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Q15652 (JHD2C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable JmjC domain-containing histone demethylation protein 2C

EC=1.14.11.-
Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name=TR-interacting protein 8
Short name=TRIP-8
Gene names
Name:JMJD1C
Synonyms:JHDM2C, KIAA1380, TRIP8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2540 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes By similarity.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subunit structure

Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Ref.6

Subcellular location

Nucleus By similarity.

Domain

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors By similarity.

Sequence similarities

Belongs to the JHDM2 histone demethylase family.

Contains 1 JmjC domain.

Sequence caution

The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171.

The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697.

The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ARP102752EBI-1224969,EBI-608057

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q15652-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q15652-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q15652-3)

Also known as: s-JMJD1C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.
Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 25402540Probable JmjC domain-containing histone demethylation protein 2C
PRO_0000084284

Regions

Domain2274 – 2498225JmjC
Zinc finger1846 – 187126C6-type Potential
Motif2066 – 20705LXXLL motif

Sites

Metal binding23361Iron; catalytic By similarity
Metal binding23381Iron; catalytic By similarity
Metal binding24661Iron; catalytic By similarity

Amino acid modifications

Modified residue3171Phosphoserine Ref.10
Modified residue3731Phosphoserine Ref.8 Ref.10
Modified residue3761Phosphoserine Ref.8
Modified residue6171Phosphoserine Ref.10
Modified residue6381Phosphoserine Ref.10
Modified residue6411Phosphoserine Ref.8 Ref.10
Modified residue6521Phosphoserine Ref.10
Modified residue19891Phosphoserine Ref.10

Natural variations

Alternative sequence1 – 219219Missing in isoform 2.
VSP_018303
Alternative sequence1 – 182182Missing in isoform 3.
VSP_043909
Alternative sequence1692 – 16998TGIPRSVL → SCHLVKTE in isoform 2.
VSP_018304
Alternative sequence1700 – 2540841Missing in isoform 2.
VSP_018305
Natural variant2721A → T.
Corresponds to variant rs34798625 [ dbSNP | Ensembl ].
VAR_049654
Natural variant3941E → D.
Corresponds to variant rs35380596 [ dbSNP | Ensembl ].
VAR_049655
Natural variant4641S → T. Ref.2
Corresponds to variant rs10761725 [ dbSNP | Ensembl ].
VAR_049656
Natural variant5911M → V.
Corresponds to variant rs41274072 [ dbSNP | Ensembl ].
VAR_061277
Natural variant13931N → Y.
Corresponds to variant rs9703886 [ dbSNP | Ensembl ].
VAR_049657
Natural variant24001D → E.
Corresponds to variant rs34491125 [ dbSNP | Ensembl ].
VAR_049658
Natural variant25351E → D. Ref.2
Corresponds to variant rs1935 [ dbSNP | Ensembl ].
VAR_049659

Experimental info

Sequence conflict4881T → A in CAD97921. Ref.2
Sequence conflict7791T → A in CAD97921. Ref.2
Sequence conflict7831T → P in CAD97921. Ref.2
Sequence conflict20931S → A in AAC41741. Ref.6
Sequence conflict21481Missing in BAA92618. Ref.5

Secondary structure

................................................................... 2540
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: 8B1727414D6B677F

FASTA2,540284,525
        10         20         30         40         50         60 
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS RNPDLAVYVE 

        70         80         90        100        110        120 
FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG SKSKQIQWPA LTFKPLVERN 

       130        140        150        160        170        180 
IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE 

       190        200        210        220        230        240 
IFMQGPYSLN GYRVRVYRQD SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM 

       250        260        270        280        290        300 
TFLDDVVHSL LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT 

       310        320        330        340        350        360 
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN KRRKPEEDEK 

       370        380        390        400        410        420 
KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE LKNKNTSKIN GEEGKPHNNE 

       430        440        450        460        470        480 
KAGEETLKNS QPPWDQIQED KKHEEAEKRK SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP 

       490        500        510        520        530        540 
QECNMDKTHT MELLPKEKFV SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN 

       550        560        570        580        590        600 
VSDSKHSIAN AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI 

       610        620        630        640        650        660 
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT HSPDSVKSKA 

       670        680        690        700        710        720 
TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK SPLIIDKNEH FTVYRDPALI 

       730        740        750        760        770        780 
GSETGANHIS PFLSQHPFPL HSSSHRTCLN PGTHHPALTP APHLLAGSSS QTPLPTINTH 

       790        800        810        820        830        840 
PLTSGPHHAV HHPHLLPTVL PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ 

       850        860        870        880        890        900 
SPHLLGQAHP SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS 

       910        920        930        940        950        960 
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL VDHHKEELER 

       970        980        990       1000       1010       1020 
KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV LNQLQRPPQE TGERLNKYKE 

      1030       1040       1050       1060       1070       1080 
EHRRILQESI DVAPFTTKIK GLEGERENYS RVASSSSSPK SHIIKQDMDV ERSVSDLYKM 

      1090       1100       1110       1120       1130       1140 
KHSVPQSLPQ SNYFTTLSNS VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI 

      1150       1160       1170       1180       1190       1200 
TSLSKPPPLI KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM 

      1210       1220       1230       1240       1250       1260 
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP PTLIPEPKDS 

      1270       1280       1290       1300       1310       1320 
QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA AMASVIVRPS SSTKTDSMPA 

      1330       1340       1350       1360       1370       1380 
MQLASKDRVS ERSSAGAHKT DCLKLAEAGE TGRIILPNVN SDSVHTKSEK NFQAVSQGSV 

      1390       1400       1410       1420       1430       1440 
PSSVMSAVNT MCNTKTDVIT SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ 

      1450       1460       1470       1480       1490       1500 
PVAQKQECKV STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS 

      1510       1520       1530       1540       1550       1560 
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL KKAWLTRHSE 

      1570       1580       1590       1600       1610       1620 
EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS KIIVDKYVKD DKVNRRKAKR 

      1630       1640       1650       1660       1670       1680 
TYESGSESGD SDESESKSEQ RTKRQPKPTY KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE 

      1690       1700       1710       1720       1730       1740 
RSKLKLQSNS NTGIPRSVLK DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK 

      1750       1760       1770       1780       1790       1800 
KGEEPAHSPV FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE 

      1810       1820       1830       1840       1850       1860 
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE ATLFNIHWVC 

      1870       1880       1890       1900       1910       1920 
QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK HLMPTQIIPG SVLTDLLDAM 

      1930       1940       1950       1960       1970       1980 
HTLREKYGIK SHCHCTNKQN LQVGNFPTMN GVSQVLQNVL NHSNKISLCM PESQQQNTPP 

      1990       2000       2010       2020       2030       2040 
KSEKNGGSSP ESDVGTDNKL TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER 

      2050       2060       2070       2080       2090       2100 
EQDNSESPNG RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK 

      2110       2120       2130       2140       2150       2160 
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN NKLYSDIPHS 

      2170       2180       2190       2200       2210       2220 
WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK MNISLWKAES ISLDFGDHQA 

      2230       2240       2250       2260       2270       2280 
DLLNCKDSII SNANVKEFWD GFEEVSKRQK NKSGETVVLK LKDWPSGEDF KTMMPARYED 

      2290       2300       2310       2320       2330       2340 
LLKSLPLPEY CNPEGKFNLA SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS 

      2350       2360       2370       2380       2390       2400 
DVVNILVYVG IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD 

      2410       2420       2430       2440       2450       2460 
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL IQFLGDAIVL 

      2470       2480       2490       2500       2510       2520 
PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL KEEINYDDKL QVKNILYHAV 

      2530       2540 
KEMVRALKIH EDEVEDMEEN 

« Hide

Isoform 2 [UniParc].

Checksum: 72DB291B3FAB25B7
Show »

FASTA1,480163,133
Isoform 3 (s-JMJD1C) [UniParc].

Checksum: 6005F440A38FC096
Show »

FASTA2,358263,157

References

« Hide 'large scale' references
[1]"A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR."
Wolf S.S., Patchev V.K., Obendorf M.
Arch. Biochem. Biophys. 460:56-66(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-2540, VARIANTS THR-464 AND ASP-2535.
Tissue: Amygdala and Cervix.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427.
Tissue: Embryo.
[5]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1275-2540.
Tissue: Brain.
[6]"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR.
[7]"Identification and characterization of TRIP8 gene in silico."
Katoh M., Katoh M.
Int. J. Mol. Med. 12:817-821(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF THE GENE.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376 AND SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-373; SER-617; SER-638; SER-641; SER-652 AND SER-1989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF068222 mRNA. Translation: ABK64187.1.
BX537954 mRNA. Translation: CAD97921.1. Frameshift.
AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems.
AL713895, AL590502 Genomic DNA. Translation: CAI10948.1.
AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1.
AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1.
AK027280 mRNA. No translation available.
AL831917 mRNA. Translation: CAD38578.1.
AB037801 mRNA. Translation: BAA92618.1.
L40411 mRNA. Translation: AAC41741.1. Frameshift.
RefSeqNP_001269877.1. NM_001282948.1.
NP_116165.1. NM_032776.2.
UniGeneHs.413416.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YPDX-ray2.10A/B2157-2540[»]
ProteinModelPortalQ15652.
SMRQ15652. Positions 1815-1873, 2157-2497.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128677. 13 interactions.
DIPDIP-38114N.
IntActQ15652. 7 interactions.
MINTMINT-8247476.
STRING9606.ENSP00000382204.

PTM databases

PhosphoSiteQ15652.

Polymorphism databases

DMDM85541650.

Proteomic databases

PaxDbQ15652.
PRIDEQ15652.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399251; ENSP00000382195; ENSG00000171988. [Q15652-2]
ENST00000399262; ENSP00000382204; ENSG00000171988. [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988. [Q15652-3]
GeneID221037.
KEGGhsa:221037.
UCSCuc001jml.3. human. [Q15652-1]

Organism-specific databases

CTD221037.
GeneCardsGC10M064926.
HGNCHGNC:12313. JMJD1C.
HPAHPA056175.
MIM604503. gene.
neXtProtNX_Q15652.
PharmGKBPA128394767.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG305537.
HOVERGENHBG079631.
InParanoidQ15652.
KOK11449.
OMAFTGIITH.
OrthoDBEOG7B5WVG.
PhylomeDBQ15652.
TreeFamTF324723.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

BgeeQ15652.
CleanExHS_JMJD1C.
GenevestigatorQ15652.

Family and domain databases

InterProIPR003347. JmjC_dom.
[Graphical view]
PfamPF02373. JmjC. 1 hit.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSJMJD1C. human.
GenomeRNAi221037.
NextBio91161.
PROQ15652.
SOURCESearch...

Entry information

Entry nameJHD2C_HUMAN
AccessionPrimary (citable) accession number: Q15652
Secondary accession number(s): A0T124 expand/collapse secondary AC list , Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM