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Q15722 (LT4R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukotriene B4 receptor 1

Short name=LTB4-R 1
Short name=LTB4-R1
Alternative name(s):
Chemoattractant receptor-like 1
G-protein coupled receptor 16
P2Y purinoceptor 7
Short name=P2Y7
Gene names
Name:LTB4R
Synonyms:BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Post-translational modification

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization. Ref.9

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAB16747.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Leukotriene B4 receptor 1
PRO_0000069708

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 4223Helical; Name=1; Potential
Topological domain43 – 5412Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9116Extracellular Potential
Transmembrane92 – 11322Helical; Name=3; Potential
Topological domain114 – 13825Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 17819Extracellular Potential
Transmembrane179 – 19921Helical; Name=5; Potential
Topological domain200 – 22122Cytoplasmic Potential
Transmembrane222 – 24221Helical; Name=6; Potential
Topological domain243 – 26826Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 35263Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential

Natural variations

Natural variant3461L → F. Ref.7 Ref.8
Corresponds to variant rs17849864 [ dbSNP | Ensembl ].
VAR_060679

Experimental info

Mutagenesis3081T → P or A: No effect on affinity for leukotriene B4, induces resistance to desensitization by GRK6, but minor effect on phosphorylation by GRK6. Ref.9
Mutagenesis3101S → A: No effect on affinity for leukotriene B4 or on desensitization by GRK6. Ref.9
Sequence conflict2461G → R in CAA67001. Ref.4
Sequence conflict2721A → V in AAC50628. Ref.1
Sequence conflict2931L → V in AAC50628. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q15722 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 5A7BFC0A659AC81C

FASTA35237,557
        10         20         30         40         50         60 
MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR SVTALMVLNL 

        70         80         90        100        110        120 
ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS MYASVLLITA MSLDRSLAVA 

       130        140        150        160        170        180 
RPFVSQKLRT KAMARRVLAG IWVLSFLLAT PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF 

       190        200        210        220        230        240 
HLIFEAVTGF LLPFLAVVAS YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV 

       250        260        270        280        290        300 
NLAEAGRALA GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 

       310        320        330        340        350 
VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE LN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells."
Akbar G.K.M., Dasari V.R., Webb T., Ayyanathan K., Pillarisetti K., Sandhu A.K., Athwal R.S., Daniel J.L., Ashby B., Barnard E.A., Kunapuli S.P.
J. Biol. Chem. 271:18363-18367(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"New members of the chemokine receptor gene family."
Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B., Godiska R., Gray P.W.
J. Leukoc. Biol. 59:18-23(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis."
Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T.
Nature 387:620-624(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of cDNA encoding a putative chemoattractant receptor."
Owman C.S.O., Nilsson C., Lolait S.J.
Genomics 37:187-194(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene."
Kato K., Yokomizo T., Izumi T., Shimizu T.
J. Exp. Med. 192:413-420(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Isolation of complete coding sequence for leukotriene B4 receptor (LTB4R)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-346.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-346.
Tissue: Lung.
[9]"Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization."
Gaudreau R., Le Gouill C., Venne M.-H., Stankova J., Rola-Pleszczynski M.
J. Biol. Chem. 277:31567-31576(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, MUTAGENESIS OF THR-308 AND SER-310.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41070 mRNA. Translation: AAC50628.1.
U33448 Genomic DNA. Translation: AAB16747.1. Different initiation.
D89079 mRNA. Translation: BAA20424.1.
D89078 mRNA. Translation: BAA20423.1.
X98356 mRNA. Translation: CAA67001.1.
AB008193 Genomic DNA. Translation: BAB00611.1.
AY322535 Genomic DNA. Translation: AAP84348.1.
BT007267 mRNA. Translation: AAP35931.1.
BC004545 mRNA. Translation: AAH04545.1.
RefSeqNP_001137391.1. NM_001143919.2.
NP_858043.1. NM_181657.3.
UniGeneHs.567248.

3D structure databases

ProteinModelPortalQ15722.
SMRQ15722. Positions 20-286.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107645. 3 interactions.
IntActQ15722. 1 interaction.
STRING9606.ENSP00000307445.

Chemistry

BindingDBQ15722.
ChEMBLCHEMBL2095160.
GuidetoPHARMACOLOGY267.

Protein family/group databases

TCDB9.A.14.13.5. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteQ15722.

Polymorphism databases

DMDM3041713.

Proteomic databases

PaxDbQ15722.
PRIDEQ15722.

Protocols and materials databases

DNASU1241.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000345363; ENSP00000307445; ENSG00000213903.
ENST00000396782; ENSP00000380002; ENSG00000213903.
ENST00000396789; ENSP00000380008; ENSG00000213903.
GeneID1241.
KEGGhsa:1241.
UCSCuc001wos.3. human.

Organism-specific databases

CTD1241.
GeneCardsGC14P024780.
H-InvDBHIX0172389.
HGNCHGNC:6713. LTB4R.
HPAHPA003873.
MIM601531. gene.
neXtProtNX_Q15722.
PharmGKBPA30476.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329990.
HOGENOMHOG000008594.
HOVERGENHBG104134.
InParanoidQ15722.
KOK04296.
OMAGCRLCHY.
PhylomeDBQ15722.
TreeFamTF330976.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ15722.
BgeeQ15722.
CleanExHS_LTB4R.
GenevestigatorQ15722.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLTB4R. human.
GeneWikiLeukotriene_B4_receptor.
GenomeRNAi1241.
NextBio5065.
PROQ15722.
SOURCESearch...

Entry information

Entry nameLT4R1_HUMAN
AccessionPrimary (citable) accession number: Q15722
Secondary accession number(s): Q13305 expand/collapse secondary AC list , Q53XV5, Q92641, Q9BSU5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries