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Reviewed, UniProtKB/Swiss-Prot Q15722 (LT4R1_HUMAN)

Last modified November 25, 2008. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Leukotriene B4 receptor 1
      Short name=LTB4-R 1
Alternative name(s):
    P2Y purinoceptor 7
      Short name=P2Y7
    Chemoattractant receptor-like 1
    G-protein coupled receptor 16
Gene names
Name: LTB4R
Synonyms: BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Post-translational modification

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Leukotriene B4 receptor 1
PRO_0000069708

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 42231 Potential
Topological domain43 – 5412Cytoplasmic Potential
Transmembrane55 – 75212 Potential
Topological domain76 – 9116Extracellular Potential
Transmembrane92 – 113223 Potential
Topological domain114 – 13825Cytoplasmic Potential
Transmembrane139 – 159214 Potential
Topological domain160 – 17819Extracellular Potential
Transmembrane179 – 199215 Potential
Topological domain200 – 22122Cytoplasmic Potential
Transmembrane222 – 242216 Potential
Topological domain243 – 26826Extracellular Potential
Transmembrane269 – 289217 Potential
Topological domain290 – 35263Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis3081T → P or A: No effect on affinity for leukotriene B4, induces resistance to desensitization by GRK6, but minor effect on phosphorylation by GRK6
Mutagenesis3101S → A: No effect on affinity for leukotriene B4 or on desensitization by GRK6
Sequence conflict2461G → R in CAA67001. Ref.4
Sequence conflict2721A → V in AAC50628. Ref.1
Sequence conflict2931L → V in AAC50628. Ref.1
Sequence conflict3461L → F in AAH04545. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q15722-1 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 5A7BFC0A659AC81C

FASTA35237,557
        10         20         30         40         50         60 
MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR SVTALMVLNL 

        70         80         90        100        110        120 
ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS MYASVLLITA MSLDRSLAVA 

       130        140        150        160        170        180 
RPFVSQKLRT KAMARRVLAG IWVLSFLLAT PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF 

       190        200        210        220        230        240 
HLIFEAVTGF LLPFLAVVAS YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV 

       250        260        270        280        290        300 
NLAEAGRALA GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 

       310        320        330        340        350 
VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE LN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells."
Akbar G.K.M., Dasari V.R., Webb T., Ayyanathan K., Pillarisetti K., Sandhu A.K., Athwal R.S., Daniel J.L., Ashby B., Barnard E.A., Kunapuli S.P.
J. Biol. Chem. 271:18363-18367(1996) [PubMed: 8702478] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"New members of the chemokine receptor gene family."
Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B., Godiska R., Gray P.W.
J. Leukoc. Biol. 59:18-23(1996) [PubMed: 8558062] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis."
Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T.
Nature 387:620-624(1997) [PubMed: 9177352] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of cDNA encoding a putative chemoattractant receptor."
Owman C.S.O., Nilsson C., Lolait S.J.
Genomics 37:187-194(1996) [PubMed: 8921391] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene."
Kato K., Yokomizo T., Izumi T., Shimizu T.
J. Exp. Med. 192:413-420(2000) [PubMed: 10934229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Isolation of complete coding sequence for leukotriene B4 receptor (LTB4R)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[8]"Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization."
Gaudreau R., Le Gouill C., Venne M.-H., Stankova J., Rola-Pleszczynski M.
J. Biol. Chem. 277:31567-31576(2002) [PubMed: 12077128] [Abstract]
Cited for: PHOSPHORYLATION, MUTAGENESIS OF THR-308 AND SER-310.
+Additional computationally mapped references.

Cross-references

Sequence databases

U41070 mRNA. Translation: AAC50628.1.
U33448 Genomic DNA. Translation: AAB16747.1. Different initiation.
D89079 mRNA. Translation: BAA20424.1.
D89078 mRNA. Translation: BAA20423.1.
X98356 mRNA. Translation: CAA67001.1.
AB008193 Genomic DNA. Translation: BAB00611.1.
AY322535 Genomic DNA. Translation: AAP84348.1.
BC004545 mRNA. Translation: AAH04545.1.
RefSeqNP_858043.1.
UniGeneHs.655431

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ15722.

Genome annotation databases

EnsemblENSG00000213903. Homo sapiens. [Contig view]
GeneID1241.
KEGGhsa:1241.

Organism-specific databases

H-InvDBHIX0011567.
HGNCHGNC:6713. LTB4R.
HPAHPA003873.
MIM601531. gene.
PharmGKBPA30476.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENQ15722.

Gene expression databases

ArrayExpressQ15722.
CleanExHS_LTB4R.
GermOnlineENSG00000196943. Homo sapiens.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR003981. LTB4_rcpt.
IPR003983. LTB4_t1_rcpt.
[Graphical view]
PANTHERPTHR19264:SF245. LTB4_t1_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio5065.
SOURCESearch...

Entry information

Entry nameLT4R1_HUMAN
AccessionPrimary (citable) accession number: Q15722
Secondary accession number(s): Q13305, Q92641, Q9BSU5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 25, 2008
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents