Q15652 (JHD2C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C
EC=1.14.11.-

Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name=TR-interacting protein 8
Short name=TRIP-8

Gene names

Name:	JMJD1C
Synonyms:	JHDM2C, KIAA1380, TRIP8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2540 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes By similarity.
Cofactor	Binds 1 Fe2+ ion per subunit By similarity.
Subunit structure	Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Ref.5
Subcellular location	Nucleus By similarity.
Domain	Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7 Ref.8
Sequence similarities	Belongs to the JHDM2 histone demethylase family. Contains 1 JmjC domain.
Sequence caution	The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171. The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697. The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	blood coagulation Traceable author statement. Source: Reactome chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Traceable author statement Ref.5. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleoplasm Traceable author statement. Source: Reactome
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW thyroid hormone receptor binding Traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AR	P10275	2	EBI-1224969,EBI-608057

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15652-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15652-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2540	2540	Probable JmjC domain-containing histone demethylation protein 2C		PRO_0000084284
Regions
	Domain	2274 – 2498	225	JmjC
	Zinc finger	1846 – 1871	26	C6-type Potential
	Motif	2066 – 2070	5	LXXLL motif
Sites
	Metal binding	2336	1	Iron; catalytic By similarity
	Metal binding	2338	1	Iron; catalytic By similarity
	Metal binding	2466	1	Iron; catalytic By similarity
Amino acid modifications
	Modified residue	317	1	Phosphoserine By similarity
	Modified residue	373	1	Phosphoserine Ref.8
	Modified residue	376	1	Phosphoserine Ref.8
	Modified residue	379	1	Phosphoserine Ref.8
	Modified residue	430	1	Phosphoserine Ref.7
	Modified residue	552	1	N6-acetyllysine Ref.9
	Modified residue	638	1	Phosphoserine Ref.8
	Modified residue	641	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 219	219	Missing in isoform 2.		VSP_018303
	Alternative sequence	1692 – 1699	8	TGIPRSVL → SCHLVKTE in isoform 2.		VSP_018304
	Alternative sequence	1700 – 2540	841	Missing in isoform 2.		VSP_018305
	Natural variant	272	1	A → T. Corresponds to variant rs34798625 [ dbSNP | Ensembl ].		VAR_049654
	Natural variant	394	1	E → D. Corresponds to variant rs35380596 [ dbSNP | Ensembl ].		VAR_049655
	Natural variant	464	1	S → T. Ref.1 Corresponds to variant rs10761725 [ dbSNP | Ensembl ].		VAR_049656
	Natural variant	591	1	M → V. Corresponds to variant rs41274072 [ dbSNP | Ensembl ].		VAR_061277
	Natural variant	1393	1	N → Y. Corresponds to variant rs9703886 [ dbSNP | Ensembl ].		VAR_049657
	Natural variant	2400	1	D → E. Corresponds to variant rs34491125 [ dbSNP | Ensembl ].		VAR_049658
	Natural variant	2535	1	E → D. Ref.1 Corresponds to variant rs1935 [ dbSNP | Ensembl ].		VAR_049659
Experimental info
	Sequence conflict	488	1	T → A in CAD97921. Ref.1
	Sequence conflict	779	1	T → A in CAD97921. Ref.1
	Sequence conflict	783	1	T → P in CAD97921. Ref.1
	Sequence conflict	2093	1	S → A in AAC41741. Ref.5
	Sequence conflict	2148	1	Missing in BAA92618. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 8B1727414D6B677F	FASTA	2,540	284,525
	10 20 30 40 50 60 MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS RNPDLAVYVE 70 80 90 100 110 120 FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG SKSKQIQWPA LTFKPLVERN 130 140 150 160 170 180 IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE 190 200 210 220 230 240 IFMQGPYSLN GYRVRVYRQD SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM 250 260 270 280 290 300 TFLDDVVHSL LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT 310 320 330 340 350 360 HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN KRRKPEEDEK 370 380 390 400 410 420 KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE LKNKNTSKIN GEEGKPHNNE 430 440 450 460 470 480 KAGEETLKNS QPPWDQIQED KKHEEAEKRK SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP 490 500 510 520 530 540 QECNMDKTHT MELLPKEKFV SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN 550 560 570 580 590 600 VSDSKHSIAN AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI 610 620 630 640 650 660 SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT HSPDSVKSKA 670 680 690 700 710 720 TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK SPLIIDKNEH FTVYRDPALI 730 740 750 760 770 780 GSETGANHIS PFLSQHPFPL HSSSHRTCLN PGTHHPALTP APHLLAGSSS QTPLPTINTH 790 800 810 820 830 840 PLTSGPHHAV HHPHLLPTVL PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ 850 860 870 880 890 900 SPHLLGQAHP SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS 910 920 930 940 950 960 PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL VDHHKEELER 970 980 990 1000 1010 1020 KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV LNQLQRPPQE TGERLNKYKE 1030 1040 1050 1060 1070 1080 EHRRILQESI DVAPFTTKIK GLEGERENYS RVASSSSSPK SHIIKQDMDV ERSVSDLYKM 1090 1100 1110 1120 1130 1140 KHSVPQSLPQ SNYFTTLSNS VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI 1150 1160 1170 1180 1190 1200 TSLSKPPPLI KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM 1210 1220 1230 1240 1250 1260 PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP PTLIPEPKDS 1270 1280 1290 1300 1310 1320 QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA AMASVIVRPS SSTKTDSMPA 1330 1340 1350 1360 1370 1380 MQLASKDRVS ERSSAGAHKT DCLKLAEAGE TGRIILPNVN SDSVHTKSEK NFQAVSQGSV 1390 1400 1410 1420 1430 1440 PSSVMSAVNT MCNTKTDVIT SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ 1450 1460 1470 1480 1490 1500 PVAQKQECKV STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS 1510 1520 1530 1540 1550 1560 ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL KKAWLTRHSE 1570 1580 1590 1600 1610 1620 EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS KIIVDKYVKD DKVNRRKAKR 1630 1640 1650 1660 1670 1680 TYESGSESGD SDESESKSEQ RTKRQPKPTY KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE 1690 1700 1710 1720 1730 1740 RSKLKLQSNS NTGIPRSVLK DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK 1750 1760 1770 1780 1790 1800 KGEEPAHSPV FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE 1810 1820 1830 1840 1850 1860 TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE ATLFNIHWVC 1870 1880 1890 1900 1910 1920 QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK HLMPTQIIPG SVLTDLLDAM 1930 1940 1950 1960 1970 1980 HTLREKYGIK SHCHCTNKQN LQVGNFPTMN GVSQVLQNVL NHSNKISLCM PESQQQNTPP 1990 2000 2010 2020 2030 2040 KSEKNGGSSP ESDVGTDNKL TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER 2050 2060 2070 2080 2090 2100 EQDNSESPNG RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK 2110 2120 2130 2140 2150 2160 SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN NKLYSDIPHS 2170 2180 2190 2200 2210 2220 WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK MNISLWKAES ISLDFGDHQA 2230 2240 2250 2260 2270 2280 DLLNCKDSII SNANVKEFWD GFEEVSKRQK NKSGETVVLK LKDWPSGEDF KTMMPARYED 2290 2300 2310 2320 2330 2340 LLKSLPLPEY CNPEGKFNLA SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS 2350 2360 2370 2380 2390 2400 DVVNILVYVG IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD 2410 2420 2430 2440 2450 2460 KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL IQFLGDAIVL 2470 2480 2490 2500 2510 2520 PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL KEEINYDDKL QVKNILYHAV 2530 2540 KEMVRALKIH EDEVEDMEEN
	Isoform 2 [UniParc]. Checksum: 72DB291B3FAB25B7	FASTA	1,480	163,133
	10 20 30 40 50 60 MIVMNDQVLE PQNVDPSMVQ MTFLDDVVHS LLKGENIGIT SRRRSRANQN VNAVHSHYTR 70 80 90 100 110 120 AQANSPRPAM NSQAAVPKQN THQQQQQRSI RPNKRKGSDS SIPDEEKMKE EKYDYISRGE 130 140 150 160 170 180 NPKGKNKHLM NKRRKPEEDE KKLNMKRLRT DNVSDFSESS DSENSNKRII DNSSEQKPEN 190 200 210 220 230 240 ELKNKNTSKI NGEEGKPHNN EKAGEETLKN SQPPWDQIQE DKKHEEAEKR KSVDTQLQED 250 260 270 280 290 300 MIIHSSEQST VSDHNSNDLL PQECNMDKTH TMELLPKEKF VSRPPTPKCV IDITNDTNLE 310 320 330 340 350 360 KVAQENSSTF GLQTLQKMDP NVSDSKHSIA NAKFLETAKK DSDQSWVSDV VKVDLTQSSV 370 380 390 400 410 420 TNASSGNDHL NMEKEKYVSY ISPLSAVSVM EDKLHKRSPP PETIKSKLNT SVDTHKIKSS 430 440 450 460 470 480 PSPEVVKPKI THSPDSVKSK ATYVNSQATG ERRLANKIEH ELSRCSFHPI PTRSSTLETT 490 500 510 520 530 540 KSPLIIDKNE HFTVYRDPAL IGSETGANHI SPFLSQHPFP