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Q15714

- T22D1_HUMAN

UniProt

Q15714 - T22D1_HUMAN

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Protein

TSC22 domain family protein 1

Gene

TSC22D1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. negative regulation of apoptotic process Source: Ensembl
  2. positive regulation of apoptotic process Source: Ensembl
  3. positive regulation of cell proliferation Source: Ensembl
  4. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 1
Alternative name(s):
Cerebral protein 2
Regulatory protein TSC-22
TGFB-stimulated clone 22 homolog
Transforming growth factor beta-1-induced transcript 4 protein
Gene namesi
Name:TSC22D1
Synonyms:KIAA1994, TGFB1I4, TSC22
ORF Names:hucep-2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:16826. TSC22D1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10731073TSC22 domain family protein 1PRO_0000219365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei263 – 2631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15714.
PaxDbiQ15714.
PRIDEiQ15714.

PTM databases

PhosphoSiteiQ15714.

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues.

Inductioni

In aortic endothelial cells, induced by cytokines, including TGFB1.

Gene expression databases

BgeeiQ15714.
CleanExiHS_TSC22D1.
ExpressionAtlasiQ15714. baseline and differential.
GenevestigatoriQ15714.

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4.

Binary interactionsi

WithEntry#Exp.IntActNotes
TPT1P136935EBI-712609,EBI-1783169

Protein-protein interaction databases

BioGridi114374. 88 interactions.
IntActiQ15714. 47 interactions.
MINTiMINT-1367987.
STRINGi9606.ENSP00000397435.

Structurei

3D structure databases

ProteinModelPortaliQ15714.
SMRiQ15714. Positions 988-1043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1006 – 102722Leucine-zipperAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 8224Pro-richAdd
BLAST
Compositional biasi195 – 24147His-richAdd
BLAST
Compositional biasi497 – 817321Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiNOG261231.
GeneTreeiENSGT00530000063062.
HOVERGENiHBG108540.
InParanoidiQ15714.
OMAiARKMAHP.
OrthoDBiEOG7RZ5PT.
PhylomeDBiQ15714.
TreeFamiTF318837.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15714-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHQPPESTAA AAAAADISAR KMAHPAMFPR RGSGSGSASA LNAAGTGVGS
60 70 80 90 100
NATSSEDFPP PSLLQPPPPA ASSTSGPQPP PPQSLNLLSQ AQLQAQPLAP
110 120 130 140 150
GGTQMKKKSG FQITSVTPAQ ISASISSNNS IAEDTESYDD LDESHTEDLS
160 170 180 190 200
SSEILDVSLS RATDLGEPER SSSEETLNNF QEAETPGAVS PNQPHLPQPH
210 220 230 240 250
LPHLPQQNVV INGNAHPHHL HHHHQIHHGH HLQHGHHHPS HVAVASASIT
260 270 280 290 300
GGPPSSPVSR KLSTTGSSDS ITPVAPTSAV SSSGSPASVM TNMRAPSTTG
310 320 330 340 350
GIGINSVTGT STVNNVNITA VGSFNPNVTS SMLGNVNIST SNIPSAAGVS
360 370 380 390 400
VGPGVTSGVN VNILSGMGNG TISSSAAVSS VPNAAAGMTG GSVSSQQQQP
410 420 430 440 450
TVNTSRFRVV KLDSSSEPFK KGRWTCTEFY EKENAVPATE GVLINKVVET
460 470 480 490 500
VKQNPIEVTS ERESTSGSSV SSSVSTLSHY TESVGSGEMG APTVVVQQQQ
510 520 530 540 550
QQQQQQQQQP ALQGVTLQQM DFGSTGPQSI PAVSIPQSIS QSQISQVQLQ
560 570 580 590 600
SQELSYQQKQ GLQPVPLQAT MSAATGIQPS PVNVVGVTSA LGQQPSISSL
610 620 630 640 650
AQPQLPYSQA APPVQTPLPG APPPQQLQYG QQQPMVSTQM APGHVKSVTQ
660 670 680 690 700
NPASEYVQQQ PILQTAMSSG QPSSAGVGAG TTVIPVAQPQ GIQLPVQPTA
710 720 730 740 750
VPAQPAGASV QPVGQAPAAV SAVPTGSQIA NIGQQANIPT AVQQPSTQVP
760 770 780 790 800
PSVIQQGAPP SSQVVPPAQT GIIHQGVQTS APSLPQQLVI ASQSSLLTVP
810 820 830 840 850
PQPQGVEPVA QGIVSQQLPA VSSLPSASSI SVTSQVSSTG PSGMPSAPTN
860 870 880 890 900
LVPPQNIAQT PATQNGNLVQ SVSQPPLIAT NTNLPLAQQI PLSSTQFSAQ
910 920 930 940 950
SLAQAIGSQI EDARRAAEPS LVGLPQTISG DSGGMSAVSD GSSSSLAASA
960 970 980 990 1000
SLFPLKVLPL TTPLVDGEDE SSSGASVVAI DNKIEQAMDL VKSHLMYAVR
1010 1020 1030 1040 1050
EEVEVLKEQI KELIEKNSQL EQENNLLKTL ASPEQLAQFQ AQLQTGSPPA
1060 1070
TTQPQGTTQP PAQPASQGSG PTA
Length:1,073
Mass (Da):109,677
Last modified:May 31, 2011 - v3
Checksum:iBFA471E36FCD06BD
GO
Isoform 2 (identifier: Q15714-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-921: Missing.
     922-970: VGLPQTISGD...TTPLVDGEDE → MKSQWCRPVA...TENASVRLDN

