Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leukotriene B4 receptor 1

Gene

LTB4R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: GO_Central
  • leukotriene B4 receptor activity Source: Ensembl
  • leukotriene receptor activity Source: ProtInc
  • nucleotide binding Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: Reactome
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
  • muscle contraction Source: ProtInc
  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiQ15722

Protein family/group databases

TCDBi9.A.14.13.5 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsiSLP:000001555

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Alternative name(s):
Chemoattractant receptor-like 1
G-protein coupled receptor 16
P2Y purinoceptor 7
Short name:
P2Y7
Gene namesi
Name:LTB4R
Synonyms:BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000213903.8
HGNCiHGNC:6713 LTB4R
MIMi601531 gene
neXtProtiNX_Q15722

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 42Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini43 – 54CytoplasmicSequence analysisAdd BLAST12
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 91ExtracellularSequence analysisAdd BLAST16
Transmembranei92 – 113Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini114 – 138CytoplasmicSequence analysisAdd BLAST25
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 178ExtracellularSequence analysisAdd BLAST19
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 221CytoplasmicSequence analysisAdd BLAST22
Transmembranei222 – 242Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini243 – 268ExtracellularSequence analysisAdd BLAST26
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 352CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi308T → P or A: No effect on affinity for leukotriene B4, induces resistance to desensitization by GRK6, but minor effect on phosphorylation by GRK6. 1 Publication1
Mutagenesisi310S → A: No effect on affinity for leukotriene B4 or on desensitization by GRK6. 1 Publication1

Organism-specific databases

DisGeNETi1241
OpenTargetsiENSG00000213903
PharmGKBiPA30476

Chemistry databases

ChEMBLiCHEMBL3911
GuidetoPHARMACOLOGYi267

Polymorphism and mutation databases

BioMutaiLTB4R
DMDMi3041713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697081 – 352Leukotriene B4 receptor 1Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15722
PeptideAtlasiQ15722
PRIDEiQ15722

PTM databases

iPTMnetiQ15722
PhosphoSitePlusiQ15722

Expressioni

Tissue specificityi

Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Gene expression databases

BgeeiENSG00000213903
CleanExiHS_LTB4R
ExpressionAtlasiQ15722 baseline and differential
GenevisibleiQ15722 HS

Organism-specific databases

HPAiHPA003873

Interactioni

Protein-protein interaction databases

BioGridi1076454 interactors.
IntActiQ15722 1 interactor.
STRINGi9606.ENSP00000307445

Chemistry databases

BindingDBiQ15722

Structurei

3D structure databases

ProteinModelPortaliQ15722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000008594
HOVERGENiHBG104134
InParanoidiQ15722
KOiK04296
OMAiYHVVNLA
OrthoDBiEOG091G0FBQ
PhylomeDBiQ15722
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003981 Leukotriene_B4_rcpt
IPR003983 Leukotriene_B4_typ-1_rcpt
PANTHERiPTHR24230:SF51 PTHR24230:SF51, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01477 LTB1RECEPTOR
PR01476 LTBRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q15722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR
60 70 80 90 100
SVTALMVLNL ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS
110 120 130 140 150
MYASVLLITA MSLDRSLAVA RPFVSQKLRT KAMARRVLAG IWVLSFLLAT
160 170 180 190 200
PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF HLIFEAVTGF LLPFLAVVAS
210 220 230 240 250
YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV NLAEAGRALA
260 270 280 290 300
GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE

LN
Length:352
Mass (Da):37,557
Last modified:July 15, 1998 - v2
Checksum:i5A7BFC0A659AC81C
GO

Sequence cautioni

The sequence AAB16747 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246G → R in CAA67001 (PubMed:8921391).Curated1
Sequence conflicti272A → V in AAC50628 (PubMed:8702478).Curated1
Sequence conflicti293L → V in AAC50628 (PubMed:8702478).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060679346L → F2 PublicationsCorresponds to variant dbSNP:rs17849864Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41070 mRNA Translation: AAC50628.1
U33448 Genomic DNA Translation: AAB16747.1 Different initiation.
D89079 mRNA Translation: BAA20424.1
D89078 mRNA Translation: BAA20423.1
X98356 mRNA Translation: CAA67001.1
AB008193 Genomic DNA Translation: BAB00611.1
AY322535 Genomic DNA Translation: AAP84348.1
BT007267 mRNA Translation: AAP35931.1
BC004545 mRNA Translation: AAH04545.1
CCDSiCCDS9626.1
RefSeqiNP_001137391.1, NM_001143919.2
NP_858043.1, NM_181657.3
UniGeneiHs.567248

Genome annotation databases

EnsembliENST00000345363; ENSP00000307445; ENSG00000213903
ENST00000396782; ENSP00000380002; ENSG00000213903
ENST00000396789; ENSP00000380008; ENSG00000213903
GeneIDi1241
KEGGihsa:1241
UCSCiuc001wos.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLT4R1_HUMAN
AccessioniPrimary (citable) accession number: Q15722
Secondary accession number(s): Q13305
, Q53XV5, Q92641, Q9BSU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome