Rho-related GTP-binding protein RhoH precursor

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Reviewed, UniProtKB/Swiss-Prot Q15669 (RHOH_HUMAN)

Last modified June 16, 2009. Version 88. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Rho-related GTP-binding protein RhoH
Alternative name(s):
GTP-binding protein TTF

Gene names

Name:	RHOH
Synonyms:	ARHH, TTF

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Transcribed only in hemopoietic cells.
Involvement in disease	A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL6.
Sequence similarities	Belongs to the small GTPase superfamily. Rho family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Chromosomal rearrangement
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Gene Ontology (GO)
Biological process	T cell differentiation Non-traceable author statement. Source: UniProtKB negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay. Source: UniProtKB regulation of transcription Non-traceable author statement. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from direct assay. Source: UniProtKB GTPase inhibitor activity Non-traceable author statement. Source: UniProtKB Rho GTPase binding Non-traceable author statement. Source: UniProtKB kinase inhibitor activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
CNKSR1	Q969H4	1	EBI-1244971,EBI-741671

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 188

188

Rho-related GTP-binding protein RhoH

PRO_0000198867

Propeptide

189 – 191

Removed in mature form By similarity

PRO_0000281218

Regions

Nucleotide binding

11 – 18

GTP By similarity

Nucleotide binding

58 – 62

GTP By similarity

Nucleotide binding

116 – 119

GTP By similarity

Motif

33 – 41

Effector region By similarity

Amino acid modifications

Modified residue

188

Cysteine methyl ester By similarity

Lipidation

188

S-geranylgeranyl cysteine By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q15669-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C5BF8929AD1E59D0
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FASTA

191

21,331

        10         20         30         40         50         60 
MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA 

        70         80         90        100        110        120 
GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIG EIRSNLPCTP VLVVATQTDQ 

       130        140        150        160        170        180 
REMGPHRASC VNAMEGKKLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR 

       190 
RLFSINECKI F

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation." Dallery E., Galiegue-Zouitina S., Collyn-D'Hooghe M., Quief S., Denis C., Hildebrand M.-P., Lantoine D., Deweindt C., Tilly H., Bastard C., Kerckaert J.-P. Oncogene 10:2171-2178(1995) [PubMed: 7784061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
+	Additional computationally mapped references.

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Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Cross-references

Sequence databases
	Z35227 mRNA. Translation: CAA84538.1. AF498975 mRNA. Translation: AAM21122.1. BC014261 mRNA. Translation: AAH14261.1.
IPI	IPI00018882.
PIR	I38367.
RefSeq	NP_004301.1.
UniGene	Hs.654594
3D structure databases
HSSP	HSSP built from PDB template 1AM4 based on UniProtKB P21181.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15669. 1 interaction.
Proteomic databases
PRIDE	Q15669.
Genome annotation databases
Ensembl	ENSG00000168421. Homo sapiens. [Contig view]
GeneID	399.
KEGG	hsa:399.
Organism-specific databases
GeneCards	GC04P039875.
H-InvDB	HIX0004171.
HGNC	HGNC:686. RHOH.
MIM	602037. gene.
PharmGKB	PA24979.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q15669.
HOVERGEN	Q15669.
OMA	Q15669. RASCVNA.
Enzyme and pathway databases
Reactome	REACT_11044. Signaling by Rho GTPases.
Gene expression databases
ArrayExpress	Q15669.
Bgee	Q15669.
CleanEx	HS_RHOH.
GermOnline	ENSG00000168421. Homo sapiens.
Family and domain databases
InterPro	IPR003578. GTPase_Rho. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	1673.
SOURCE	Search...

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Entry information

Entry name

RHOH_HUMAN

Accession

Primary (citable) accession number: Q15669

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents