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Q15726

- KISS1_HUMAN

UniProt

Q15726 - KISS1_HUMAN

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Protein
Metastasis-suppressor KiSS-1
Gene
KISS1, PP5098
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.9 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei118 – 1192Cleavage; by MMP2 and MMP9

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cytoskeleton organization Source: ProtInc
  2. generation of ovulation cycle rhythm Source: Ensembl
  3. negative regulation of cell proliferation Source: Ensembl
  4. positive regulation of MAPK cascade Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  6. positive regulation of growth hormone secretion Source: Ensembl
  7. positive regulation of luteinizing hormone secretion Source: Ensembl
  8. positive regulation of synaptic transmission Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-suppressor KiSS-1
Alternative name(s):
Kisspeptin-1
Cleaved into the following 4 chains:
Alternative name(s):
Kisspeptin-54
Gene namesi
Name:KISS1
ORF Names:PP5098
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6341. KISS1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular region Source: Reactome
  4. extracellular space Source: Ensembl
  5. neuron projection Source: Ensembl
  6. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 13 with or without anosmia (HH13) [MIM:614842]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151N → K in HH13; significantly reduced efficacy as well as potency. 1 Publication
VAR_069179

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism

Organism-specific databases

MIMi614842. phenotype.
Orphaneti432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBiPA30127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 138119Metastasis-suppressor KiSS-1
PRO_0000021544Add
BLAST
Peptidei68 – 12154Metastin
PRO_0000021545Add
BLAST
Peptidei108 – 12114Kisspeptin-14
PRO_0000021546Add
BLAST
Peptidei109 – 12113Kisspeptin-13
PRO_0000021547Add
BLAST
Peptidei112 – 12110Kisspeptin-10
PRO_0000021548

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121Phosphotyrosine1 Publication
Modified residuei121 – 1211Phenylalanine amide1 Publication

Post-translational modificationi

Processed by MMP2 and MMP9.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiQ15726.
PRIDEiQ15726.

PTM databases

PhosphoSiteiQ15726.

Miscellaneous databases

PMAP-CutDBQ15726.

Expressioni

Tissue specificityi

Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.3 Publications

Inductioni

Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting reduced NF-kappa-B binding to the promoter.1 Publication

Gene expression databases

BgeeiQ15726.
CleanExiHS_KISS1.
GenevestigatoriQ15726.

Organism-specific databases

HPAiCAB017775.
HPA035542.

Interactioni

Protein-protein interaction databases

BioGridi110014. 2 interactions.
STRINGi9606.ENSP00000356162.

Structurei

3D structure databases

ProteinModelPortaliQ15726.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni112 – 12110Essential for receptor binding and receptor activation

Sequence similaritiesi

Belongs to the KISS1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG28509.
HOGENOMiHOG000013123.
HOVERGENiHBG052261.
InParanoidiQ15726.
OMAiFLCATHF.
OrthoDBiEOG79GT8B.
PhylomeDBiQ15726.
TreeFamiTF338233.

Family and domain databases

InterProiIPR020207. Metastasis-suppressor_KiSS-1.
[Graphical view]
PfamiPF15152. Kisspeptin. 1 hit.
[Graphical view]
ProDomiPD088121. Metastasis-suppressor_KiSS-1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15726-1 [UniParc]FASTAAdd to Basket

« Hide

MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS    50
LPCTERKPAA TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA 100
VLVQREKDLP NYNWNSFGLR FGKREAAPGN HGRSAGRG 138
Length:138
Mass (Da):14,705
Last modified:March 23, 2010 - v4
Checksum:i0F0A1E1D66EDC22A
GO

Sequence cautioni

The sequence AAC79512.1 differs from that shown. Reason: Frameshift at position 138.
The sequence AAM78592.1 differs from that shown. Reason: Frameshift at position 138.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201E → K.1 Publication
Corresponds to variant rs12998 [ dbSNP | Ensembl ].
VAR_021396
Natural varianti36 – 361Q → R.1 Publication
Corresponds to variant rs35431622 [ dbSNP | Ensembl ].
VAR_021397
Natural varianti81 – 811P → R.3 Publications
Corresponds to variant rs4889 [ dbSNP | Ensembl ].
VAR_021398
Natural varianti115 – 1151N → K in HH13; significantly reduced efficacy as well as potency. 1 Publication
VAR_069179

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43527 mRNA. Translation: AAC79512.1. Frameshift.
AY117143 mRNA. Translation: AAM78592.1. Frameshift.
AF218017 mRNA. Translation: AAG17259.1.
AL592114 Genomic DNA. Translation: CAH71226.1.
AK291695 mRNA. Translation: BAF84384.1.
BC022819 mRNA. Translation: AAH22819.1.
CCDSiCCDS41454.1.
RefSeqiNP_002247.3. NM_002256.3.
UniGeneiHs.95008.

Genome annotation databases

EnsembliENST00000367194; ENSP00000356162; ENSG00000170498.
GeneIDi3814.
KEGGihsa:3814.
UCSCiuc001har.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Tintin's blight - Issue 58 of May 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43527 mRNA. Translation: AAC79512.1 . Frameshift.
AY117143 mRNA. Translation: AAM78592.1 . Frameshift.
AF218017 mRNA. Translation: AAG17259.1 .
AL592114 Genomic DNA. Translation: CAH71226.1 .
AK291695 mRNA. Translation: BAF84384.1 .
BC022819 mRNA. Translation: AAH22819.1 .
CCDSi CCDS41454.1.
RefSeqi NP_002247.3. NM_002256.3.
UniGenei Hs.95008.

3D structure databases

ProteinModelPortali Q15726.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110014. 2 interactions.
STRINGi 9606.ENSP00000356162.

PTM databases

PhosphoSitei Q15726.

Proteomic databases

PaxDbi Q15726.
PRIDEi Q15726.

Protocols and materials databases

DNASUi 3814.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367194 ; ENSP00000356162 ; ENSG00000170498 .
GeneIDi 3814.
KEGGi hsa:3814.
UCSCi uc001har.3. human.

Organism-specific databases

CTDi 3814.
GeneCardsi GC01M204159.
GeneReviewsi KISS1.
HGNCi HGNC:6341. KISS1.
HPAi CAB017775.
HPA035542.
MIMi 603286. gene.
614842. phenotype.
neXtProti NX_Q15726.
Orphaneti 432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBi PA30127.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28509.
HOGENOMi HOG000013123.
HOVERGENi HBG052261.
InParanoidi Q15726.
OMAi FLCATHF.
OrthoDBi EOG79GT8B.
PhylomeDBi Q15726.
TreeFami TF338233.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSi KISS1. human.
GeneWikii Kisspeptin.
GenomeRNAii 3814.
NextBioi 14991.
PMAP-CutDB Q15726.
PROi Q15726.
SOURCEi Search...

Gene expression databases

Bgeei Q15726.
CleanExi HS_KISS1.
Genevestigatori Q15726.

Family and domain databases

InterProi IPR020207. Metastasis-suppressor_KiSS-1.
[Graphical view ]
Pfami PF15152. Kisspeptin. 1 hit.
[Graphical view ]
ProDomi PD088121. Metastasis-suppressor_KiSS-1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Lee J.-H., Miele M.E., Hicks D.J., Phillips K.K., Trent J.M., Weissman B.E., Welch D.R.
    J. Natl. Cancer Inst. 89:1549-1549(1997)
  3. "Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)."
    West A., Vojta P.J., Welch D.R., Weissman B.E.
    Genomics 54:145-148(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-81.
  4. "Cloned KiSS-1 gene from human term placenta."
    Qiao C., Lin Q.D., Xu W.X., He Y., Wang C.H.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-81.
    Tissue: Term placenta.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  9. Cited for: PROTEIN SEQUENCE OF 68-88, AMIDATION AT PHE-121, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  10. "Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1."
    Lee J.-H., Welch D.R.
    Cancer Res. 57:2384-2387(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTION ON BREAST CARCINOMA.
  11. "Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display."
    Lee J.-H., Welch D.R.
    Int. J. Cancer 71:1035-1044(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."
    Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.-M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., Parmentier M.
    J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  13. Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION.
  14. "KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation."
    Yan C., Wang H., Boyd D.D.
    J. Biol. Chem. 276:1164-1172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REPRESSION OF MPP9 EXPRESSION.
  15. "Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23."
    Shirasaki F., Takata M., Hatta N., Takehara K.
    Cancer Res. 61:7422-7425(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DOWN-REGULATION DURING THE PROGRESSION OF MELANOMA.
  16. "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
    Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D.
    J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.
  17. "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."
    Ringel M.D., Hardy E., Bernet V.J., Burch H.B., Schuppert F., Burman K.D., Saji M.
    J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN THYROID CANCER.
  18. "Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome."
    Sanchez-Carbayo M., Capodieci P., Cordon-Cardo C.
    Am. J. Pathol. 162:609-617(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POTENTIAL TUMOR SUPPRESSION ROLE IN BLADDER CANCER.
  19. "Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans."
    Horikoshi Y., Matsumoto H., Takatsu Y., Ohtaki T., Kitada C., Usuki S., Fujino M.
    J. Clin. Endocrinol. Metab. 88:914-919(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION AS A PLACENTA-DERIVED HORMONE.
  20. "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."
    Takino T., Koshikawa N., Miyamori H., Tanaka M., Sasaki T., Okada Y., Seiki M., Sato H.
    Oncogene 22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING BY MMP2 AND MMP9, POSSIBLE USE AS AN ANTIMETASTATIC AGENT.
  21. "Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."
    Ikeguchi M., Hirooka Y., Kaibara N.
    J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA.
  22. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  23. "Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."
    Ikeguchi M., Yamaguchi K., Kaibara N.
    Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGAL SQUAMOUS CELL CARCINOMA.
  24. "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."
    Bilban M., Ghaffari-Tabrizi N., Hintermann E., Bauer S., Molzer S., Zoratti C., Malli R., Sharabi A., Hiden U., Graier W., Knoefler M., Andreae F., Wagner O., Quaranta V., Desoye G.
    J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN THROPHOBLAST MIGRATION AND INVASION.
  25. "Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma."
    Dhar D.K., Naora H., Kubota H., Maruyama R., Yoshimura H., Tonomoto Y., Tachibana M., Ono T., Otani H., Nagasue N.
    Int. J. Cancer 111:868-872(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE ROLE IN GASTRIC CANCER INVASION.
  26. "Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat."
    Matsui H., Takatsu Y., Kumano S., Matsumoto H., Ohtaki T.
    Biochem. Biophys. Res. Commun. 320:383-388(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE ROLE IN GONADOPTROPIN RELEASE.
  27. "Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis."
    Thompson E.L., Patterson M., Murphy K.G., Smith K.L., Dhillo W.S., Todd J.F., Ghatei M.A., Bloom S.R.
    J. Neuroendocrinol. 16:850-858(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN STIMULATION OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS.
  28. "Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."
    Becker J.A.J., Mirjolet J.-F., Bernard J., Burgeon E., Simons M.-J., Vassart G., Parmentier M., Libert F.
    Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES.
  29. "Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."
    Semple R.K., Achermann J.C., Ellery J., Farooqi I.S., Karet F.E., Stanhope R.G., O'rahilly S., Aparicio S.A.
    J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-20; ARG-36 AND ARG-81.
  30. Cited for: VARIANT HH13 LYS-115, CHARACTERIZATION OF VARIANT HH13 LYS-115.

Entry informationi

Entry nameiKISS1_HUMAN
AccessioniPrimary (citable) accession number: Q15726
Secondary accession number(s): A8K6N0, Q9HBP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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