Q15743Q13334Q4VBB4Q6IX34OGR1_HUMANOvarian cancer G-protein coupled receptor 1OGR-1G-protein coupled receptor 68GPR12ASphingosylphosphorylcholine receptorGPR68OGR1Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoCloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.NUCLEOTIDE SEQUENCE [MRNA]Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14.NUCLEOTIDE SEQUENCE [GENOMIC DNA]Isolation of cDNA coding for human orphan G protein receptor 68.NUCLEOTIDE SEQUENCE [MRNA]cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The DNA sequence and analysis of human chromosome 14.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.RETRACTED PAPERERRATUM OF PUBMED:10806476RETRACTION NOTICE OF PUBMED:10806476Proton-sensing G-protein-coupled receptors.FUNCTIONTISSUE SPECIFICITYMUTAGENESIS OF HIS-17; HIS-20; HIS-84; HIS-89; HIS-159; HIS-175; HIS-245 AND HIS-269Mutations in the pH-sensing G-protein-coupled receptor GPR68 cause amelogenesis imperfecta.INVOLVEMENT IN AI2A6VARIANT AI2A6 PRO-74Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.VARIANT SER-39Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).Cell membraneMulti-pass membrane proteinFound at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.Amelogenesis imperfecta, hypomaturation type, 2A6
AI2A6
A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.The disease is caused by variants affecting the gene represented in this entry.Belongs to the G-protein coupled receptor 1 family.Was originally (PubMed:10806476) thought to be a receptor for sphingosylphosphorylcholine (SPC). However, this work has been retracted (PubMed:16508674).Amelogenesis imperfectaCell membraneDisease variantDisulfide bondG-protein coupled receptorGlycoproteinMembraneReceptorReference proteomeTransducerTransmembraneTransmembrane helixTumor suppressorNSRQLPHFHFHFHFHFHFHFHFHFGVSRVTMGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEVIEDENQHRVCFEHYPIQAWQRAINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASCDFAKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLA
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