LHSSSHRTCL NPGTHHPALT 550 560 570 580 590 600 PAPHLLAGSS SQTPLPTINT HPLTSGPHHA VHHPHLLPTV LPGVPTASLL GGHPRLESAH 610 620 630 640 650 660 ASSLSHLALA HQQQQQLLQH QSPHLLGQAH PSASYNQLGL YPIIWQYPNG THAYSGLGLP 670 680 690 700 710 720 SSKWVHPENA VNAEASLRRN SPSPWLHQPT PVTSADGIGL LSHIPVRPSS AEPHRPLKIT 730 740 750 760 770 780 AHSSPPLTKT LVDHHKEELE RKAFMEPLRS VASTSAKNDL DLNRSQTGKD CHLHRHFVDP 790 800 810 820 830 840 VLNQLQRPPQ ETGERLNKYK EEHRRILQES IDVAPFTTKI KGLEGERENY SRVASSSSSP 850 860 870 880 890 900 KSHIIKQDMD VERSVSDLYK MKHSVPQSLP QSNYFTTLSN SVVNEPPRSY PSKEVSNIYG 910 920 930 940 950 960 DKQSNALAAA AANPQTLTSF ITSLSKPPPL IKHQPESEGL VGKIPEHLPH QIASHSVTTF 970 980 990 1000 1010 1020 RNDCRSPTHL TVSSTNTLRS MPALHRAPVF HPPIHHSLER KEGSYSSLSP PTLTPVMPVN 1030 1040 1050 1060 1070 1080 AGGKVQESQK PPTLIPEPKD SQANFKSSSE QSLTEMWRPN NNLSKEKTEW HVEKSSGKLQ 1090 1100 1110 1120 1130 1140 AAMASVIVRP SSSTKTDSMP AMQLASKDRV SERSSAGAHK TDCLKLAEAG ETGRIILPNV 1150 1160 1170 1180 1190 1200 NSDSVHTKSE KNFQAVSQGS VPSSVMSAVN TMCNTKTDVI TSAADTTSVS SWGGSEVISS 1210 1220 1230 1240 1250 1260 LSNTILASTS SECVSSKSVS QPVAQKQECK VSTTAPVTLA SSKTGSVVQP SSGFSGTTDF 1270 1280 1290 1300 1310 1320 IHLKKHKAAL AAAQYKSSNA SETEPNAIKN QTLSASLPLD STVICSTINK ANSVGNGQAS 1330 1340 1350 1360 1370 1380 QTSQPNYHTK LKKAWLTRHS EEDKNTNKME NSGNSVSEII KPCSVNLIAS TSSDIQNSVD 1390 1400 1410 1420 1430 1440 SKIIVDKYVK DDKVNRRKAK RTYESGSESG DSDESESKSE QRTKRQPKPT YKKKQNDLQK 1450 1460 1470 1480 RKGEIEEDLK PNGVLSRSAK ERSKLKLQSN SNSCHLVKTE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-2540, VARIANTS THR-464 AND ASP-2535. Tissue: Amygdala and Cervix.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427. Tissue: Embryo.
[4]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1275-2540. Tissue: Brain.
[5]	"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor." Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D. Mol. Endocrinol. 9:243-254(1995) [PubMed: 7776974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR.
[6]	"Identification and characterization of TRIP8 gene in silico." Katoh M., Katoh M. Int. J. Mol. Med. 12:817-821(2003) [PubMed: 14533015] [Abstract] Cited for: IDENTIFICATION OF THE GENE.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376; SER-379; SER-638 AND SER-641, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-552, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX537954 mRNA. Translation: CAD97921.1. Frameshift. AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems. AL713895, AL590502 Genomic DNA. Translation: CAI10948.1. AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1. AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1. AK027280 mRNA. No translation available. AL831917 mRNA. Translation: CAD38578.1. AB037801 mRNA. Translation: BAA92618.1. L40411 mRNA. Translation: AAC41741.1. Frameshift.
IPI	IPI00384202. IPI00902772.
RefSeq	NP_004232.2. NM_004241.2. NP_116165.1. NM_032776.1.
UniGene	Hs.413416.
3D structure databases
ProteinModelPortal	Q15652.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15652. 1 interaction.
STRING	Q15652.
PTM databases
PhosphoSite	Q15652.
Polymorphism databases
DMDM	85541650.
Proteomic databases
PRIDE	Q15652.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000399262; ENSP00000382204; ENSG00000171988.
GeneID	221037.
KEGG	hsa:221037.
NMPDR	fig|9606.3.peg.4012.
UCSC	uc001jml.1. human. uc001jmn.1. human.
Organism-specific databases
CTD	221037.
GeneCards	GC10M064926.
HGNC	HGNC:12313. JMJD1C.
MIM	604503. gene.
neXtProt	NX_Q15652.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063039.
HOVERGEN	HBG079631.
InParanoid	Q15652.
OMA	MKHSVPQ.
OrthoDB	EOG447FS9.
PhylomeDB	Q15652.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q15652.
Bgee	Q15652.
CleanEx	HS_JMJD1C.
Genevestigator	Q15652.
GermOnline	ENSG00000171988. Homo sapiens.
Family and domain databases
InterPro	IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. [Graphical view]
KO	K11449.
Pfam	PF02373. JmjC. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91161.
SOURCE	Search...

Entry information

Entry name

JHD2C_HUMAN

Accession

Primary (citable) accession number: Q15652
Secondary accession number(s): Q5SQZ8 , Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 10, 2006
Last modified:	January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.