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Protein

NF-kappa-B inhibitor beta

Gene

NFKBIB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

GO - Molecular functioni

  • signal transducer activity Source: ProtInc
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

  • cellular response to lipopolysaccharide Source: Ensembl
  • signal transduction Source: ProtInc
  • transcription, DNA-templated Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-933542 TRAF6 mediated NF-kB activation
SABIO-RKQ15653
SignaLinkiQ15653
SIGNORiQ15653

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor beta
Short name:
NF-kappa-BIB
Alternative name(s):
I-kappa-B-beta
Short name:
IkB-B
Short name:
IkB-beta
Short name:
IkappaBbeta
Thyroid receptor-interacting protein 9
Short name:
TR-interacting protein 9
Short name:
TRIP-9
Gene namesi
Name:NFKBIB
Synonyms:IKBB, TRIP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104825.16
HGNCiHGNC:7798 NFKBIB
MIMi604495 gene
neXtProtiNX_Q15653

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19S → A: No degradation; when associated with A-23. 1 Publication1
Mutagenesisi23S → A: No degradation; when associated with A-19. 1 Publication1

Organism-specific databases

DisGeNETi4793
OpenTargetsiENSG00000104825
PharmGKBiPA31602

Polymorphism and mutation databases

BioMutaiNFKBIB
DMDMi57015399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670041 – 356NF-kappa-B inhibitor betaAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Phosphoserine; by RPS6KA11 Publication1
Modified residuei23Phosphoserine; by RPS6KA11 Publication1
Modified residuei183PhosphoserineCombined sources1
Modified residuei313Phosphoserine; by CK21 Publication1
Modified residuei315Phosphoserine; by CK21 Publication1

Post-translational modificationi

Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15653
MaxQBiQ15653
PaxDbiQ15653
PeptideAtlasiQ15653
PRIDEiQ15653

PTM databases

iPTMnetiQ15653
PhosphoSitePlusiQ15653

Expressioni

Tissue specificityi

Expressed in all tissues examined.

Gene expression databases

BgeeiENSG00000104825
CleanExiHS_NFKBIB
ExpressionAtlasiQ15653 baseline and differential
GenevisibleiQ15653 HS

Organism-specific databases

HPAiCAB010447
HPA063734

Interactioni

Subunit structurei

Interacts with THRB (via ligand-binding domain) (PubMed:7776974). Interacts with RELA and REL (By similarity). Interacts with COMMD1 (PubMed:16573520). Interacts with inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2 (PubMed:10657303, PubMed:12672800, PubMed:15024091).By similarity5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110860, 35 interactors
CORUMiQ15653
DIPiDIP-27532N
ELMiQ15653
IntActiQ15653, 33 interactors
STRINGi9606.ENSP00000312988

Structurei

3D structure databases

ProteinModelPortaliQ15653
SMRiQ15653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 86ANK 1Add BLAST30
Repeati93 – 122ANK 2Add BLAST30
Repeati126 – 155ANK 3Add BLAST30
Repeati206 – 235ANK 4Add BLAST30
Repeati240 – 269ANK 5Add BLAST30
Repeati273 – 302ANK 6Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 195Asp/Glu-rich (acidic)10

Sequence similaritiesi

Belongs to the NF-kappa-B inhibitor family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOVERGENiHBG019039
InParanoidiQ15653
KOiK02581
OMAiDEWCDSG
OrthoDBiEOG091G092R
PhylomeDBiQ15653
TreeFamiTF320166

Family and domain databases

CDDicd00204 ANK, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15653-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVACLGKA ADADEWCDSG LGSLGPDAAA PGGPGLGAEL GPGLSWAPLV
60 70 80 90 100
FGYVTEDGDT ALHLAVIHQH EPFLDFLLGF SAGTEYMDLQ NDLGQTALHL
110 120 130 140 150
AAILGETSTV EKLYAAGAGL CVAERRGHTA LHLACRVGAH ACARALLQPR
160 170 180 190 200
PRRPREAPDT YLAQGPDRTP DTNHTPVALY PDSDLEKEEE ESEEDWKLQL
210 220 230 240 250
EAENYEGHTP LHVAVIHKDV EMVRLLRDAG ADLDKPEPTC GRSPLHLAVE
260 270 280 290 300
AQAADVLELL LRAGANPAAR MYGGRTPLGS AMLRPNPILA RLLRAHGAPE
310 320 330 340 350
PEGEDEKSGP CSSSSDSDSG DEGDEYDDIV VHSSRSQTRL PPTPASKPLP

DDPRPV
Length:356
Mass (Da):37,771
Last modified:January 4, 2005 - v2
Checksum:iE84575971B6F81CC
GO
Isoform 2 (identifier: Q15653-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-338: DEYDDIVVHSSRSQT → VSQEERQGSPAGGSG
     339-356: Missing.

Show »
Length:338
Mass (Da):35,530
Checksum:iF024666B851DF976
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19S → T in AAC41742 (PubMed:7776974).Curated1
Sequence conflicti319S → G in AAC41742 (PubMed:7776974).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020771339R → W1 PublicationCorresponds to variant dbSNP:rs17886215Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012409324 – 338DEYDD…SRSQT → VSQEERQGSPAGGSG in isoform 2. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_012410339 – 356Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40407 Genomic DNA Translation: AAC41742.1
BT006743 mRNA Translation: AAP35389.1
AY736284 Genomic DNA Translation: AAU10088.1
AK290569 mRNA Translation: BAF83258.1
CH471126 Genomic DNA Translation: EAW56843.1
BC007197 mRNA Translation: AAH07197.1
BC015528 mRNA Translation: AAH15528.1
CCDSiCCDS12524.1 [Q15653-1]
RefSeqiNP_001230045.1, NM_001243116.1
NP_002494.2, NM_002503.4 [Q15653-1]
UniGeneiHs.9731

Genome annotation databases

EnsembliENST00000313582; ENSP00000312988; ENSG00000104825 [Q15653-1]
ENST00000572515; ENSP00000459728; ENSG00000104825 [Q15653-2]
ENST00000634647; ENSP00000489145; ENSG00000282905 [Q15653-2]
ENST00000635517; ENSP00000489138; ENSG00000282905 [Q15653-1]
GeneIDi4793
KEGGihsa:4793
UCSCiuc002ojw.4 human [Q15653-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIKBB_HUMAN
AccessioniPrimary (citable) accession number: Q15653
Secondary accession number(s): A8K3F4, Q96BJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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