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Protein

Thyroid receptor-interacting protein 6

Gene

TRIP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.4 Publications

GO - Molecular functioni

  • interleukin-1 receptor binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

  • focal adhesion assembly Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • release of cytoplasmic sequestered NF-kappaB Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processCell adhesion, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ15654.
SIGNORiQ15654.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid receptor-interacting protein 6
Short name:
TR-interacting protein 6
Short name:
TRIP-6
Alternative name(s):
Opa-interacting protein 1
Short name:
OIP-1
Zyxin-related protein 1
Short name:
ZRP-1
Gene namesi
Name:TRIP6
Synonyms:OIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000087077.11.
HGNCiHGNC:12311. TRIP6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi101S → A: Exclusively located in nucleus. 1 Publication1
Mutagenesisi102S → A: Exclusively located in nucleus. 1 Publication1
Mutagenesisi474T → A: Reduces interaction with MAGI1. 1 Publication1

Organism-specific databases

DisGeNETi7205.
OpenTargetsiENSG00000087077.
PharmGKBiPA36989.

Polymorphism and mutation databases

BioMutaiTRIP6.
DMDMi20981729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759081 – 476Thyroid receptor-interacting protein 6Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei25Omega-N-methylarginine; alternateCombined sources1
Modified residuei55Phosphotyrosine; by SRC2 Publications1
Modified residuei92PhosphoserineCombined sources1
Modified residuei111Omega-N-methylarginineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei179Omega-N-methylarginineCombined sources1
Modified residuei186Omega-N-methylarginineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei205Omega-N-methylarginineCombined sources1
Modified residuei236Omega-N-methylarginineCombined sources1
Modified residuei238Omega-N-methylarginineCombined sources1
Modified residuei249PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ15654.
MaxQBiQ15654.
PaxDbiQ15654.
PeptideAtlasiQ15654.
PRIDEiQ15654.

PTM databases

iPTMnetiQ15654.
PhosphoSitePlusiQ15654.

Expressioni

Tissue specificityi

Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.1 Publication

Gene expression databases

BgeeiENSG00000087077.
CleanExiHS_TRIP6.
ExpressionAtlasiQ15654. baseline and differential.
GenevisibleiQ15654. HS.

Organism-specific databases

HPAiCAB046454.
CAB046460.
HPA052813.