Show »
Length:144
Mass (Da):15,680
Checksum:iB8AEF42657C50892
GO
Isoform 3 (identifier: Q15714-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-488: Missing.

Show »
Length:585
Mass (Da):59,863
Checksum:iB2DDBF5D12954ABE
GO
Isoform 4 (identifier: Q15714-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-570: QQKQGLQPVPLQAT → LTMKVVLLIVYLCM
     571-1073: Missing.

Note: No experimental confirmation available.

Show »
Length:570
Mass (Da):58,859
Checksum:iB6A604F32A6CB638
GO

Sequence cautioni

The sequence BAC02703.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti332 – 3321M → I in BAC02703. (PubMed:12056414)Curated
Sequence conflicti581 – 5811P → L in CAH10539. (PubMed:15489334)Curated
Sequence conflicti661 – 6611P → S in CAH10539. (PubMed:15489334)Curated
Isoform 2 (identifier: Q15714-2)
Sequence conflicti15 – 151V → A in BAB46917. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti652 – 6521P → S.
Corresponds to variant rs9525983 [ dbSNP | Ensembl ].
VAR_057311

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 921921Missing in isoform 2. 7 PublicationsVSP_035325Add
BLAST
Alternative sequencei1 – 488488Missing in isoform 3. 1 PublicationVSP_035324Add
BLAST
Alternative sequencei557 – 57014QQKQG…PLQAT → LTMKVVLLIVYLCM in isoform 4. 1 PublicationVSP_044939Add
BLAST
Alternative sequencei571 – 1073503Missing in isoform 4. 1 PublicationVSP_044940Add
BLAST
Alternative sequencei922 – 97049VGLPQ…DGEDE → MKSQWCRPVAMDLGVYQLRH FSISFLSSLLGTENASVRLD N in isoform 2. 7 PublicationsVSP_035326Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35048 mRNA. Translation: AAC50566.1.
D38585 mRNA. Translation: BAA07598.1.
AJ222700 mRNA. Translation: CAA10951.1.
D87061 mRNA. Translation: BAB46917.1.
AF256226 Genomic DNA. Translation: AAG53077.1.
AB082525 mRNA. Translation: BAC02703.1. Different initiation.
AK091854 mRNA. Translation: BAG52429.1.
AK312345 mRNA. Translation: BAG35266.1.
CR456711 mRNA. Translation: CAG32992.1.
CR627459 mRNA. Translation: CAH10539.1.
AL138960, AL139184 Genomic DNA. Translation: CAI12991.1.
AL139184, AL138960 Genomic DNA. Translation: CAI16499.1.
AL356107 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08710.1.
BC000456 mRNA. Translation: AAH00456.1.
BC016867 mRNA. Translation: AAH16867.1.
BC069207 mRNA. Translation: AAH69207.1.
BC105277 mRNA. Translation: AAI05278.1.
BC136475 mRNA. Translation: AAI36476.1.
BC136482 mRNA. Translation: AAI36483.1.
BC146664 mRNA. Translation: AAI46665.1.
BC146679 mRNA. Translation: AAI46680.1.
CCDSiCCDS31966.1. [Q15714-1]
CCDS58291.1. [Q15714-4]
CCDS9392.1. [Q15714-2]
PIRiJC4813.
RefSeqiNP_001230728.1. NM_001243799.1. [Q15714-4]
NP_006013.1. NM_006022.3. [Q15714-2]
NP_904358.2. NM_183422.3. [Q15714-1]
XP_006719950.1. XM_006719887.1. [Q15714-1]
UniGeneiHs.436383.

Genome annotation databases

EnsembliENST00000261489; ENSP00000261489; ENSG00000102804. [Q15714-2]
ENST00000458659; ENSP00000397435; ENSG00000102804. [Q15714-1]
ENST00000501704; ENSP00000437414; ENSG00000102804. [Q15714-4]
GeneIDi8848.
KEGGihsa:8848.
UCSCiuc001uzm.4. human. [Q15714-2]
uc001uzn.4. human. [Q15714-1]
uc001uzo.2. human.

Polymorphism databases

DMDMi334302874.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35048 mRNA. Translation: AAC50566.1 .
D38585 mRNA. Translation: BAA07598.1 .
AJ222700 mRNA. Translation: CAA10951.1 .
D87061 mRNA. Translation: BAB46917.1 .
AF256226 Genomic DNA. Translation: AAG53077.1 .
AB082525 mRNA. Translation: BAC02703.1 . Different initiation.
AK091854 mRNA. Translation: BAG52429.1 .
AK312345 mRNA. Translation: BAG35266.1 .
CR456711 mRNA. Translation: CAG32992.1 .
CR627459 mRNA. Translation: CAH10539.1 .
AL138960 , AL139184 Genomic DNA. Translation: CAI12991.1 .
AL139184 , AL138960 Genomic DNA. Translation: CAI16499.1 .
AL356107 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08710.1 .
BC000456 mRNA. Translation: AAH00456.1 .
BC016867 mRNA. Translation: AAH16867.1 .
BC069207 mRNA. Translation: AAH69207.1 .
BC105277 mRNA. Translation: AAI05278.1 .
BC136475 mRNA. Translation: AAI36476.1 .
BC136482 mRNA. Translation: AAI36483.1 .
BC146664 mRNA. Translation: AAI46665.1 .
BC146679 mRNA. Translation: AAI46680.1 .
CCDSi CCDS31966.1. [Q15714-1 ]
CCDS58291.1. [Q15714-4 ]
CCDS9392.1. [Q15714-2 ]
PIRi JC4813.
RefSeqi NP_001230728.1. NM_001243799.1. [Q15714-4 ]
NP_006013.1. NM_006022.3. [Q15714-2 ]
NP_904358.2. NM_183422.3. [Q15714-1 ]
XP_006719950.1. XM_006719887.1. [Q15714-1 ]
UniGenei Hs.436383.

3D structure databases

ProteinModelPortali Q15714.
SMRi Q15714. Positions 988-1043.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114374. 88 interactions.
IntActi Q15714. 47 interactions.
MINTi MINT-1367987.
STRINGi 9606.ENSP00000397435.

PTM databases

PhosphoSitei Q15714.

Polymorphism databases

DMDMi 334302874.

Proteomic databases

MaxQBi Q15714.
PaxDbi Q15714.
PRIDEi Q15714.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261489 ; ENSP00000261489 ; ENSG00000102804 . [Q15714-2 ]
ENST00000458659 ; ENSP00000397435 ; ENSG00000102804 . [Q15714-1 ]
ENST00000501704 ; ENSP00000437414 ; ENSG00000102804 . [Q15714-4 ]
GeneIDi 8848.
KEGGi hsa:8848.
UCSCi uc001uzm.4. human. [Q15714-2 ]
uc001uzn.4. human. [Q15714-1 ]
uc001uzo.2. human.

Organism-specific databases

CTDi 8848.
GeneCardsi GC13M045007.
H-InvDB HIX0037340.
HGNCi HGNC:16826. TSC22D1.
MIMi 607715. gene.
neXtProti NX_Q15714.
PharmGKBi PA134887618.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG261231.
GeneTreei ENSGT00530000063062.
HOVERGENi HBG108540.
InParanoidi Q15714.
OMAi ARKMAHP.
OrthoDBi EOG7RZ5PT.
PhylomeDBi Q15714.
TreeFami TF318837.

Miscellaneous databases

ChiTaRSi TSC22D1. human.
GeneWikii TSC22D1.
GenomeRNAii 8848.
NextBioi 33215.
PROi Q15714.
SOURCEi Search...

Gene expression databases

Bgeei Q15714.
CleanExi HS_TSC22D1.
ExpressionAtlasi Q15714. baseline and differential.
Genevestigatori Q15714.

Family and domain databases

InterProi IPR000580. TSC-22_Dip_Bun.
[Graphical view ]
PANTHERi PTHR12348. PTHR12348. 1 hit.
Pfami PF01166. TSC22. 1 hit.
[Graphical view ]
ProDomi PD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS01289. TSC22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene."
    Jay P., Wei J.W., Marsollier C., Taviaux S., Berge-Lefranc J.-L., Berta P.
    Biochem. Biophys. Res. Commun. 222:821-826(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter."
    Ohta S., Shimekake Y., Nagata K.
    Eur. J. Biochem. 242:460-466(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Kidney.
  3. "The characteristics of different types of mRNA expressed in the human brain."
    Dmitrenko V.V., Garifulin O.M., Shostak E.A., Smikodub A.I., Kavsan V.M.
    Cyt. Genet. 30:41-47(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Hucep-2, a gene which is expressed in the human brain, is a homologue of rodent and chicken TSC-22."
    Yazaki M., Takayama K., Matsumoto K., Yoshimoto M.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain cortex.
  5. "Cloning and characterization of human TSC-22 genomic DNA."
    Kawamata H., Uchida D., Omotehara F., Hino S., Nakashiro K., Miwa Y., Begum N., Hoque M.O., Yoshida H., Sato M.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method."
    Ohara O., Nagase T., Mitsui G., Kohga H., Kikuno R., Hiraoka S., Takahashi Y., Kitajima S., Saga Y., Koseki H.
    DNA Res. 9:47-57(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain cortex and Lung.
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Fetal brain.
  10. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Colon, Lung, Ovary and Testis.
  13. "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity."
    Kester H.A., Blanchetot C., den Hertog J., van der Saag P.T., van der Burg B.
    J. Biol. Chem. 274:27439-27447(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiT22D1_HUMAN
AccessioniPrimary (citable) accession number: Q15714
Secondary accession number(s): B3KRL7
, B9EGI0, O00666, Q6AHX5, Q6IBU1, Q8NCN1, Q96JS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 31, 2011
Last modified: October 29, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3