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Protein

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

Gene

ZRSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19929C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33828C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
Alternative name(s):
CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1
U2(RNU2) small nuclear RNA auxiliary factor 1-like 1
Gene namesi
Name:ZRSR1
Synonyms:U2AF1-RS1, U2AF1L1, U2AF1P, U2AF1RS1, U2AFBPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:12456. ZRSR1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. ribonucleoprotein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1PRO_0000081999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei354 – 3541PhosphoserineBy similarity
Modified residuei389 – 3891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15695.
PaxDbiQ15695.
PRIDEiQ15695.

PTM databases

PhosphoSiteiQ15695.

Expressioni

Gene expression databases

GenevestigatoriQ15695.

Organism-specific databases

HPAiHPA047500.

Structurei

3D structure databases

ProteinModelPortaliQ15695.
SMRiQ15695. Positions 233-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 309107RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri171 – 19929C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33828C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG304335.
GeneTreeiENSGT00530000063193.
HOGENOMiHOG000049279.
HOVERGENiHBG054605.
InParanoidiQ15695.
OMAiQWKEQQR.
OrthoDBiEOG70089G.
PhylomeDBiQ15695.
TreeFamiTF324447.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR009145. U2_small.
IPR000571. Znf_CCCH.
[Graphical view]
PANTHERiPTHR12620. PTHR12620. 1 hit.
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
PRINTSiPR01848. U2AUXFACTOR.
SMARTiSM00360. RRM. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALEKMTFP KKMTFPEKPS HKKYRAALKK EKRKKRRQEL ARLRDSGLSQ
60 70 80 90 100
EEEEDTFIEE QQLEEEKLLE RERERLHEEW LLREQKAQEE FRIKKEKEEA
110 120 130 140 150
AKKWLEEQER KLKEQWKEQQ RKEREEEEQK QQEKKEKEEA VQKMLDQAEN
160 170 180 190 200
DLENSTTWQN PEPPVDFRVM EKDRANCPFY SKTGACRFGD RCSRKHNFPT
210 220 230 240 250
SSPTLLIKSM FTTFGMEQCR RDDYDPDASL EYSEEETYQQ FLDFYEDVLP
260 270 280 290 300
EFKNVGKVIQ FKVSCNLEPH LRGNVYVQYQ SEEECQAALS LFNGRWYAGR
310 320 330 340 350
QLQCEFCPVT RWKMAICGLF EIQQCPRGKH CNFLHVFRNP NNEFWEANRD
360 370 380 390 400
IYLSSDQTGS SFGKNSERRE KMGHHDHYYS RQRGRRNPSP DHTYKRNGES
410 420 430 440 450
ERKKSSHRGK KSHKRTSKSR ERHNSPSRGR NRHRSWDQGR RSQSRRSHRS
460 470
RSQSSSRCRS RGRRKSGNRD RTVQSPQSK
Length:479
Mass (Da):57,643
Last modified:October 31, 1997 - v2
Checksum:i96F326694BD4E7C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351K → E in BAG36348 (PubMed:14702039).Curated
Sequence conflicti195 – 1951K → R in BAG36348 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49676 mRNA. Translation: BAA08532.1.
U51224 Genomic DNA. Translation: AAA98669.1.
AK313576 mRNA. Translation: BAG36348.1.
UniGeneiHs.637001.

Genome annotation databases

EnsembliENST00000391338; ENSP00000375133; ENSG00000212643.
UCSCiuc021ycm.1. human.

Polymorphism databases

DMDMi2833265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49676 mRNA. Translation: BAA08532.1.
U51224 Genomic DNA. Translation: AAA98669.1.
AK313576 mRNA. Translation: BAG36348.1.
UniGeneiHs.637001.

3D structure databases

ProteinModelPortaliQ15695.
SMRiQ15695. Positions 233-308.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ15695.

Polymorphism databases

DMDMi2833265.

Proteomic databases

MaxQBiQ15695.
PaxDbiQ15695.
PRIDEiQ15695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391338; ENSP00000375133; ENSG00000212643.
UCSCiuc021ycm.1. human.

Organism-specific databases

GeneCardsiGC05P112228.
HGNCiHGNC:12456. ZRSR1.
HPAiHPA047500.
MIMi601079. gene.
neXtProtiNX_Q15695.
PharmGKBiPA37106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG304335.
GeneTreeiENSGT00530000063193.
HOGENOMiHOG000049279.
HOVERGENiHBG054605.
InParanoidiQ15695.
OMAiQWKEQQR.
OrthoDBiEOG70089G.
PhylomeDBiQ15695.
TreeFamiTF324447.

Miscellaneous databases

PROiQ15695.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ15695.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR009145. U2_small.
IPR000571. Znf_CCCH.
[Graphical view]
PANTHERiPTHR12620. PTHR12620. 1 hit.
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
PRINTSiPR01848. U2AUXFACTOR.
SMARTiSM00360. RRM. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1."
    Kitagawa K., Wang X., Hatada I., Yamaoka T., Nojima H., Inazawa J., Abe T., Mitsuya K., Oshimura M., Murata A., Monden M., Mukai T.
    Genomics 30:257-263(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.

Entry informationi

Entry nameiU2AFL_HUMAN
AccessioniPrimary (citable) accession number: Q15695
Secondary accession number(s): B2R901, Q13570, Q2M3R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: March 3, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.