Q15695 (U2AFL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

Alternative name(s):
CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1
U2(RNU2) small nuclear RNA auxiliary factor 1-like 1

Gene names

Name:	ZRSR1
Synonyms:	U2AF1-RS1, U2AF1L1, U2AF1P, U2AF1RS1, U2AFBPL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Contains 2 C3H1-type zinc fingers. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding RNA-binding Zinc
Molecular function	Ribonucleoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Non-traceable author statement. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1		PRO_0000081999
Regions
	Domain	203 – 309	107	RRM
	Zinc finger	171 – 199	29	C3H1-type 1
	Zinc finger	311 – 338	28	C3H1-type 2
Experimental info
	Sequence conflict	135	1	K → E in BAG36348. Ref.3
	Sequence conflict	195	1	K → R in BAG36348. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q15695 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 96F326694BD4E7C0	FASTA	479	57,643
	10 20 30 40 50 60 MAALEKMTFP KKMTFPEKPS HKKYRAALKK EKRKKRRQEL ARLRDSGLSQ EEEEDTFIEE 70 80 90 100 110 120 QQLEEEKLLE RERERLHEEW LLREQKAQEE FRIKKEKEEA AKKWLEEQER KLKEQWKEQQ 130 140 150 160 170 180 RKEREEEEQK QQEKKEKEEA VQKMLDQAEN DLENSTTWQN PEPPVDFRVM EKDRANCPFY 190 200 210 220 230 240 SKTGACRFGD RCSRKHNFPT SSPTLLIKSM FTTFGMEQCR RDDYDPDASL EYSEEETYQQ 250 260 270 280 290 300 FLDFYEDVLP EFKNVGKVIQ FKVSCNLEPH LRGNVYVQYQ SEEECQAALS LFNGRWYAGR 310 320 330 340 350 360 QLQCEFCPVT RWKMAICGLF EIQQCPRGKH CNFLHVFRNP NNEFWEANRD IYLSSDQTGS 370 380 390 400 410 420 SFGKNSERRE KMGHHDHYYS RQRGRRNPSP DHTYKRNGES ERKKSSHRGK KSHKRTSKSR 430 440 450 460 470 ERHNSPSRGR NRHRSWDQGR RSQSRRSHRS RSQSSSRCRS RGRRKSGNRD RTVQSPQSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1." Kitagawa K., Wang X., Hatada I., Yamaoka T., Nojima H., Inazawa J., Abe T., Mitsuya K., Oshimura M., Murata A., Monden M., Mukai T. Genomics 30:257-263(1995) [PubMed: 8586425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs." Pearsall R.S., Shibata H., Brozowska A., Yoshino K., Okuda K., Dejong P.J., Plass C., Chapman V.M., Hayashizaki Y., Held W.A. Biochem. Biophys. Res. Commun. 222:171-177(1996) [PubMed: 8630064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49676 mRNA. Translation: BAA08532.1. U51224 Genomic DNA. Translation: AAA98669.1. AK313576 mRNA. Translation: BAG36348.1.
IPI	IPI00018952.
UniGene	Hs.637001.
3D structure databases
ProteinModelPortal	Q15695.
SMR	Q15695. Positions 202-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15695.
PTM databases
PhosphoSite	Q15695.
Polymorphism databases
DMDM	2833265.
Proteomic databases
PRIDE	Q15695.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391338; ENSP00000375133; ENSG00000212643.
UCSC	uc003kqd.2. human.
Organism-specific databases
GeneCards	GC05P112228.
H-InvDB	HIX0017758.
HGNC	HGNC:12456. ZRSR1.
MIM	601079. gene.
neXtProt	NX_Q15695.
PharmGKB	PA37106.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19602.
GeneTree	ENSGT00530000063193.
HOGENOM	HBG525917.
HOVERGEN	HBG054605.
InParanoid	Q15695.
OMA	ERLHEEW.
OrthoDB	EOG4CNQRM.
PhylomeDB	Q15695.
Gene expression databases
ArrayExpress	Q15695.
Genevestigator	Q15695.
GermOnline	ENSG00000174044. Homo sapiens.
Family and domain databases
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. IPR009145. U2_small. IPR000571. Znf_CCCH. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
PANTHER	PTHR12620. U2_small. 1 hit.
Pfam	PF00076. RRM_1. 1 hit. PF00642. zf-CCCH. 1 hit. [Graphical view]
PRINTS	PR01848. U2AUXFACTOR.
SMART	SM00360. RRM. 1 hit. SM00356. ZnF_C3H1. 2 hits. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. PS50103. ZF_C3H1. 2 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

U2AFL_HUMAN

Accession

Primary (citable) accession number: Q15695
Secondary accession number(s): B2R901, Q13570, Q2M3R8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.