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Q15723

- ELF2_HUMAN

UniProt

Q15723 - ELF2_HUMAN

Protein

ETS-related transcription factor Elf-2

Gene

ELF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
    Isoform 2 may function in repression of RUNX1-mediated transactivation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi208 – 29083ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ15723.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS-related transcription factor Elf-2
    Alternative name(s):
    E74-like factor 2
    New ETS-related factor
    Gene namesi
    Name:ELF2Imported
    Synonyms:NERF1 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3317. ELF2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27745.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593ETS-related transcription factor Elf-2PRO_0000204087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851Phosphoserine1 Publication
    Modified residuei191 – 1911Phosphoserine1 Publication
    Modified residuei372 – 3721Phosphoserine1 Publication
    Modified residuei430 – 4301Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15723.
    PaxDbiQ15723.
    PRIDEiQ15723.

    Expressioni

    Tissue specificityi

    Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ15723.
    BgeeiQ15723.
    CleanExiHS_ELF2.
    GenevestigatoriQ15723.

    Organism-specific databases

    HPAiHPA006057.

    Interactioni

    Subunit structurei

    Interacts with the LIM domains of LMO2 By similarity. Interacts via its N-terminal region with RUNX1.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RUNX1Q011962EBI-956941,EBI-925904

    Protein-protein interaction databases

    BioGridi108313. 7 interactions.
    IntActiQ15723. 7 interactions.
    MINTiMINT-4533234.
    STRINGi9606.ENSP00000265495.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15723.
    SMRiQ15723. Positions 210-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Sequence Analysis
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG291231.
    HOGENOMiHOG000049253.
    HOVERGENiHBG007183.
    InParanoidiQ15723.
    KOiK09428.
    OMAiLTQCQLQ.
    OrthoDBiEOG73RBD1.
    PhylomeDBiQ15723.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 51 Publication (identifier: Q15723-5) [UniParc]FASTAAdd to Basket

    Also known as: NERF-2b1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSAVVDSGG TILELSSNGV ENQEESEKVS EYPAVIVEPV PSARLEQGYA    50
    AQVLVYDDET YMMQDVAEEQ EVETENVETV EASVHSSNAH CTDKTIEAAE 100
    ALLHMESPTC LRDSRSPVEV FVPPCVSTPE FIHAAMRPDV ITETVVEVST 150
    EESEPMDTSP IPTSPDSHEP MKKKKVGRKP KTQQSPISNG SPELGIKKKP 200
    REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL VDSKAVSKLW 250
    GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID 300
    DDKSETCNED LAGTTDEKSL ERVSLSAESL LKAASSVRSG KNSSPINCSR 350
    AEKGVARVVN ITSPGHDASS RSPTTTASVS ATAAPRTVRV AMQVPVVMTS 400
    LGQKISTVAV QSVNAGAPLI TSTSPTTATS PKVVIQTIPT VMPASTENGD 450
    KITMQPAKII TIPATQLAQC QLQTKSNLTG SGSINIVGTP LAVRALTPVS 500
    IAHGTPVMRL SMPTQQASGQ TPPRVISAVI KGPEVKSEAV AKKQEHDVKT 550
    LQLVEEKPAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK 593
    Length:593
    Mass (Da):63,967
    Last modified:June 21, 2005 - v2
    Checksum:iB67013B453559910
    GO
    Isoform 11 Publication (identifier: Q15723-1) [UniParc]FASTAAdd to Basket

    Also known as: NERF-21 Publication

    , NERF-2a1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         117-129: PVEVFVPPCVSTP → P

    Show »
    Length:581
    Mass (Da):62,711
    Checksum:i5D5E3169FF486A90
    GO
    Isoform 21 Publication (identifier: Q15723-2) [UniParc]FASTAAdd to Basket

    Also known as: NERF-1a1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA
         117-129: PVEVFVPPCVSTP → P

    Show »
    Length:521
    Mass (Da):56,133
    Checksum:iA54F8DAA008C164D
    GO
    Isoform 31 Publication (identifier: Q15723-3) [UniParc]FASTAAdd to Basket

    Also known as: NERF-1b1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA

    Show »
    Length:533
    Mass (Da):57,389
    Checksum:iDA45A5D12ECFD7E6
    GO
    Isoform 4Curated (identifier: Q15723-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: MTSAVVDSGG...QEVETENVET → MATSLHEGPTNQLDLLIRA
         175-203: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:504
    Mass (Da):54,261
    Checksum:i0C6A1D98E54342CE
    GO

    Sequence cautioni

    The sequence AAH65025.1 differs from that shown. Reason: Frameshift at position 541.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979MTSAV…ENVET → MATSLHEGPTNQLDLLIRA in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_014154Add
    BLAST
    Alternative sequencei117 – 12913PVEVF…CVSTP → P in isoform 1 and isoform 2. 2 PublicationsVSP_014155Add
    BLAST
    Alternative sequencei175 – 20329Missing in isoform 4. 1 PublicationVSP_014156Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43188 mRNA. Translation: AAB37759.1.
    U43189 mRNA. Translation: AAB37760.1.
    U43189 mRNA. Translation: AAB37761.1.
    AF256222 mRNA. Translation: AAF67195.1.
    AF256223 mRNA. Translation: AAF67196.1.
    AC024032 Genomic DNA. No translation available.
    AC093602 Genomic DNA. No translation available.
    BC034951 mRNA. Translation: AAH34951.1.
    BC065025 mRNA. Translation: AAH65025.1. Frameshift.
    CCDSiCCDS3744.1. [Q15723-1]
    CCDS3745.1. [Q15723-3]
    CCDS64062.1. [Q15723-2]
    CCDS64063.1. [Q15723-4]
    PIRiG02318.
    RefSeqiNP_001263386.1. NM_001276457.1.
    NP_001263387.1. NM_001276458.1. [Q15723-2]
    NP_001263388.1. NM_001276459.1.
    NP_006865.1. NM_006874.3. [Q15723-3]
    NP_973728.1. NM_201999.2. [Q15723-1]
    XP_005262860.1. XM_005262803.1. [Q15723-5]
    XP_005262861.1. XM_005262804.1. [Q15723-1]
    UniGeneiHs.634040.

    Genome annotation databases

    EnsembliENST00000358635; ENSP00000351458; ENSG00000109381. [Q15723-3]
    ENST00000379549; ENSP00000368867; ENSG00000109381. [Q15723-4]
    ENST00000379550; ENSP00000368868; ENSG00000109381. [Q15723-5]
    ENST00000394235; ENSP00000377782; ENSG00000109381. [Q15723-1]
    ENST00000510408; ENSP00000426997; ENSG00000109381. [Q15723-2]
    GeneIDi1998.
    KEGGihsa:1998.
    UCSCiuc003ihm.2. human. [Q15723-3]
    uc003ihp.1. human. [Q15723-1]

    Polymorphism databases

    DMDMi68052029.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43188 mRNA. Translation: AAB37759.1 .
    U43189 mRNA. Translation: AAB37760.1 .
    U43189 mRNA. Translation: AAB37761.1 .
    AF256222 mRNA. Translation: AAF67195.1 .
    AF256223 mRNA. Translation: AAF67196.1 .
    AC024032 Genomic DNA. No translation available.
    AC093602 Genomic DNA. No translation available.
    BC034951 mRNA. Translation: AAH34951.1 .
    BC065025 mRNA. Translation: AAH65025.1 . Frameshift.
    CCDSi CCDS3744.1. [Q15723-1 ]
    CCDS3745.1. [Q15723-3 ]
    CCDS64062.1. [Q15723-2 ]
    CCDS64063.1. [Q15723-4 ]
    PIRi G02318.
    RefSeqi NP_001263386.1. NM_001276457.1.
    NP_001263387.1. NM_001276458.1. [Q15723-2 ]
    NP_001263388.1. NM_001276459.1.
    NP_006865.1. NM_006874.3. [Q15723-3 ]
    NP_973728.1. NM_201999.2. [Q15723-1 ]
    XP_005262860.1. XM_005262803.1. [Q15723-5 ]
    XP_005262861.1. XM_005262804.1. [Q15723-1 ]
    UniGenei Hs.634040.

    3D structure databases

    ProteinModelPortali Q15723.
    SMRi Q15723. Positions 210-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108313. 7 interactions.
    IntActi Q15723. 7 interactions.
    MINTi MINT-4533234.
    STRINGi 9606.ENSP00000265495.

    Polymorphism databases

    DMDMi 68052029.

    Proteomic databases

    MaxQBi Q15723.
    PaxDbi Q15723.
    PRIDEi Q15723.

    Protocols and materials databases

    DNASUi 1998.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358635 ; ENSP00000351458 ; ENSG00000109381 . [Q15723-3 ]
    ENST00000379549 ; ENSP00000368867 ; ENSG00000109381 . [Q15723-4 ]
    ENST00000379550 ; ENSP00000368868 ; ENSG00000109381 . [Q15723-5 ]
    ENST00000394235 ; ENSP00000377782 ; ENSG00000109381 . [Q15723-1 ]
    ENST00000510408 ; ENSP00000426997 ; ENSG00000109381 . [Q15723-2 ]
    GeneIDi 1998.
    KEGGi hsa:1998.
    UCSCi uc003ihm.2. human. [Q15723-3 ]
    uc003ihp.1. human. [Q15723-1 ]

    Organism-specific databases

    CTDi 1998.
    GeneCardsi GC04M139978.
    H-InvDB HIX0164010.
    HGNCi HGNC:3317. ELF2.
    HPAi HPA006057.
    neXtProti NX_Q15723.
    PharmGKBi PA27745.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291231.
    HOGENOMi HOG000049253.
    HOVERGENi HBG007183.
    InParanoidi Q15723.
    KOi K09428.
    OMAi LTQCQLQ.
    OrthoDBi EOG73RBD1.
    PhylomeDBi Q15723.
    TreeFami TF318679.

    Enzyme and pathway databases

    SignaLinki Q15723.

    Miscellaneous databases

    GeneWikii ELF2.
    GenomeRNAii 1998.
    NextBioi 35501567.
    PROi Q15723.

    Gene expression databases

    ArrayExpressi Q15723.
    Bgeei Q15723.
    CleanExi HS_ELF2.
    Genevestigatori Q15723.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1."
      Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T.A.
      Mol. Cell. Biol. 16:5091-5106(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 5), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Fetal brain1 Publication, Fetal liver1 Publication and SpleenImported.
    2. Wilkinson D.A., Neale G.A.M., Mao S., Fernandes E.R., Davenport J.W., Naeve C.W., Goorha R.M.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Chronic myeloid leukemia cell.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: TestisImported.
    5. "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias."
      Mao S., Frank R.C., Zhang J., Miyazaki Y., Nimer S.D.
      Mol. Cell. Biol. 19:3635-3644(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RUNX1.
    6. "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene."
      Cho J.-Y., Akbarali Y., Zerbini L.F., Gu X., Boltax J., Wang Y., Oettgen P., Zhang D.-E., Libermann T.A.
      J. Biol. Chem. 279:19512-19522(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RUNX1.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185 AND SER-430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiELF2_HUMAN
    AccessioniPrimary (citable) accession number: Q15723
    Secondary accession number(s): E9PCX3
    , Q15724, Q15725, Q6P1K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3