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Protein

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

Gene

ZRSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 199C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri311 – 338C3H1-type 2PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
Alternative name(s):
CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1
U2(RNU2) small nuclear RNA auxiliary factor 1-like 1
Gene namesi
Name:ZRSR1
Synonyms:U2AF1-RS1, U2AF1L1, U2AF1P, U2AF1RS1, U2AFBPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000212643.2.
HGNCiHGNC:12456. ZRSR1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7310.
OpenTargetsiENSG00000212643.
PharmGKBiPA37106.

Polymorphism and mutation databases

DMDMi2833265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819991 – 479U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei354PhosphoserineBy similarity1
Modified residuei389PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15695.
MaxQBiQ15695.
PaxDbiQ15695.
PeptideAtlasiQ15695.
PRIDEiQ15695.

PTM databases

iPTMnetiQ15695.
PhosphoSitePlusiQ15695.
SwissPalmiQ15695.

Expressioni

Gene expression databases

BgeeiENSG00000212643.
GenevisibleiQ15695. HS.

Interactioni

Protein-protein interaction databases

IntActiQ15695. 3 interactors.
STRINGi9606.ENSP00000375133.

Structurei

3D structure databases

ProteinModelPortaliQ15695.
SMRiQ15695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 309RRMPROSITE-ProRule annotationAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 199C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri311 – 338C3H1-type 2PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2202. Eukaryota.
ENOG410Z5PX. LUCA.
GeneTreeiENSGT00530000063193.
HOGENOMiHOG000049279.
HOVERGENiHBG054605.
InParanoidiQ15695.
OMAiDAMMESM.
OrthoDBiEOG091G0CUI.
PhylomeDBiQ15695.
TreeFamiTF324447.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiView protein in InterPro
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
IPR009145. U2AF_small.
IPR000571. Znf_CCCH.
IPR036855. Znf_CCCH_sf.
PANTHERiPTHR12620. PTHR12620. 1 hit.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
PF00642. zf-CCCH. 2 hits.
PRINTSiPR01848. U2AUXFACTOR.
SMARTiView protein in SMART
SM00361. RRM_1. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.

Sequencei

Sequence statusi: Complete.

Q15695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALEKMTFP KKMTFPEKPS HKKYRAALKK EKRKKRRQEL ARLRDSGLSQ
60 70 80 90 100
EEEEDTFIEE QQLEEEKLLE RERERLHEEW LLREQKAQEE FRIKKEKEEA
110 120 130 140 150
AKKWLEEQER KLKEQWKEQQ RKEREEEEQK QQEKKEKEEA VQKMLDQAEN
160 170 180 190 200
DLENSTTWQN PEPPVDFRVM EKDRANCPFY SKTGACRFGD RCSRKHNFPT
210 220 230 240 250
SSPTLLIKSM FTTFGMEQCR RDDYDPDASL EYSEEETYQQ FLDFYEDVLP
260 270 280 290 300
EFKNVGKVIQ FKVSCNLEPH LRGNVYVQYQ SEEECQAALS LFNGRWYAGR
310 320 330 340 350
QLQCEFCPVT RWKMAICGLF EIQQCPRGKH CNFLHVFRNP NNEFWEANRD
360 370 380 390 400
IYLSSDQTGS SFGKNSERRE KMGHHDHYYS RQRGRRNPSP DHTYKRNGES
410 420 430 440 450
ERKKSSHRGK KSHKRTSKSR ERHNSPSRGR NRHRSWDQGR RSQSRRSHRS
460 470
RSQSSSRCRS RGRRKSGNRD RTVQSPQSK
Length:479
Mass (Da):57,643
Last modified:November 1, 1997 - v2
Checksum:i96F326694BD4E7C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135K → E in BAG36348 (PubMed:14702039).Curated1
Sequence conflicti195K → R in BAG36348 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49676 mRNA. Translation: BAA08532.1.
U51224 Genomic DNA. Translation: AAA98669.1.
AK313576 mRNA. Translation: BAG36348.1.
UniGeneiHs.637001.

Genome annotation databases

EnsembliENST00000391338; ENSP00000375133; ENSG00000212643.
UCSCiuc021ycm.2. human.

Similar proteinsi

Entry informationi

Entry nameiU2AFL_HUMAN
AccessioniPrimary (citable) accession number: Q15695
Secondary accession number(s): B2R901, Q13570, Q2M3R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot