Q15726 (KISS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metastasis-suppressor KiSS-1

Alternative name(s):
Kisspeptin-1

Cleaved into the following 4 chains:

1. Metastin
   Alternative name(s):
   Kisspeptin-54
2. Kisspeptin-14
3. Kisspeptin-13
4. Kisspeptin-10

Gene names

Name:	KISS1
ORF Names:	PP5098

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Ref.9 Ref.11 Ref.12 Ref.14 Ref.18 Ref.19 Ref.25 Ref.26 Ref.27
Subcellular location	Secreted.
Tissue specificity	Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. Ref.9 Ref.16 Ref.24
Induction	Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting reduced NF-kappa-B binding to the promoter. Ref.15
Post-translational modification	Processed by MMP2 and MMP9.
Involvement in disease	Hypogonadotropic hypogonadism 13 with or without anosmia (HH13) [MIM:614842]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.30
Sequence similarities	Belongs to the KISS1 family.
Sequence caution	The sequence AAC79512.1 differs from that shown. Reason: Frameshift at position 138. The sequence AAM78592.1 differs from that shown. Reason: Frameshift at position 138.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Disease	Disease mutation Hypogonadotropic hypogonadism
Domain	Signal
PTM	Amidation Cleavage on pair of basic residues Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cytoskeleton organization Traceable author statement Ref.10. Source: ProtInc elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from electronic annotation. Source: Compara generation of ovulation cycle rhythm Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of growth hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of luteinizing hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: Compara neuron projection Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 138	119	Metastasis-suppressor KiSS-1		PRO_0000021544
	Peptide	68 – 121	54	Metastin		PRO_0000021545
	Peptide	108 – 121	14	Kisspeptin-14		PRO_0000021546
	Peptide	109 – 121	13	Kisspeptin-13		PRO_0000021547
	Peptide	112 – 121	10	Kisspeptin-10		PRO_0000021548
Regions
	Region	112 – 121	10	Essential for receptor binding and receptor activation
Sites
	Site	118 – 119	2	Cleavage; by MMP2 and MMP9
Amino acid modifications
	Modified residue	112	1	Phosphotyrosine Ref.22
	Modified residue	121	1	Phenylalanine amide Ref.9
Natural variations
	Natural variant	20	1	E → K. Ref.29 Corresponds to variant rs12998 [ dbSNP | Ensembl ].		VAR_021396
	Natural variant	36	1	Q → R. Ref.29 Corresponds to variant rs35431622 [ dbSNP | Ensembl ].		VAR_021397
	Natural variant	81	1	P → R. Ref.3 Ref.4 Ref.29 Corresponds to variant rs4889 [ dbSNP | Ensembl ].		VAR_021398
	Natural variant	115	1	N → K in HH13; significantly reduced efficacy as well as potency. Ref.30		VAR_069179

Sequences

	Sequence		Length	Mass (Da)
	Q15726 [UniParc]. Last modified March 23, 2010. Version 4. Checksum: 0F0A1E1D66EDC22A	FASTA	138	14,705
	10 20 30 40 50 60 MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA 70 80 90 100 110 120 TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR 130 FGKREAAPGN HGRSAGRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"KiSS-1, a novel human malignant melanoma metastasis-suppressor gene." Lee J.-H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., Welch D.R. J. Natl. Cancer Inst. 88:1731-1737(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Erratum Lee J.-H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., Welch D.R. J. Natl. Cancer Inst. 89:1549-1549(1997)
[3]	"Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)." West A., Vojta P.J., Welch D.R., Weissman B.E. Genomics 54:145-148(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-81.
[4]	"Cloned KiSS-1 gene from human term placenta." Qiao C., Lin Q.D., Xu W.X., He Y., Wang C.H. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-81. Tissue: Term placenta.
[5]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[7]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[9]	"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor." Ohtaki T., Shintani Y., Honda S., Matsumoto H., Hori A., Kanehashi K., Terao Y., Kumano S., Takatsu Y., Masuda Y., Ishibashi Y., Watanabe T., Asada M., Yamada T., Suenaga M., Kitada C., Usuki S., Kurokawa T. , Onda H., Nishimura O., Fujino M. Nature 411:613-617(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 68-88, AMIDATION AT PHE-121, FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[10]	"Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1." Lee J.-H., Welch D.R. Cancer Res. 57:2384-2387(1997) [PubMed] [Europe PMC] [Abstract] Cited for: ACTION ON BREAST CARCINOMA.
[11]	"Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display." Lee J.-H., Welch D.R. Int. J. Cancer 71:1035-1044(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[12]	"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54." Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.-M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., Parmentier M. J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE FUNCTION.
[13]	"Metastin suppresses the motility and growth of CHO cells transfected with its receptor." Hori A., Honda S., Asada M., Ohtaki T., Oda K., Watanabe T., Shintani Y., Yamada T., Suenaga M., Kitada C., Onda H., Kurokawa T., Nishimura O., Fujino M. Biochem. Biophys. Res. Commun. 286:958-963(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION.
[14]	"KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation." Yan C., Wang H., Boyd D.D. J. Biol. Chem. 276:1164-1172(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN REPRESSION OF MPP9 EXPRESSION.
[15]	"Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23." Shirasaki F., Takata M., Hatta N., Takehara K. Cancer Res. 61:7422-7425(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, DOWN-REGULATION DURING THE PROGRESSION OF MELANOMA.
[16]	"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells." Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D. J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.
[17]	"Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells." Ringel M.D., Hardy E., Bernet V.J., Burch H.B., Schuppert F., Burman K.D., Saji M. J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN THYROID CANCER.
[18]	"Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome." Sanchez-Carbayo M., Capodieci P., Cordon-Cardo C. Am. J. Pathol. 162:609-617(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POTENTIAL TUMOR SUPPRESSION ROLE IN BLADDER CANCER.
[19]	"Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans." Horikoshi Y., Matsumoto H., Takatsu Y., Ohtaki T., Kitada C., Usuki S., Fujino M. J. Clin. Endocrinol. Metab. 88:914-919(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE FUNCTION AS A PLACENTA-DERIVED HORMONE.
[20]	"Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases." Takino T., Koshikawa N., Miyamori H., Tanaka M., Sasaki T., Okada Y., Seiki M., Sato H. Oncogene 22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEOLYTIC PROCESSING BY MMP2 AND MMP9, POSSIBLE USE AS AN ANTIMETASTATIC AGENT.
[21]	"Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma." Ikeguchi M., Hirooka Y., Kaibara N. J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA.
[22]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-112, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[23]	"Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma." Ikeguchi M., Yamaguchi K., Kaibara N. Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGAL SQUAMOUS CELL CARCINOMA.
[24]	"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts." Bilban M., Ghaffari-Tabrizi N., Hintermann E., Bauer S., Molzer S., Zoratti C., Malli R., Sharabi A., Hiden U., Graier W., Knoefler M., Andreae F., Wagner O., Quaranta V., Desoye G. J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN THROPHOBLAST MIGRATION AND INVASION.
[25]	"Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma." Dhar D.K., Naora H., Kubota H., Maruyama R., Yoshimura H., Tonomoto Y., Tachibana M., Ono T., Otani H., Nagasue N. Int. J. Cancer 111:868-872(2004) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE ROLE IN GASTRIC CANCER INVASION.
[26]	"Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat." Matsui H., Takatsu Y., Kumano S., Matsumoto H., Ohtaki T. Biochem. Biophys. Res. Commun. 320:383-388(2004) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE ROLE IN GONADOPTROPIN RELEASE.
[27]	"Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis." Thompson E.L., Patterson M., Murphy K.G., Smith K.L., Dhillo W.S., Todd J.F., Ghatei M.A., Bloom S.R. J. Neuroendocrinol. 16:850-858(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN STIMULATION OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS.
[28]	"Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors." Becker J.A.J., Mirjolet J.-F., Bernard J., Burgeon E., Simons M.-J., Vassart G., Parmentier M., Libert F. Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES.
[29]	"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism." Semple R.K., Achermann J.C., Ellery J., Farooqi I.S., Karet F.E., Stanhope R.G., O'rahilly S., Aparicio S.A. J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LYS-20; ARG-36 AND ARG-81.
[30]	"Inactivating KISS1 mutation and hypogonadotropic hypogonadism." Topaloglu A.K., Tello J.A., Kotan L.D., Ozbek M.N., Yilmaz M.B., Erdogan S., Gurbuz F., Temiz F., Millar R.P., Yuksel B. N. Engl. J. Med. 366:629-635(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HH13 LYS-115, CHARACTERIZATION OF VARIANT HH13 LYS-115.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Tintin's blight - Issue 58 of May 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43527 mRNA. Translation: AAC79512.1. Frameshift. AY117143 mRNA. Translation: AAM78592.1. Frameshift. AF218017 mRNA. Translation: AAG17259.1. AL592114 Genomic DNA. Translation: CAH71226.1. AK291695 mRNA. Translation: BAF84384.1. BC022819 mRNA. Translation: AAH22819.1.
IPI	IPI00301950.
RefSeq	NP_002247.3. NM_002256.3.
UniGene	Hs.95008.
3D structure databases
ProteinModelPortal	Q15726.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000356162.
PTM databases
PhosphoSite	Q15726.
Proteomic databases
PaxDb	Q15726.
PRIDE	Q15726.
Protocols and materials databases
DNASU	3814.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367194; ENSP00000356162; ENSG00000170498.
GeneID	3814.
KEGG	hsa:3814.
UCSC	uc001har.3. human.
Organism-specific databases
CTD	3814.
GeneCards	GC01M204159.
HGNC	HGNC:6341. KISS1.
HPA	CAB017775.
MIM	603286. gene. 614842. phenotype.
neXtProt	NX_Q15726.
Orphanet	432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKB	PA30127.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG28509.
HOGENOM	HOG000013123.
HOVERGEN	HBG052261.
InParanoid	Q15726.
OMA	SRQIPAP.
OrthoDB	EOG46Q6V0.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q15726.
CleanEx	HS_KISS1.
Genevestigator	Q15726.
GermOnline	ENSG00000170498. Homo sapiens.
Family and domain databases
InterPro	IPR020207. Metastasis-suppressor_KiSS-1. [Graphical view]
ProDom	PD088121. Metastasis-suppressor_KiSS-1. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
ChiTaRS	KISS1. human.
GenomeRNAi	3814.
NextBio	14991.
PMAP-CutDB	Q15726.
SOURCE	Search...

Entry information

Entry name

KISS1_HUMAN

Accession

Primary (citable) accession number: Q15726
Secondary accession number(s): A8K6N0, Q9HBP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 107 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.