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Q15697 (ZN174_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 174
Alternative name(s):
AW-1
Zinc finger and SCAN domain-containing protein 8
Gene names
Name:ZNF174
Synonyms:ZSCAN8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor. Ref.1

Subunit structure

Homodimer. Ref.4

Subcellular location

Nucleus.

Tissue specificity

Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q15697-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q15697-2)

The sequence of this isoform differs from the canonical sequence as follows:
     210-234: APRMRSDNKENPQQEGAKGAKPCAV → LLIEKTDPNMATDELPCKLWLSFIA
     235-407: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Zinc finger protein 174
PRO_0000047439

Regions

Domain59 – 12466SCAN box
Zinc finger326 – 34823C2H2-type 1
Zinc finger354 – 37623C2H2-type 2
Zinc finger382 – 40524C2H2-type 3

Natural variations

Alternative sequence210 – 23425APRMR…KPCAV → LLIEKTDPNMATDELPCKLW LSFIA in isoform 2.
VSP_006897
Alternative sequence235 – 407173Missing in isoform 2.
VSP_006898

Secondary structure

............ 407
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1FAB4A631EA2ABCC

FASTA40746,455
        10         20         30         40         50         60 
MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR RFCYQEVSGP 

        70         80         90        100        110        120 
QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP EIQARVRHRC PMSSKEIVTL 

       130        140        150        160        170        180 
VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG SQLGEQELPD FQPQTPRRDL RESSPAEPSQ 

       190        200        210        220        230        240 
AGAYDRLSPH HWEKSPLLQE PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK 

       250        260        270        280        290        300 
GNGLQNPEPR GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS 

       310        320        330        340        350        360 
KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG ERPYTCGECG 

       370        380        390        400 
NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH HRLHHGD 

« Hide

Isoform 2 [UniParc].

Checksum: A2A40D0A1AA96BC6
Show »

FASTA23426,884

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel zinc-finger protein with transcription repressor activity."
Williams A.J., Khachigian L.M., Shows T., Collins T.
J. Biol. Chem. 270:22143-22152(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Cervix and Lung.
[4]"Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain."
Ivanov D., Stone J.R., Maki J.L., Collins T., Wagner G.
Mol. Cell 17:137-143(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 37-132, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31248 mRNA. Translation: AAB04897.1.
BT006923 mRNA. Translation: AAP35569.1.
BC000876 mRNA. Translation: AAH00876.1.
BC001161 mRNA. Translation: AAH01161.1.
CCDSCCDS10504.1. [Q15697-1]
CCDS32380.1. [Q15697-2]
PIRI39152.
RefSeqNP_001027463.1. NM_001032292.2. [Q15697-2]
NP_003441.1. NM_003450.2. [Q15697-1]
UniGeneHs.155204.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y7QNMR-A/B37-132[»]
ProteinModelPortalQ15697.
SMRQ15697. Positions 37-132, 254-407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113516. 8 interactions.
IntActQ15697. 2 interactions.
STRING9606.ENSP00000268655.

PTM databases

PhosphoSiteQ15697.

Polymorphism databases

DMDM3123173.

Proteomic databases

MaxQBQ15697.
PaxDbQ15697.
PRIDEQ15697.

Protocols and materials databases

DNASU7727.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268655; ENSP00000268655; ENSG00000103343. [Q15697-1]
ENST00000344823; ENSP00000339781; ENSG00000103343. [Q15697-2]
ENST00000571936; ENSP00000460397; ENSG00000103343. [Q15697-1]
ENST00000575752; ENSP00000461502; ENSG00000103343. [Q15697-2]
GeneID7727.
KEGGhsa:7727.
UCSCuc002cvb.3. human. [Q15697-2]
uc002cvc.3. human. [Q15697-1]

Organism-specific databases

CTD7727.
GeneCardsGC16P003451.
HGNCHGNC:12963. ZNF174.
HPAHPA009656.
MIM603900. gene.
neXtProtNX_Q15697.
PharmGKBPA37545.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234619.
HOVERGENHBG018163.
InParanoidQ15697.
KOK09230.
OMARIFMIAK.
OrthoDBEOG73RBBH.
PhylomeDBQ15697.
TreeFamTF338582.

Gene expression databases

ArrayExpressQ15697.
BgeeQ15697.
CleanExHS_ZNF174.
GenevestigatorQ15697.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR027778. Zfp174.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF10. PTHR10032:SF10. 1 hit.
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF174. human.
EvolutionaryTraceQ15697.
GenomeRNAi7727.
NextBio29924.
PROQ15697.
SOURCESearch...

Entry information

Entry nameZN174_HUMAN
AccessionPrimary (citable) accession number: Q15697
Secondary accession number(s): Q53Y68, Q9BQ34
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM