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Q15697

- ZN174_HUMAN

UniProt

Q15697 - ZN174_HUMAN

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Protein

Zinc finger protein 174

Gene

ZNF174

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri326 – 34823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein homodimerization activity Source: UniProtKB
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 174
Alternative name(s):
AW-1
Zinc finger and SCAN domain-containing protein 8
Gene namesi
Name:ZNF174
Synonyms:ZSCAN8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:12963. ZNF174.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. cytoplasm Source: HPA
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Zinc finger protein 174PRO_0000047439Add
BLAST

Proteomic databases

MaxQBiQ15697.
PaxDbiQ15697.
PRIDEiQ15697.

PTM databases

PhosphoSiteiQ15697.

Expressioni

Tissue specificityi

Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Gene expression databases

BgeeiQ15697.
CleanExiHS_ZNF174.
ExpressionAtlasiQ15697. baseline and differential.
GenevestigatoriQ15697.

Organism-specific databases

HPAiHPA009656.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi113516. 13 interactions.
IntActiQ15697. 2 interactions.
STRINGi9606.ENSP00000268655.

Structurei

Secondary structure

1
407
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 433Combined sources
Helixi44 – 507Combined sources
Helixi61 – 7515Combined sources
Helixi82 – 9716Combined sources
Helixi101 – 1077Combined sources
Helixi114 – 12512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y7QNMR-A/B37-132[»]
ProteinModelPortaliQ15697.
SMRiQ15697. Positions 37-132, 254-407.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15697.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 12466SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri326 – 34823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40524C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120491.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ15697.
KOiK09230.
OMAiRIFMIAK.
OrthoDBiEOG73RBBH.
PhylomeDBiQ15697.
TreeFamiTF338582.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR027778. Zfp174.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF10. PTHR10032:SF10. 1 hit.
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15697-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR
60 70 80 90 100
RFCYQEVSGP QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP
110 120 130 140 150
EIQARVRHRC PMSSKEIVTL VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG
160 170 180 190 200
SQLGEQELPD FQPQTPRRDL RESSPAEPSQ AGAYDRLSPH HWEKSPLLQE
210 220 230 240 250
PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK GNGLQNPEPR
260 270 280 290 300
GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS
310 320 330 340 350
KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG
360 370 380 390 400
ERPYTCGECG NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH

HRLHHGD
Length:407
Mass (Da):46,455
Last modified:November 1, 1996 - v1
Checksum:i1FAB4A631EA2ABCC
GO
Isoform 2 (identifier: Q15697-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-234: APRMRSDNKENPQQEGAKGAKPCAV → LLIEKTDPNMATDELPCKLWLSFIA
     235-407: Missing.

Show »
Length:234
Mass (Da):26,884
Checksum:iA2A40D0A1AA96BC6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei210 – 23425APRMR…KPCAV → LLIEKTDPNMATDELPCKLW LSFIA in isoform 2. 2 PublicationsVSP_006897Add
BLAST
Alternative sequencei235 – 407173Missing in isoform 2. 2 PublicationsVSP_006898Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31248 mRNA. Translation: AAB04897.1.
BT006923 mRNA. Translation: AAP35569.1.
BC000876 mRNA. Translation: AAH00876.1.
BC001161 mRNA. Translation: AAH01161.1.
CCDSiCCDS10504.1. [Q15697-1]
CCDS32380.1. [Q15697-2]
PIRiI39152.
RefSeqiNP_001027463.1. NM_001032292.2. [Q15697-2]
NP_003441.1. NM_003450.2. [Q15697-1]
UniGeneiHs.155204.

Genome annotation databases

EnsembliENST00000268655; ENSP00000268655; ENSG00000103343. [Q15697-1]
ENST00000344823; ENSP00000339781; ENSG00000103343. [Q15697-2]
ENST00000571936; ENSP00000460397; ENSG00000103343. [Q15697-1]
ENST00000575752; ENSP00000461502; ENSG00000103343. [Q15697-2]
GeneIDi7727.
KEGGihsa:7727.
UCSCiuc002cvb.3. human. [Q15697-2]
uc002cvc.3. human. [Q15697-1]

Polymorphism databases

DMDMi3123173.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31248 mRNA. Translation: AAB04897.1 .
BT006923 mRNA. Translation: AAP35569.1 .
BC000876 mRNA. Translation: AAH00876.1 .
BC001161 mRNA. Translation: AAH01161.1 .
CCDSi CCDS10504.1. [Q15697-1 ]
CCDS32380.1. [Q15697-2 ]
PIRi I39152.
RefSeqi NP_001027463.1. NM_001032292.2. [Q15697-2 ]
NP_003441.1. NM_003450.2. [Q15697-1 ]
UniGenei Hs.155204.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Y7Q NMR - A/B 37-132 [» ]
ProteinModelPortali Q15697.
SMRi Q15697. Positions 37-132, 254-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113516. 13 interactions.
IntActi Q15697. 2 interactions.
STRINGi 9606.ENSP00000268655.

PTM databases

PhosphoSitei Q15697.

Polymorphism databases

DMDMi 3123173.

Proteomic databases

MaxQBi Q15697.
PaxDbi Q15697.
PRIDEi Q15697.

Protocols and materials databases

DNASUi 7727.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268655 ; ENSP00000268655 ; ENSG00000103343 . [Q15697-1 ]
ENST00000344823 ; ENSP00000339781 ; ENSG00000103343 . [Q15697-2 ]
ENST00000571936 ; ENSP00000460397 ; ENSG00000103343 . [Q15697-1 ]
ENST00000575752 ; ENSP00000461502 ; ENSG00000103343 . [Q15697-2 ]
GeneIDi 7727.
KEGGi hsa:7727.
UCSCi uc002cvb.3. human. [Q15697-2 ]
uc002cvc.3. human. [Q15697-1 ]

Organism-specific databases

CTDi 7727.
GeneCardsi GC16P003451.
HGNCi HGNC:12963. ZNF174.
HPAi HPA009656.
MIMi 603900. gene.
neXtProti NX_Q15697.
PharmGKBi PA37545.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120491.
HOGENOMi HOG000234619.
HOVERGENi HBG018163.
InParanoidi Q15697.
KOi K09230.
OMAi RIFMIAK.
OrthoDBi EOG73RBBH.
PhylomeDBi Q15697.
TreeFami TF338582.

Miscellaneous databases

ChiTaRSi ZNF174. human.
EvolutionaryTracei Q15697.
GenomeRNAii 7727.
NextBioi 29924.
PROi Q15697.
SOURCEi Search...

Gene expression databases

Bgeei Q15697.
CleanExi HS_ZNF174.
ExpressionAtlasi Q15697. baseline and differential.
Genevestigatori Q15697.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR027778. Zfp174.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
PTHR10032:SF10. PTHR10032:SF10. 1 hit.
Pfami PF02023. SCAN. 1 hit.
[Graphical view ]
SMARTi SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel zinc-finger protein with transcription repressor activity."
    Williams A.J., Khachigian L.M., Shows T., Collins T.
    J. Biol. Chem. 270:22143-22152(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cervix and Lung.
  4. "Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain."
    Ivanov D., Stone J.R., Maki J.L., Collins T., Wagner G.
    Mol. Cell 17:137-143(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 37-132, SUBUNIT.

Entry informationi

Entry nameiZN174_HUMAN
AccessioniPrimary (citable) accession number: Q15697
Secondary accession number(s): Q53Y68, Q9BQ34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3