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Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

JMJD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2336Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2338Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi2466Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171988-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name:
TR-interacting protein 8
Short name:
TRIP-8
Gene namesi
Name:JMJD1C
Synonyms:JHDM2C, KIAA1380, TRIP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:12313. JMJD1C.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: GO_Central
  • intracellular Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221037.
MalaCardsiJMJD1C.
OpenTargetsiENSG00000171988.
Orphaneti91352. Germinoma of the central nervous system.
PharmGKBiPA128394767.

Polymorphism and mutation databases

BioMutaiJMJD1C.
DMDMi85541650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842841 – 2540Probable JmjC domain-containing histone demethylation protein 2CAdd BLAST2540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei317PhosphoserineCombined sources1
Modified residuei320PhosphoserineBy similarity1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei501PhosphoserineCombined sources1
Modified residuei505PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Modified residuei1989PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15652.
MaxQBiQ15652.
PaxDbiQ15652.
PeptideAtlasiQ15652.
PRIDEiQ15652.

PTM databases

iPTMnetiQ15652.
PhosphoSitePlusiQ15652.

Expressioni

Gene expression databases

BgeeiENSG00000171988.
CleanExiHS_JMJD1C.
ExpressionAtlasiQ15652. baseline and differential.
GenevisibleiQ15652. HS.

Organism-specific databases

HPAiHPA056175.
HPA066195.

Interactioni

Subunit structurei

Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-1224969,EBI-608057

GO - Molecular functioni

  • thyroid hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128677. 14 interactors.
DIPiDIP-38114N.
IntActiQ15652. 9 interactors.
MINTiMINT-8247476.
STRINGi9606.ENSP00000382204.

Structurei

Secondary structure

12540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2159 – 2162Combined sources4
Turni2163 – 2166Combined sources4
Beta strandi2167 – 2170Combined sources4
Helixi2178 – 2186Combined sources9
Turni2187 – 2189Combined sources3
Beta strandi2192 – 2194Combined sources3
Helixi2197 – 2199Combined sources3
Helixi2203 – 2206Combined sources4
Helixi2208 – 2215Combined sources8
Turni2225 – 2227Combined sources3
Helixi2235 – 2243Combined sources9
Helixi2245 – 2247Combined sources3
Beta strandi2259 – 2261Combined sources3
Beta strandi2264 – 2266Combined sources3
Helixi2268 – 2273Combined sources6
Helixi2275 – 2284Combined sources10
Helixi2288 – 2291Combined sources4
Turni2300 – 2302Combined sources3
Helixi2305 – 2307Combined sources3
Beta strandi2315 – 2319Combined sources5
Turni2323 – 2326Combined sources4
Beta strandi2332 – 2337Combined sources6
Beta strandi2339 – 2350Combined sources12
Helixi2360 – 2368Combined sources9
Helixi2374 – 2381Combined sources8
Beta strandi2387 – 2394Combined sources8
Helixi2396 – 2398Combined sources3
Helixi2399 – 2412Combined sources14
Helixi2423 – 2426Combined sources4
Helixi2433 – 2443Combined sources11
Beta strandi2448 – 2453Combined sources6
Beta strandi2457 – 2460Combined sources4
Beta strandi2465 – 2481Combined sources17
Helixi2484 – 2486Combined sources3
Helixi2487 – 2496Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPDX-ray2.10A/B2157-2540[»]
5FZOX-ray1.84A/B2157-2500[»]
ProteinModelPortaliQ15652.
SMRiQ15652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2274 – 2498JmjCPROSITE-ProRule annotationAdd BLAST225

