Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

TAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei484Required for interaction with MAP3K71 Publication1

GO - Molecular functioni

  • enzyme activator activity Source: ProtInc
  • kinase activator activity Source: Ensembl
  • protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100324-MONOMER.
ReactomeiR-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-446652. Interleukin-1 signaling.
R-HSA-450302. activated TAK1 mediates p38 MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-937042. IRAK2 mediated activation of TAK1 complex.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
SignaLinkiQ15750.
SIGNORiQ15750.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name:
TAK1-binding protein 1
Gene namesi
Name:TAB1
Synonyms:MAP3K7IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18157. TAB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi213D → A: Loss of interaction with XIAP. 1 Publication1
Mutagenesisi216F → A: Loss of interaction with XIAP. 1 Publication1
Mutagenesisi438S → A: Loss of phosphorylation site. 1 Publication1
Mutagenesisi484F → A: Abolishes interaction with MAP3K7. 1 Publication1

Organism-specific databases

DisGeNETi10454.
OpenTargetsiENSG00000100324.
PharmGKBiPA30604.

Chemistry databases

ChEMBLiCHEMBL5605.

Polymorphism and mutation databases

BioMutaiTAB1.
DMDMi10720303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577971 – 504TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1 Publication1
Modified residuei442PhosphothreonineCombined sources1

Post-translational modificationi

Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15750.
MaxQBiQ15750.
PaxDbiQ15750.
PeptideAtlasiQ15750.
PRIDEiQ15750.

PTM databases

iPTMnetiQ15750.
PhosphoSitePlusiQ15750.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000100324.
CleanExiHS_MAP3K7IP1.
ExpressionAtlasiQ15750. baseline and differential.
GenevisibleiQ15750. HS.

Organism-specific databases

HPAiCAB032328.
HPA039988.
HPA057104.

Interactioni

Subunit structurei

Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARRB2P321213EBI-358643,EBI-714559
MAP3K7O433182EBI-358643,EBI-358684
MAP3K7O43318-23EBI-358643,EBI-358700
MAPK14Q165392EBI-358643,EBI-73946
TAB2Q9NYJ85EBI-358643,EBI-358708

Protein-protein interaction databases

BioGridi115717. 127 interactors.
DIPiDIP-27524N.
IntActiQ15750. 81 interactors.
MINTiMINT-88613.
STRINGi9606.ENSP00000216160.

Chemistry databases

BindingDBiQ15750.

Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni18 – 20Combined sources3
Beta strandi27 – 32Combined sources6
Beta strandi35 – 37Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi51 – 58Combined sources8
Turni59 – 61Combined sources3
Beta strandi62 – 74Combined sources13
Helixi75 – 86Combined sources12
Beta strandi89 – 92Combined sources4
Beta strandi94 – 96Combined sources3
Helixi99 – 133Combined sources35
Helixi141 – 143Combined sources3
Helixi146 – 148Combined sources3
Helixi149 – 162Combined sources14
Beta strandi165 – 174Combined sources10
Beta strandi177 – 185Combined sources9
Beta strandi187 – 193Combined sources7
Beta strandi195 – 202Combined sources8
Helixi212 – 219Combined sources8
Turni220 – 222Combined sources3
Helixi225 – 231Combined sources7
Beta strandi234 – 236Combined sources3
Beta strandi239 – 241Combined sources3
Helixi246 – 250Combined sources5
Helixi252 – 254Combined sources3
Turni256 – 260Combined sources5
Beta strandi265 – 267Combined sources3
Beta strandi271 – 277Combined sources7
Beta strandi283 – 288Combined sources6
Helixi290 – 300Combined sources11
Beta strandi302 – 304Combined sources3
Helixi305 – 319Combined sources15
Helixi323 – 343Combined sources21
Helixi348 – 351Combined sources4
Beta strandi353 – 355Combined sources3
Beta strandi358 – 366Combined sources9
Beta strandi474 – 476Combined sources3
Helixi485 – 495Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J4OX-ray2.25A1-401[»]
2POMX-ray2.27A1-370[»]
2POPX-ray3.10A/C1-370[»]
2YDSX-ray2.55T392-398[»]
2YIYX-ray2.49A468-497[»]
4AY5X-ray3.15I/J/K/L389-399[»]
4AY6X-ray3.30E/F/G/H389-401[»]
4GS6X-ray2.20A468-504[»]
4KA3X-ray2.71B395-415[»]
4L3PX-ray2.68A468-504[»]
4L53X-ray2.55A468-496[»]
4O91X-ray2.39A468-504[»]
5DIYX-ray2.06P/Q392-398[»]
5E7RX-ray2.11A468-504[»]
5JGAX-ray2.00A468-504[»]
5JGBX-ray2.80A468-504[»]
5JGDX-ray3.10A468-504[»]
ProteinModelPortaliQ15750.
SMRiQ15750.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15750.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 365PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi452 – 457Poly-Ser6

Sequence similaritiesi

Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00510000048276.
HOGENOMiHOG000044226.
HOVERGENiHBG007302.
InParanoidiQ15750.
KOiK04403.
OMAiSTNQIYR.
OrthoDBiEOG091G0B0E.
PhylomeDBiQ15750.
TreeFamiTF317785.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15750-1) [UniParc]FASTAAdd to basket
Also known as: TAB1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
60 70 80 90 100
DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA
110 120 130 140 150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK
160 170 180 190 200
ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV
210 220 230 240 250
TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY
260 270 280 290 300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
310 320 330 340 350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR
360 370 380 390 400
FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST
410 420 430 440 450
SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT
460 470 480 490 500
QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV

VTAP
Length:504
Mass (Da):54,644
Last modified:November 1, 1996 - v1
Checksum:iA45743288718983A
GO
Isoform 2 (identifier: Q15750-2) [UniParc]FASTAAdd to basket
Also known as: TAB1beta

The sequence of this isoform differs from the canonical sequence as follows:
     436-504: NQSPTLTLQS...HGEQSVVTAP → KDPSRPASDLTAIPQCQLNLLGSLTPG

Note: Does not bind nor activate MAP3K7/TAK1.
Show »
Length:462
Mass (Da):49,917
Checksum:iE26443BBE3BD3404
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039271224D → E.Corresponds to variant rs17001096dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042024436 – 504NQSPT…VVTAP → KDPSRPASDLTAIPQCQLNL LGSLTPG in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49928 mRNA. Translation: AAC12660.1.
AF425640 mRNA. Translation: AAN32760.1.
DQ314876 Genomic DNA. Translation: ABC40735.1.
AL022312 Genomic DNA. No translation available.
Z83845 Genomic DNA. Translation: CAB55304.1.
Z83845 Genomic DNA. Translation: CAQ07045.1.
CH471095 Genomic DNA. Translation: EAW60326.1.
BC050554 mRNA. Translation: AAH50554.1.
CCDSiCCDS13992.1. [Q15750-2]
CCDS13993.1. [Q15750-1]
RefSeqiNP_006107.1. NM_006116.2. [Q15750-1]
NP_705717.1. NM_153497.2. [Q15750-2]
UniGeneiHs.507681.
Hs.729080.

Genome annotation databases

EnsembliENST00000216160; ENSP00000216160; ENSG00000100324. [Q15750-1]
ENST00000331454; ENSP00000333049; ENSG00000100324. [Q15750-2]
GeneIDi10454.
KEGGihsa:10454.
UCSCiuc003axt.4. human. [Q15750-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49928 mRNA. Translation: AAC12660.1.
AF425640 mRNA. Translation: AAN32760.1.
DQ314876 Genomic DNA. Translation: ABC40735.1.
AL022312 Genomic DNA. No translation available.
Z83845 Genomic DNA. Translation: CAB55304.1.
Z83845 Genomic DNA. Translation: CAQ07045.1.
CH471095 Genomic DNA. Translation: EAW60326.1.
BC050554 mRNA. Translation: AAH50554.1.
CCDSiCCDS13992.1. [Q15750-2]
CCDS13993.1. [Q15750-1]
RefSeqiNP_006107.1. NM_006116.2. [Q15750-1]
NP_705717.1. NM_153497.2. [Q15750-2]
UniGeneiHs.507681.
Hs.729080.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J4OX-ray2.25A1-401[»]
2POMX-ray2.27A1-370[»]
2POPX-ray3.10A/C1-370[»]
2YDSX-ray2.55T392-398[»]
2YIYX-ray2.49A468-497[»]
4AY5X-ray3.15I/J/K/L389-399[»]
4AY6X-ray3.30E/F/G/H389-401[»]
4GS6X-ray2.20A468-504[»]
4KA3X-ray2.71B395-415[»]
4L3PX-ray2.68A468-504[»]
4L53X-ray2.55A468-496[»]
4O91X-ray2.39A468-504[»]
5DIYX-ray2.06P/Q392-398[»]
5E7RX-ray2.11A468-504[»]
5JGAX-ray2.00A468-504[»]
5JGBX-ray2.80A468-504[»]
5JGDX-ray3.10A468-504[»]
ProteinModelPortaliQ15750.
SMRiQ15750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115717. 127 interactors.
DIPiDIP-27524N.
IntActiQ15750. 81 interactors.
MINTiMINT-88613.
STRINGi9606.ENSP00000216160.

Chemistry databases

BindingDBiQ15750.
ChEMBLiCHEMBL5605.

PTM databases

iPTMnetiQ15750.
PhosphoSitePlusiQ15750.

Polymorphism and mutation databases

BioMutaiTAB1.
DMDMi10720303.

Proteomic databases

EPDiQ15750.
MaxQBiQ15750.
PaxDbiQ15750.
PeptideAtlasiQ15750.
PRIDEiQ15750.

Protocols and materials databases

DNASUi10454.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216160; ENSP00000216160; ENSG00000100324. [Q15750-1]
ENST00000331454; ENSP00000333049; ENSG00000100324. [Q15750-2]
GeneIDi10454.
KEGGihsa:10454.
UCSCiuc003axt.4. human. [Q15750-1]

Organism-specific databases

CTDi10454.
DisGeNETi10454.
GeneCardsiTAB1.
HGNCiHGNC:18157. TAB1.
HPAiCAB032328.
HPA039988.
HPA057104.
MIMi602615. gene.
neXtProtiNX_Q15750.
OpenTargetsiENSG00000100324.
PharmGKBiPA30604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00510000048276.
HOGENOMiHOG000044226.
HOVERGENiHBG007302.
InParanoidiQ15750.
KOiK04403.
OMAiSTNQIYR.
OrthoDBiEOG091G0B0E.
PhylomeDBiQ15750.
TreeFamiTF317785.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100324-MONOMER.
ReactomeiR-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-446652. Interleukin-1 signaling.
R-HSA-450302. activated TAK1 mediates p38 MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-937042. IRAK2 mediated activation of TAK1 complex.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
SignaLinkiQ15750.
SIGNORiQ15750.

Miscellaneous databases

ChiTaRSiTAB1. human.
EvolutionaryTraceiQ15750.
GeneWikiiMAP3K7IP1.
GenomeRNAii10454.
PROiQ15750.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100324.
CleanExiHS_MAP3K7IP1.
ExpressionAtlasiQ15750. baseline and differential.
GenevisibleiQ15750. HS.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAB1_HUMAN
AccessioniPrimary (citable) accession number: Q15750
Secondary accession number(s): Q2PP09, Q8IZW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.