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Q15750

- TAB1_HUMAN

UniProt

Q15750 - TAB1_HUMAN

Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

TAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. enzyme activator activity Source: ProtInc
    3. kinase activator activity Source: Ensembl
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPK activity Source: Reactome
    2. activation of MAPKKK activity Source: ProtInc
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. heart morphogenesis Source: Ensembl
    5. I-kappaB kinase/NF-kappaB signaling Source: Reactome
    6. innate immune response Source: Reactome
    7. in utero embryonic development Source: Ensembl
    8. JNK cascade Source: Reactome
    9. lung development Source: Ensembl
    10. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    11. MyD88-independent toll-like receptor signaling pathway Source: Reactome
    12. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
    13. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
    14. positive regulation of NF-kappaB transcription factor activity Source: Reactome
    15. stress-activated MAPK cascade Source: Reactome
    16. toll-like receptor 10 signaling pathway Source: Reactome
    17. toll-like receptor 2 signaling pathway Source: Reactome
    18. toll-like receptor 3 signaling pathway Source: Reactome
    19. toll-like receptor 4 signaling pathway Source: Reactome
    20. toll-like receptor 5 signaling pathway Source: Reactome
    21. toll-like receptor 9 signaling pathway Source: Reactome
    22. toll-like receptor signaling pathway Source: Reactome
    23. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    24. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
    25. transforming growth factor beta receptor signaling pathway Source: Ensembl
    26. TRIF-dependent toll-like receptor signaling pathway Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_163994. FCERI mediated NF-kB activation.
    REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_21399. activated TAK1 mediates p38 MAPK activation.
    REACT_22442. Interleukin-1 signaling.
    REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_25351. TRAF6 mediated induction of TAK1 complex.
    REACT_25380. IRAK2 mediated activation of TAK1 complex.
    REACT_75776. NOD1/2 Signaling Pathway.
    SignaLinkiQ15750.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Alternative name(s):
    Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
    TGF-beta-activated kinase 1-binding protein 1
    Short name:
    TAK1-binding protein 1
    Gene namesi
    Name:TAB1
    Synonyms:MAP3K7IP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:18157. TAB1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. endosome membrane Source: Reactome
    4. nucleus Source: HPA
    5. protein complex Source: Ensembl

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi213 – 2131D → A: Loss of interaction with XIAP. 1 Publication
    Mutagenesisi216 – 2161F → A: Loss of interaction with XIAP. 1 Publication
    Mutagenesisi438 – 4381S → A: Loss of phosphorylation site. 1 Publication

    Organism-specific databases

    PharmGKBiPA30604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504TGF-beta-activated kinase 1 and MAP3K7-binding protein 1PRO_0000057797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71Phosphoserine2 Publications
    Modified residuei378 – 3781Phosphoserine1 Publication
    Modified residuei438 – 4381Phosphoserine1 Publication

    Post-translational modificationi

    Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ15750.
    PaxDbiQ15750.
    PRIDEiQ15750.

    PTM databases

    PhosphoSiteiQ15750.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ15750.
    BgeeiQ15750.
    CleanExiHS_MAP3K7IP1.
    GenevestigatoriQ15750.

    Organism-specific databases

    HPAiCAB032328.
    HPA039988.

    Interactioni

    Subunit structurei

    Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARRB2P321213EBI-358643,EBI-714559
    MAP3K7O433182EBI-358643,EBI-358684
    MAP3K7O43318-23EBI-358643,EBI-358700
    MAPK14Q165392EBI-358643,EBI-73946
    TAB2Q9NYJ84EBI-358643,EBI-358708

    Protein-protein interaction databases

    BioGridi115717. 81 interactions.
    DIPiDIP-27524N.
    IntActiQ15750. 71 interactions.
    MINTiMINT-88613.

