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Protein

Zinc finger protein 174

Gene

ZNF174

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri326 – 348C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103343-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 174
Alternative name(s):
AW-1
Zinc finger and SCAN domain-containing protein 8
Gene namesi
Name:ZNF174
Synonyms:ZSCAN8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:12963. ZNF174.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103343.
PharmGKBiPA37545.

Polymorphism and mutation databases

BioMutaiZNF174.
DMDMi3123173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474391 – 407Zinc finger protein 174Add BLAST407

Proteomic databases

EPDiQ15697.
MaxQBiQ15697.
PaxDbiQ15697.
PeptideAtlasiQ15697.
PRIDEiQ15697.

PTM databases

iPTMnetiQ15697.
PhosphoSitePlusiQ15697.

Expressioni

Tissue specificityi

Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Gene expression databases

BgeeiENSG00000103343.
CleanExiHS_ZNF174.
ExpressionAtlasiQ15697. baseline and differential.
GenevisibleiQ15697. HS.

Organism-specific databases

HPAiHPA009656.

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi113516. 19 interactors.
IntActiQ15697. 4 interactors.
STRINGi9606.ENSP00000268655.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 43Combined sources3
Helixi44 – 50Combined sources7
Helixi61 – 75Combined sources15
Helixi82 – 97Combined sources16
Helixi101 – 107Combined sources7
Helixi114 – 125Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y7QNMR-A/B37-132[»]
ProteinModelPortaliQ15697.
SMRiQ15697.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15697.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri326 – 348C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 405C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ15697.
KOiK09230.
OMAiVSPPNAQ.
OrthoDBiEOG091G09O3.
PhylomeDBiQ15697.
TreeFamiTF338582.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027778. Zfp174.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF10. PTHR10032:SF10. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15697-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR
60 70 80 90 100
RFCYQEVSGP QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP
110 120 130 140 150
EIQARVRHRC PMSSKEIVTL VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG
160 170 180 190 200
SQLGEQELPD FQPQTPRRDL RESSPAEPSQ AGAYDRLSPH HWEKSPLLQE
210 220 230 240 250
PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK GNGLQNPEPR
260 270 280 290 300
GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS
310 320 330 340 350
KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG
360 370 380 390 400
ERPYTCGECG NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH

HRLHHGD
Length:407
Mass (Da):46,455
Last modified:November 1, 1996 - v1
Checksum:i1FAB4A631EA2ABCC
GO
Isoform 2 (identifier: Q15697-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-234: APRMRSDNKENPQQEGAKGAKPCAV → LLIEKTDPNMATDELPCKLWLSFIA
     235-407: Missing.

Show »
Length:234
Mass (Da):26,884
Checksum:iA2A40D0A1AA96BC6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006897210 – 234APRMR…KPCAV → LLIEKTDPNMATDELPCKLW LSFIA in isoform 2. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_006898235 – 407Missing in isoform 2. 2 PublicationsAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31248 mRNA. Translation: AAB04897.1.
BT006923 mRNA. Translation: AAP35569.1.
BC000876 mRNA. Translation: AAH00876.1.
BC001161 mRNA. Translation: AAH01161.1.
CCDSiCCDS10504.1. [Q15697-1]
CCDS32380.1. [Q15697-2]
PIRiI39152.
RefSeqiNP_001027463.1. NM_001032292.2. [Q15697-2]
NP_003441.1. NM_003450.2. [Q15697-1]
UniGeneiHs.155204.

Genome annotation databases

EnsembliENST00000268655; ENSP00000268655; ENSG00000103343. [Q15697-1]
ENST00000344823; ENSP00000339781; ENSG00000103343. [Q15697-2]
ENST00000571936; ENSP00000460397; ENSG00000103343. [Q15697-1]
ENST00000575752; ENSP00000461502; ENSG00000103343. [Q15697-2]
GeneIDi7727.
KEGGihsa:7727.
UCSCiuc002cvb.4. human. [Q15697-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31248 mRNA. Translation: AAB04897.1.
BT006923 mRNA. Translation: AAP35569.1.
BC000876 mRNA. Translation: AAH00876.1.
BC001161 mRNA. Translation: AAH01161.1.
CCDSiCCDS10504.1. [Q15697-1]
CCDS32380.1. [Q15697-2]
PIRiI39152.
RefSeqiNP_001027463.1. NM_001032292.2. [Q15697-2]
NP_003441.1. NM_003450.2. [Q15697-1]
UniGeneiHs.155204.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y7QNMR-A/B37-132[»]
ProteinModelPortaliQ15697.
SMRiQ15697.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113516. 19 interactors.
IntActiQ15697. 4 interactors.
STRINGi9606.ENSP00000268655.

PTM databases

iPTMnetiQ15697.
PhosphoSitePlusiQ15697.

Polymorphism and mutation databases

BioMutaiZNF174.
DMDMi3123173.

Proteomic databases

EPDiQ15697.
MaxQBiQ15697.
PaxDbiQ15697.
PeptideAtlasiQ15697.
PRIDEiQ15697.

Protocols and materials databases

DNASUi7727.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268655; ENSP00000268655; ENSG00000103343. [Q15697-1]
ENST00000344823; ENSP00000339781; ENSG00000103343. [Q15697-2]
ENST00000571936; ENSP00000460397; ENSG00000103343. [Q15697-1]
ENST00000575752; ENSP00000461502; ENSG00000103343. [Q15697-2]
GeneIDi7727.
KEGGihsa:7727.
UCSCiuc002cvb.4. human. [Q15697-1]

Organism-specific databases

CTDi7727.
GeneCardsiZNF174.
HGNCiHGNC:12963. ZNF174.
HPAiHPA009656.
MIMi603900. gene.
neXtProtiNX_Q15697.
OpenTargetsiENSG00000103343.
PharmGKBiPA37545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ15697.
KOiK09230.
OMAiVSPPNAQ.
OrthoDBiEOG091G09O3.
PhylomeDBiQ15697.
TreeFamiTF338582.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103343-MONOMER.

Miscellaneous databases

ChiTaRSiZNF174. human.
EvolutionaryTraceiQ15697.
GenomeRNAii7727.
PROiQ15697.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103343.
CleanExiHS_ZNF174.
ExpressionAtlasiQ15697. baseline and differential.
GenevisibleiQ15697. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027778. Zfp174.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF10. PTHR10032:SF10. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN174_HUMAN
AccessioniPrimary (citable) accession number: Q15697
Secondary accession number(s): Q53Y68, Q9BQ34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.