Interactioni

Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. Interacts with PTPN13. Interacts with SVIL isoform 2. Interacts with LPAR2 but not other LPA receptors. Interacts with PRKAA2. Interacts with MAGI1. Interacts with SCRIB (By similarity). Binds to S.typhimurium protein sseI.By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5W1503EBI-742327,EBI-10248148
Q95HA43EBI-742327,EBI-10236795
ABI2Q9NYB93EBI-742327,EBI-743598
ADAMTSL4Q6UY14-33EBI-742327,EBI-10173507
AQP1P299726EBI-742327,EBI-745213
ATN1P542592EBI-742327,EBI-945980
ATP5OP480473EBI-742327,EBI-355815
BIT61P470413EBI-742327,EBI-25889From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BOL3P397243EBI-742327,EBI-2343154From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BYSLQ138956EBI-742327,EBI-358049
CATSPER1Q8NEC56EBI-742327,EBI-744545
CEP57L1Q8IYX8-23EBI-742327,EBI-10181988
CNTFP264413EBI-742327,EBI-1050897
CREB5Q02930-33EBI-742327,EBI-10192698
CRYBA4P536733EBI-742327,EBI-7519711
CTAG2O756383EBI-742327,EBI-10188927
DMRT3Q9NQL93EBI-742327,EBI-9679045
DTX2Q86UW93EBI-742327,EBI-740376
EFHC1Q5JVL43EBI-742327,EBI-743105
EXOC3-AS1Q8N2X66EBI-742327,EBI-749333
FASLGP480233EBI-742327,EBI-495538
FRS3O435595EBI-742327,EBI-725515
GATA1P15976-23EBI-742327,EBI-9090198
GDPD5Q9HBR33EBI-742327,EBI-10310206
GNAI2P048993EBI-742327,EBI-353997
GNEQ9Y223-24EBI-742327,EBI-11975289
GPS2Q132274EBI-742327,EBI-713355
GSE1Q146873EBI-742327,EBI-372619
HEL-S-42V9HWD03EBI-742327,EBI-10330219
Hoxa1P090223EBI-742327,EBI-3957603From Mus musculus.
HOXA9P312694EBI-742327,EBI-742314
HOXB9P174823EBI-742327,EBI-745290
HYKKA0A0C4DGM43EBI-742327,EBI-10236738
INCA1Q0VD863EBI-742327,EBI-6509505
KIR2DL4Q997063EBI-742327,EBI-10294579
KLK15Q9H2R53EBI-742327,EBI-8645371
KRTAP26-1Q6PEX33EBI-742327,EBI-3957672
LMO2P257913EBI-742327,EBI-739696
MAPKBP1O603363EBI-742327,EBI-947402
MEMO1Q9Y3163EBI-742327,EBI-1104564
METTL17Q9H7H04EBI-742327,EBI-749353
MSRB3Q8IXL73EBI-742327,EBI-8634060
NCK2O436396EBI-742327,EBI-713635
NEDD9Q145113EBI-742327,EBI-2108053
NEU4Q8WWR8-23EBI-742327,EBI-10277551
OIP5O434823EBI-742327,EBI-536879
OTUB2Q9BWI93EBI-742327,EBI-10300896
PDGFRBP096193EBI-742327,EBI-641237
PIN1Q135263EBI-742327,EBI-714158
POM121L1PQ3SYA93EBI-742327,EBI-10241319
PPP1R16AQ96I343EBI-742327,EBI-710402
PRKAA1Q131313EBI-742327,EBI-1181405
PRKAA2P546463EBI-742327,EBI-1383852
PTPN14Q156784EBI-742327,EBI-1237156
RAD23AP547253EBI-742327,EBI-746453
RANBP3LQ86VV44EBI-742327,EBI-12028066
RFX3P483803EBI-742327,EBI-742557
RHOAP615863EBI-742327,EBI-446668
RNF213Q63HN8-63EBI-742327,EBI-10248548
SAXO1Q8IYX73EBI-742327,EBI-3957636
SCRIBQ141605EBI-742327,EBI-357345
SIK3Q9Y2K2-33EBI-742327,EBI-10326390
SLC15A3Q05CH43EBI-742327,EBI-10223741
SLC25A6P122363EBI-742327,EBI-356254
STK16O757163EBI-742327,EBI-749295
SVILO463855EBI-742327,EBI-6995105From Bos taurus.
TCAF1Q9Y4C23EBI-742327,EBI-750484
TEKT4Q8WW243EBI-742327,EBI-750487
TMSB4XQ0P5Q03EBI-742327,EBI-10226570
TPM3Q5VU623EBI-742327,EBI-10184033
TRAF3IP2O437343EBI-742327,EBI-744798
TRAPPC2LQ9UL333EBI-742327,EBI-747601
TRIM29Q141343EBI-742327,EBI-702370
TRX3P253723EBI-742327,EBI-19616From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TTLL10Q6ZVT03EBI-742327,EBI-7844656
TXN2Q997573EBI-742327,EBI-2932492
TXNDC5Q86UY03EBI-742327,EBI-2825190
VID24P382633EBI-742327,EBI-20304From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
WT1-ASQ062503EBI-742327,EBI-10223946
XRCC6BP1Q8N4L53EBI-742327,EBI-10265517
YLR347W-AQ8TGM23EBI-742327,EBI-11537624From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ZBP1A2RRL93EBI-742327,EBI-10173066
ZNF541Q9H0D24EBI-742327,EBI-3957075

GO - Molecular functioni

  • interleukin-1 receptor binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113056. 197 interactors.
CORUMiQ15654.
DIPiDIP-34466N.
IntActiQ15654. 186 interactors.
MINTiMINT-1366827.
STRINGi9606.ENSP00000200457.

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi280 – 282Combined sources3
Beta strandi288 – 290Combined sources3
Beta strandi296 – 300Combined sources5
Turni302 – 304Combined sources3
Beta strandi308 – 310Combined sources3
Beta strandi319 – 324Combined sources6
Beta strandi326 – 328Combined sources3
Helixi329 – 337Combined sources9
Turni340 – 342Combined sources3
Beta strandi351 – 353Combined sources3
Beta strandi356 – 358Combined sources3
Turni360 – 362Combined sources3
Beta strandi366 – 368Combined sources3
Helixi388 – 394Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X61NMR-A279-337[»]
2DLONMR-A329-396[»]
ProteinModelPortaliQ15654.
SMRiQ15654.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 316LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST38
Domaini339 – 398LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini399 – 467LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni469 – 476Interaction with MAGI1 and PTPN131 Publication8