    Structurei

    Secondary structure

    1
    504
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni18 – 203
    Beta strandi27 – 326
    Beta strandi35 – 373
    Beta strandi39 – 424
    Beta strandi51 – 588
    Turni59 – 613
    Beta strandi62 – 7413
    Helixi75 – 8612
    Beta strandi89 – 924
    Beta strandi94 – 963
    Helixi99 – 13335
    Helixi141 – 1433
    Helixi146 – 1483
    Helixi149 – 16214
    Beta strandi165 – 17410
    Beta strandi177 – 1859
    Beta strandi187 – 1937
    Beta strandi195 – 2028
    Helixi212 – 2198
    Turni220 – 2223
    Helixi225 – 2317
    Beta strandi234 – 2363
    Beta strandi239 – 2413
    Helixi246 – 2505
    Helixi252 – 2543
    Turni256 – 2605
    Beta strandi265 – 2673
    Beta strandi271 – 2777
    Beta strandi283 – 2886
    Helixi290 – 30011
    Beta strandi302 – 3043
    Helixi305 – 31915
    Helixi323 – 34321
    Helixi348 – 3514
    Beta strandi353 – 3553
    Beta strandi358 – 3669
    Beta strandi475 – 4784
    Helixi485 – 49511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2J4OX-ray2.25A1-401[»]
    2POMX-ray2.27A1-370[»]
    2POPX-ray3.10A/C1-370[»]
    2YDSX-ray2.55T392-398[»]
    2YIYX-ray2.49A468-497[»]
    4AY5X-ray3.15I/J/K/L389-399[»]
    4AY6X-ray3.30E/F/G/H389-401[»]
    4GS6X-ray2.20A468-504[»]
    4KA3X-ray2.71B395-415[»]
    4L3PX-ray2.68A468-504[»]
    4L53X-ray2.55A468-496[»]
    ProteinModelPortaliQ15750.
    SMRiQ15750. Positions 16-370, 468-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15750.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 368305PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi452 – 4576Poly-Ser

    Sequence similaritiesi

    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiNOG320352.
    HOGENOMiHOG000044226.
    HOVERGENiHBG007302.
    InParanoidiQ15750.
    KOiK04403.
    OMAiSHPPEDN.
    OrthoDBiEOG7W41C0.
    PhylomeDBiQ15750.
    TreeFamiTF317785.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15750-1) [UniParc]FASTAAdd to Basket

    Also known as: TAB1alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE    50
    DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA 100
    DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK 150
    ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV 200
    TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY 250
    GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300
    GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR 350
    FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST 400
    SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT 450
    QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV 500
    VTAP 504
    Length:504
    Mass (Da):54,644
    Last modified:November 1, 1996 - v1
    Checksum:iA45743288718983A
    GO
    Isoform 2 (identifier: Q15750-2) [UniParc]FASTAAdd to Basket

    Also known as: TAB1beta

    The sequence of this isoform differs from the canonical sequence as follows:
         436-504: NQSPTLTLQS...HGEQSVVTAP → KDPSRPASDLTAIPQCQLNLLGSLTPG

    Note: Does not bind nor activate MAP3K7/TAK1.

    Show »
    Length:462
    Mass (Da):49,917
    Checksum:iE26443BBE3BD3404
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241D → E.
    Corresponds to variant rs17001096 [ dbSNP | Ensembl ].
    VAR_039271

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei436 – 50469NQSPT…VVTAP → KDPSRPASDLTAIPQCQLNL LGSLTPG in isoform 2. 1 PublicationVSP_042024Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49928 mRNA. Translation: AAC12660.1.
    AF425640 mRNA. Translation: AAN32760.1.
    DQ314876 Genomic DNA. Translation: ABC40735.1.
    AL022312 Genomic DNA. No translation available.
    Z83845 Genomic DNA. Translation: CAB55304.1.
    Z83845 Genomic DNA. Translation: CAQ07045.1.
    CH471095 Genomic DNA. Translation: EAW60326.1.
    BC050554 mRNA. Translation: AAH50554.1.
    CCDSiCCDS13992.1. [Q15750-2]
    CCDS13993.1. [Q15750-1]
    RefSeqiNP_006107.1. NM_006116.2. [Q15750-1]
    NP_705717.1. NM_153497.2. [Q15750-2]
    UniGeneiHs.507681.
    Hs.729080.

    Genome annotation databases

    EnsembliENST00000216160; ENSP00000216160; ENSG00000100324. [Q15750-1]
    ENST00000331454; ENSP00000333049; ENSG00000100324. [Q15750-2]
    GeneIDi10454.
    KEGGihsa:10454.
    UCSCiuc003axt.3. human. [Q15750-1]
    uc003axu.1. human. [Q15750-2]

    Polymorphism databases

    DMDMi10720303.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49928 mRNA. Translation: AAC12660.1 .
    AF425640 mRNA. Translation: AAN32760.1 .
    DQ314876 Genomic DNA. Translation: ABC40735.1 .
    AL022312 Genomic DNA. No translation available.
    Z83845 Genomic DNA. Translation: CAB55304.1 .
    Z83845 Genomic DNA. Translation: CAQ07045.1 .
    CH471095 Genomic DNA. Translation: EAW60326.1 .
    BC050554 mRNA. Translation: AAH50554.1 .
    CCDSi CCDS13992.1. [Q15750-2 ]
    CCDS13993.1. [Q15750-1 ]
    RefSeqi NP_006107.1. NM_006116.2. [Q15750-1 ]
    NP_705717.1. NM_153497.2. [Q15750-2 ]
    UniGenei Hs.507681.
    Hs.729080.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2J4O X-ray 2.25 A 1-401 [» ]
    2POM X-ray 2.27 A 1-370 [» ]
    2POP X-ray 3.10 A/C 1-370 [» ]
    2YDS X-ray 2.55 T 392-398 [» ]
    2YIY X-ray 2.49 A 468-497 [» ]
    4AY5 X-ray 3.15 I/J/K/L 389-399 [» ]
    4AY6 X-ray 3.30 E/F/G/H 389-401 [» ]
    4GS6 X-ray 2.20 A 468-504 [» ]
    4KA3 X-ray 2.71 B 395-415 [» ]
    4L3P X-ray 2.68 A 468-504 [» ]
    4L53 X-ray 2.55 A 468-496 [» ]
    ProteinModelPortali Q15750.
    SMRi Q15750. Positions 16-370, 468-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115717. 81 interactions.
    DIPi DIP-27524N.
    IntActi Q15750. 71 interactions.
    MINTi MINT-88613.

