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Protein

Ovarian cancer G-protein coupled receptor 1

Gene

GPR68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian cancer G-protein coupled receptor 1
Short name:
OGR-1
Alternative name(s):
G-protein coupled receptor 68
GPR12A
Sphingosylphosphorylcholine receptor
Gene namesi
Name:GPR68
Synonyms:OGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:4519. GPR68.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4625Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 5812CytoplasmicSequence analysisAdd
BLAST
Transmembranei59 – 8022Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 9515ExtracellularSequence analysisAdd
BLAST
Transmembranei96 – 11722Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13619CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15822Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 18325ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20522Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini206 – 22823CytoplasmicSequence analysisAdd
BLAST
Transmembranei229 – 24921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini250 – 26314ExtracellularSequence analysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini285 – 36581CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi17 – 171H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication
Mutagenesisi20 – 201H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication
Mutagenesisi84 – 841H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication
Mutagenesisi89 – 891H → F: No effect on pH-sensing activity. 1 Publication
Mutagenesisi159 – 1591H → F: No effect on pH-sensing activity. 1 Publication
Mutagenesisi169 – 1691H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH.
Mutagenesisi175 – 1751H → F: No effect on pH-sensing activity. 1 Publication
Mutagenesisi245 – 2451H → F: Severe loss pH-sensing activity. 1 Publication
Mutagenesisi269 – 2691H → F: Failed to stimulate IP formation at pH 6.8, activity is restored at more acid pH. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA28911.

Polymorphism and mutation databases

BioMutaiGPR68.
DMDMi3024266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Ovarian cancer G-protein coupled receptor 1PRO_0000070113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15743.
PeptideAtlasiQ15743.
PRIDEiQ15743.

PTM databases

iPTMnetiQ15743.
PhosphoSiteiQ15743.
SwissPalmiQ15743.

Expressioni

Tissue specificityi

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.1 Publication

Gene expression databases

BgeeiENSG00000119714.
CleanExiHS_GPR68.
ExpressionAtlasiQ15743. baseline and differential.
GenevisibleiQ15743. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000434045.

Structurei

3D structure databases

ProteinModelPortaliQ15743.
SMRiQ15743. Positions 13-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ15743.
KOiK08408.
OMAiDRHRVCF.
OrthoDBiEOG091G06ZG.
PhylomeDBiQ15743.
TreeFamiTF331803.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005389. OGR1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01564. OGR1RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNITADNSS MSCTIDHTIH QTLAPVVYVT VLVVGFPANC LSLYFGYLQI
60 70 80 90 100
KARNELGVYL CNLTVADLFY ICSLPFWLQY VLQHDNWSHG DLSCQVCGIL
110 120 130 140 150
LYENIYISVG FLCCISVDRY LAVAHPFRFH QFRTLKAAVG VSVVIWAKEL
160 170 180 190 200
LTSIYFLMHE EVIEDENQHR VCFEHYPIQA WQRAINYYRF LVGFLFPICL
210 220 230 240 250
LLASYQGILR AVRRSHGTQK SRKDQIQRLV LSTVVIFLAC FLPYHVLLLV
260 270 280 290 300
RSVWEASCDF AKGVFNAYHF SLLLTSFNCV ADPVLYCFVS ETTHRDLARL
310 320 330 340 350
RGACLAFLTC SRTGRAREAY PLGAPEASGK SGAQGEEPEL LTKLHPAFQT
360
PNSPGSGGFP TGRLA
Length:365
Mass (Da):41,077
Last modified:November 1, 1996 - v1
Checksum:i05919AFD5B842CCD
GO

Sequence cautioni

The sequence AAH96071 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH96072 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH96073 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH96074 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH98567 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAT38917 differs from that shown. Reason: Erroneous initiation. Curated
The sequence ACG60649 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW81447 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1423GVS → RVT in AAA79060 (PubMed:7498459).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391N → S Found in a renal cell carcinoma case; somatic mutation. 1 Publication
VAR_064716
Natural varianti53 – 531R → Q.
Corresponds to variant rs2230339 [ dbSNP | Ensembl ].
VAR_058714

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35398 mRNA. Translation: AAA79060.1.
U48405 Genomic DNA. Translation: AAC50596.1.
EU883575 mRNA. Translation: ACG60649.1. Different initiation.
AY615372 mRNA. Translation: AAT38917.1. Different initiation.
AL135818 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81447.1. Different initiation.
BC067472 mRNA. Translation: AAH67472.1.
BC069592 mRNA. Translation: AAH69592.1.
BC096071 mRNA. Translation: AAH96071.1. Different initiation.
BC096072 mRNA. Translation: AAH96072.1. Different initiation.
BC096073 mRNA. Translation: AAH96073.1. Different initiation.
BC096074 mRNA. Translation: AAH96074.1. Different initiation.
BC098567 mRNA. Translation: AAH98567.1. Different initiation.
CCDSiCCDS9894.2.
PIRiS68208.
RefSeqiNP_001171147.1. NM_001177676.1.
NP_003476.3. NM_003485.3.
XP_005268167.1. XM_005268110.4.
XP_005268168.1. XM_005268111.3.
XP_005268169.1. XM_005268112.3.
XP_006720325.1. XM_006720262.3.
XP_011535498.1. XM_011537196.2.
XP_011535499.1. XM_011537197.2.
XP_011535500.1. XM_011537198.2.
XP_011535501.1. XM_011537199.2.
UniGeneiHs.8882.

Genome annotation databases

EnsembliENST00000531499; ENSP00000434045; ENSG00000119714.
ENST00000535815; ENSP00000440797; ENSG00000119714.
GeneIDi8111.
KEGGihsa:8111.
UCSCiuc001xzg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35398 mRNA. Translation: AAA79060.1.
U48405 Genomic DNA. Translation: AAC50596.1.
EU883575 mRNA. Translation: ACG60649.1. Different initiation.
AY615372 mRNA. Translation: AAT38917.1. Different initiation.
AL135818 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81447.1. Different initiation.
BC067472 mRNA. Translation: AAH67472.1.
BC069592 mRNA. Translation: AAH69592.1.
BC096071 mRNA. Translation: AAH96071.1. Different initiation.
BC096072 mRNA. Translation: AAH96072.1. Different initiation.
BC096073 mRNA. Translation: AAH96073.1. Different initiation.
BC096074 mRNA. Translation: AAH96074.1. Different initiation.
BC098567 mRNA. Translation: AAH98567.1. Different initiation.
CCDSiCCDS9894.2.
PIRiS68208.
RefSeqiNP_001171147.1. NM_001177676.1.
NP_003476.3. NM_003485.3.
XP_005268167.1. XM_005268110.4.
XP_005268168.1. XM_005268111.3.
XP_005268169.1. XM_005268112.3.
XP_006720325.1. XM_006720262.3.
XP_011535498.1. XM_011537196.2.
XP_011535499.1. XM_011537197.2.
XP_011535500.1. XM_011537198.2.
XP_011535501.1. XM_011537199.2.
UniGeneiHs.8882.

3D structure databases

ProteinModelPortaliQ15743.
SMRiQ15743. Positions 13-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000434045.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15743.
PhosphoSiteiQ15743.
SwissPalmiQ15743.

Polymorphism and mutation databases

BioMutaiGPR68.
DMDMi3024266.

Proteomic databases

PaxDbiQ15743.
PeptideAtlasiQ15743.
PRIDEiQ15743.

Protocols and materials databases

DNASUi8111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531499; ENSP00000434045; ENSG00000119714.
ENST00000535815; ENSP00000440797; ENSG00000119714.
GeneIDi8111.
KEGGihsa:8111.
UCSCiuc001xzg.4. human.

Organism-specific databases

CTDi8111.
GeneCardsiGPR68.
HGNCiHGNC:4519. GPR68.
MIMi601404. gene.
neXtProtiNX_Q15743.
PharmGKBiPA28911.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ15743.
KOiK08408.
OMAiDRHRVCF.
OrthoDBiEOG091G06ZG.
PhylomeDBiQ15743.
TreeFamiTF331803.

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiGPR68.
GenomeRNAii8111.
PROiQ15743.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119714.
CleanExiHS_GPR68.
ExpressionAtlasiQ15743. baseline and differential.
GenevisibleiQ15743. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005389. OGR1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01564. OGR1RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOGR1_HUMAN
AccessioniPrimary (citable) accession number: Q15743
Secondary accession number(s): Q13334, Q4VBB4, Q6IX34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (PubMed:10806476) thought to be a receptor for sphingosylphosphorylcholine (SPC). However, this work has been retracted (PubMed:16508674).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.