Thyroid receptor-interacting protein 6

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Reviewed, UniProtKB/Swiss-Prot Q15654 (TRIP6_HUMAN)

Last modified July 7, 2009. Version 81. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Thyroid receptor-interacting protein 6
      Short name=TRIP-6
Alternative name(s):
    OPA-interacting protein 1
    Zyxin-related protein 1
      Short name=ZRP-1

Gene names

Name:	TRIP6
Synonyms:	OIP1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May relays signals from the cell surface to the nucleus.
Subunit structure	Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13. Interacts with SVIL isoform 2.
Tissue specificity	Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas.
Sequence similarities	Belongs to the zyxin/ajuba family. Contains 3 LIM zinc-binding domains.

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Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	focal adhesion formation Non-traceable author statement. Source: UniProtKB positive regulation of cell migration Inferred from mutant phenotype. Source: UniProtKB release of cytoplasmic sequestered NF-kappaB Inferred from direct assay. Source: UniProtKB
Cellular component	focal adhesion Inferred from direct assay. Source: UniProtKB
Molecular function	identical protein binding Inferred from physical interaction. Source: IntAct interleukin-1 receptor binding Inferred from direct assay. Source: UniProtKB kinase binding Inferred from physical interaction. Source: UniProtKB thyroid hormone receptor binding Ref.1 Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
itself		1	EBI-742327,EBI-742327
AFAP1L1	Q8TED9	1	EBI-742327,EBI-1053644
ATN1	P54259	1	EBI-742327,EBI-945980
CMBL	Q96DG6	1	EBI-742327,EBI-1044268
HOXA9	P31269	1	EBI-742327,EBI-742314
KCTD5	Q9NXV2	1	EBI-742327,EBI-1056857
LYZ	P61626	1	EBI-742327,EBI-355360
MOBKL1B	Q9H8S9	1	EBI-742327,EBI-748229
P4HB	P07237	1	EBI-742327,EBI-395883
RNMTL1	Q9HC36	1	EBI-742327,EBI-1045440
RPS14	P62263	1	EBI-742327,EBI-352783
STOM	P27105	1	EBI-742327,EBI-1211440
THRAP3	Q9Y2W1	1	EBI-742327,EBI-352039

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 476

476

Thyroid receptor-interacting protein 6

PRO_0000075908

Regions

Domain

279 – 316

LIM zinc-binding 1

Domain

339 – 398

LIM zinc-binding 2

Domain

399 – 467

LIM zinc-binding 3

Amino acid modifications

Modified residue

Phosphoserine Ref.6

Modified residue

142

Phosphoserine Ref.8

Modified residue

147

Phosphoserine Ref.8

Natural variations

Natural variant

230

V → I: dbSNP rs2075756. Ref.4

VAR_050171

Natural variant

296

L → F Ref.4

VAR_013309

Experimental info

Sequence conflict

39 – 40

Missing in AAH02680. Ref.4

Sequence conflict

102

S → T in AAB62222. Ref.2

Sequence conflict

106

E → K in AAB62222. Ref.2

Sequence conflict

111

R → Q in AAK21007. Ref.3

Sequence conflict

135

S → C in CAA05080. Ref.1

Sequence conflict

310 – 313

CRAQ → MPGP Ref.5

Sequence conflict

461 – 476

SAWRI…VTTDC → RPGASRSSQPPSGLTAESSM KKYLLGSQFQFPSFD Ref.5

Secondary structure

476

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q15654-1 [UniParc].

