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Q15714

- T22D1_HUMAN

UniProt

Q15714 - T22D1_HUMAN

Protein

TSC22 domain family protein 1

Gene

TSC22D1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (31 May 2011)
      Previous versions | rss
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    Functioni

    Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of apoptotic process Source: Ensembl
    2. positive regulation of apoptotic process Source: Ensembl
    3. positive regulation of cell proliferation Source: Ensembl
    4. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TSC22 domain family protein 1
    Alternative name(s):
    Cerebral protein 2
    Regulatory protein TSC-22
    TGFB-stimulated clone 22 homolog
    Transforming growth factor beta-1-induced transcript 4 protein
    Gene namesi
    Name:TSC22D1
    Synonyms:KIAA1994, TGFB1I4, TSC22
    ORF Names:hucep-2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:16826. TSC22D1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134887618.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10731073TSC22 domain family protein 1PRO_0000219365Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei263 – 2631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15714.
    PaxDbiQ15714.
    PRIDEiQ15714.

    PTM databases

    PhosphoSiteiQ15714.

    Expressioni

    Tissue specificityi

    Widely expressed in fetal and adult tissues.

    Inductioni

    In aortic endothelial cells, induced by cytokines, including TGFB1.

    Gene expression databases

    ArrayExpressiQ15714.
    BgeeiQ15714.
    CleanExiHS_TSC22D1.
    GenevestigatoriQ15714.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer. Can form a heterodimer with TSC22D4.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TPT1P136935EBI-712609,EBI-1783169

    Protein-protein interaction databases

    BioGridi114374. 85 interactions.
    IntActiQ15714. 47 interactions.
    MINTiMINT-1367987.
    STRINGi9606.ENSP00000397435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15714.
    SMRiQ15714. Positions 988-1043.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1006 – 102722Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 8224Pro-richAdd
    BLAST
    Compositional biasi195 – 24147His-richAdd
    BLAST
    Compositional biasi497 – 817321Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TSC-22/Dip/Bun family.Curated

    Phylogenomic databases

    eggNOGiNOG261231.
    HOVERGENiHBG108540.
    InParanoidiQ15714.
    OMAiARKMAHP.
    OrthoDBiEOG7RZ5PT.
    PhylomeDBiQ15714.
    TreeFamiTF318837.

    Family and domain databases

    InterProiIPR000580. TSC-22_Dip_Bun.
    [Graphical view]
    PANTHERiPTHR12348. PTHR12348. 1 hit.
    PfamiPF01166. TSC22. 1 hit.
    [Graphical view]
    ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS01289. TSC22. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15714-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGSGSASA LNAAGTGVGS     50
    NATSSEDFPP PSLLQPPPPA ASSTSGPQPP PPQSLNLLSQ AQLQAQPLAP 100
    GGTQMKKKSG FQITSVTPAQ ISASISSNNS IAEDTESYDD LDESHTEDLS 150
    SSEILDVSLS RATDLGEPER SSSEETLNNF QEAETPGAVS PNQPHLPQPH 200
    LPHLPQQNVV INGNAHPHHL HHHHQIHHGH HLQHGHHHPS HVAVASASIT 250
    GGPPSSPVSR KLSTTGSSDS ITPVAPTSAV SSSGSPASVM TNMRAPSTTG 300
    GIGINSVTGT STVNNVNITA VGSFNPNVTS SMLGNVNIST SNIPSAAGVS 350
    VGPGVTSGVN VNILSGMGNG TISSSAAVSS VPNAAAGMTG GSVSSQQQQP 400
    TVNTSRFRVV KLDSSSEPFK KGRWTCTEFY EKENAVPATE GVLINKVVET 450
    VKQNPIEVTS ERESTSGSSV SSSVSTLSHY TESVGSGEMG APTVVVQQQQ 500
    QQQQQQQQQP ALQGVTLQQM DFGSTGPQSI PAVSIPQSIS QSQISQVQLQ 550
    SQELSYQQKQ GLQPVPLQAT MSAATGIQPS PVNVVGVTSA LGQQPSISSL 600
    AQPQLPYSQA APPVQTPLPG APPPQQLQYG QQQPMVSTQM APGHVKSVTQ 650
    NPASEYVQQQ PILQTAMSSG QPSSAGVGAG TTVIPVAQPQ GIQLPVQPTA 700
    VPAQPAGASV QPVGQAPAAV SAVPTGSQIA NIGQQANIPT AVQQPSTQVP 750
    PSVIQQGAPP SSQVVPPAQT GIIHQGVQTS APSLPQQLVI ASQSSLLTVP 800
    PQPQGVEPVA QGIVSQQLPA VSSLPSASSI SVTSQVSSTG PSGMPSAPTN 850
    LVPPQNIAQT PATQNGNLVQ SVSQPPLIAT NTNLPLAQQI PLSSTQFSAQ 900
    SLAQAIGSQI EDARRAAEPS LVGLPQTISG DSGGMSAVSD GSSSSLAASA 950
    SLFPLKVLPL TTPLVDGEDE SSSGASVVAI DNKIEQAMDL VKSHLMYAVR 1000
    EEVEVLKEQI KELIEKNSQL EQENNLLKTL ASPEQLAQFQ AQLQTGSPPA 1050
    TTQPQGTTQP PAQPASQGSG PTA 1073
    Length:1,073
    Mass (Da):109,677
    Last modified:May 31, 2011 - v3
    Checksum:iBFA471E36FCD06BD
    GO
    Isoform 2 (identifier: Q15714-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-921: Missing.
         922-970: VGLPQTISGD...TTPLVDGEDE → MKSQWCRPVA...TENASVRLDN

    Show »
    Length:144
    Mass (Da):15,680
    Checksum:iB8AEF42657C50892
    GO
    Isoform 3 (identifier: Q15714-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-488: Missing.

    Show »
    Length:585
    Mass (Da):59,863
    Checksum:iB2DDBF5D12954ABE
    GO
    Isoform 4 (identifier: Q15714-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         557-570: QQKQGLQPVPLQAT → LTMKVVLLIVYLCM
         571-1073: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:570
    Mass (Da):58,859
    Checksum:iB6A604F32A6CB638
    GO

    Sequence cautioni

    The sequence BAC02703.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti332 – 3321M → I in BAC02703. (PubMed:12056414)Curated
    Sequence conflicti581 – 5811P → L in CAH10539. (PubMed:15489334)Curated
    Sequence conflicti661 – 6611P → S in CAH10539. (PubMed:15489334)Curated
    Isoform 2 (identifier: Q15714-2)
    Sequence conflicti15 – 151V → A in BAB46917. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti652 – 6521P → S.
    Corresponds to variant rs9525983 [ dbSNP | Ensembl ].
    VAR_057311

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 921921Missing in isoform 2. 7 PublicationsVSP_035325Add
    BLAST
    Alternative sequencei1 – 488488Missing in isoform 3. 1 PublicationVSP_035324Add
    BLAST
    Alternative sequencei557 – 57014QQKQG…PLQAT → LTMKVVLLIVYLCM in isoform 4. 1 PublicationVSP_044939Add
    BLAST
    Alternative sequencei571 – 1073503Missing in isoform 4. 1 PublicationVSP_044940Add
    BLAST
    Alternative sequencei922 – 97049VGLPQ…DGEDE → MKSQWCRPVAMDLGVYQLRH FSISFLSSLLGTENASVRLD N in isoform 2. 7 PublicationsVSP_035326Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35048 mRNA. Translation: AAC50566.1.
    D38585 mRNA. Translation: BAA07598.1.
    AJ222700 mRNA. Translation: CAA10951.1.
    D87061 mRNA. Translation: BAB46917.1.
    AF256226 Genomic DNA. Translation: AAG53077.1.
    AB082525 mRNA. Translation: BAC02703.1. Different initiation.
    AK091854 mRNA. Translation: BAG52429.1.
    AK312345 mRNA. Translation: BAG35266.1.
    CR456711 mRNA. Translation: CAG32992.1.
    CR627459 mRNA. Translation: CAH10539.1.
    AL138960, AL139184 Genomic DNA. Translation: CAI12991.1.
    AL139184, AL138960 Genomic DNA. Translation: CAI16499.1.
    AL356107 Genomic DNA. No translation available.
    CH471075 Genomic DNA. Translation: EAX08710.1.
    BC000456 mRNA. Translation: AAH00456.1.
    BC016867 mRNA. Translation: AAH16867.1.
    BC069207 mRNA. Translation: AAH69207.1.
    BC105277 mRNA. Translation: AAI05278.1.
    BC136475 mRNA. Translation: AAI36476.1.
    BC136482 mRNA. Translation: AAI36483.1.
    BC146664 mRNA. Translation: AAI46665.1.
    BC146679 mRNA. Translation: AAI46680.1.
    CCDSiCCDS31966.1. [Q15714-1]
    CCDS58291.1. [Q15714-4]
    CCDS9392.1. [Q15714-2]
    PIRiJC4813.
    RefSeqiNP_001230728.1. NM_001243799.1. [Q15714-4]
    NP_006013.1. NM_006022.3. [Q15714-2]
    NP_904358.2. NM_183422.3. [Q15714-1]
    XP_006719950.1. XM_006719887.1. [Q15714-1]
    UniGeneiHs.436383.

    Genome annotation databases

    EnsembliENST00000261489; ENSP00000261489; ENSG00000102804. [Q15714-2]
    ENST00000458659; ENSP00000397435; ENSG00000102804. [Q15714-1]
    ENST00000501704; ENSP00000437414; ENSG00000102804. [Q15714-4]
    GeneIDi8848.
    KEGGihsa:8848.
    UCSCiuc001uzm.4. human. [Q15714-2]
    uc001uzn.4. human. [Q15714-1]
    uc001uzo.2. human.

    Polymorphism databases

    DMDMi334302874.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35048 mRNA. Translation: AAC50566.1 .
    D38585 mRNA. Translation: BAA07598.1 .
    AJ222700 mRNA. Translation: CAA10951.1 .
    D87061 mRNA. Translation: BAB46917.1 .
    AF256226 Genomic DNA. Translation: AAG53077.1 .
    AB082525 mRNA. Translation: BAC02703.1 . Different initiation.
    AK091854 mRNA. Translation: BAG52429.1 .
    AK312345 mRNA. Translation: BAG35266.1 .
    CR456711 mRNA. Translation: CAG32992.1 .
    CR627459 mRNA. Translation: CAH10539.1 .
    AL138960 , AL139184 Genomic DNA. Translation: CAI12991.1 .
    AL139184 , AL138960 Genomic DNA. Translation: CAI16499.1 .
    AL356107 Genomic DNA. No translation available.
    CH471075 Genomic DNA. Translation: EAX08710.1 .
    BC000456 mRNA. Translation: AAH00456.1 .
    BC016867 mRNA. Translation: AAH16867.1 .
    BC069207 mRNA. Translation: AAH69207.1 .
    BC105277 mRNA. Translation: AAI05278.1 .
    BC136475 mRNA. Translation: AAI36476.1 .
    BC136482 mRNA. Translation: AAI36483.1 .
    BC146664 mRNA. Translation: AAI46665.1 .
    BC146679 mRNA. Translation: AAI46680.1 .
    CCDSi CCDS31966.1. [Q15714-1 ]
    CCDS58291.1. [Q15714-4 ]
    CCDS9392.1. [Q15714-2 ]
    PIRi JC4813.
    RefSeqi NP_001230728.1. NM_001243799.1. [Q15714-4 ]
    NP_006013.1. NM_006022.3. [Q15714-2 ]
    NP_904358.2. NM_183422.3. [Q15714-1 ]
    XP_006719950.1. XM_006719887.1. [Q15714-1 ]
    UniGenei Hs.436383.

    3D structure databases

    ProteinModelPortali Q15714.
    SMRi Q15714. Positions 988-1043.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114374. 85 interactions.
    IntActi Q15714. 47 interactions.
    MINTi MINT-1367987.
    STRINGi 9606.ENSP00000397435.

    PTM databases

    PhosphoSitei Q15714.

    Polymorphism databases

    DMDMi 334302874.

    Proteomic databases

    MaxQBi Q15714.
    PaxDbi Q15714.
    PRIDEi Q15714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261489 ; ENSP00000261489 ; ENSG00000102804 . [Q15714-2 ]
    ENST00000458659 ; ENSP00000397435 ; ENSG00000102804 . [Q15714-1 ]
    ENST00000501704 ; ENSP00000437414 ; ENSG00000102804 . [Q15714-4 ]
    GeneIDi 8848.
    KEGGi hsa:8848.
    UCSCi uc001uzm.4. human. [Q15714-2 ]
    uc001uzn.4. human. [Q15714-1 ]
    uc001uzo.2. human.

    Organism-specific databases

    CTDi 8848.
    GeneCardsi GC13M045007.
    H-InvDB HIX0037340.
    HGNCi HGNC:16826. TSC22D1.
    MIMi 607715. gene.
    neXtProti NX_Q15714.
    PharmGKBi PA134887618.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261231.
    HOVERGENi HBG108540.
    InParanoidi Q15714.
    OMAi ARKMAHP.
    OrthoDBi EOG7RZ5PT.
    PhylomeDBi Q15714.
    TreeFami TF318837.

    Miscellaneous databases

    ChiTaRSi TSC22D1. human.
    GeneWikii TSC22D1.
    GenomeRNAii 8848.
    NextBioi 33215.
    PROi Q15714.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15714.
    Bgeei Q15714.
    CleanExi HS_TSC22D1.
    Genevestigatori Q15714.

    Family and domain databases

    InterProi IPR000580. TSC-22_Dip_Bun.
    [Graphical view ]
    PANTHERi PTHR12348. PTHR12348. 1 hit.
    Pfami PF01166. TSC22. 1 hit.
    [Graphical view ]
    ProDomi PD007152. TSC-22_Dip_Bun. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS01289. TSC22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene."
      Jay P., Wei J.W., Marsollier C., Taviaux S., Berge-Lefranc J.-L., Berta P.
      Biochem. Biophys. Res. Commun. 222:821-826(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter."
      Ohta S., Shimekake Y., Nagata K.
      Eur. J. Biochem. 242:460-466(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Kidney.
    3. "The characteristics of different types of mRNA expressed in the human brain."
      Dmitrenko V.V., Garifulin O.M., Shostak E.A., Smikodub A.I., Kavsan V.M.
      Cyt. Genet. 30:41-47(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Hucep-2, a gene which is expressed in the human brain, is a homologue of rodent and chicken TSC-22."
      Yazaki M., Takayama K., Matsumoto K., Yoshimoto M.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain cortex.
    5. "Cloning and characterization of human TSC-22 genomic DNA."
      Kawamata H., Uchida D., Omotehara F., Hino S., Nakashiro K., Miwa Y., Begum N., Hoque M.O., Yoshida H., Sato M.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method."
      Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S., Takahashi Y., Kitajima S., Saga Y., Koseki H.
      DNA Res. 9:47-57(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Brain cortex and Lung.
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Fetal brain.
    10. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Colon, Lung, Ovary and Testis.
    13. "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity."
      Kester H.A., Blanchetot C., den Hertog J., van der Saag P.T., van der Burg B.
      J. Biol. Chem. 274:27439-27447(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiT22D1_HUMAN
    AccessioniPrimary (citable) accession number: Q15714
    Secondary accession number(s): B3KRL7
    , B9EGI0, O00666, Q6AHX5, Q6IBU1, Q8NCN1, Q96JS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3