation of MAPKKK activity Source: ProtInc
  3. Fc-epsilon receptor signaling pathway Source: Reactome
  4. heart morphogenesis Source: Ensembl
  5. I-kappaB kinase/NF-kappaB signaling Source: Reactome
  6. innate immune response Source: Reactome
  7. in utero embryonic development Source: Ensembl
  8. JNK cascade Source: Reactome
  9. lung development Source: Ensembl
  10. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  11. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  12. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
  13. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
  14. positive regulation of NF-kappaB transcription factor activity Source: Reactome
  15. stress-activated MAPK cascade Source: Reactome
  16. toll-like receptor 10 signaling pathway Source: Reactome
  17. toll-like receptor 2 signaling pathway Source: Reactome
  18. toll-like receptor 3 signaling pathway Source: Reactome
  19. toll-like receptor 4 signaling pathway Source: Reactome
  20. toll-like receptor 5 signaling pathway Source: Reactome
  21. toll-like receptor 9 signaling pathway Source: Reactome
  22. toll-like receptor signaling pathway Source: Reactome
  23. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  24. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  25. transforming growth factor beta receptor signaling pathway Source: Ensembl
  26. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_163994. FCERI mediated NF-kB activation.
REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_75776. NOD1/2 Signaling Pathway.
SignaLinkiQ15750.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name:
TAK1-binding protein 1
Gene namesi
Name:TAB1
Synonyms:MAP3K7IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:18157. TAB1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. endosome membrane Source: Reactome
  4. nucleus Source: HPA
  5. protein complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi213 – 2131D → A: Loss of interaction with XIAP. 1 Publication
Mutagenesisi216 – 2161F → A: Loss of interaction with XIAP. 1 Publication
Mutagenesisi438 – 4381S → A: Loss of phosphorylation site. 1 Publication

Organism-specific databases

PharmGKBiPA30604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504TGF-beta-activated kinase 1 and MAP3K7-binding protein 1PRO_0000057797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine2 Publications
Modified residuei378 – 3781Phosphoserine1 Publication
Modified residuei438 – 4381Phosphoserine1 Publication

Post-translational modificationi

Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ15750.
PaxDbiQ15750.
PRIDEiQ15750.

PTM databases

PhosphoSiteiQ15750.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ15750.
BgeeiQ15750.
CleanExiHS_MAP3K7IP1.
GenevestigatoriQ15750.

Organism-specific databases

HPAiCAB032328.
HPA039988.

Interactioni

Subunit structurei

Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP3K7O43318-23EBI-358643,EBI-358700
TAB2Q9NYJ84EBI-358643,EBI-358708

Protein-protein interaction databases

BioGridi115717. 81 interactions.
DIPiDIP-27524N.
IntActiQ15750. 67 interactions.
MINTiMINT-88613.

Structurei

Secondary structure

1
504
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni18 – 203
Beta strandi27 – 326
Beta strandi35 – 373
Beta strandi39 – 424
Beta strandi51 – 588
Turni59 – 613
Beta strandi62 – 7413
Helixi75 – 8612
Beta strandi89 – 924
Beta strandi94 – 963
Helixi99 – 13335
Helixi141 – 1433
Helixi146 – 1483
Helixi149 – 16214
Beta strandi165 – 17410
Beta strandi177 – 1859
Beta strandi187 – 1937
Beta strandi195 – 2028
Helixi212 – 2198
Turni220 – 2223
Helixi225 – 2317
Beta strandi234 – 2363
Beta strandi239 – 2413
Helixi246 – 2505
Helixi252 – 2543
Turni256 – 2605
Beta strandi265 – 2673
Beta strandi271 – 2777
Beta strandi283 – 2886
Helixi290 – 30011
Beta strandi302 – 3043
Helixi305 – 31915
Helixi323 – 34321
Helixi348 – 3514
Beta strandi353 – 3553
Beta strandi358 – 3669
Beta strandi475 – 4784
Helixi485 – 49511

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J4OX-ray2.25A1-401[»]
2POMX-ray2.27A1-370[»]
2POPX-ray3.10A/C1-370[»]
2YDSX-ray2.55T392-398[»]
2YIYX-ray2.49A468-497[»]
4AY5X-ray3.15I/J/K/L389-399[»]
4AY6X-ray3.30E/F/G/H389-401[»]
4GS6X-ray2.20A468-504[»]
4KA3X-ray2.71B395-415[»]
4L3PX-ray2.68A468-504[»]
4L53X-ray2.55A468-496[»]
ProteinModelPortaliQ15750.
SMRiQ15750. Positions 16-370, 468-496.

Miscellaneous databases

EvolutionaryTraceiQ15750.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 368305PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi452 – 4576Poly-Ser

Sequence similaritiesi

Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiNOG320352.
HOGENOMiHOG000044226.
HOVERGENiHBG007302.
InParanoidiQ15750.
KOiK04403.
OMAiSHPPEDN.
OrthoDBiEOG7W41C0.
PhylomeDBiQ15750.
TreeFamiTF317785.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15750-1) [UniParc]FASTAAdd to Basket

Also known as: TAB1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE    50
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA 100
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK 150
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV 200
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY 250
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR 350
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST 400
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT 450
QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV 500
VTAP 504
Length:504
Mass (Da):54,644
Last modified:November 1, 1996 - v1
Checksum:iA45743288718983A
GO
Isoform 2 (identifier: Q15750-2) [UniParc]FASTAAdd to Basket

Also known as: TAB1beta

The sequence of this isoform differs from the canonical sequence as follows:
     436-504: NQSPTLTLQS...HGEQSVVTAP → KDPSRPASDLTAIPQCQLNLLGSLTPG

Note: Does not bind nor activate MAP3K7/TAK1.

Show »
Length:462
Mass (Da):49,917
Checksum:iE26443BBE3BD3404
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti224 – 2241D → E.
Corresponds to variant rs17001096 [ dbSNP | Ensembl ].
VAR_039271

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei436 – 50469NQSPT…VVTAP → KDPSRPASDLTAIPQCQLNL LGSLTPG in isoform 2. VSP_042024Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49928 mRNA. Translation: AAC12660.1.
AF425640 mRNA. Translation: AAN32760.1.
DQ314876 Genomic DNA. Translation: ABC40735.1.
AL022312 Genomic DNA. No translation available.
Z83845 Genomic DNA. Translation: CAB55304.1.
Z83845 Genomic DNA. Translation: CAQ07045.1.
CH471095 Genomic DNA. Translation: EAW60326.1.
BC050554 mRNA. Translation: AAH50554.1.
CCDSiCCDS13992.1. [Q15750-2]
CCDS13993.1. [Q15750-1]
RefSeqiNP_006107.1. NM_006116.2. [Q15750-1]
NP_705717.1. NM_153497.2. [Q15750-2]
UniGeneiHs.507681.
Hs.729080.

Genome annotation databases

EnsembliENST00000216160; ENSP00000216160; ENSG00000100324. [Q15750-1]
ENST00000331454; ENSP00000333049; ENSG00000100324. [Q15750-2]
GeneIDi10454.
KEGGihsa:10454.
UCSCiuc003axt.3. human. [Q15750-1]
uc003axu.1. human. [Q15750-2]

Polymorphism databases

DMDMi10720303.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49928 mRNA. Translation: AAC12660.1 .
AF425640 mRNA. Translation: AAN32760.1 .
DQ314876 Genomic DNA. Translation: ABC40735.1 .
AL022312 Genomic DNA. No translation available.
Z83845 Genomic DNA. Translation: CAB55304.1 .
Z83845 Genomic DNA. Translation: CAQ07045.1 .
CH471095 Genomic DNA. Translation: EAW60326.1 .
BC050554 mRNA. Translation: AAH50554.1 .
CCDSi CCDS13992.1. [Q15750-2 ]
CCDS13993.1. [Q15750-1 ]
RefSeqi NP_006107.1. NM_006116.2. [Q15750-1 ]
NP_705717.1. NM_153497.2. [Q15750-2 ]
UniGenei Hs.507681.
Hs.729080.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2J4O X-ray 2.25 A 1-401 [» ]
2POM X-ray 2.27 A 1-370 [» ]
2POP X-ray 3.10 A/C 1-370 [» ]
2YDS X-ray 2.55 T 392-398 [» ]
2YIY X-ray 2.49 A 468-497 [» ]
4AY5 X-ray 3.15 I/J/K/L 389-399 [» ]
4AY6 X-ray 3.30 E/F/G/H 389-401 [» ]
4GS6 X-ray 2.20 A 468-504 [» ]
4KA3 X-ray 2.71 B 395-415 [» ]
4L3P X-ray 2.68 A 468-504 [» ]
4L53 X-ray 2.55 A 468-496 [» ]
ProteinModelPortali Q15750.
SMRi Q15750. Positions 16-370, 468-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115717. 81 interactions.
DIPi DIP-27524N.
IntActi Q15750. 67 interactions.
MINTi MINT-88613.

