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Q15695 (U2AFL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
Alternative name(s):
CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1
U2(RNU2) small nuclear RNA auxiliary factor 1-like 1
Gene names
Name:ZRSR1
Synonyms:U2AF1-RS1, U2AF1L1, U2AF1P, U2AF1RS1, U2AFBPL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 2 C3H1-type zinc fingers.

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
RNA-binding
Zinc
   Molecular functionRibonucleoprotein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonucleoprotein complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
PRO_0000081999

Regions

Domain203 – 309107RRM
Zinc finger171 – 19929C3H1-type 1
Zinc finger311 – 33828C3H1-type 2

Amino acid modifications

Modified residue3541Phosphoserine By similarity
Modified residue3891Phosphoserine By similarity

Experimental info

Sequence conflict1351K → E in BAG36348. Ref.3
Sequence conflict1951K → R in BAG36348. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q15695 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 96F326694BD4E7C0

FASTA47957,643
        10         20         30         40         50         60 
MAALEKMTFP KKMTFPEKPS HKKYRAALKK EKRKKRRQEL ARLRDSGLSQ EEEEDTFIEE 

        70         80         90        100        110        120 
QQLEEEKLLE RERERLHEEW LLREQKAQEE FRIKKEKEEA AKKWLEEQER KLKEQWKEQQ 

       130        140        150        160        170        180 
RKEREEEEQK QQEKKEKEEA VQKMLDQAEN DLENSTTWQN PEPPVDFRVM EKDRANCPFY 

       190        200        210        220        230        240 
SKTGACRFGD RCSRKHNFPT SSPTLLIKSM FTTFGMEQCR RDDYDPDASL EYSEEETYQQ 

       250        260        270        280        290        300 
FLDFYEDVLP EFKNVGKVIQ FKVSCNLEPH LRGNVYVQYQ SEEECQAALS LFNGRWYAGR 

       310        320        330        340        350        360 
QLQCEFCPVT RWKMAICGLF EIQQCPRGKH CNFLHVFRNP NNEFWEANRD IYLSSDQTGS 

       370        380        390        400        410        420 
SFGKNSERRE KMGHHDHYYS RQRGRRNPSP DHTYKRNGES ERKKSSHRGK KSHKRTSKSR 

       430        440        450        460        470 
ERHNSPSRGR NRHRSWDQGR RSQSRRSHRS RSQSSSRCRS RGRRKSGNRD RTVQSPQSK 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1."
Kitagawa K., Wang X., Hatada I., Yamaoka T., Nojima H., Inazawa J., Abe T., Mitsuya K., Oshimura M., Murata A., Monden M., Mukai T.
Genomics 30:257-263(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs."
Pearsall R.S., Shibata H., Brozowska A., Yoshino K., Okuda K., Dejong P.J., Plass C., Chapman V.M., Hayashizaki Y., Held W.A.
Biochem. Biophys. Res. Commun. 222:171-177(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49676 mRNA. Translation: BAA08532.1.
U51224 Genomic DNA. Translation: AAA98669.1.
AK313576 mRNA. Translation: BAG36348.1.
UniGeneHs.637001.

3D structure databases

ProteinModelPortalQ15695.
SMRQ15695. Positions 233-308.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ15695.

Polymorphism databases

DMDM2833265.

Proteomic databases

PaxDbQ15695.
PRIDEQ15695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391338; ENSP00000375133; ENSG00000212643.
UCSCuc021ycm.1. human.

Organism-specific databases

GeneCardsGC05P112228.
HGNCHGNC:12456. ZRSR1.
HPAHPA047500.
MIM601079. gene.
neXtProtNX_Q15695.
PharmGKBPA37106.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304335.
HOGENOMHOG000049279.
HOVERGENHBG054605.
InParanoidQ15695.
OMAQWKEQQR.
OrthoDBEOG70089G.
PhylomeDBQ15695.
TreeFamTF324447.

Gene expression databases

GenevestigatorQ15695.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR009145. U2_small.
IPR000571. Znf_CCCH.
[Graphical view]
PANTHERPTHR12620. PTHR12620. 1 hit.
PfamPF00642. zf-CCCH. 1 hit.
[Graphical view]
PRINTSPR01848. U2AUXFACTOR.
SMARTSM00360. RRM. 1 hit.
SM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ15695.
SOURCESearch...

Entry information

Entry nameU2AFL_HUMAN
AccessionPrimary (citable) accession number: Q15695
Secondary accession number(s): B2R901, Q13570, Q2M3R8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM