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Q15722

- LT4R1_HUMAN

UniProt

Q15722 - LT4R1_HUMAN

Protein

Leukotriene B4 receptor 1

Gene

LTB4R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

    GO - Molecular functioni

    1. leukotriene B4 receptor activity Source: Ensembl
    2. leukotriene receptor activity Source: ProtInc
    3. nucleotide binding Source: ProtInc

    GO - Biological processi

    1. cellular component movement Source: ProtInc
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. immune response Source: ProtInc
    4. inflammatory response Source: ProtInc
    5. muscle contraction Source: ProtInc
    6. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18302. Leukotriene receptors.

    Protein family/group databases

    TCDBi9.A.14.13.5. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukotriene B4 receptor 1
    Short name:
    LTB4-R 1
    Short name:
    LTB4-R1
    Alternative name(s):
    Chemoattractant receptor-like 1
    G-protein coupled receptor 16
    P2Y purinoceptor 7
    Short name:
    P2Y7
    Gene namesi
    Name:LTB4R
    Synonyms:BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6713. LTB4R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi308 – 3081T → P or A: No effect on affinity for leukotriene B4, induces resistance to desensitization by GRK6, but minor effect on phosphorylation by GRK6. 1 Publication
    Mutagenesisi310 – 3101S → A: No effect on affinity for leukotriene B4 or on desensitization by GRK6. 1 Publication

    Organism-specific databases

    PharmGKBiPA30476.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Leukotriene B4 receptor 1PRO_0000069708Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ15722.
    PRIDEiQ15722.

    PTM databases

    PhosphoSiteiQ15722.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

    Gene expression databases

    ArrayExpressiQ15722.
    BgeeiQ15722.
    CleanExiHS_LTB4R.
    GenevestigatoriQ15722.

    Organism-specific databases

    HPAiHPA003873.

    Interactioni

    Protein-protein interaction databases

    BioGridi107645. 3 interactions.
    IntActiQ15722. 1 interaction.
    STRINGi9606.ENSP00000307445.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15722.
    SMRiQ15722. Positions 20-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 5412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini76 – 9116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini114 – 13825CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 17819ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 22122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini243 – 26826ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 35263CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4223Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG329990.
    HOGENOMiHOG000008594.
    HOVERGENiHBG104134.
    InParanoidiQ15722.
    KOiK04296.
    OMAiGCRLCHY.
    PhylomeDBiQ15722.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003981. Leukotriene_B4_rcpt.
    IPR003983. Leukotriene_B4_typ-1_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01477. LTB1RECEPTOR.
    PR01476. LTBRECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15722-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR    50
    SVTALMVLNL ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS 100
    MYASVLLITA MSLDRSLAVA RPFVSQKLRT KAMARRVLAG IWVLSFLLAT 150
    PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF HLIFEAVTGF LLPFLAVVAS 200
    YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV NLAEAGRALA 250
    GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 300
    VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE 350
    LN 352
    Length:352
    Mass (Da):37,557
    Last modified:July 15, 1998 - v2
    Checksum:i5A7BFC0A659AC81C
    GO

    Sequence cautioni

    The sequence AAB16747.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461G → R in CAA67001. (PubMed:8921391)Curated
    Sequence conflicti272 – 2721A → V in AAC50628. (PubMed:8702478)Curated
    Sequence conflicti293 – 2931L → V in AAC50628. (PubMed:8702478)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti346 – 3461L → F.2 Publications
    Corresponds to variant rs17849864 [ dbSNP | Ensembl ].
    VAR_060679

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41070 mRNA. Translation: AAC50628.1.
    U33448 Genomic DNA. Translation: AAB16747.1. Different initiation.
    D89079 mRNA. Translation: BAA20424.1.
    D89078 mRNA. Translation: BAA20423.1.
    X98356 mRNA. Translation: CAA67001.1.
    AB008193 Genomic DNA. Translation: BAB00611.1.
    AY322535 Genomic DNA. Translation: AAP84348.1.
    BT007267 mRNA. Translation: AAP35931.1.
    BC004545 mRNA. Translation: AAH04545.1.
    CCDSiCCDS9626.1.
    RefSeqiNP_001137391.1. NM_001143919.2.
    NP_858043.1. NM_181657.3.
    UniGeneiHs.567248.

    Genome annotation databases

    EnsembliENST00000345363; ENSP00000307445; ENSG00000213903.
    ENST00000396782; ENSP00000380002; ENSG00000213903.
    ENST00000396789; ENSP00000380008; ENSG00000213903.
    GeneIDi1241.
    KEGGihsa:1241.
    UCSCiuc001wos.3. human.

    Polymorphism databases

    DMDMi3041713.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41070 mRNA. Translation: AAC50628.1 .
    U33448 Genomic DNA. Translation: AAB16747.1 . Different initiation.
    D89079 mRNA. Translation: BAA20424.1 .
    D89078 mRNA. Translation: BAA20423.1 .
    X98356 mRNA. Translation: CAA67001.1 .
    AB008193 Genomic DNA. Translation: BAB00611.1 .
    AY322535 Genomic DNA. Translation: AAP84348.1 .
    BT007267 mRNA. Translation: AAP35931.1 .
    BC004545 mRNA. Translation: AAH04545.1 .
    CCDSi CCDS9626.1.
    RefSeqi NP_001137391.1. NM_001143919.2.
    NP_858043.1. NM_181657.3.
    UniGenei Hs.567248.

    3D structure databases

    ProteinModelPortali Q15722.
    SMRi Q15722. Positions 20-286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107645. 3 interactions.
    IntActi Q15722. 1 interaction.
    STRINGi 9606.ENSP00000307445.

    Chemistry

    BindingDBi Q15722.
    ChEMBLi CHEMBL2095160.
    GuidetoPHARMACOLOGYi 267.

    Protein family/group databases

    TCDBi 9.A.14.13.5. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q15722.

    Polymorphism databases

    DMDMi 3041713.

    Proteomic databases

    PaxDbi Q15722.
    PRIDEi Q15722.

    Protocols and materials databases

    DNASUi 1241.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345363 ; ENSP00000307445 ; ENSG00000213903 .
    ENST00000396782 ; ENSP00000380002 ; ENSG00000213903 .
    ENST00000396789 ; ENSP00000380008 ; ENSG00000213903 .
    GeneIDi 1241.
    KEGGi hsa:1241.
    UCSCi uc001wos.3. human.

    Organism-specific databases

    CTDi 1241.
    GeneCardsi GC14P024780.
    H-InvDB HIX0172389.
    HGNCi HGNC:6713. LTB4R.
    HPAi HPA003873.
    MIMi 601531. gene.
    neXtProti NX_Q15722.
    PharmGKBi PA30476.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329990.
    HOGENOMi HOG000008594.
    HOVERGENi HBG104134.
    InParanoidi Q15722.
    KOi K04296.
    OMAi GCRLCHY.
    PhylomeDBi Q15722.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18302. Leukotriene receptors.

    Miscellaneous databases

    ChiTaRSi LTB4R. human.
    GeneWikii Leukotriene_B4_receptor.
    GenomeRNAii 1241.
    NextBioi 5065.
    PROi Q15722.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15722.
    Bgeei Q15722.
    CleanExi HS_LTB4R.
    Genevestigatori Q15722.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003981. Leukotriene_B4_rcpt.
    IPR003983. Leukotriene_B4_typ-1_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01477. LTB1RECEPTOR.
    PR01476. LTBRECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "New members of the chemokine receptor gene family."
      Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B., Godiska R., Gray P.W.
      J. Leukoc. Biol. 59:18-23(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis."
      Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T.
      Nature 387:620-624(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of cDNA encoding a putative chemoattractant receptor."
      Owman C.S.O., Nilsson C., Lolait S.J.
      Genomics 37:187-194(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene."
      Kato K., Yokomizo T., Izumi T., Shimizu T.
      J. Exp. Med. 192:413-420(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Isolation of complete coding sequence for leukotriene B4 receptor (LTB4R)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-346.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-346.
      Tissue: Lung.
    9. "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization."
      Gaudreau R., Le Gouill C., Venne M.-H., Stankova J., Rola-Pleszczynski M.
      J. Biol. Chem. 277:31567-31576(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, MUTAGENESIS OF THR-308 AND SER-310.

    Entry informationi

    Entry nameiLT4R1_HUMAN
    AccessioniPrimary (citable) accession number: Q15722
    Secondary accession number(s): Q13305
    , Q53XV5, Q92641, Q9BSU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3