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Q15744 (CEBPE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CCAAT/enhancer-binding protein epsilon

Short name=C/EBP epsilon
Gene names
Name:CEBPE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

Subunit structure

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.

Subcellular location

Nucleus.

Tissue specificity

Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

Post-translational modification

Phosphorylated.

Sequence similarities

Belongs to the bZIP family. C/EBP subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence caution

The sequence AAC51130.1 differs from that shown. Reason: Frameshift at position 4.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281CCAAT/enhancer-binding protein epsilon
PRO_0000076624

Regions

Domain204 – 26764bZIP
Region208 – 22821Basic motif By similarity
Region230 – 2378Leucine-zipper By similarity

Experimental info

Sequence conflict641P → S in AAC51130. Ref.2
Sequence conflict681G → R in AAC50708. Ref.1
Sequence conflict681G → R in AAC50709. Ref.1
Sequence conflict2521Q → E in AAC51130. Ref.2

Secondary structure

..... 281
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q15744 [UniParc].

Last modified April 12, 2005. Version 2.
Checksum: B0A1DFA88C04C3D0

FASTA28130,603
        10         20         30         40         50         60 
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE EQLLSDLFAV 

        70         80         90        100        110        120 
KPAPEARGLK GPGTPAFPHY LPPDPRPFAY PPHTFGPDRK ALGPGIYSSP GSYDPRAVAV 

       130        140        150        160        170        180 
KEEPRGPEGS RAASRGSYNP LQYQVAHCGQ TAMHLPPTLA APGQPLRVLK APLATAAPPC 

       190        200        210        220        230        240 
SPLLKAPSPA GPLHKGKKAV NKDSLEYRLR RERNNIAVRK SRDKAKRRIL ETQQKVLEYM 

       250        260        270        280 
AENERLRSRV EQLTQELDTL RNLFRQIPEA ANLIKGVGGC S 

« Hide

References

« Hide 'large scale' references
[1]"A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus."
Antonson P., Stellan B., Yamanaka R., Xanthopoulos K.G.
Genomics 35:30-38(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor."
Chumakov A.M., Grillier I., Chumakova E., Chih D., Slater J., Koeffler H.P.
Mol. Cell. Biol. 17:1375-1386(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

CEBPEbase

CEBPE mutation db

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U48865 Genomic DNA. Translation: AAC50708.1.
U48866 mRNA. Translation: AAC50709.1.
U80982 Genomic DNA. Translation: AAC51130.1. Frameshift.
BC035797 mRNA. Translation: AAH35797.2.
CCDSCCDS9589.1.
RefSeqNP_001796.2. NM_001805.3.
UniGeneHs.558308.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3T92X-ray1.50A37-61[»]
ProteinModelPortalQ15744.
SMRQ15744. Positions 206-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107482. 44 interactions.
IntActQ15744. 8 interactions.
MINTMINT-6609345.
STRING9606.ENSP00000206513.

PTM databases

PhosphoSiteQ15744.

Polymorphism databases

DMDM62512175.

Proteomic databases

MaxQBQ15744.
PRIDEQ15744.

Protocols and materials databases

DNASU1053.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000206513; ENSP00000206513; ENSG00000092067.
GeneID1053.
KEGGhsa:1053.
UCSCuc001wiv.2. human.

Organism-specific databases

CTD1053.
GeneCardsGC14M023586.
HGNCHGNC:1836. CEBPE.
HPACAB005113.
HPA002928.
MIM600749. gene.
neXtProtNX_Q15744.
Orphanet169142. Recurrent infection due to specific granule deficiency.
PharmGKBPA26379.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG244516.
HOGENOMHOG000013112.
HOVERGENHBG050879.
InParanoidQ15744.
KOK10051.
OMAPAGPLHK.
OrthoDBEOG7R56TQ.
PhylomeDBQ15744.
TreeFamTF105008.

Gene expression databases

BgeeQ15744.
CleanExHS_CEBPE.
GenevestigatorQ15744.

Family and domain databases

InterProIPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCEBPE.
GenomeRNAi1053.
NextBio4409.
PROQ15744.
SOURCESearch...

Entry information

Entry nameCEBPE_HUMAN
AccessionPrimary (citable) accession number: Q15744
Secondary accession number(s): Q15745, Q8IYI2, Q99803
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM