Q15700 (DLG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disks large homolog 2

Alternative name(s):
Channel-associated protein of synapse-110
Short name=Chapsyn-110
Postsynaptic density protein PSD-93

Gene names

Name:

DLG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	870 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses By similarity.
Subunit structure	Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain By similarity. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Membrane; Lipid-anchor By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cell junction › synapse By similarity. Note: Concentrated in soma and postsynaptic density of a subset of neurons By similarity.
Domain	An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
Post-translational modification	Palmitoylation of isoform 1 is not required for targeting to postsynaptic density By similarity.
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 3 PDZ (DHR) domains. Contains 1 SH3 domain.
Sequence caution	The sequence BAD92489.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat SH3 domain
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of phosphatase activity Inferred from direct assay PubMed 19389623. Source: UniProtKB sensory perception of pain Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW juxtaparanode region of axon Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement Ref.1. Source: ProtInc postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	guanylate kinase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Kcnj2	P35561	6	EBI-663057,EBI-703793	From a different organism.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15700-1)

Also known as: PSD93-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15700-2)

Also known as: PSD93-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MFFACYCALRTNVK → MGIFKSSLFQ...PAWMPVHHCT

Isoform 3 (identifier: Q15700-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     52-86: IENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPY → MQRPSVSRAENYQLLWDTIASLKQCEQAMQHAFIP
     341-392: Missing.
     627-659: SFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPE → DIPGLGDDGYGTKTL

Isoform 4 (identifier: Q15700-4)

Also known as: PSD93-delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: MFFACYCALR...VLQSHISPLK → MNAYLTKQHS...CPHGWFSPAQ

Isoform 5 (identifier: Q15700-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-518: Missing.
     627-659: SFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPE → DIPGLGDDGYGTKTL

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 870

870

Disks large homolog 2

PRO_0000094553

Regions

Domain

98 – 184

87

PDZ 1

Domain

193 – 279

87

PDZ 2

Domain

421 – 501

81

PDZ 3

Domain

536 – 606

71

SH3

Domain

680 – 855

176

Guanylate kinase-like

Amino acid modifications

Modified residue

28

1

Phosphoserine By similarity

Modified residue

58

1

Phosphotyrosine By similarity

Modified residue

62

1

Phosphoserine By similarity

Modified residue

175

1

Phosphoserine By similarity

Modified residue

340

1

Phosphotyrosine By similarity

Modified residue

348

1

Phosphotyrosine By similarity

Modified residue

365

1

Phosphoserine By similarity

Modified residue

406

1

Phosphoserine By similarity

Modified residue

414

1

Phosphoserine By similarity

Modified residue

500

1

Phosphotyrosine By similarity

Modified residue

505

1

Phosphotyrosine By similarity

Modified residue

750

1

Phosphotyrosine By similarity

Modified residue

755

1

Phosphotyrosine By similarity

Lipidation

5

1

S-palmitoyl cysteine By similarity

Lipidation

7

1

S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence

1 – 518

518

Missing in isoform 5.

VSP_045634

Alternative sequence

1 – 68

68

MFFAC…ISPLK → MNAYLTKQHSCSRGSDGMDA VRSAPTLIRDAHCACGWQRN CQGLGYSSQTMPSSGPGGPA SNRTGGSSFNRTLWDSVRKS PHKTSTKGKGTCGEHCTCPH GWFSPAQ in isoform 4.

VSP_015511

Alternative sequence

1 – 51

51

Missing in isoform 3.

VSP_015512

Alternative sequence

1 – 14

14

MFFAC…RTNVK → MGIFKSSLFQALLDIQEFYE VTLLNSQKSCEQKIEEANQV LQKWEKTSLLAPCHDRLQKS SELTDCSGSKENASCIEQNK ENQSFENETDETTTQNQGRC PAQNCSVEAPAWMPVHHCT in isoform 2.

VSP_015513

Alternative sequence

52 – 86

35

IENVH…DTIPY → MQRPSVSRAENYQLLWDTIA SLKQCEQAMQHAFIP in isoform 3.

VSP_015514

Alternative sequence

341 – 392

52

Missing in isoform 3.

VSP_015515

Alternative sequence

627 – 659

33

SFNDK…TSDPE → DIPGLGDDGYGTKTL in isoform 3 and isoform 5.

VSP_015516

Experimental info

Sequence conflict

177

1

V → A in AAB04949. Ref.1

Sequence conflict

278

1

K → N in AAB04949. Ref.1

Sequence conflict

704

1

K → E in CAI45970. Ref.3

Sequence conflict

803

1

P → S in AAB04949. Ref.1

Sequence conflict

861

1

F → L in CAH18680. Ref.3

Isoform 5:

Sequence conflict

116

1

D → E in CAI45970. Ref.3

Secondary structure

1

.

.

.

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.

.

.

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.

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870

Helix Strand Turn

Details...

Beta strand

190 – 197

8

Beta strand

202 – 209

8

Beta strand

222 – 227

6

Helix

232 – 236

5

Beta strand

244 – 248

5

Helix

258 – 266

9

Beta strand

270 – 281

12

Beta strand

420 – 425

6

Beta strand

432 – 439

8

Beta strand

444 – 449

6

Helix

454 – 458

5

Beta strand

465 – 470

6

Helix

480 – 489

10

Beta strand

492 – 500

9

Helix

502 – 510

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PSD93-alpha) [UniParc]. Last modified November 25, 2008. Version 3. Checksum: BC51554590060E48	FASTA	870	97,552
	10 20 30 40 50 60 MFFACYCALR TNVKKYRYQD EDAPHDHSLP RLTHEVRGPE LVHVSEKNLS QIENVHGYVL 70 80 90 100 110 120 QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT LERGNSGLGF SIAGGTDNPH 130 140 150 160 170 180 IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY 190 200 210 220 230 240 VRRRRPILET VVEIKLFKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ 250 260 270 280 290 300 VGDRLLMVNN YSLEEVTHEE AVAILKNTSE VVYLKVGKPT TIYMTDPYGP PDITHSYSPP 310 320 330 340 350 360 MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLVDDDY TRPPEPVYST VNKLCDKPAS 370 380 390 400 410 420 PRHYSPVECD KSFLLSAPYS HYHLGLLPDS EMTSHSQHST ATRQPSMTLQ RAVSLEGEPR 430 440 450 460 470 480 KVVLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LQRGDQILSV NGIDLRGASH 490 500 510 520 530 540 EQAAAALKGA GQTVTIIAQY QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY 550 560 570 580 590 600 VRAMFDYDKS KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVMLEGDS EEMGVIPSKR 610 620 630 640 650 660 RVERKERARL KTVKFNAKPG VIDSKGSFND KRKKSFIFSR KFPFYKNKEQ SEQETSDPER 670 680 690 700 710 720 GQEDLILSYE PVTRQEINYT RPVIILGPMK DRINDDLISE FPDKFGSCVP HTTRPKRDYE 730 740 750 760 770 780 VDGRDYHFVI SREQMEKDIQ EHKFIEAGQY NDNLYGTSVQ SVRFVAERGK HCILDVSGNA 790 800 810 820 830 840 IKRLQVAQLY PIAIFIKPRS LEPLMEMNKR LTEEQAKKTY DRAIKLEQEF GEYFTAIVQG 850 860 870 DTLEDIYNQC KLVIEEQSGP FIWIPSKEKL
	Isoform 2 (PSD93-beta) [UniParc]. Checksum: B4677B45F351C12D	FASTA	975	109,371
	10 20 30 40 50 60 MGIFKSSLFQ ALLDIQEFYE VTLLNSQKSC EQKIEEANQV LQKWEKTSLL APCHDRLQKS 70 80 90 100 110 120 SELTDCSGSK ENASCIEQNK ENQSFENETD ETTTQNQGRC PAQNCSVEAP AWMPVHHCTK 130 140 150 160 170 180 YRYQDEDAPH DHSLPRLTHE VRGPELVHVS EKNLSQIENV HGYVLQSHIS PLKASPAPII 190 200 210 220 230 240 VNTDTLDTIP YVNGTEIEYE FEEITLERGN SGLGFSIAGG TDNPHIGDDP GIFITKIIPG 250 260 270 280 290 300 GAAAEDGRLR VNDCILRVNE VDVSEVSHSK AVEALKEAGS IVRLYVRRRR PILETVVEIK 310 320 330 340 350 360 LFKGPKGLGF SIAGGVGNQH IPGDNSIYVT KIIDGGAAQK DGRLQVGDRL LMVNNYSLEE 370 380 390 400 410 420 VTHEEAVAIL KNTSEVVYLK VGKPTTIYMT DPYGPPDITH SYSPPMENHL LSGNNGTLEY 430 440 450 460 470 480 KTSLPPISPG RYSPIPKHML VDDDYTRPPE PVYSTVNKLC DKPASPRHYS PVECDKSFLL 490 500 510 520 530 540 SAPYSHYHLG LLPDSEMTSH SQHSTATRQP SMTLQRAVSL EGEPRKVVLH KGSTGLGFNI 550 560 570 580 590 600 VGGEDGEGIF VSFILAGGPA DLSGELQRGD QILSVNGIDL RGASHEQAAA ALKGAGQTVT 610 620 630 640 650 660 IIAQYQPEDY ARFEAKIHDL REQMMNHSMS SGSGSLRTNQ KRSLYVRAMF DYDKSKDSGL 670 680 690 700 710 720 PSQGLSFKYG DILHVINASD DEWWQARRVM LEGDSEEMGV IPSKRRVERK ERARLKTVKF 730 740 750 760 770 780 NAKPGVIDSK GSFNDKRKKS FIFSRKFPFY KNKEQSEQET SDPERGQEDL ILSYEPVTRQ 790 800 810 820 830 840 EINYTRPVII LGPMKDRIND DLISEFPDKF GSCVPHTTRP KRDYEVDGRD YHFVISREQM 850 860 870 880 890 900 EKDIQEHKFI EAGQYNDNLY GTSVQSVRFV AERGKHCILD VSGNAIKRLQ VAQLYPIAIF 910 920 930 940 950 960 IKPRSLEPLM EMNKRLTEEQ AKKTYDRAIK LEQEFGEYFT AIVQGDTLED IYNQCKLVIE 970 EQSGPFIWIP SKEKL
	Isoform 3 [UniParc]. Checksum: 6E4FC590B5EE8BED	FASTA	749	83,405
	10 20 30 40 50 60 MQRPSVSRAE NYQLLWDTIA SLKQCEQAMQ HAFIPVNGTE IEYEFEEITL ERGNSGLGFS 70 80 90 100 110 120 IAGGTDNPHI GDDPGIFITK IIPGGAAAED GRLRVNDCIL RVNEVDVSEV SHSKAVEALK 130 140 150 160 170 180 EAGSIVRLYV RRRRPILETV VEIKLFKGPK GLGFSIAGGV GNQHIPGDNS IYVTKIIDGG 190 200 210 220 230 240 AAQKDGRLQV GDRLLMVNNY SLEEVTHEEA VAILKNTSEV VYLKVGKPTT IYMTDPYGPP 250 260 270 280 290 300 DITHSYSPPM ENHLLSGNNG TLEYKTSLPP ISPGRYSPIP KHMLVDDDYT SHSQHSTATR 310 320 330 340 350 360 QPSMTLQRAV SLEGEPRKVV LHKGSTGLGF NIVGGEDGEG IFVSFILAGG PADLSGELQR 370 380 390 400 410 420 GDQILSVNGI DLRGASHEQA AAALKGAGQT VTIIAQYQPE DYARFEAKIH DLREQMMNHS 430 440 450 460 470 480 MSSGSGSLRT NQKRSLYVRA MFDYDKSKDS GLPSQGLSFK YGDILHVINA SDDEWWQARR 490 500 510 520 530 540 VMLEGDSEEM GVIPSKRRVE RKERARLKTV KFNAKPGVID SKGDIPGLGD DGYGTKTLRG 550 560 570 580 590 600 QEDLILSYEP VTRQEINYTR PVIILGPMKD RINDDLISEF PDKFGSCVPH TTRPKRDYEV 610 620 630 640 650 660 DGRDYHFVIS REQMEKDIQE HKFIEAGQYN DNLYGTSVQS VRFVAERGKH CILDVSGNAI 670 680 690 700 710 720 KRLQVAQLYP IAIFIKPRSL EPLMEMNKRL TEEQAKKTYD RAIKLEQEFG EYFTAIVQGD 730 740 TLEDIYNQCK LVIEEQSGPF IWIPSKEKL
	Isoform 4 (PSD93-delta) [UniParc]. Checksum: 2A857BA09A6587E0	FASTA	909	100,981
	10 20 30 40 50 60 MNAYLTKQHS CSRGSDGMDA VRSAPTLIRD AHCACGWQRN CQGLGYSSQT MPSSGPGGPA 70 80 90 100 110 120 SNRTGGSSFN RTLWDSVRKS PHKTSTKGKG TCGEHCTCPH GWFSPAQASP APIIVNTDTL 130 140 150 160 170 180 DTIPYVNGTE IEYEFEEITL ERGNSGLGFS IAGGTDNPHI GDDPGIFITK IIPGGAAAED 190 200 210 220 230 240 GRLRVNDCIL RVNEVDVSEV SHSKAVEALK EAGSIVRLYV RRRRPILETV VEIKLFKGPK 250 260 270 280 290 300 GLGFSIAGGV GNQHIPGDNS IYVTKIIDGG AAQKDGRLQV GDRLLMVNNY SLEEVTHEEA 310 320 330 340 350 360 VAILKNTSEV VYLKVGKPTT IYMTDPYGPP DITHSYSPPM ENHLLSGNNG TLEYKTSLPP 370 380 390 400 410 420 ISPGRYSPIP KHMLVDDDYT RPPEPVYSTV NKLCDKPASP RHYSPVECDK SFLLSAPYSH 430 440 450 460 470 480 YHLGLLPDSE MTSHSQHSTA TRQPSMTLQR AVSLEGEPRK VVLHKGSTGL GFNIVGGEDG 490 500 510 520 530 540 EGIFVSFILA GGPADLSGEL QRGDQILSVN GIDLRGASHE QAAAALKGAG QTVTIIAQYQ 550 560 570 580 590 600 PEDYARFEAK IHDLREQMMN HSMSSGSGSL RTNQKRSLYV RAMFDYDKSK DSGLPSQGLS 610 620 630 640 650 660 FKYGDILHVI NASDDEWWQA RRVMLEGDSE EMGVIPSKRR VERKERARLK TVKFNAKPGV 670 680 690 700 710 720 IDSKGSFNDK RKKSFIFSRK FPFYKNKEQS EQETSDPERG QEDLILSYEP VTRQEINYTR 730 740 750 760 770 780 PVIILGPMKD RINDDLISEF PDKFGSCVPH TTRPKRDYEV DGRDYHFVIS REQMEKDIQE 790 800 810 820 830 840 HKFIEAGQYN DNLYGTSVQS VRFVAERGKH CILDVSGNAI KRLQVAQLYP IAIFIKPRSL 850 860 870 880 890 900 EPLMEMNKRL TEEQAKKTYD RAIKLEQEFG EYFTAIVQGD TLEDIYNQCK LVIEEQSGPF IWIPSKEKL
	Isoform 5 [UniParc]. Checksum: DED1A839B4181509	FASTA	334	38,404
	10 20 30 40 50 60 MMNHSMSSGS GSLRTNQKRS LYVRAMFDYD KSKDSGLPSQ GLSFKYGDIL HVINASDDEW 70 80 90 100 110 120 WQARRVMLEG DSEEMGVIPS KRRVERKERA RLKTVKFNAK PGVIDSKGDI PGLGDDGYGT 130 140 150 160 170 180 KTLRGQEDLI LSYEPVTRQE INYTRPVIIL GPMKDRINDD LISEFPDKFG SCVPHTTRPK 190 200 210 220 230 240 RDYEVDGRDY HFVISREQME KDIQEHKFIE AGQYNDNLYG TSVQSVRFVA ERGKHCILDV 250 260 270 280 290 300 SGNAIKRLQV AQLYPIAIFI KPRSLEPLME MNKRLTEEQA KKTYDRAIKL EQEFGEYFTA 310 320 330 IVQGDTLEDI YNQCKLVIEE QSGPFIWIPS KEKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins." Kim E., Cho K.-O., Rothschild A., Sheng M. Neuron 17:103-113(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Cerebellum.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5). Tissue: Retina.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-542 (ISOFORM 1). Tissue: Brain.
[6]	"An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1." Leyland M.L., Dart C. J. Biol. Chem. 279:43427-43436(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH KCNJ2.
[7]	"SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses." Ko J., Kim S., Chung H.S., Kim K., Han K., Kim H., Jun H., Kaang B.-K., Kim E. Neuron 50:233-245(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH LRFN1; LRFN2 AND LRFN4.
[8]	"Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis." Lee H.W., Choi J., Shin H., Kim K., Yang J., Na M., Choi S.Y., Kang G.B., Eom S.H., Kim H., Kim E. J. Neurosci. 28:14546-14556(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FRMPD4.
[9]	"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening." Voss M., Lettau M., Janssen O. BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FASLG.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions." Elkins J.M., Papagrigoriou E., Berridge G., Yang X., Phillips C., Gileadi C., Savitsky P., Doyle D.A. Protein Sci. 16:683-694(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 190-283, X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 418-513.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U32376 mRNA. Translation: AAB04949.1.
AK126776 mRNA. Translation: BAC86685.1.
CR749820 mRNA. Translation: CAH18680.1.
CR933674 mRNA. Translation: CAI45970.1.
AC023118 Genomic DNA. No translation available.
AP000639 Genomic DNA. No translation available.
AP000642 Genomic DNA. No translation available.
AP000773 Genomic DNA. No translation available.
AP000852 Genomic DNA. No translation available.
AP000857 Genomic DNA. No translation available.
AP001791 Genomic DNA. No translation available.
AP001825 Genomic DNA. No translation available.
AP001984 Genomic DNA. No translation available.
AP002370 Genomic DNA. No translation available.
AP002751 Genomic DNA. No translation available.
AP002797 Genomic DNA. No translation available.
AP002803 Genomic DNA. No translation available.
AP002878 Genomic DNA. No translation available.
AP003026 Genomic DNA. No translation available.
AP003035 Genomic DNA. No translation available.
AP003093 Genomic DNA. No translation available.
AP003095 Genomic DNA. No translation available.
AP003305 Genomic DNA. No translation available.
AB209252 mRNA. Translation: BAD92489.1. Different initiation.

IPI

IPI00444727.
IPI00444938.
IPI00646771.
IPI00647950.
IPI00973875.

PIR

G01974.
S60315.

RefSeq

NP_001136171.1. NM_001142699.1.
NP_001136172.1. NM_001142700.1.
NP_001136174.1. NM_001142702.1.
NP_001193698.1. NM_001206769.1.
NP_001355.2. NM_001364.3.

UniGene

Hs.367656.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BYG	X-ray	1.85	A	190-283	[»]
2HE2	X-ray	1.50	A/B	418-513	[»]

ProteinModelPortal

Q15700.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15700. 8 interactions.

MINT

MINT-470785.

STRING

9606.ENSP00000365272.

PTM databases

PhosphoSite

Q15700.

Polymorphism databases

DMDM

215274165.

Proteomic databases

PaxDb

Q15700.

PRIDE

Q15700.

Protocols and materials databases

DNASU

1740.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000280241; ENSP00000280241; ENSG00000150672.
ENST00000376104; ENSP00000365272; ENSG00000150672.
ENST00000376106; ENSP00000365274; ENSG00000150672.
ENST00000398309; ENSP00000381355; ENSG00000150672.
ENST00000418306; ENSP00000402275; ENSG00000150672.
ENST00000426717; ENSP00000393049; ENSG00000150672.
ENST00000543673; ENSP00000441994; ENSG00000150672.

GeneID

1740.

KEGG

hsa:1740.

UCSC

uc001pai.2. human.
uc001paj.2. human.
uc001pak.2. human.
uc021qof.1. human.

Organism-specific databases

CTD

1740.

GeneCards

GC11M083166.

HGNC

HGNC:2901. DLG2.

HPA

HPA021307.

MIM

603583. gene.

neXtProt

NX_Q15700.

PharmGKB

PA164741388.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0194.

HOGENOM

HOG000232102.

HOVERGEN

HBG107814.

KO

K12075.

OrthoDB

EOG447FSN.

Gene expression databases

ArrayExpress

Q15700.

Bgee

Q15700.

CleanEx

HS_DLG2.

Genevestigator

Q15700.

GermOnline

ENSG00000150672. Homo sapiens.

Family and domain databases

InterPro

IPR008144. Guanylate_kin.
IPR008145. Guanylate_kin/L-typ_Ca_channel.
IPR020590. Guanylate_kinase_CS.
IPR016313. M-assoc_guanylate_kinase.
IPR019590. MAGUK_PEST_N.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]

PIRSF

PIRSF001741. MAGUK_DLGH. 1 hit.

SMART

SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 3 hits.
SSF50044. SH3. 1 hit.

PROSITE

PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q15700.

GenomeRNAi

1740.

NextBio

7057.

SOURCE

Search...

Entry information

Entry name

DLG2_HUMAN

Accession

Primary (citable) accession number: Q15700
Secondary accession number(s): B7WNY8 , F8W9V6, Q59G57, Q5H9Q4, Q68CQ8, Q6ZTA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 135 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.