Reviewed,
UniProtKB/Swiss-Prot Q15652 (JHD2C_HUMAN)
Last modified
November 25, 2008.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable JmjC domain-containing histone demethylation protein 2C EC=1.14.11.- Alternative name(s): Jumonji domain-containing protein 1C Thyroid receptor-interacting protein 8 Short name=TRIP-8 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 2540 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes By similarity. |
| Cofactor | Binds 1 Fe(2+) ion per subunit By similarity. |
| Subunit structure | Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. |
| Subcellular location | NucleusBy similarity. |
| Domain | Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors By similarity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Sequence similarities | Belongs to the JHDM2 histone demethylase family. Contains 1 JmjC domain. |
| Sequence caution | The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171. The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697. The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q15652-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q15652-2) The sequence of this isoform differs from the canonical sequence as follows: 1-219: Missing. 1692-1699: TGIPRSVL → SCHLVKTE 1700-2540: Missing. | ||||||
| Notes: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2540 | 2540 | Probable JmjC domain-containing histone demethylation protein 2C | PRO_0000084284 | |||||
Regions | |||||||||
| Domain | 2274 – 2498 | 225 | JmjC | ||||||
| Zinc finger | 1846 – 1871 | 26 | C6-type Potential | ||||||
| Motif | 2066 – 2070 | 5 | LXXLL motif | ||||||
Sites | |||||||||
| Metal binding | 2336 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 2338 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 2466 | 1 | Iron; catalytic By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 373 | 1 | Phosphoserine | ||||||
| Modified residue | 376 | 1 | Phosphoserine | ||||||
| Modified residue | 379 | 1 | Phosphoserine | ||||||
| Modified residue | 430 | 1 | Phosphoserine | ||||||
| Modified residue | 638 | 1 | Phosphoserine | ||||||
| Modified residue | 641 | 1 | Phosphoserine | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 219 | 219 | Missing in isoform 2. | VSP_018303 | |||||
| Alternative sequence | 1692 – 1699 | 8 | TGIPRSVL → SCHLVKTE in isoform 2. | VSP_018304 | |||||
| Alternative sequence | 1700 – 2540 | 841 | Missing in isoform 2. | VSP_018305 | |||||
Experimental info | |||||||||
| Sequence conflict | 464 | 1 | S → T in CAD38578. Ref.1 | ||||||
| Sequence conflict | 488 | 1 | T → A in CAD97921. Ref.1 | ||||||
| Sequence conflict | 779 | 1 | T → A in CAD97921. Ref.1 | ||||||
| Sequence conflict | 783 | 1 | T → P in CAD97921. Ref.1 | ||||||
| Sequence conflict | 2093 | 1 | S → A in AAC41741. Ref.5 | ||||||
| Sequence conflict | 2148 | 1 | Missing in BAA92618. Ref.4 | ||||||
| Sequence conflict | 2535 | 1 | E → D in CAD38578. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | The German cDNA consortium Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-2540. Tissue: Amygdala and Cervix. |
| [2] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427. Tissue: Embryo. |
| [4] | "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1275-2540. Tissue: Brain. |
| [5] | "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor." Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D. Mol. Endocrinol. 9:243-254(1995) [PubMed: 7776974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR. |
| [6] | "Identification and characterization of TRIP8 gene in silico." Katoh M., Katoh M. Int. J. Mol. Med. 12:817-821(2003) [PubMed: 14533015] [Abstract] Cited for: IDENTIFICATION OF THE GENE. |
| [7] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376; SER-379; SER-638 AND SER-641, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| BX537954 mRNA. Translation: CAD97921.1. Frameshift. AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems. AL713895, AL590502 Genomic DNA. Translation: CAI10948.1. AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1. AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1. AK027280 mRNA. Translation: BAB55015.1. AL831917 mRNA. Translation: CAD38578.1. AB037801 mRNA. Translation: BAA92618.1. L40411 mRNA. Translation: AAC41741.1. Frameshift. | |
| RefSeq | NP_004232.2. NP_116165.1. |
| UniGene | Hs.413416 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15652. |
PTM databases | |
| PhosphoSite | Q15652. |
Genome annotation databases | |
| Ensembl | ENSG00000171988. Homo sapiens. [Contig view] |
| GeneID | 221037. |
| KEGG | hsa:221037. |
| NMPDR | fig|9606.3.peg.4012. |
Organism-specific databases | |
| HGNC | HGNC:12313. JMJD1C. |
| MIM | 604503. gene. |
| PharmGKB | PA128394767. |
| HUGE | Search... |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | Q15652. |
Gene expression databases | |
| ArrayExpress | Q15652. |
| CleanEx | HS_JMJD1C. |
| GermOnline | ENSG00000171988. Homo sapiens. |

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