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Protein

CCAAT/enhancer-binding protein epsilon

Gene

CEBPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: Ensembl
  2. cytokine biosynthetic process Source: Ensembl
  3. defense response Source: ProtInc
  4. defense response to bacterium Source: Ensembl
  5. macrophage differentiation Source: Ensembl
  6. phagocytosis Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein epsilon
Short name:
C/EBP epsilon
Gene namesi
Name:CEBPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1836. CEBPE.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti169142. Recurrent infection due to specific granule deficiency.
PharmGKBiPA26379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281CCAAT/enhancer-binding protein epsilonPRO_0000076624Add
BLAST

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15744.
PRIDEiQ15744.

PTM databases

PhosphoSiteiQ15744.

Expressioni

Tissue specificityi

Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

Gene expression databases

BgeeiQ15744.
CleanExiHS_CEBPE.
GenevestigatoriQ15744.

Organism-specific databases

HPAiCAB005113.
HPA002928.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.

Protein-protein interaction databases

BioGridi107482. 44 interactions.
IntActiQ15744. 8 interactions.
MINTiMINT-6609345.
STRINGi9606.ENSP00000206513.

Structurei

Secondary structure

1
281
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi37 – 4711Combined sources
Helixi50 – 578Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T92X-ray1.50A37-61[»]
ProteinModelPortaliQ15744.
SMRiQ15744. Positions 206-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26764bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 22821Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni230 – 2378Leucine-zipperPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG244516.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiQ15744.
KOiK10051.
OMAiPAGPLHK.
OrthoDBiEOG7R56TQ.
PhylomeDBiQ15744.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE
60 70 80 90 100
EQLLSDLFAV KPAPEARGLK GPGTPAFPHY LPPDPRPFAY PPHTFGPDRK
110 120 130 140 150
ALGPGIYSSP GSYDPRAVAV KEEPRGPEGS RAASRGSYNP LQYQVAHCGQ
160 170 180 190 200
TAMHLPPTLA APGQPLRVLK APLATAAPPC SPLLKAPSPA GPLHKGKKAV
210 220 230 240 250
NKDSLEYRLR RERNNIAVRK SRDKAKRRIL ETQQKVLEYM AENERLRSRV
260 270 280
EQLTQELDTL RNLFRQIPEA ANLIKGVGGC S
Length:281
Mass (Da):30,603
Last modified:April 12, 2005 - v2
Checksum:iB0A1DFA88C04C3D0
GO

Sequence cautioni

The sequence AAC51130.1 differs from that shown. Reason: Frameshift at position 4. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641P → S in AAC51130 (PubMed:9032264).Curated
Sequence conflicti68 – 681G → R in AAC50708 (PubMed:8661101).Curated
Sequence conflicti68 – 681G → R in AAC50709 (PubMed:8661101).Curated
Sequence conflicti252 – 2521Q → E in AAC51130 (PubMed:9032264).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48865 Genomic DNA. Translation: AAC50708.1.
U48866 mRNA. Translation: AAC50709.1.
U80982 Genomic DNA. Translation: AAC51130.1. Frameshift.
BC035797 mRNA. Translation: AAH35797.2.
CCDSiCCDS9589.1.
RefSeqiNP_001796.2. NM_001805.3.
UniGeneiHs.558308.

Genome annotation databases

EnsembliENST00000206513; ENSP00000206513; ENSG00000092067.
GeneIDi1053.
KEGGihsa:1053.
UCSCiuc001wiv.2. human.

Polymorphism databases

DMDMi62512175.

Cross-referencesi

Web resourcesi

CEBPEbase

CEBPE mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48865 Genomic DNA. Translation: AAC50708.1.
U48866 mRNA. Translation: AAC50709.1.
U80982 Genomic DNA. Translation: AAC51130.1. Frameshift.
BC035797 mRNA. Translation: AAH35797.2.
CCDSiCCDS9589.1.
RefSeqiNP_001796.2. NM_001805.3.
UniGeneiHs.558308.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T92X-ray1.50A37-61[»]
ProteinModelPortaliQ15744.
SMRiQ15744. Positions 206-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107482. 44 interactions.
IntActiQ15744. 8 interactions.
MINTiMINT-6609345.
STRINGi9606.ENSP00000206513.

PTM databases

PhosphoSiteiQ15744.

Polymorphism databases

DMDMi62512175.

Proteomic databases

MaxQBiQ15744.
PRIDEiQ15744.

Protocols and materials databases

DNASUi1053.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206513; ENSP00000206513; ENSG00000092067.
GeneIDi1053.
KEGGihsa:1053.
UCSCiuc001wiv.2. human.

Organism-specific databases

CTDi1053.
GeneCardsiGC14M023586.
HGNCiHGNC:1836. CEBPE.
HPAiCAB005113.
HPA002928.
MIMi600749. gene.
neXtProtiNX_Q15744.
Orphaneti169142. Recurrent infection due to specific granule deficiency.
PharmGKBiPA26379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG244516.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiQ15744.
KOiK10051.
OMAiPAGPLHK.
OrthoDBiEOG7R56TQ.
PhylomeDBiQ15744.
TreeFamiTF105008.

Miscellaneous databases

GeneWikiiCEBPE.
GenomeRNAii1053.
NextBioi4409.
PROiQ15744.
SOURCEiSearch...

Gene expression databases

BgeeiQ15744.
CleanExiHS_CEBPE.
GenevestigatoriQ15744.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus."
    Antonson P., Stellan B., Yamanaka R., Xanthopoulos K.G.
    Genomics 35:30-38(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor."
    Chumakov A.M., Grillier I., Chumakova E., Chih D., Slater J., Koeffler H.P.
    Mol. Cell. Biol. 17:1375-1386(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCEBPE_HUMAN
AccessioniPrimary (citable) accession number: Q15744
Secondary accession number(s): Q15745, Q8IYI2, Q99803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: February 4, 2015
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.