    Chemistry

    BindingDBi Q15750.
    ChEMBLi CHEMBL5605.

    PTM databases

    PhosphoSitei Q15750.

    Polymorphism databases

    DMDMi 10720303.

    Proteomic databases

    MaxQBi Q15750.
    PaxDbi Q15750.
    PRIDEi Q15750.

    Protocols and materials databases

    DNASUi 10454.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216160 ; ENSP00000216160 ; ENSG00000100324 . [Q15750-1 ]
    ENST00000331454 ; ENSP00000333049 ; ENSG00000100324 . [Q15750-2 ]
    GeneIDi 10454.
    KEGGi hsa:10454.
    UCSCi uc003axt.3. human. [Q15750-1 ]
    uc003axu.1. human. [Q15750-2 ]

    Organism-specific databases

    CTDi 10454.
    GeneCardsi GC22P039796.
    HGNCi HGNC:18157. TAB1.
    HPAi CAB032328.
    HPA039988.
    MIMi 602615. gene.
    neXtProti NX_Q15750.
    PharmGKBi PA30604.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320352.
    HOGENOMi HOG000044226.
    HOVERGENi HBG007302.
    InParanoidi Q15750.
    KOi K04403.
    OMAi SHPPEDN.
    OrthoDBi EOG7W41C0.
    PhylomeDBi Q15750.
    TreeFami TF317785.

    Enzyme and pathway databases

    Reactomei REACT_163994. FCERI mediated NF-kB activation.
    REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_21399. activated TAK1 mediates p38 MAPK activation.
    REACT_22442. Interleukin-1 signaling.
    REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_25351. TRAF6 mediated induction of TAK1 complex.
    REACT_25380. IRAK2 mediated activation of TAK1 complex.
    REACT_75776. NOD1/2 Signaling Pathway.
    SignaLinki Q15750.

    Miscellaneous databases

    ChiTaRSi TAB1. human.
    EvolutionaryTracei Q15750.
    GeneWikii MAP3K7IP1.
    GenomeRNAii 10454.
    NextBioi 39627.
    PROi Q15750.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15750.
    Bgeei Q15750.
    CleanExi HS_MAP3K7IP1.
    Genevestigatori Q15750.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction."
      Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., Irie K., Nishida E., Matsumoto K.
      Science 272:1179-1182(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MAP3K7.
      Tissue: Brain.
    2. "TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1."
      Ge B., Xiong X., Jing Q., Mosley J.L., Filose A., Bian D., Huang S., Han J.
      J. Biol. Chem. 278:2286-2293(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: PNS.
    7. "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."
      Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z., Matsumoto K.
      Nature 398:252-256(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF6 AND MAP3K7.
    8. "TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
      Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., Chen Z.J.
      Nature 412:346-351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, IDENTIFICATION IN THE TRIKA2 COMPLEX.
    9. "The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway."
      Thiefes A., Wolf A., Doerrie A., Grassl G.A., Matsumoto K., Autenrieth I., Bohn E., Sakurai H., Niedenthal R., Resch K., Kracht M.
      EMBO Rep. 7:838-844(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, PHOSPHORYLATION AT SER-438, MUTAGENESIS OF SER-438, DEUBIQUITINATION BY YOPP.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1-401, ABSENCE OF FUNCTION AS A PHOSPHATASE.
    16. "XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization."
      Lu M., Lin S.-C., Huang Y., Kang Y.J., Rich R., Lo Y.-C., Myszka D., Han J., Wu H.
      Mol. Cell 26:689-702(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 1-370 IN COMPLEX WITH XIAP, MUTAGENESIS OF ASP-213 AND PHE-216.

    Entry informationi

    Entry nameiTAB1_HUMAN
    AccessioniPrimary (citable) accession number: Q15750
    Secondary accession number(s): Q2PP09, Q8IZW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3