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Q15697

- ZN174_HUMAN

UniProt

Q15697 - ZN174_HUMAN

Protein

Zinc finger protein 174

Gene

ZNF174

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcriptional repressor.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri326 – 34823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri382 – 40524C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein homodimerization activity Source: UniProtKB
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 174
    Alternative name(s):
    AW-1
    Zinc finger and SCAN domain-containing protein 8
    Gene namesi
    Name:ZNF174
    Synonyms:ZSCAN8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:12963. ZNF174.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: HPA
    2. cytoplasm Source: HPA
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37545.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Zinc finger protein 174PRO_0000047439Add
    BLAST

    Proteomic databases

    MaxQBiQ15697.
    PaxDbiQ15697.
    PRIDEiQ15697.

    PTM databases

    PhosphoSiteiQ15697.

    Expressioni

    Tissue specificityi

    Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

    Gene expression databases

    ArrayExpressiQ15697.
    BgeeiQ15697.
    CleanExiHS_ZNF174.
    GenevestigatoriQ15697.

    Organism-specific databases

    HPAiHPA009656.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi113516. 8 interactions.
    IntActiQ15697. 2 interactions.
    STRINGi9606.ENSP00000268655.

    Structurei

    Secondary structure

    1
    407
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi41 – 433
    Helixi44 – 507
    Helixi61 – 7515
    Helixi82 – 9716
    Helixi101 – 1077
    Helixi114 – 12512

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Y7QNMR-A/B37-132[»]
    ProteinModelPortaliQ15697.
    SMRiQ15697. Positions 37-132, 254-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15697.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 12466SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri326 – 34823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri382 – 40524C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiQ15697.
    KOiK09230.
    OMAiRIFMIAK.
    OrthoDBiEOG73RBBH.
    PhylomeDBiQ15697.
    TreeFamiTF338582.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR027778. Zfp174.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF10. PTHR10032:SF10. 1 hit.
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15697-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR    50
    RFCYQEVSGP QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP 100
    EIQARVRHRC PMSSKEIVTL VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG 150
    SQLGEQELPD FQPQTPRRDL RESSPAEPSQ AGAYDRLSPH HWEKSPLLQE 200
    PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK GNGLQNPEPR 250
    GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS 300
    KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG 350
    ERPYTCGECG NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH 400
    HRLHHGD 407
    Length:407
    Mass (Da):46,455
    Last modified:November 1, 1996 - v1
    Checksum:i1FAB4A631EA2ABCC
    GO
    Isoform 2 (identifier: Q15697-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-234: APRMRSDNKENPQQEGAKGAKPCAV → LLIEKTDPNMATDELPCKLWLSFIA
         235-407: Missing.

    Show »
    Length:234
    Mass (Da):26,884
    Checksum:iA2A40D0A1AA96BC6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei210 – 23425APRMR…KPCAV → LLIEKTDPNMATDELPCKLW LSFIA in isoform 2. 2 PublicationsVSP_006897Add
    BLAST
    Alternative sequencei235 – 407173Missing in isoform 2. 2 PublicationsVSP_006898Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31248 mRNA. Translation: AAB04897.1.
    BT006923 mRNA. Translation: AAP35569.1.
    BC000876 mRNA. Translation: AAH00876.1.
    BC001161 mRNA. Translation: AAH01161.1.
    CCDSiCCDS10504.1. [Q15697-1]
    CCDS32380.1. [Q15697-2]
    PIRiI39152.
    RefSeqiNP_001027463.1. NM_001032292.2. [Q15697-2]
    NP_003441.1. NM_003450.2. [Q15697-1]
    UniGeneiHs.155204.

    Genome annotation databases

    EnsembliENST00000268655; ENSP00000268655; ENSG00000103343. [Q15697-1]
    ENST00000344823; ENSP00000339781; ENSG00000103343. [Q15697-2]
    ENST00000571936; ENSP00000460397; ENSG00000103343. [Q15697-1]
    ENST00000575752; ENSP00000461502; ENSG00000103343. [Q15697-2]
    GeneIDi7727.
    KEGGihsa:7727.
    UCSCiuc002cvb.3. human. [Q15697-2]
    uc002cvc.3. human. [Q15697-1]

    Polymorphism databases

    DMDMi3123173.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31248 mRNA. Translation: AAB04897.1 .
    BT006923 mRNA. Translation: AAP35569.1 .
    BC000876 mRNA. Translation: AAH00876.1 .
    BC001161 mRNA. Translation: AAH01161.1 .
    CCDSi CCDS10504.1. [Q15697-1 ]
    CCDS32380.1. [Q15697-2 ]
    PIRi I39152.
    RefSeqi NP_001027463.1. NM_001032292.2. [Q15697-2 ]
    NP_003441.1. NM_003450.2. [Q15697-1 ]
    UniGenei Hs.155204.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Y7Q NMR - A/B 37-132 [» ]
    ProteinModelPortali Q15697.
    SMRi Q15697. Positions 37-132, 254-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113516. 8 interactions.
    IntActi Q15697. 2 interactions.
    STRINGi 9606.ENSP00000268655.

    PTM databases

    PhosphoSitei Q15697.

    Polymorphism databases

    DMDMi 3123173.

    Proteomic databases

    MaxQBi Q15697.
    PaxDbi Q15697.
    PRIDEi Q15697.

    Protocols and materials databases

    DNASUi 7727.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268655 ; ENSP00000268655 ; ENSG00000103343 . [Q15697-1 ]
    ENST00000344823 ; ENSP00000339781 ; ENSG00000103343 . [Q15697-2 ]
    ENST00000571936 ; ENSP00000460397 ; ENSG00000103343 . [Q15697-1 ]
    ENST00000575752 ; ENSP00000461502 ; ENSG00000103343 . [Q15697-2 ]
    GeneIDi 7727.
    KEGGi hsa:7727.
    UCSCi uc002cvb.3. human. [Q15697-2 ]
    uc002cvc.3. human. [Q15697-1 ]

    Organism-specific databases

    CTDi 7727.
    GeneCardsi GC16P003451.
    HGNCi HGNC:12963. ZNF174.
    HPAi HPA009656.
    MIMi 603900. gene.
    neXtProti NX_Q15697.
    PharmGKBi PA37545.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi Q15697.
    KOi K09230.
    OMAi RIFMIAK.
    OrthoDBi EOG73RBBH.
    PhylomeDBi Q15697.
    TreeFami TF338582.

    Miscellaneous databases

    ChiTaRSi ZNF174. human.
    EvolutionaryTracei Q15697.
    GenomeRNAii 7727.
    NextBioi 29924.
    PROi Q15697.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15697.
    Bgeei Q15697.
    CleanExi HS_ZNF174.
    Genevestigatori Q15697.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR027778. Zfp174.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF10. PTHR10032:SF10. 1 hit.
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel zinc-finger protein with transcription repressor activity."
      Williams A.J., Khachigian L.M., Shows T., Collins T.
      J. Biol. Chem. 270:22143-22152(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cervix and Lung.
    4. "Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain."
      Ivanov D., Stone J.R., Maki J.L., Collins T., Wagner G.
      Mol. Cell 17:137-143(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 37-132, SUBUNIT.

    Entry informationi

    Entry nameiZN174_HUMAN
    AccessioniPrimary (citable) accession number: Q15697
    Secondary accession number(s): Q53Y68, Q9BQ34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 143 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3