Last modified May 15, 2002. Version 3.
Checksum: 2BA7C747DF30A8FD
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FASTA

476

50,288

        10         20         30         40         50         60 
MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP SEQCYQAPGG 

        70         80         90        100        110        120 
PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL SSTLAELNGG RGHASRRPDR 

       130        140        150        160        170        180 
QAYEPPPPPA YRTGSLKPNP ASPLPASPYG GPTPASYTTA STPAGPAFPV QVKVAQPVRG 

       190        200        210        220        230        240 
CGPPRRGASQ ASGPLPGPHF PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG 

       250        260        270        280        290        300 
EHGPQVPLSQ PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF 

       310        320        330        340        350        360 
HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI LRAMGKAYHP 

       370        380        390        400        410        420 
GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS VCGGAIMPEP GQEETVRIVA 

       430        440        450        460        470 
LDRSFHIGCY KCEECGLLLS SEGECQGCYP LDGHILCKAC SAWRIQELSA TVTTDC

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis." Yi J., Beckerle M.C. Genomics 49:314-316(1998) [PubMed: 9598321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E." Murthy K.K., Clark K., Fortin Y., Shen S.-H., Banville D. J. Biol. Chem. 274:20679-20687(1999) [PubMed: 10400701] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5." Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F. Nucleic Acids Res. 29:1352-1365(2001) [PubMed: 11239002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-230 AND PHE-296. Tissue: Cervix, Kidney and Pancreas.
[5]	"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor." Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D. Mol. Endocrinol. 9:243-254(1995) [PubMed: 7776974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 310-476.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Supervillin modulation of focal adhesions involving TRIP6/ZRP-1." Takizawa N., Smith T.C., Nebl T., Crowley J.L., Palmieri S.J., Lifshitz L.M., Ehrhardt A.G., Hoffman L.M., Beckerle M.C., Luna E.J. J. Cell Biol. 174:447-458(2006) [PubMed: 16880273] [Abstract] Cited for: INTERACTION WITH SVIL.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142 AND SER-147, MASS SPECTROMETRY.
[9]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[10]	"Solution structure of the first and second LIM domain of thyroid receptor interacting protein 6 (TRIP6)." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 279-396.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AJ001902 mRNA. Translation: CAA05080.1.
AF000974 mRNA. Translation: AAB62222.1.
AF093836, AF093834, AF093835 Genomic DNA. Translation: AAD03037.1.
AF312032 Genomic DNA. Translation: AAK21007.1.
BC002680 mRNA. Translation: AAH02680.1.
BC004249 mRNA. Translation: AAH04249.1.
BC004999 mRNA. Translation: AAH04999.1.
BC021540 mRNA. Translation: AAH21540.1.
BC028985 mRNA. Translation: AAH28985.1.
L40374 mRNA. Translation: AAC41740.1.

IPI

IPI00301561.

RefSeq

NP_003293.2.

UniGene

Hs.534360

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X61	NMR	-	A	279-337	[»]
2DLO	NMR	-	A	329-396	[»]

SMR

Q15654. Positions 331-396.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15654. 33 interactions.

PTM databases

PhosphoSite

Q15654.

Proteomic databases

PeptideAtlas

Q15654.

PRIDE

Q15654.

Genome annotation databases

Ensembl

ENSG00000087077. Homo sapiens. [Contig view]

GeneID

7205.

KEGG

hsa:7205.

UCSC

uc003uww.1. human.

Organism-specific databases

GeneCards

GC07P100302.

H-InvDB

HIX0021212.

HGNC

HGNC:12311. TRIP6.

MIM

602933. gene.

PharmGKB

PA36989.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q15654.

OMA

Q15654. RPDRQAY.

Enzyme and pathway databases

Pathway_Interaction_DB

lysophospholipid_pathway. LPA receptor mediated events.

Gene expression databases

ArrayExpress

Q15654.

Bgee

Q15654.

CleanEx

HS_TRIP6.

GermOnline

ENSG00000087077. Homo sapiens.

Family and domain databases

InterPro

IPR001781. Znf_LIM.
[Graphical view]

Pfam

PF00412. LIM. 3 hits.
[Graphical view]

ProDom

PD000094. LIM. 3 hits.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00132. LIM. 3 hits.
[Graphical view]

PROSITE

PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

28238.

SOURCE

Search...

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Entry information

Entry name

TRIP6_HUMAN

Accession

Primary (citable) accession number: Q15654
Secondary accession number(s): O15170

Q9UNT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 15, 2002
Last modified:	July 7, 2009
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents