Reviewed,
UniProtKB/Swiss-Prot Q15717 (ELAV1_HUMAN)
Last modified
June 16, 2009.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ELAV-like protein 1 Alternative name(s): Hu-antigen R Short name=HuR | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 326 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. |
| Subunit structure | Interacts with ANP32A. Ref.3 |
| Tissue specificity | Ubiquitous. |
| Post-translational modification | Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge. Ref.4 |
| Sequence similarities | Belongs to the RRM elav family. Contains 3 RRM (RNA recognition motif) domains. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat |
| Ligand | RNA-binding |
| PTM | Methylation Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | multicellular organismal development Traceable author statement. Source: ProtInc |
| Molecular function | identical protein binding Inferred from physical interaction. Source: IntAct mRNA bindingTraceable author statement. Source: ProtInc nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 326 | 326 | ELAV-like protein 1 | PRO_0000081577 | |||||
Regions | |||||||||
| Domain | 20 – 98 | 79 | RRM 1 | ||||||
| Domain | 106 – 186 | 81 | RRM 2 | ||||||
| Domain | 244 – 322 | 79 | RRM 3 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 202 | 1 | Phosphoserine Ref.5 Ref.6 Ref.7 Ref.8 | ||||||
| Modified residue | 217 | 1 | Omega-N-methylated arginine; by CARM1 Ref.4 | ||||||
Experimental info | |||||||||
| Sequence conflict | 180 | 1 | T → A in AAB41913. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein." Ma W.-J., Cheng S., Campbell C., Wright A., Furneaux H.M. J. Biol. Chem. 271:8144-8151(1996) [PubMed: 8626503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix. |
| [3] | "Delineation of mRNA export pathways by the use of cell-permeable peptides." Gallouzi I.-E., Steitz J.A. Science 294:1895-1901(2001) [PubMed: 11729309] [Abstract] Cited for: INTERACTION WITH ANP32A. |
| [4] | "Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase." Li H., Park S., Kilburn B., Jelinek M.A., Henschen-Edman A., Aswad D.W., Stallcup M.R., Laird-Offringa I.A. J. Biol. Chem. 277:44623-44630(2002) [PubMed: 12237300] [Abstract] Cited for: METHYLATION AT ARG-217. |
| [5] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, MASS SPECTROMETRY. Tissue: Epithelium. |
| [6] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U38175 mRNA. Translation: AAB41913.1. BC003376 mRNA. Translation: AAH03376.1. | |
| IPI | IPI00301936. |
| RefSeq | NP_001410.2. |
| UniGene | Hs.184492 Hs.713744 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FXL based on UniProtKB P26378. |
| SMR | Q15717. Positions 19-184. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15717. 3 interactions. |
PTM databases | |
| PhosphoSite | Q15717. |
Proteomic databases | |
| PeptideAtlas | Q15717. |
| PRIDE | Q15717. |
Genome annotation databases | |
| Ensembl | ENSG00000066044. Homo sapiens. [Contig view] |
| GeneID | 1994. |
| KEGG | hsa:1994. |
Organism-specific databases | |
| GeneCards | GC19M007929. |
| H-InvDB | HIX0017616. |
| HGNC | HGNC:3312. ELAVL1. |
| HPA | CAB005256. |
| MIM | 603466. gene. |
| PharmGKB | PA27740. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q15717. |
| HOVERGEN | Q15717. |
| OMA | Q15717. SFNGLRL. |
Gene expression databases | |
| ArrayExpress | Q15717. |
| Bgee | Q15717. |
| CleanEx | HS_ELAVL1. |
| GermOnline | ENSG00000066044. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012677. a_b_plait_nuc_bd. IPR006548. ELAD_HUD_SF. IPR002343. Hud_Sxl_RNA. IPR000504. RRM_RNP1. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 3 hits. |
| Pfam | PF00076. RRM_1. 3 hits. [Graphical view] |
| PRINTS | PR00961. HUDSXLRNA. |
| SMART | SM00360. RRM. 3 hits. [Graphical view] |
| TIGRFAMs | TIGR01661. ELAV_HUD_SF. 1 hit. |
| PROSITE | PS50102. RRM. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 8063. |
| SOURCE | Search... |
Entry information
| Entry name | ELAV1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15717 Secondary accession number(s): Q9BTT1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


