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Q15726 (KISS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metastasis-suppressor KiSS-1
Alternative name(s):
Kisspeptin-1

Cleaved into the following 4 chains:

  1. Metastin
    Alternative name(s):
    Kisspeptin-54
  2. Kisspeptin-14
  3. Kisspeptin-13
  4. Kisspeptin-10
Gene names
Name:KISS1
ORF Names:PP5098
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Ref.9 Ref.11 Ref.12 Ref.14 Ref.18 Ref.19 Ref.25 Ref.26 Ref.27

Subcellular location

Secreted.

Tissue specificity

Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. Ref.9 Ref.16 Ref.24

Induction

Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting reduced NF-kappa-B binding to the promoter. Ref.15

Post-translational modification

Processed by MMP2 and MMP9.

Involvement in disease

Hypogonadotropic hypogonadism 13 with or without anosmia (HH13) [MIM:614842]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.30

Sequence similarities

Belongs to the KISS1 family.

Sequence caution

The sequence AAC79512.1 differs from that shown. Reason: Frameshift at position 138.

The sequence AAM78592.1 differs from that shown. Reason: Frameshift at position 138.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
Hypogonadotropic hypogonadism
   DomainSignal
   PTMAmidation
Cleavage on pair of basic residues
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcytoskeleton organization

Traceable author statement Ref.10. Source: ProtInc

generation of ovulation cycle rhythm

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of growth hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of luteinizing hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: Ensembl

neuron projection

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 11387329. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 138119Metastasis-suppressor KiSS-1
PRO_0000021544
Peptide68 – 12154Metastin
PRO_0000021545
Peptide108 – 12114Kisspeptin-14
PRO_0000021546
Peptide109 – 12113Kisspeptin-13
PRO_0000021547
Peptide112 – 12110Kisspeptin-10
PRO_0000021548

Regions

Region112 – 12110Essential for receptor binding and receptor activation

Sites

Site118 – 1192Cleavage; by MMP2 and MMP9

Amino acid modifications

Modified residue1121Phosphotyrosine Ref.22
Modified residue1211Phenylalanine amide Ref.9

Natural variations

Natural variant201E → K. Ref.29
Corresponds to variant rs12998 [ dbSNP | Ensembl ].
VAR_021396
Natural variant361Q → R. Ref.29
Corresponds to variant rs35431622 [ dbSNP | Ensembl ].
VAR_021397
Natural variant811P → R. Ref.3 Ref.4 Ref.29
Corresponds to variant rs4889 [ dbSNP | Ensembl ].
VAR_021398
Natural variant1151N → K in HH13; significantly reduced efficacy as well as potency. Ref.30
VAR_069179

Sequences

Sequence LengthMass (Da)Tools
Q15726 [UniParc].

Last modified March 23, 2010. Version 4.
Checksum: 0F0A1E1D66EDC22A

FASTA13814,705
        10         20         30         40         50         60 
MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA 

        70         80         90        100        110        120 
TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR 

       130 
FGKREAAPGN HGRSAGRG 

« Hide

References

« Hide 'large scale' references
[1]"KiSS-1, a novel human malignant melanoma metastasis-suppressor gene."
Lee J.-H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., Welch D.R.
J. Natl. Cancer Inst. 88:1731-1737(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Erratum
Lee J.-H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., Welch D.R.
J. Natl. Cancer Inst. 89:1549-1549(1997)
[3]"Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)."
West A., Vojta P.J., Welch D.R., Weissman B.E.
Genomics 54:145-148(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-81.
[4]"Cloned KiSS-1 gene from human term placenta."
Qiao C., Lin Q.D., Xu W.X., He Y., Wang C.H.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-81.
Tissue: Term placenta.
[5]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[7]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[9]"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor."
Ohtaki T., Shintani Y., Honda S., Matsumoto H., Hori A., Kanehashi K., Terao Y., Kumano S., Takatsu Y., Masuda Y., Ishibashi Y., Watanabe T., Asada M., Yamada T., Suenaga M., Kitada C., Usuki S., Kurokawa T. expand/collapse author list , Onda H., Nishimura O., Fujino M.
Nature 411:613-617(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 68-88, AMIDATION AT PHE-121, FUNCTION, TISSUE SPECIFICITY.
Tissue: Placenta.
[10]"Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1."
Lee J.-H., Welch D.R.
Cancer Res. 57:2384-2387(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: ACTION ON BREAST CARCINOMA.
[11]"Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display."
Lee J.-H., Welch D.R.
Int. J. Cancer 71:1035-1044(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."
Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.-M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., Parmentier M.
J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION.
[13]"Metastin suppresses the motility and growth of CHO cells transfected with its receptor."
Hori A., Honda S., Asada M., Ohtaki T., Oda K., Watanabe T., Shintani Y., Yamada T., Suenaga M., Kitada C., Onda H., Kurokawa T., Nishimura O., Fujino M.
Biochem. Biophys. Res. Commun. 286:958-963(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION.
[14]"KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation."
Yan C., Wang H., Boyd D.D.
J. Biol. Chem. 276:1164-1172(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN REPRESSION OF MPP9 EXPRESSION.
[15]"Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23."
Shirasaki F., Takata M., Hatta N., Takehara K.
Cancer Res. 61:7422-7425(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, DOWN-REGULATION DURING THE PROGRESSION OF MELANOMA.
[16]"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D.
J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.
[17]"Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."
Ringel M.D., Hardy E., Bernet V.J., Burch H.B., Schuppert F., Burman K.D., Saji M.
J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN THYROID CANCER.
[18]"Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome."
Sanchez-Carbayo M., Capodieci P., Cordon-Cardo C.
Am. J. Pathol. 162:609-617(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POTENTIAL TUMOR SUPPRESSION ROLE IN BLADDER CANCER.
[19]"Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans."
Horikoshi Y., Matsumoto H., Takatsu Y., Ohtaki T., Kitada C., Usuki S., Fujino M.
J. Clin. Endocrinol. Metab. 88:914-919(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION AS A PLACENTA-DERIVED HORMONE.
[20]"Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."
Takino T., Koshikawa N., Miyamori H., Tanaka M., Sasaki T., Okada Y., Seiki M., Sato H.
Oncogene 22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING BY MMP2 AND MMP9, POSSIBLE USE AS AN ANTIMETASTATIC AGENT.
[21]"Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."
Ikeguchi M., Hirooka Y., Kaibara N.
J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA.
[22]"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[23]"Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."
Ikeguchi M., Yamaguchi K., Kaibara N.
Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGAL SQUAMOUS CELL CARCINOMA.
[24]"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."
Bilban M., Ghaffari-Tabrizi N., Hintermann E., Bauer S., Molzer S., Zoratti C., Malli R., Sharabi A., Hiden U., Graier W., Knoefler M., Andreae F., Wagner O., Quaranta V., Desoye G.
J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN THROPHOBLAST MIGRATION AND INVASION.
[25]"Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma."
Dhar D.K., Naora H., Kubota H., Maruyama R., Yoshimura H., Tonomoto Y., Tachibana M., Ono T., Otani H., Nagasue N.
Int. J. Cancer 111:868-872(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE ROLE IN GASTRIC CANCER INVASION.
[26]"Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat."
Matsui H., Takatsu Y., Kumano S., Matsumoto H., Ohtaki T.
Biochem. Biophys. Res. Commun. 320:383-388(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE ROLE IN GONADOPTROPIN RELEASE.
[27]"Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis."
Thompson E.L., Patterson M., Murphy K.G., Smith K.L., Dhillo W.S., Todd J.F., Ghatei M.A., Bloom S.R.
J. Neuroendocrinol. 16:850-858(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN STIMULATION OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS.
[28]"Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."
Becker J.A.J., Mirjolet J.-F., Bernard J., Burgeon E., Simons M.-J., Vassart G., Parmentier M., Libert F.
Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES.
[29]"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."
Semple R.K., Achermann J.C., Ellery J., Farooqi I.S., Karet F.E., Stanhope R.G., O'rahilly S., Aparicio S.A.
J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LYS-20; ARG-36 AND ARG-81.
[30]"Inactivating KISS1 mutation and hypogonadotropic hypogonadism."
Topaloglu A.K., Tello J.A., Kotan L.D., Ozbek M.N., Yilmaz M.B., Erdogan S., Gurbuz F., Temiz F., Millar R.P., Yuksel B.
N. Engl. J. Med. 366:629-635(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HH13 LYS-115, CHARACTERIZATION OF VARIANT HH13 LYS-115.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Tintin's blight - Issue 58 of May 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43527 mRNA. Translation: AAC79512.1. Frameshift.
AY117143 mRNA. Translation: AAM78592.1. Frameshift.
AF218017 mRNA. Translation: AAG17259.1.
AL592114 Genomic DNA. Translation: CAH71226.1.
AK291695 mRNA. Translation: BAF84384.1.
BC022819 mRNA. Translation: AAH22819.1.
CCDSCCDS41454.1.
RefSeqNP_002247.3. NM_002256.3.
UniGeneHs.95008.

3D structure databases

ProteinModelPortalQ15726.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110014. 2 interactions.
STRING9606.ENSP00000356162.

PTM databases

PhosphoSiteQ15726.

Proteomic databases

PaxDbQ15726.
PRIDEQ15726.

Protocols and materials databases

DNASU3814.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367194; ENSP00000356162; ENSG00000170498.
GeneID3814.
KEGGhsa:3814.
UCSCuc001har.3. human.

Organism-specific databases

CTD3814.
GeneCardsGC01M204159.
GeneReviewsKISS1.
HGNCHGNC:6341. KISS1.
HPACAB017775.
HPA035542.
MIM603286. gene.
614842. phenotype.
neXtProtNX_Q15726.
Orphanet432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBPA30127.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28509.
HOGENOMHOG000013123.
HOVERGENHBG052261.
InParanoidQ15726.
OMAFLCATHF.
OrthoDBEOG79GT8B.
PhylomeDBQ15726.
TreeFamTF338233.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ15726.
CleanExHS_KISS1.
GenevestigatorQ15726.

Family and domain databases

InterProIPR020207. Metastasis-suppressor_KiSS-1.
[Graphical view]
PfamPF15152. Kisspeptin. 1 hit.
[Graphical view]
ProDomPD088121. Metastasis-suppressor_KiSS-1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

ChiTaRSKISS1. human.
GeneWikiKisspeptin.
GenomeRNAi3814.
NextBio14991.
PMAP-CutDBQ15726.
PROQ15726.
SOURCESearch...

Entry information

Entry nameKISS1_HUMAN
AccessionPrimary (citable) accession number: Q15726
Secondary accession number(s): A8K6N0, Q9HBP1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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