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Q15695

- U2AFL_HUMAN

UniProt

Q15695 - U2AFL_HUMAN

Protein

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

Gene

ZRSR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri171 – 19929C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri311 – 33828C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
    Alternative name(s):
    CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1
    U2(RNU2) small nuclear RNA auxiliary factor 1-like 1
    Gene namesi
    Name:ZRSR1
    Synonyms:U2AF1-RS1, U2AF1L1, U2AF1P, U2AF1RS1, U2AFBPL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:12456. ZRSR1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. ribonucleoprotein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37106.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1PRO_0000081999Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei354 – 3541PhosphoserineBy similarity
    Modified residuei389 – 3891PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15695.
    PaxDbiQ15695.
    PRIDEiQ15695.

    PTM databases

    PhosphoSiteiQ15695.

    Expressioni

    Gene expression databases

    GenevestigatoriQ15695.

    Organism-specific databases

    HPAiHPA047500.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15695.
    SMRiQ15695. Positions 233-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini203 – 309107RRMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri171 – 19929C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri311 – 33828C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG304335.
    HOGENOMiHOG000049279.
    HOVERGENiHBG054605.
    InParanoidiQ15695.
    OMAiQWKEQQR.
    OrthoDBiEOG70089G.
    PhylomeDBiQ15695.
    TreeFamiTF324447.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR009145. U2_small.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PANTHERiPTHR12620. PTHR12620. 1 hit.
    PfamiPF00642. zf-CCCH. 1 hit.
    [Graphical view]
    PRINTSiPR01848. U2AUXFACTOR.
    SMARTiSM00360. RRM. 1 hit.
    SM00356. ZnF_C3H1. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    PS50103. ZF_C3H1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15695-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALEKMTFP KKMTFPEKPS HKKYRAALKK EKRKKRRQEL ARLRDSGLSQ    50
    EEEEDTFIEE QQLEEEKLLE RERERLHEEW LLREQKAQEE FRIKKEKEEA 100
    AKKWLEEQER KLKEQWKEQQ RKEREEEEQK QQEKKEKEEA VQKMLDQAEN 150
    DLENSTTWQN PEPPVDFRVM EKDRANCPFY SKTGACRFGD RCSRKHNFPT 200
    SSPTLLIKSM FTTFGMEQCR RDDYDPDASL EYSEEETYQQ FLDFYEDVLP 250
    EFKNVGKVIQ FKVSCNLEPH LRGNVYVQYQ SEEECQAALS LFNGRWYAGR 300
    QLQCEFCPVT RWKMAICGLF EIQQCPRGKH CNFLHVFRNP NNEFWEANRD 350
    IYLSSDQTGS SFGKNSERRE KMGHHDHYYS RQRGRRNPSP DHTYKRNGES 400
    ERKKSSHRGK KSHKRTSKSR ERHNSPSRGR NRHRSWDQGR RSQSRRSHRS 450
    RSQSSSRCRS RGRRKSGNRD RTVQSPQSK 479
    Length:479
    Mass (Da):57,643
    Last modified:November 1, 1997 - v2
    Checksum:i96F326694BD4E7C0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351K → E in BAG36348. (PubMed:14702039)Curated
    Sequence conflicti195 – 1951K → R in BAG36348. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49676 mRNA. Translation: BAA08532.1.
    U51224 Genomic DNA. Translation: AAA98669.1.
    AK313576 mRNA. Translation: BAG36348.1.
    UniGeneiHs.637001.

    Genome annotation databases

    EnsembliENST00000391338; ENSP00000375133; ENSG00000212643.
    UCSCiuc021ycm.1. human.

    Polymorphism databases

    DMDMi2833265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49676 mRNA. Translation: BAA08532.1 .
    U51224 Genomic DNA. Translation: AAA98669.1 .
    AK313576 mRNA. Translation: BAG36348.1 .
    UniGenei Hs.637001.

    3D structure databases

    ProteinModelPortali Q15695.
    SMRi Q15695. Positions 233-308.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q15695.

    Polymorphism databases

    DMDMi 2833265.

    Proteomic databases

    MaxQBi Q15695.
    PaxDbi Q15695.
    PRIDEi Q15695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391338 ; ENSP00000375133 ; ENSG00000212643 .
    UCSCi uc021ycm.1. human.

    Organism-specific databases

    GeneCardsi GC05P112228.
    HGNCi HGNC:12456. ZRSR1.
    HPAi HPA047500.
    MIMi 601079. gene.
    neXtProti NX_Q15695.
    PharmGKBi PA37106.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304335.
    HOGENOMi HOG000049279.
    HOVERGENi HBG054605.
    InParanoidi Q15695.
    OMAi QWKEQQR.
    OrthoDBi EOG70089G.
    PhylomeDBi Q15695.
    TreeFami TF324447.

    Miscellaneous databases

    PROi Q15695.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q15695.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR009145. U2_small.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    PANTHERi PTHR12620. PTHR12620. 1 hit.
    Pfami PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    PRINTSi PR01848. U2AUXFACTOR.
    SMARTi SM00360. RRM. 1 hit.
    SM00356. ZnF_C3H1. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    PS50103. ZF_C3H1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1."
      Kitagawa K., Wang X., Hatada I., Yamaoka T., Nojima H., Inazawa J., Abe T., Mitsuya K., Oshimura M., Murata A., Monden M., Mukai T.
      Genomics 30:257-263(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.

    Entry informationi

    Entry nameiU2AFL_HUMAN
    AccessioniPrimary (citable) accession number: Q15695
    Secondary accession number(s): B2R901, Q13570, Q2M3R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3