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Reviewed, UniProtKB/Swiss-Prot Q15744 (CEBPE_HUMAN)

Last modified November 25, 2008. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CCAAT/enhancer-binding protein epsilon
      Short name=C/EBP epsilon
Gene names
Name: CEBPE
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

Subunit structure

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.

Subcellular location

Nucleus.

Tissue specificity

Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

Post-translational modification

Phosphorylated.

Sequence similarities

Belongs to the bZIP family. C/EBP subfamily.

Contains 1 bZIP domain.

Sequence caution

The sequence AAC51130.1 differs from that shown. Reason: Frameshift at position 4.

Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein

Gene Ontology (GO)

   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein dimerization activity

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281CCAAT/enhancer-binding protein epsilon
PRO_0000076624

Regions

Domain239 – 26729Leucine-zipper
DNA binding208 – 22821Basic motif

Experimental info

Sequence conflict641P → S in AAC51130. Ref.2
Sequence conflict681G → R in AAC50708 and AAC50709. Ref.1
Sequence conflict2521Q → E in AAC51130. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q15744-1 [UniParc].

Last modified April 12, 2005. Version 2.
Checksum: B0A1DFA88C04C3D0

FASTA28130,603
        10         20         30         40         50         60 
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE EQLLSDLFAV 

        70         80         90        100        110        120 
KPAPEARGLK GPGTPAFPHY LPPDPRPFAY PPHTFGPDRK ALGPGIYSSP GSYDPRAVAV 

       130        140        150        160        170        180 
KEEPRGPEGS RAASRGSYNP LQYQVAHCGQ TAMHLPPTLA APGQPLRVLK APLATAAPPC 

       190        200        210        220        230        240 
SPLLKAPSPA GPLHKGKKAV NKDSLEYRLR RERNNIAVRK SRDKAKRRIL ETQQKVLEYM 

       250        260        270        280 
AENERLRSRV EQLTQELDTL RNLFRQIPEA ANLIKGVGGC S 

« Hide

References

« Hide 'large scale' references
[1]"A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus."
Antonson P., Stellan B., Yamanaka R., Xanthopoulos K.G.
Genomics 35:30-38(1996) [PubMed: 8661101] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor."
Chumakov A.M., Grillier I., Chumakova E., Chih D., Slater J., Koeffler H.P.
Mol. Cell. Biol. 17:1375-1386(1997) [PubMed: 9032264] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

CEBPEbase

CEBPE mutation db

Cross-references

Sequence databases

U48865 Genomic DNA. Translation: AAC50708.1.
U48866 mRNA. Translation: AAC50709.1.
U80982 Genomic DNA. Translation: AAC51130.1. Frameshift.
BC035797 mRNA. Translation: AAH35797.2.
RefSeqNP_001796.2.
UniGeneHs.558308

3D structure databases

HSSPHSSP built from PDB template 1H89 based on UniProtKB P17676.
SMRQ15744. Positions 198-267.
ModBaseSearch...

PTM databases

PhosphoSiteQ15744.

Genome annotation databases

EnsemblENSG00000092067. Homo sapiens. [Contig view]
GeneID1053.
KEGGhsa:1053.

Organism-specific databases

H-InvDBHIX0037738.
HGNCHGNC:1836. CEBPE.
HPACAB005113.
HPA002928.
MIM600749. gene.
PharmGKBPA26379.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ15744.
HOVERGENQ15744.

Gene expression databases

ArrayExpressQ15744.
CleanExHS_CEBPE.
GermOnlineENSG00000092067. Homo sapiens.

Family and domain databases

InterProIPR011700. bZIP_2.
IPR016468. CCAAT/enhancer-binding.
IPR004827. TF_bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubQ15744.
NextBio4409.
SOURCESearch...

Entry information

Entry nameCEBPE_HUMAN
AccessionPrimary (citable) accession number: Q15744
Secondary accession number(s): Q15745, Q8IYI2, Q99803
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: November 25, 2008
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents