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Q15652

- JHD2C_HUMAN

UniProt

Q15652 - JHD2C_HUMAN

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Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

JMJD1C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2336 – 23361Iron; catalyticPROSITE-ProRule annotation
Metal bindingi2338 – 23381Iron; catalyticPROSITE-ProRule annotation
Metal bindingi2466 – 24661Iron; catalyticPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1846 – 187126C6-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. dioxygenase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. chromatin modification Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name:
TR-interacting protein 8
Short name:
TRIP-8
Gene namesi
Name:JMJD1C
Synonyms:JHDM2C, KIAA1380, TRIP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:12313. JMJD1C.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. intracellular Source: UniProtKB
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25402540Probable JmjC domain-containing histone demethylation protein 2CPRO_0000084284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei317 – 3171Phosphoserine1 Publication
Modified residuei373 – 3731Phosphoserine2 Publications
Modified residuei376 – 3761Phosphoserine1 Publication
Modified residuei617 – 6171Phosphoserine1 Publication
Modified residuei638 – 6381Phosphoserine1 Publication
Modified residuei641 – 6411Phosphoserine2 Publications
Modified residuei652 – 6521Phosphoserine1 Publication
Modified residuei1989 – 19891Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15652.
PaxDbiQ15652.
PRIDEiQ15652.

PTM databases

PhosphoSiteiQ15652.

Expressioni

Gene expression databases

BgeeiQ15652.
CleanExiHS_JMJD1C.
GenevestigatoriQ15652.

Organism-specific databases

HPAiHPA056175.

Interactioni

Subunit structurei

Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-1224969,EBI-608057

Protein-protein interaction databases

BioGridi128677. 13 interactions.
DIPiDIP-38114N.
IntActiQ15652. 7 interactions.
MINTiMINT-8247476.
STRINGi9606.ENSP00000382204.

Structurei

Secondary structure

1
2540
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2159 – 21624Combined sources
Turni2163 – 21664Combined sources
Beta strandi2167 – 21704Combined sources
Helixi2178 – 21869Combined sources
Turni2187 – 21893Combined sources
Beta strandi2192 – 21943Combined sources
Helixi2197 – 22004Combined sources
Helixi2203 – 22064Combined sources
Helixi2208 – 22158Combined sources
Turni2225 – 22273Combined sources
Helixi2235 – 22406Combined sources
Beta strandi2242 – 22443Combined sources
Helixi2245 – 22473Combined sources
Beta strandi2259 – 22613Combined sources
Beta strandi2263 – 22664Combined sources
Helixi2268 – 22736Combined sources
Helixi2275 – 228410Combined sources
Helixi2288 – 22914Combined sources
Turni2300 – 23023Combined sources
Helixi2305 – 23073Combined sources
Beta strandi2315 – 23195Combined sources
Turni2323 – 23264Combined sources
Beta strandi2332 – 23376Combined sources
Beta strandi2339 – 235012Combined sources
Helixi2360 – 23689Combined sources
Helixi2374 – 23807Combined sources
Beta strandi2387 – 23948Combined sources
Helixi2396 – 23983Combined sources
Helixi2399 – 241315Combined sources
Helixi2423 – 24264Combined sources
Helixi2433 – 244311Combined sources
Beta strandi2448 – 24536Combined sources
Beta strandi2457 – 24604Combined sources
Beta strandi2465 – 248117Combined sources
Helixi2484 – 24863Combined sources
Helixi2487 – 249610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YPDX-ray2.10A/B2157-2540[»]
ProteinModelPortaliQ15652.
SMRiQ15652. Positions 2157-2497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2274 – 2498225JmjCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2066 – 20705LXXLL motif

Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1846 – 187126C6-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG305537.
GeneTreeiENSGT00530000063039.
HOVERGENiHBG079631.
InParanoidiQ15652.
KOiK11449.
OMAiFTGIITH.
OrthoDBiEOG7B5WVG.
PhylomeDBiQ15652.
TreeFamiTF324723.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15652-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS
60 70 80 90 100
RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG
110 120 130 140 150
SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD
160 170 180 190 200
DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD
210 220 230 240 250
SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL
260 270 280 290 300
LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT
310 320 330 340 350
HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN
360 370 380 390 400
KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE
410 420 430 440 450
LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK
460 470 480 490 500
SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV
510 520 530 540 550
SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN
560 570 580 590 600
AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI
610 620 630 640 650
SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT
660 670 680 690 700
HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK
710 720 730 740 750
SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN
760 770 780 790 800
PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL
810 820 830 840 850
PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP
860 870 880 890 900
SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS
910 920 930 940 950
PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL
960 970 980 990 1000
VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV
1010 1020 1030 1040 1050
LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS
1060 1070 1080 1090 1100
RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS
1110 1120 1130 1140 1150
VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI
1160 1170 1180 1190 1200
KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM
1210 1220 1230 1240 1250
PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP
1260 1270 1280 1290 1300
PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA
1310 1320 1330 1340 1350
AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE
1360 1370 1380 1390 1400
TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT
1410 1420 1430 1440 1450
SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV
1460 1470 1480 1490 1500
STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS
1510 1520 1530 1540 1550
ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL
1560 1570 1580 1590 1600
KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS
1610 1620 1630 1640 1650
KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY
1660 1670 1680 1690 1700
KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK
1710 1720 1730 1740 1750
DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV
1760 1770 1780 1790 1800
FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE
1810 1820 1830 1840 1850
TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE
1860 1870 1880 1890 1900
ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK
1910 1920 1930 1940 1950
HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN
1960 1970 1980 1990 2000
GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL
2010 2020 2030 2040 2050
TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG
2060 2070 2080 2090 2100
RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK
2110 2120 2130 2140 2150
SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN
2160 2170 2180 2190 2200
NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK
2210 2220 2230 2240 2250
MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK
2260 2270 2280 2290 2300
NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA
2310 2320 2330 2340 2350
SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG
2360 2370 2380 2390 2400
IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD
2410 2420 2430 2440 2450
KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL
2460 2470 2480 2490 2500
IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL
2510 2520 2530 2540
KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN
Length:2,540
Mass (Da):284,525
Last modified:January 10, 2006 - v2
Checksum:i8B1727414D6B677F
GO
Isoform 2 (identifier: Q15652-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

Note: No experimental confirmation available.

Show »
Length:1,480
Mass (Da):163,133
Checksum:i72DB291B3FAB25B7
GO
Isoform 3 (identifier: Q15652-3) [UniParc]FASTAAdd to Basket

Also known as: s-JMJD1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.

Show »
Length:2,358
Mass (Da):263,157
Checksum:i6005F440A38FC096
GO

Sequence cautioni

The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171. Curated
The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697. Curated
The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti488 – 4881T → A in CAD97921. (PubMed:17974005)Curated
Sequence conflicti779 – 7791T → A in CAD97921. (PubMed:17974005)Curated
Sequence conflicti783 – 7831T → P in CAD97921. (PubMed:17974005)Curated
Sequence conflicti2093 – 20931S → A in AAC41741. (PubMed:7776974)Curated
Sequence conflicti2148 – 21481Missing in BAA92618. (PubMed:10718198)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti272 – 2721A → T.
Corresponds to variant rs34798625 [ dbSNP | Ensembl ].
VAR_049654
Natural varianti394 – 3941E → D.
Corresponds to variant rs35380596 [ dbSNP | Ensembl ].
VAR_049655
Natural varianti464 – 4641S → T.1 Publication
Corresponds to variant rs10761725 [ dbSNP | Ensembl ].
VAR_049656
Natural varianti591 – 5911M → V.
Corresponds to variant rs41274072 [ dbSNP | Ensembl ].
VAR_061277
Natural varianti1393 – 13931N → Y.
Corresponds to variant rs9703886 [ dbSNP | Ensembl ].
VAR_049657
Natural varianti2400 – 24001D → E.
Corresponds to variant rs34491125 [ dbSNP | Ensembl ].
VAR_049658
Natural varianti2535 – 25351E → D.1 Publication
Corresponds to variant rs1935 [ dbSNP | Ensembl ].
VAR_049659

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 219219Missing in isoform 2. 1 PublicationVSP_018303Add
BLAST
Alternative sequencei1 – 182182Missing in isoform 3. 1 PublicationVSP_043909Add
BLAST
Alternative sequencei1692 – 16998TGIPRSVL → SCHLVKTE in isoform 2. 1 PublicationVSP_018304
Alternative sequencei1700 – 2540841Missing in isoform 2. 1 PublicationVSP_018305Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA. Translation: ABK64187.1.
BX537954 mRNA. Translation: CAD97921.1. Frameshift.
AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems.
AL713895, AL590502 Genomic DNA. Translation: CAI10948.1.
AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1.
AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1.
AK027280 mRNA. No translation available.
AL831917 mRNA. Translation: CAD38578.1.
AB037801 mRNA. Translation: BAA92618.1.
L40411 mRNA. Translation: AAC41741.1. Frameshift.
CCDSiCCDS41532.1. [Q15652-1]
CCDS60538.1. [Q15652-3]
RefSeqiNP_001269877.1. NM_001282948.1. [Q15652-3]
NP_116165.1. NM_032776.2. [Q15652-1]
XP_006717770.1. XM_006717707.1. [Q15652-3]
UniGeneiHs.413416.

Genome annotation databases

EnsembliENST00000399262; ENSP00000382204; ENSG00000171988. [Q15652-1]
ENST00000542921; ENSP00000444682; ENSG00000171988. [Q15652-3]
GeneIDi221037.
KEGGihsa:221037.
UCSCiuc001jml.3. human. [Q15652-1]

Polymorphism databases

DMDMi85541650.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF068222 mRNA. Translation: ABK64187.1 .
BX537954 mRNA. Translation: CAD97921.1 . Frameshift.
AL713895 Genomic DNA. Translation: CAI10947.1 . Sequence problems.
AL713895 , AL590502 Genomic DNA. Translation: CAI10948.1 .
AL713895 , AL607128 , AC022022 Genomic DNA. Translation: CAI10950.1 .
AL607128 , AL713895 , AC022022 Genomic DNA. Translation: CAI14188.1 .
AK027280 mRNA. No translation available.
AL831917 mRNA. Translation: CAD38578.1 .
AB037801 mRNA. Translation: BAA92618.1 .
L40411 mRNA. Translation: AAC41741.1 . Frameshift.
CCDSi CCDS41532.1. [Q15652-1 ]
CCDS60538.1. [Q15652-3 ]
RefSeqi NP_001269877.1. NM_001282948.1. [Q15652-3 ]
NP_116165.1. NM_032776.2. [Q15652-1 ]
XP_006717770.1. XM_006717707.1. [Q15652-3 ]
UniGenei Hs.413416.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YPD X-ray 2.10 A/B 2157-2540 [» ]
ProteinModelPortali Q15652.
SMRi Q15652. Positions 2157-2497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128677. 13 interactions.
DIPi DIP-38114N.
IntActi Q15652. 7 interactions.
MINTi MINT-8247476.
STRINGi 9606.ENSP00000382204.

PTM databases

PhosphoSitei Q15652.

Polymorphism databases

DMDMi 85541650.

Proteomic databases

MaxQBi Q15652.
PaxDbi Q15652.
PRIDEi Q15652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399262 ; ENSP00000382204 ; ENSG00000171988 . [Q15652-1 ]
ENST00000542921 ; ENSP00000444682 ; ENSG00000171988 . [Q15652-3 ]
GeneIDi 221037.
KEGGi hsa:221037.
UCSCi uc001jml.3. human. [Q15652-1 ]

Organism-specific databases

CTDi 221037.
GeneCardsi GC10M064926.
HGNCi HGNC:12313. JMJD1C.
HPAi HPA056175.
MIMi 604503. gene.
neXtProti NX_Q15652.
PharmGKBi PA128394767.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305537.
GeneTreei ENSGT00530000063039.
HOVERGENi HBG079631.
InParanoidi Q15652.
KOi K11449.
OMAi FTGIITH.
OrthoDBi EOG7B5WVG.
PhylomeDBi Q15652.
TreeFami TF324723.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi JMJD1C. human.
GenomeRNAii 221037.
NextBioi 91161.
PROi Q15652.
SOURCEi Search...

Gene expression databases

Bgeei Q15652.
CleanExi HS_JMJD1C.
Genevestigatori Q15652.

Family and domain databases

InterProi IPR003347. JmjC_dom.
[Graphical view ]
Pfami PF02373. JmjC. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR."
    Wolf S.S., Patchev V.K., Obendorf M.
    Arch. Biochem. Biophys. 460:56-66(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-2540, VARIANTS THR-464 AND ASP-2535.
    Tissue: Amygdala and Cervix.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427.
    Tissue: Embryo.
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1275-2540.
    Tissue: Brain.
  6. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
    Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
    Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR.
  7. "Identification and characterization of TRIP8 gene in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 12:817-821(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF THE GENE.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376 AND SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-373; SER-617; SER-638; SER-641; SER-652 AND SER-1989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJHD2C_HUMAN
AccessioniPrimary (citable) accession number: Q15652
Secondary accession number(s): A0T124
, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 10, 2006
Last modified: November 26, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3