Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q15722

- LT4R1_HUMAN

UniProt

Q15722 - LT4R1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leukotriene B4 receptor 1

Gene

LTB4R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

GO - Molecular functioni

  1. leukotriene B4 receptor activity Source: Ensembl
  2. leukotriene receptor activity Source: ProtInc
  3. nucleotide binding Source: ProtInc

GO - Biological processi

  1. cellular component movement Source: ProtInc
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. immune response Source: ProtInc
  4. inflammatory response Source: ProtInc
  5. muscle contraction Source: ProtInc
  6. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Protein family/group databases

TCDBi9.A.14.13.5. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Alternative name(s):
Chemoattractant receptor-like 1
G-protein coupled receptor 16
P2Y purinoceptor 7
Short name:
P2Y7
Gene namesi
Name:LTB4R
Synonyms:BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:6713. LTB4R.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi308 – 3081T → P or A: No effect on affinity for leukotriene B4, induces resistance to desensitization by GRK6, but minor effect on phosphorylation by GRK6. 1 Publication
Mutagenesisi310 – 3101S → A: No effect on affinity for leukotriene B4 or on desensitization by GRK6. 1 Publication

Organism-specific databases

PharmGKBiPA30476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Leukotriene B4 receptor 1PRO_0000069708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15722.
PRIDEiQ15722.

PTM databases

PhosphoSiteiQ15722.

Expressioni

Tissue specificityi

Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Gene expression databases

BgeeiQ15722.
CleanExiHS_LTB4R.
ExpressionAtlasiQ15722. baseline and differential.
GenevestigatoriQ15722.

Organism-specific databases

HPAiHPA003873.

Interactioni

Protein-protein interaction databases

BioGridi107645. 3 interactions.
IntActiQ15722. 1 interaction.
STRINGi9606.ENSP00000307445.

Structurei

3D structure databases

ProteinModelPortaliQ15722.
SMRiQ15722. Positions 20-286.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
BLAST
Topological domaini43 – 5412CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini76 – 9116ExtracellularSequence AnalysisAdd
BLAST
Topological domaini114 – 13825CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini160 – 17819ExtracellularSequence AnalysisAdd
BLAST
Topological domaini200 – 22122CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini243 – 26826ExtracellularSequence AnalysisAdd
BLAST
Topological domaini290 – 35263CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei92 – 11322Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei222 – 24221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329990.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ15722.
KOiK04296.
OMAiGCRLCHY.
PhylomeDBiQ15722.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15722-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR
60 70 80 90 100
SVTALMVLNL ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS
110 120 130 140 150
MYASVLLITA MSLDRSLAVA RPFVSQKLRT KAMARRVLAG IWVLSFLLAT
160 170 180 190 200
PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF HLIFEAVTGF LLPFLAVVAS
210 220 230 240 250
YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV NLAEAGRALA
260 270 280 290 300
GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE

LN
Length:352
Mass (Da):37,557
Last modified:July 15, 1998 - v2
Checksum:i5A7BFC0A659AC81C
GO

Sequence cautioni

The sequence AAB16747.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461G → R in CAA67001. (PubMed:8921391)Curated
Sequence conflicti272 – 2721A → V in AAC50628. (PubMed:8702478)Curated
Sequence conflicti293 – 2931L → V in AAC50628. (PubMed:8702478)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti346 – 3461L → F.2 Publications
Corresponds to variant rs17849864 [ dbSNP | Ensembl ].
VAR_060679

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41070 mRNA. Translation: AAC50628.1.
U33448 Genomic DNA. Translation: AAB16747.1. Different initiation.
D89079 mRNA. Translation: BAA20424.1.
D89078 mRNA. Translation: BAA20423.1.
X98356 mRNA. Translation: CAA67001.1.
AB008193 Genomic DNA. Translation: BAB00611.1.
AY322535 Genomic DNA. Translation: AAP84348.1.
BT007267 mRNA. Translation: AAP35931.1.
BC004545 mRNA. Translation: AAH04545.1.
CCDSiCCDS9626.1.
RefSeqiNP_001137391.1. NM_001143919.2.
NP_858043.1. NM_181657.3.
UniGeneiHs.567248.

Genome annotation databases

EnsembliENST00000345363; ENSP00000307445; ENSG00000213903.
ENST00000396782; ENSP00000380002; ENSG00000213903.
ENST00000396789; ENSP00000380008; ENSG00000213903.
GeneIDi1241.
KEGGihsa:1241.
UCSCiuc001wos.3. human.

Polymorphism databases

DMDMi3041713.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41070 mRNA. Translation: AAC50628.1 .
U33448 Genomic DNA. Translation: AAB16747.1 . Different initiation.
D89079 mRNA. Translation: BAA20424.1 .
D89078 mRNA. Translation: BAA20423.1 .
X98356 mRNA. Translation: CAA67001.1 .
AB008193 Genomic DNA. Translation: BAB00611.1 .
AY322535 Genomic DNA. Translation: AAP84348.1 .
BT007267 mRNA. Translation: AAP35931.1 .
BC004545 mRNA. Translation: AAH04545.1 .
CCDSi CCDS9626.1.
RefSeqi NP_001137391.1. NM_001143919.2.
NP_858043.1. NM_181657.3.
UniGenei Hs.567248.

3D structure databases

ProteinModelPortali Q15722.
SMRi Q15722. Positions 20-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107645. 3 interactions.
IntActi Q15722. 1 interaction.
STRINGi 9606.ENSP00000307445.

Chemistry

BindingDBi Q15722.
ChEMBLi CHEMBL2095160.
GuidetoPHARMACOLOGYi 267.

Protein family/group databases

TCDBi 9.A.14.13.5. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q15722.

Polymorphism databases

DMDMi 3041713.

Proteomic databases

PaxDbi Q15722.
PRIDEi Q15722.

Protocols and materials databases

DNASUi 1241.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345363 ; ENSP00000307445 ; ENSG00000213903 .
ENST00000396782 ; ENSP00000380002 ; ENSG00000213903 .
ENST00000396789 ; ENSP00000380008 ; ENSG00000213903 .
GeneIDi 1241.
KEGGi hsa:1241.
UCSCi uc001wos.3. human.

Organism-specific databases

CTDi 1241.
GeneCardsi GC14P024780.
H-InvDB HIX0172389.
HGNCi HGNC:6713. LTB4R.
HPAi HPA003873.
MIMi 601531. gene.
neXtProti NX_Q15722.
PharmGKBi PA30476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329990.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000008594.
HOVERGENi HBG104134.
InParanoidi Q15722.
KOi K04296.
OMAi GCRLCHY.
PhylomeDBi Q15722.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Miscellaneous databases

ChiTaRSi LTB4R. human.
GeneWikii Leukotriene_B4_receptor.
GenomeRNAii 1241.
NextBioi 5065.
PROi Q15722.
SOURCEi Search...

Gene expression databases

Bgeei Q15722.
CleanExi HS_LTB4R.
ExpressionAtlasi Q15722. baseline and differential.
Genevestigatori Q15722.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "New members of the chemokine receptor gene family."
    Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B., Godiska R., Gray P.W.
    J. Leukoc. Biol. 59:18-23(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis."
    Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T.
    Nature 387:620-624(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of cDNA encoding a putative chemoattractant receptor."
    Owman C.S.O., Nilsson C., Lolait S.J.
    Genomics 37:187-194(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene."
    Kato K., Yokomizo T., Izumi T., Shimizu T.
    J. Exp. Med. 192:413-420(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Isolation of complete coding sequence for leukotriene B4 receptor (LTB4R)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-346.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-346.
    Tissue: Lung.
  9. "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization."
    Gaudreau R., Le Gouill C., Venne M.-H., Stankova J., Rola-Pleszczynski M.
    J. Biol. Chem. 277:31567-31576(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, MUTAGENESIS OF THR-308 AND SER-310.

Entry informationi

Entry nameiLT4R1_HUMAN
AccessioniPrimary (citable) accession number: Q15722
Secondary accession number(s): Q13305
, Q53XV5, Q92641, Q9BSU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3