Domaini

The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOVERGENiHBG093602.
InParanoidiQ15654.
KOiK12792.
OrthoDBiEOG091G085F.
PhylomeDBiQ15654.
TreeFamiTF320310.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 3 hits.
SMARTiView protein in SMART
SM00132. LIM. 3 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15654-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP
60 70 80 90 100
SEQCYQAPGG PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL
110 120 130 140 150
SSTLAELNGG RGHASRRPDR QAYEPPPPPA YRTGSLKPNP ASPLPASPYG
160 170 180 190 200
GPTPASYTTA STPAGPAFPV QVKVAQPVRG CGPPRRGASQ ASGPLPGPHF
210 220 230 240 250
PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG EHGPQVPLSQ
260 270 280 290 300
PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF
310 320 330 340 350
HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI
360 370 380 390 400
LRAMGKAYHP GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS
410 420 430 440 450
VCGGAIMPEP GQEETVRIVA LDRSFHIGCY KCEECGLLLS SEGECQGCYP
460 470
LDGHILCKAC SAWRIQELSA TVTTDC
Length:476
Mass (Da):50,288
Last modified:May 15, 2002 - v3
Checksum:i2BA7C747DF30A8FD
GO
Isoform 2 (identifier: Q15654-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-106: ALQPHPRVNF...IDLLSSTLAE → VLPGPRGTGG...CVTATRPTGI
     107-476: Missing.

Show »
Length:106
Mass (Da):10,602
Checksum:i33931B3C4BFC4DAB
GO
Isoform 3 (identifier: Q15654-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-80: ALQPHPRVNF...SHGVLQHTQG → GAPCRQGGPS...CVTATRPTGI
     81-476: Missing.

Show »
Length:80
Mass (Da):8,277
Checksum:iC6244DB637740E54
GO

Sequence cautioni

The sequence AAC41740 differs from that shown. Reason: Frameshift at position 461.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39 – 40Missing in AAH02680 (PubMed:15489334).Curated2
Sequence conflicti102S → T in AAB62222 (PubMed:10400701).Curated1
Sequence conflicti106E → K in AAB62222 (PubMed:10400701).Curated1
Sequence conflicti135S → C in CAA05080 (PubMed:9598321).Curated1
Sequence conflicti310 – 313CRAQ → MPGP in AAC41740 (PubMed:7776974).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062262111R → Q1 PublicationCorresponds to variant dbSNP:rs2437100Ensembl.1
Natural variantiVAR_050171230V → I1 PublicationCorresponds to variant dbSNP:rs2075756Ensembl.1
Natural variantiVAR_013309296L → F1 PublicationCorresponds to variant dbSNP:rs17855370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04762137 – 106ALQPH…STLAE → VLPGPRGTGGSGAGVGGVPW STPAHAGAPCRQGGPSPWKP GRRDRLAEQHAGRAEWGSGS CVTATRPTGI in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_04762237 – 80ALQPH…QHTQG → GAPCRQGGPSPWKPGRRDRL AEQHAGRAEWGSGSCVTATR PTGI in isoform 3. CuratedAdd BLAST44
Alternative sequenceiVSP_04762381 – 476Missing in isoform 3. CuratedAdd BLAST396
Alternative sequenceiVSP_047624107 – 476Missing in isoform 2. 1 PublicationAdd BLAST370

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001902 mRNA. Translation: CAA05080.1.
AF000974 mRNA. Translation: AAB62222.1.
AF093836, AF093834, AF093835 Genomic DNA. Translation: AAD03037.1.
AF312032 Genomic DNA. Translation: AAK21007.1.
AB628086 mRNA. Translation: BAK20497.1.
AB628087 mRNA. Translation: BAK20498.1.
AK291906 mRNA. Translation: BAF84595.1.
AC011895 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23817.1.
CH471091 Genomic DNA. Translation: EAW76472.1.
BC002680 mRNA. Translation: AAH02680.1.
BC004249 mRNA. Translation: AAH04249.1.
BC004999 mRNA. Translation: AAH04999.1.
BC021540 mRNA. Translation: AAH21540.1.
BC028985 mRNA. Translation: AAH28985.1.
L40374 mRNA. Translation: AAC41740.1. Frameshift.
CCDSiCCDS5708.1. [Q15654-1]
RefSeqiNP_003293.2. NM_003302.2. [Q15654-1]
UniGeneiHs.534360.

Genome annotation databases

EnsembliENST00000200457; ENSP00000200457; ENSG00000087077. [Q15654-1]
ENST00000417475; ENSP00000413817; ENSG00000087077. [Q15654-2]
ENST00000437505; ENSP00000410736; ENSG00000087077. [Q15654-3]
ENST00000619988; ENSP00000479865; ENSG00000087077. [Q15654-3]
GeneIDi7205.
KEGGihsa:7205.
UCSCiuc003uww.4. human. [Q15654-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRIP6_HUMAN
AccessioniPrimary (citable) accession number: Q15654
Secondary accession number(s): A4D2E7
, F2ZC07, F2ZC08, O15170, O15275, Q9BTB2, Q9BUE5, Q9BXP3, Q9UNT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 15, 2002
Last modified: September 27, 2017
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families