Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q15744

- CEBPE_HUMAN

UniProt

Q15744 - CEBPE_HUMAN

Protein

CCAAT/enhancer-binding protein epsilon

Gene

CEBPE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (12 Apr 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: Ensembl
    2. cytokine biosynthetic process Source: Ensembl
    3. defense response Source: ProtInc
    4. defense response to bacterium Source: Ensembl
    5. macrophage differentiation Source: Ensembl
    6. phagocytosis Source: Ensembl
    7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCAAT/enhancer-binding protein epsilon
    Short name:
    C/EBP epsilon
    Gene namesi
    Name:CEBPE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1836. CEBPE.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti169142. Recurrent infection due to specific granule deficiency.
    PharmGKBiPA26379.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281CCAAT/enhancer-binding protein epsilonPRO_0000076624Add
    BLAST

    Post-translational modificationi

    Phosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15744.
    PRIDEiQ15744.

    PTM databases

    PhosphoSiteiQ15744.

    Expressioni

    Tissue specificityi

    Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

    Gene expression databases

    BgeeiQ15744.
    CleanExiHS_CEBPE.
    GenevestigatoriQ15744.

    Organism-specific databases

    HPAiCAB005113.
    HPA002928.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.

    Protein-protein interaction databases

    BioGridi107482. 44 interactions.
    IntActiQ15744. 8 interactions.
    MINTiMINT-6609345.
    STRINGi9606.ENSP00000206513.

    Structurei

    Secondary structure

    1
    281
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi37 – 4711
    Helixi50 – 578

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3T92X-ray1.50A37-61[»]
    ProteinModelPortaliQ15744.
    SMRiQ15744. Positions 206-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 26764bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni208 – 22821Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni230 – 2378Leucine-zipperPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the bZIP family. C/EBP subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG244516.
    HOGENOMiHOG000013112.
    HOVERGENiHBG050879.
    InParanoidiQ15744.
    KOiK10051.
    OMAiPAGPLHK.
    OrthoDBiEOG7R56TQ.
    PhylomeDBiQ15744.
    TreeFamiTF105008.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR016468. CCAAT/enhancer-binding.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15744-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE    50
    EQLLSDLFAV KPAPEARGLK GPGTPAFPHY LPPDPRPFAY PPHTFGPDRK 100
    ALGPGIYSSP GSYDPRAVAV KEEPRGPEGS RAASRGSYNP LQYQVAHCGQ 150
    TAMHLPPTLA APGQPLRVLK APLATAAPPC SPLLKAPSPA GPLHKGKKAV 200
    NKDSLEYRLR RERNNIAVRK SRDKAKRRIL ETQQKVLEYM AENERLRSRV 250
    EQLTQELDTL RNLFRQIPEA ANLIKGVGGC S 281
    Length:281
    Mass (Da):30,603
    Last modified:April 12, 2005 - v2
    Checksum:iB0A1DFA88C04C3D0
    GO

    Sequence cautioni

    The sequence AAC51130.1 differs from that shown. Reason: Frameshift at position 4.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641P → S in AAC51130. (PubMed:9032264)Curated
    Sequence conflicti68 – 681G → R in AAC50708. (PubMed:8661101)Curated
    Sequence conflicti68 – 681G → R in AAC50709. (PubMed:8661101)Curated
    Sequence conflicti252 – 2521Q → E in AAC51130. (PubMed:9032264)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48865 Genomic DNA. Translation: AAC50708.1.
    U48866 mRNA. Translation: AAC50709.1.
    U80982 Genomic DNA. Translation: AAC51130.1. Frameshift.
    BC035797 mRNA. Translation: AAH35797.2.
    CCDSiCCDS9589.1.
    RefSeqiNP_001796.2. NM_001805.3.
    UniGeneiHs.558308.

    Genome annotation databases

    EnsembliENST00000206513; ENSP00000206513; ENSG00000092067.
    GeneIDi1053.
    KEGGihsa:1053.
    UCSCiuc001wiv.2. human.

    Polymorphism databases

    DMDMi62512175.

    Cross-referencesi

    Web resourcesi

    CEBPEbase

    CEBPE mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48865 Genomic DNA. Translation: AAC50708.1 .
    U48866 mRNA. Translation: AAC50709.1 .
    U80982 Genomic DNA. Translation: AAC51130.1 . Frameshift.
    BC035797 mRNA. Translation: AAH35797.2 .
    CCDSi CCDS9589.1.
    RefSeqi NP_001796.2. NM_001805.3.
    UniGenei Hs.558308.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3T92 X-ray 1.50 A 37-61 [» ]
    ProteinModelPortali Q15744.
    SMRi Q15744. Positions 206-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107482. 44 interactions.
    IntActi Q15744. 8 interactions.
    MINTi MINT-6609345.
    STRINGi 9606.ENSP00000206513.

    PTM databases

    PhosphoSitei Q15744.

    Polymorphism databases

    DMDMi 62512175.

    Proteomic databases

    MaxQBi Q15744.
    PRIDEi Q15744.

    Protocols and materials databases

    DNASUi 1053.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000206513 ; ENSP00000206513 ; ENSG00000092067 .
    GeneIDi 1053.
    KEGGi hsa:1053.
    UCSCi uc001wiv.2. human.

    Organism-specific databases

    CTDi 1053.
    GeneCardsi GC14M023586.
    HGNCi HGNC:1836. CEBPE.
    HPAi CAB005113.
    HPA002928.
    MIMi 600749. gene.
    neXtProti NX_Q15744.
    Orphaneti 169142. Recurrent infection due to specific granule deficiency.
    PharmGKBi PA26379.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG244516.
    HOGENOMi HOG000013112.
    HOVERGENi HBG050879.
    InParanoidi Q15744.
    KOi K10051.
    OMAi PAGPLHK.
    OrthoDBi EOG7R56TQ.
    PhylomeDBi Q15744.
    TreeFami TF105008.

    Miscellaneous databases

    GeneWikii CEBPE.
    GenomeRNAii 1053.
    NextBioi 4409.
    PROi Q15744.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15744.
    CleanExi HS_CEBPE.
    Genevestigatori Q15744.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR016468. CCAAT/enhancer-binding.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005879. CCAAT/enhancer-binding. 1 hit.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus."
      Antonson P., Stellan B., Yamanaka R., Xanthopoulos K.G.
      Genomics 35:30-38(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor."
      Chumakov A.M., Grillier I., Chumakova E., Chih D., Slater J., Koeffler H.P.
      Mol. Cell. Biol. 17:1375-1386(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCEBPE_HUMAN
    AccessioniPrimary (citable) accession number: Q15744
    Secondary accession number(s): Q15745, Q8IYI2, Q99803
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3