Chemistry

BindingDBi Q15750.
ChEMBLi CHEMBL5605.

PTM databases

PhosphoSitei Q15750.

Polymorphism databases

DMDMi 10720303.

Proteomic databases

MaxQBi Q15750.
PaxDbi Q15750.
PRIDEi Q15750.

Protocols and materials databases

DNASUi 10454.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216160 ; ENSP00000216160 ; ENSG00000100324 . [Q15750-1 ]
ENST00000331454 ; ENSP00000333049 ; ENSG00000100324 . [Q15750-2 ]
GeneIDi 10454.
KEGGi hsa:10454.
UCSCi uc003axt.3. human. [Q15750-1 ]
uc003axu.1. human. [Q15750-2 ]

Organism-specific databases

CTDi 10454.
GeneCardsi GC22P039796.
HGNCi HGNC:18157. TAB1.
HPAi CAB032328.
HPA039988.
MIMi 602615. gene.
neXtProti NX_Q15750.
PharmGKBi PA30604.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320352.
HOGENOMi HOG000044226.
HOVERGENi HBG007302.
InParanoidi Q15750.
KOi K04403.
OMAi SHPPEDN.
OrthoDBi EOG7W41C0.
PhylomeDBi Q15750.
TreeFami TF317785.

Enzyme and pathway databases

Reactomei REACT_163994. FCERI mediated NF-kB activation.
REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_75776. NOD1/2 Signaling Pathway.
SignaLinki Q15750.

Miscellaneous databases

ChiTaRSi TAB1. human.
EvolutionaryTracei Q15750.
GeneWikii MAP3K7IP1.
GenomeRNAii 10454.
NextBioi 39627.
PROi Q15750.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15750.
Bgeei Q15750.
CleanExi HS_MAP3K7IP1.
Genevestigatori Q15750.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction."
    Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., Irie K., Nishida E., Matsumoto K.
    Science 272:1179-1182(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MAP3K7.
    Tissue: Brain.
  2. "TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1."
    Ge B., Xiong X., Jing Q., Mosley J.L., Filose A., Bian D., Huang S., Han J.
    J. Biol. Chem. 278:2286-2293(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: PNS.
  7. "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."
    Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z., Matsumoto K.
    Nature 398:252-256(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF6 AND MAP3K7.
  8. "TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
    Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., Chen Z.J.
    Nature 412:346-351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN THE TRIKA2 COMPLEX.
  9. "The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway."
    Thiefes A., Wolf A., Doerrie A., Grassl G.A., Matsumoto K., Autenrieth I., Bohn E., Sakurai H., Niedenthal R., Resch K., Kracht M.
    EMBO Rep. 7:838-844(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, PHOSPHORYLATION AT SER-438, MUTAGENESIS OF SER-438, DEUBIQUITINATION BY YOPP.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1-401, ABSENCE OF FUNCTION AS A PHOSPHATASE.
  16. "XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization."
    Lu M., Lin S.-C., Huang Y., Kang Y.J., Rich R., Lo Y.-C., Myszka D., Han J., Wu H.
    Mol. Cell 26:689-702(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 1-370 IN COMPLEX WITH XIAP, MUTAGENESIS OF ASP-213 AND PHE-216.

Entry informationi

Entry nameiTAB1_HUMAN
AccessioniPrimary (citable) accession number: Q15750
Secondary accession number(s): Q2PP09, Q8IZW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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