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Protein

CCAAT/enhancer-binding protein epsilon

Gene

CEBPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092067-MONOMER.
SIGNORiQ15744.

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein epsilon
Short name:
C/EBP epsilon
Gene namesi
Name:CEBPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1836. CEBPE.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1053.
MalaCardsiCEBPE.
OpenTargetsiENSG00000092067.
Orphaneti169142. Recurrent infection due to specific granule deficiency.
PharmGKBiPA26379.

Polymorphism and mutation databases

BioMutaiCEBPE.
DMDMi62512175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766241 – 281CCAAT/enhancer-binding protein epsilonAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei181PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15744.
MaxQBiQ15744.
PaxDbiQ15744.
PeptideAtlasiQ15744.
PRIDEiQ15744.

PTM databases

iPTMnetiQ15744.
PhosphoSitePlusiQ15744.

Expressioni

Tissue specificityi

Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

Gene expression databases

BgeeiENSG00000092067.
CleanExiHS_CEBPE.
GenevisibleiQ15744. HS.

Organism-specific databases

HPAiCAB005113.
HPA002928.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.

Protein-protein interaction databases

BioGridi107482. 44 interactors.
IntActiQ15744. 8 interactors.
MINTiMINT-6609345.
STRINGi9606.ENSP00000206513.

Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 47Combined sources11
Helixi50 – 57Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T92X-ray1.50A37-61[»]
ProteinModelPortaliQ15744.
SMRiQ15744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 267bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni208 – 228Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni230 – 237Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISXR. Eukaryota.
ENOG4111HY3. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiQ15744.
KOiK10051.
OMAiCDHEASI.
OrthoDBiEOG091G11FC.
PhylomeDBiQ15744.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE
60 70 80 90 100
EQLLSDLFAV KPAPEARGLK GPGTPAFPHY LPPDPRPFAY PPHTFGPDRK
110 120 130 140 150
ALGPGIYSSP GSYDPRAVAV KEEPRGPEGS RAASRGSYNP LQYQVAHCGQ
160 170 180 190 200
TAMHLPPTLA APGQPLRVLK APLATAAPPC SPLLKAPSPA GPLHKGKKAV
210 220 230 240 250
NKDSLEYRLR RERNNIAVRK SRDKAKRRIL ETQQKVLEYM AENERLRSRV
260 270 280
EQLTQELDTL RNLFRQIPEA ANLIKGVGGC S
Length:281
Mass (Da):30,603
Last modified:April 12, 2005 - v2
Checksum:iB0A1DFA88C04C3D0
GO

Sequence cautioni

The sequence AAC51130 differs from that shown. Reason: Frameshift at position 4.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64P → S in AAC51130 (PubMed:9032264).Curated1
Sequence conflicti68G → R in AAC50708 (PubMed:8661101).Curated1
Sequence conflicti68G → R in AAC50709 (PubMed:8661101).Curated1
Sequence conflicti252Q → E in AAC51130 (PubMed:9032264).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48865 Genomic DNA. Translation: AAC50708.1.
U48866 mRNA. Translation: AAC50709.1.
U80982 Genomic DNA. Translation: AAC51130.1. Frameshift.
BC035797 mRNA. Translation: AAH35797.2.
CCDSiCCDS9589.1.
RefSeqiNP_001796.2. NM_001805.3.
UniGeneiHs.558308.

Genome annotation databases

EnsembliENST00000206513; ENSP00000206513; ENSG00000092067.
GeneIDi1053.
KEGGihsa:1053.
UCSCiuc001wiv.3. human.

Cross-referencesi

Web resourcesi

CEBPEbase

CEBPE mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48865 Genomic DNA. Translation: AAC50708.1.
U48866 mRNA. Translation: AAC50709.1.
U80982 Genomic DNA. Translation: AAC51130.1. Frameshift.
BC035797 mRNA. Translation: AAH35797.2.
CCDSiCCDS9589.1.
RefSeqiNP_001796.2. NM_001805.3.
UniGeneiHs.558308.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T92X-ray1.50A37-61[»]
ProteinModelPortaliQ15744.
SMRiQ15744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107482. 44 interactors.
IntActiQ15744. 8 interactors.
MINTiMINT-6609345.
STRINGi9606.ENSP00000206513.

PTM databases

iPTMnetiQ15744.
PhosphoSitePlusiQ15744.

Polymorphism and mutation databases

BioMutaiCEBPE.
DMDMi62512175.

Proteomic databases

EPDiQ15744.
MaxQBiQ15744.
PaxDbiQ15744.
PeptideAtlasiQ15744.
PRIDEiQ15744.

Protocols and materials databases

DNASUi1053.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206513; ENSP00000206513; ENSG00000092067.
GeneIDi1053.
KEGGihsa:1053.
UCSCiuc001wiv.3. human.

Organism-specific databases

CTDi1053.
DisGeNETi1053.
GeneCardsiCEBPE.
HGNCiHGNC:1836. CEBPE.
HPAiCAB005113.
HPA002928.
MalaCardsiCEBPE.
MIMi600749. gene.
neXtProtiNX_Q15744.
OpenTargetsiENSG00000092067.
Orphaneti169142. Recurrent infection due to specific granule deficiency.
PharmGKBiPA26379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISXR. Eukaryota.
ENOG4111HY3. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiQ15744.
KOiK10051.
OMAiCDHEASI.
OrthoDBiEOG091G11FC.
PhylomeDBiQ15744.
TreeFamiTF105008.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092067-MONOMER.
SIGNORiQ15744.

Miscellaneous databases

GeneWikiiCEBPE.
GenomeRNAii1053.
PROiQ15744.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092067.
CleanExiHS_CEBPE.
GenevisibleiQ15744. HS.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEBPE_HUMAN
AccessioniPrimary (citable) accession number: Q15744
Secondary accession number(s): Q15745, Q8IYI2, Q99803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.