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2066 – 2070LXXLL motif5

Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1846 – 1871C6-typeSequence analysisAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1356. Eukaryota.
ENOG410XTAA. LUCA.
GeneTreeiENSGT00530000063039.
HOVERGENiHBG079631.
InParanoidiQ15652.
KOiK11449.
OMAiHDIGTTN.
OrthoDBiEOG091G00RB.
PhylomeDBiQ15652.
TreeFamiTF324723.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15652-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS
60 70 80 90 100
RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG
110 120 130 140 150
SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD
160 170 180 190 200
DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD
210 220 230 240 250
SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL
260 270 280 290 300
LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT
310 320 330 340 350
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN
360 370 380 390 400
KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE
410 420 430 440 450
LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK
460 470 480 490 500
SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV
510 520 530 540 550
SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN
560 570 580 590 600
AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI
610 620 630 640 650
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT
660 670 680 690 700
HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK
710 720 730 740 750
SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN
760 770 780 790 800
PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL
810 820 830 840 850
PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP
860 870 880 890 900
SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS
910 920 930 940 950
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL
960 970 980 990 1000
VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV
1010 1020 1030 1040 1050
LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS
1060 1070 1080 1090 1100
RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS
1110 1120 1130 1140 1150
VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI
1160 1170 1180 1190 1200
KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM
1210 1220 1230 1240 1250
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP
1260 1270 1280 1290 1300
PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA
1310 1320 1330 1340 1350
AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE
1360 1370 1380 1390 1400
TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT
1410 1420 1430 1440 1450
SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV
1460 1470 1480 1490 1500
STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS
1510 1520 1530 1540 1550
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL
1560 1570 1580 1590 1600
KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS
1610 1620 1630 1640 1650
KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY
1660 1670 1680 1690 1700
KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK
1710 1720 1730 1740 1750
DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV
1760 1770 1780 1790 1800
FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE
1810 1820 1830 1840 1850
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE
1860 1870 1880 1890 1900
ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK
1910 1920 1930 1940 1950
HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN
1960 1970 1980 1990 2000
GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL
2010 2020 2030 2040 2050
TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG
2060 2070 2080 2090 2100
RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK
2110 2120 2130 2140 2150
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN
2160 2170 2180 2190 2200
NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK
2210 2220 2230 2240 2250
MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK
2260 2270 2280 2290 2300
NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA
2310 2320 2330 2340 2350
SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG
2360 2370 2380 2390 2400
IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD
2410 2420 2430 2440 2450
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL
2460 2470 2480 2490 2500
IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL
2510 2520 2530 2540
KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN
Length:2,540
Mass (Da):284,525
Last modified:January 10, 2006 - v2
Checksum:i8B1727414D6B677F
GO
Isoform 2 (identifier: Q15652-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

Note: No experimental confirmation available.
Show »
Length:1,480
Mass (Da):163,133
Checksum:i72DB291B3FAB25B7
GO
Isoform 3 (identifier: Q15652-3) [UniParc]FASTAAdd to basket
Also known as: s-JMJD1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.
Show »
Length:2,358
Mass (Da):263,157
Checksum:i6005F440A38FC096
GO

Sequence cautioni

The sequence AAC41741 differs from that shown. Reason: Frameshift at position 2171.Curated
The sequence CAD97921 differs from that shown. Reason: Frameshift at position 1697.Curated
The sequence CAI10947 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti488T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti779T → A in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti783T → P in CAD97921 (PubMed:17974005).Curated1
Sequence conflicti2093S → A in AAC41741 (PubMed:7776974).Curated1
Sequence conflicti2148Missing in BAA92618 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049654272A → T.Corresponds to variant rs34798625dbSNPEnsembl.1
Natural variantiVAR_049655394E → D.Corresponds to variant rs35380596dbSNPEnsembl.1
Natural variantiVAR_049656464S → T.1 PublicationCorresponds to variant rs10761725dbSNPEnsembl.1
Natural variantiVAR_061277591M → V.Corresponds to variant rs41274072dbSNPEnsembl.1
Natural variantiVAR_0496571393N → Y.Corresponds to variant rs9703886dbSNPEnsembl.1
Natural variantiVAR_0496582400D → E.Corresponds to variant rs34491125dbSNPEnsembl.1
Natural variantiVAR_0496592535E → D.1 PublicationCorresponds to variant rs1935dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183031 – 219Missing in isoform 2. 1 PublicationAdd BLAST219
Alternative sequenceiVSP_0439091 – 182Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_0183041692 – 1699TGIPRSVL → SCHLVKTE in isoform 2. 1 Publication8
Alternative sequenceiVSP_0183051700 – 2540Missing in isoform 2. 1 PublicationAdd BLAST841

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA. Translation: ABK64187.1.
BX537954 mRNA. Translation: CAD97921.1. Frameshift.
AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems.
AL713895, AL590502 Genomic DNA. Translation: CAI10948.1.
AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1.
AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1.
AK027280 mRNA. No translation available.
AL831917 mRNA. Translation: CAD38578.1.
AB037801 mRNA. Translation: BAA92618.1.
L40411 mRNA. Translation: AAC41741.1. Frameshift.
CCDSiCCDS41532.1. [Q15652-1]
CCDS60538.1. [Q15652-3]
RefSeqiNP_001269877.1. NM_001282948.1. [Q15652-3]
NP_001305082.1. NM_001318153.1.
NP_001305083.1. NM_001318154.1. [Q15652-3]
NP_001309181.1. NM_001322252.1.
NP_001309183.1. NM_001322254.1.
NP_001309187.1. NM_001322258.1.
NP_116165.1. NM_032776.2. [Q15652-1]
XP_016871386.1. XM_017015897.1. [Q15652-3]
XP_016871387.1. XM_017015898.1. [Q15652-3]
UniGeneiHs.413416.

Genome annotation databases

EnsembliENST00000399262; ENSP00000382204; ENSG00000171988. [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988. [Q15652-3]
GeneIDi221037.
KEGGihsa:221037.
UCSCiuc001jmn.5. human. [Q15652-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA. Translation: ABK64187.1.
BX537954 mRNA. Translation: CAD97921.1. Frameshift.
AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems.
AL713895, AL590502 Genomic DNA. Translation: CAI10948.1.
AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1.
AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1.
AK027280 mRNA. No translation available.
AL831917 mRNA. Translation: CAD38578.1.
AB037801 mRNA. Translation: BAA92618.1.
L40411 mRNA. Translation: AAC41741.1. Frameshift.
CCDSiCCDS41532.1. [Q15652-1]
CCDS60538.1. [Q15652-3]
RefSeqiNP_001269877.1. NM_001282948.1. [Q15652-3]
NP_001305082.1. NM_001318153.1.
NP_001305083.1. NM_001318154.1. [Q15652-3]
NP_001309181.1. NM_001322252.1.
NP_001309183.1. NM_001322254.1.
NP_001309187.1. NM_001322258.1.
NP_116165.1. NM_032776.2. [Q15652-1]
XP_016871386.1. XM_017015897.1. [Q15652-3]
XP_016871387.1. XM_017015898.1. [Q15652-3]
UniGeneiHs.413416.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPDX-ray2.10A/B2157-2540[»]
5FZOX-ray1.84A/B2157-2500[»]
ProteinModelPortaliQ15652.
SMRiQ15652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128677. 14 interactors.
DIPiDIP-38114N.
IntActiQ15652. 9 interactors.
MINTiMINT-8247476.
STRINGi9606.ENSP00000382204.

PTM databases

iPTMnetiQ15652.
PhosphoSitePlusiQ15652.

Polymorphism and mutation databases

BioMutaiJMJD1C.
DMDMi85541650.

Proteomic databases

EPDiQ15652.
MaxQBiQ15652.
PaxDbiQ15652.
PeptideAtlasiQ15652.
PRIDEiQ15652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399262; ENSP00000382204; ENSG00000171988. [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988. [Q15652-3]
GeneIDi221037.
KEGGihsa:221037.
UCSCiuc001jmn.5. human. [Q15652-1]

Organism-specific databases

CTDi221037.
DisGeNETi221037.
GeneCardsiJMJD1C.
HGNCiHGNC:12313. JMJD1C.
HPAiHPA056175.
HPA066195.
MalaCardsiJMJD1C.
MIMi604503. gene.
neXtProtiNX_Q15652.
OpenTargetsiENSG00000171988.
Orphaneti91352. Germinoma of the central nervous system.
PharmGKBiPA128394767.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1356. Eukaryota.
ENOG410XTAA. LUCA.
GeneTreeiENSGT00530000063039.
HOVERGENiHBG079631.
InParanoidiQ15652.
KOiK11449.
OMAiHDIGTTN.
OrthoDBiEOG091G00RB.
PhylomeDBiQ15652.
TreeFamiTF324723.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171988-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSiJMJD1C. human.
GenomeRNAii221037.
PROiQ15652.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171988.
CleanExiHS_JMJD1C.
ExpressionAtlasiQ15652. baseline and differential.
GenevisibleiQ15652. HS.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJHD2C_HUMAN
AccessioniPrimary (citable) accession number: Q15652
Secondary accession number(s): A0T124
, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.