Q15652 (JHD2C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable JmjC domain-containing histone demethylation protein 2C
EC=1.14.11.-

Alternative name(s):
Jumonji domain-containing protein 1C
Thyroid receptor-interacting protein 8
Short name=TR-interacting protein 8
Short name=TRIP-8

Gene names

Name:	JMJD1C
Synonyms:	JHDM2C, KIAA1380, TRIP8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2540 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes By similarity.
Cofactor	Binds 1 Fe2+ ion per subunit By similarity.
Subunit structure	Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Ref.6
Subcellular location	Nucleus By similarity.
Domain	Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors By similarity.
Sequence similarities	Belongs to the JHDM2 histone demethylase family. Contains 1 JmjC domain.
Sequence caution	The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171. The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697. The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Traceable author statement Ref.6. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW thyroid hormone receptor binding Traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AR	P10275	2	EBI-1224969,EBI-608057

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15652-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15652-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.
     1692-1699: TGIPRSVL → SCHLVKTE
     1700-2540: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q15652-3)

Also known as: s-JMJD1C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2540

2540

Probable JmjC domain-containing histone demethylation protein 2C

PRO_0000084284

Regions

Domain

2274 – 2498

225

JmjC

Zinc finger

1846 – 1871

26

C6-type Potential

Motif

2066 – 2070

5

LXXLL motif

Sites

Metal binding

2336

1

Iron; catalytic By similarity

Metal binding

2338

1

Iron; catalytic By similarity

Metal binding

2466

1

Iron; catalytic By similarity

Amino acid modifications

Modified residue

317

1

Phosphoserine Ref.10

Modified residue

373

1

Phosphoserine Ref.8 Ref.10

Modified residue

376

1

Phosphoserine Ref.8

Modified residue

617

1

Phosphoserine Ref.10

Modified residue

638

1

Phosphoserine Ref.10

Modified residue

641

1

Phosphoserine Ref.8 Ref.10

Modified residue

652

1

Phosphoserine Ref.10

Modified residue

1989

1

Phosphoserine Ref.10

Natural variations

Alternative sequence

1 – 219

219

Missing in isoform 2.

VSP_018303

Alternative sequence

1 – 182

182

Missing in isoform 3.

VSP_043909

Alternative sequence

1692 – 1699

8

TGIPRSVL → SCHLVKTE in isoform 2.

VSP_018304

Alternative sequence

1700 – 2540

841

Missing in isoform 2.

VSP_018305

Natural variant

272

1

A → T.
Corresponds to variant rs34798625 [ dbSNP | Ensembl ].

VAR_049654

Natural variant

394

1

E → D.
Corresponds to variant rs35380596 [ dbSNP | Ensembl ].

VAR_049655

Natural variant

464

1

S → T. Ref.2
Corresponds to variant rs10761725 [ dbSNP | Ensembl ].

VAR_049656

Natural variant

591

1

M → V.
Corresponds to variant rs41274072 [ dbSNP | Ensembl ].

VAR_061277

Natural variant

1393

1

N → Y.
Corresponds to variant rs9703886 [ dbSNP | Ensembl ].

VAR_049657

Natural variant

2400

1

D → E.
Corresponds to variant rs34491125 [ dbSNP | Ensembl ].

VAR_049658

Natural variant

2535

1

E → D. Ref.2
Corresponds to variant rs1935 [ dbSNP | Ensembl ].

VAR_049659

Experimental info

Sequence conflict

488

1

T → A in CAD97921. Ref.2

Sequence conflict

779

1

T → A in CAD97921. Ref.2

Sequence conflict

783

1

T → P in CAD97921. Ref.2

Sequence conflict

2093

1

S → A in AAC41741. Ref.6

Sequence conflict

2148

1

Missing in BAA92618. Ref.5

Secondary structure

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2540

Helix Strand Turn

Details...

Beta strand

2159 – 2162

4

Turn

2163 – 2166

4

Beta strand

2167 – 2170

4

Helix

2178 – 2186

9

Turn

2187 – 2189

3

Beta strand

2192 – 2194

3

Helix

2197 – 2200

4

Helix

2203 – 2206

4

Helix

2208 – 2215

8

Turn

2225 – 2227

3

Helix

2235 – 2240

6

Beta strand

2242 – 2244

3

Helix

2245 – 2247

3

Beta strand

2259 – 2261

3

Beta strand

2263 – 2266

4

Helix

2268 – 2273

6

Helix

2275 – 2284

10

Helix

2288 – 2291

4

Turn

2300 – 2302

3

Helix

2305 – 2307

3

Beta strand

2315 – 2319

5

Turn

2323 – 2326

4

Beta strand

2332 – 2337

6

Beta strand

2339 – 2350

12

Helix

2360 – 2368

9

Helix

2374 – 2380

7

Beta strand

2387 – 2394

8

Helix

2396 – 2398

3

Helix

2399 – 2413

15

Helix

2423 – 2426

4

Helix

2433 – 2443

11

Beta strand

2448 – 2453

6

Beta strand

2457 – 2460

4

Beta strand

2465 – 2481

17

Helix

2484 – 2486

3

Helix

2487 – 2496

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 8B1727414D6B677F	FASTA	2,540	284,525
	10 20 30 40 50 60 MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS RNPDLAVYVE 70 80 90 100 110 120 FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG SKSKQIQWPA LTFKPLVERN 130 140 150 160 170 180 IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE 190 200 210 220 230 240 IFMQGPYSLN GYRVRVYRQD SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM 250 260 270 280 290 300 TFLDDVVHSL LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT 310 320 330 340 350 360 HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN KRRKPEEDEK 370 380 390 400 410 420 KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE LKNKNTSKIN GEEGKPHNNE 430 440 450 460 470 480 KAGEETLKNS QPPWDQIQED KKHEEAEKRK SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP 490 500 510 520 530 540 QECNMDKTHT MELLPKEKFV SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN 550 560 570 580 590 600 VSDSKHSIAN AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI 610 620 630 640 650 660 SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT HSPDSVKSKA 670 680 690 700 710 720 TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK SPLIIDKNEH FTVYRDPALI 730 740 750 760 770 780 GSETGANHIS PFLSQHPFPL HSSSHRTCLN PGTHHPALTP APHLLAGSSS QTPLPTINTH 790 800 810 820 830 840 PLTSGPHHAV HHPHLLPTVL PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ 850 860 870 880 890 900 SPHLLGQAHP SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS 910 920 930 940 950 960 PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL VDHHKEELER 970 980 990 1000 1010 1020 KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV LNQLQRPPQE TGERLNKYKE 1030 1040 1050 1060 1070 1080 EHRRILQESI DVAPFTTKIK GLEGERENYS RVASSSSSPK SHIIKQDMDV ERSVSDLYKM 1090 1100 1110 1120 1130 1140 KHSVPQSLPQ SNYFTTLSNS VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI 1150 1160 1170 1180 1190 1200 TSLSKPPPLI KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM 1210 1220 1230 1240 1250 1260 PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP PTLIPEPKDS 1270 1280 1290 1300 1310 1320 QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA AMASVIVRPS SSTKTDSMPA 1330 1340 1350 1360 1370 1380 MQLASKDRVS ERSSAGAHKT DCLKLAEAGE TGRIILPNVN SDSVHTKSEK NFQAVSQGSV 1390 1400 1410 1420 1430 1440 PSSVMSAVNT MCNTKTDVIT SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ 1450 1460 1470 1480 1490 1500 PVAQKQECKV STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS 1510 1520 1530 1540 1550 1560 ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL KKAWLTRHSE 1570 1580 1590 1600 1610 1620 EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS KIIVDKYVKD DKVNRRKAKR 1630 1640 1650 1660 1670 1680 TYESGSESGD SDESESKSEQ RTKRQPKPTY KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE 1690 1700 1710 1720 1730 1740 RSKLKLQSNS NTGIPRSVLK DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK 1750 1760 1770 1780 1790 1800 KGEEPAHSPV FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE 1810 1820 1830 1840 1850 1860 TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE ATLFNIHWVC 1870 1880 1890 1900 1910 1920 QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK HLMPTQIIPG SVLTDLLDAM 1930 1940 1950 1960 1970 1980 HTLREKYGIK SHCHCTNKQN LQVGNFPTMN GVSQVLQNVL NHSNKISLCM PESQQQNTPP 1990 2000 2010 2020 2030 2040 KSEKNGGSSP ESDVGTDNKL TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER 2050 2060 2070 2080 2090 2100 EQDNSESPNG RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK 2110 2120 2130 2140 2150 2160 SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN NKLYSDIPHS 2170 2180 2190 2200 2210 2220 WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK MNISLWKAES ISLDFGDHQA 2230 2240 2250 2260 2270 2280 DLLNCKDSII SNANVKEFWD GFEEVSKRQK NKSGETVVLK LKDWPSGEDF KTMMPARYED 2290 2300 2310 2320 2330 2340 LLKSLPLPEY CNPEGKFNLA SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS 2350 2360 2370 2380 2390 2400 DVVNILVYVG IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD 2410 2420 2430 2440 2450 2460 KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL IQFLGDAIVL 2470 2480 2490 2500 2510 2520 PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL KEEINYDDKL QVKNILYHAV 2530 2540 KEMVRALKIH EDEVEDMEEN
	Isoform 2 [UniParc]. Checksum: 72DB291B3FAB25B7	FASTA	1,480	163,133
	10 20 30 40 50 60 MIVMNDQVLE PQNVDPSMVQ MTFLDDVVHS LLKGENIGIT SRRRSRANQN VNAVHSHYTR 70 80 90 100 110 120 AQANSPRPAM NSQAAVPKQN THQQQQQRSI RPNKRKGSDS SIPDEEKMKE EKYDYISRGE 130 140 150 160 170 180 NPKGKNKHLM NKRRKPEEDE KKLNMKRLRT DNVSDFSESS DSENSNKRII DNSSEQKPEN 190 200 210 220 230 240 ELKNKNTSKI NGEEGKPHNN EKAGEETLKN SQPPWDQIQE DKKHEEAEKR KSVDTQLQED 250 260 270 280 290 300 MIIHSSEQST VSDHNSNDLL PQECNMDKTH TMELLPKEKF VSRPPTPKCV IDITNDTNLE 310 320 330 340 350 360 KVAQENSSTF GLQTLQKMDP NVSDSKHSIA NAKFLETAKK DSDQSWVSDV VKVDLTQSSV 370 380 390 400 410 420 TNASSGNDHL NMEKEKYVSY ISPLSAVSVM EDKLHKRSPP PETIKSKLNT SVDTHKIKSS 430 440 450 460 470 480 PSPEVVKPKI THSPDSVKSK ATYVNSQATG ERRLANKIEH ELSRCSFHPI PTRSSTLETT 490 500 510 520 530 540 KSPLIIDKNE HFTVYRDPAL IGSETGANHI SPFLSQHPFP LHSSSHRTCL NPGTHHPALT 550 560 570 580 590 600 PAPHLLAGSS SQTPLPTINT HPLTSGPHHA VHHPHLLPTV LPGVPTASLL GGHPRLESAH 610 620 630 640 650 660 ASSLSHLALA HQQQQQLLQH QSPHLLGQAH PSASYNQLGL YPIIWQYPNG THAYSGLGLP 670 680 690 700 710 720 SSKWVHPENA VNAEASLRRN SPSPWLHQPT PVTSADGIGL LSHIPVRPSS AEPHRPLKIT 730 740 750 760 770 780 AHSSPPLTKT LVDHHKEELE RKAFMEPLRS VASTSAKNDL DLNRSQTGKD CHLHRHFVDP 790 800 810 820 830 840 VLNQLQRPPQ ETGERLNKYK EEHRRILQES IDVAPFTTKI KGLEGERENY SRVASSSSSP 850 860 870 880 890 900 KSHIIKQDMD VERSVSDLYK MKHSVPQSLP QSNYFTTLSN SVVNEPPRSY PSKEVSNIYG 910 920 930 940 950 960 DKQSNALAAA AANPQTLTSF ITSLSKPPPL IKHQPESEGL VGKIPEHLPH QIASHSVTTF 970 980 990 1000 1010 1020 RNDCRSPTHL TVSSTNTLRS MPALHRAPVF HPPIHHSLER KEGSYSSLSP PTLTPVMPVN 1030 1040 1050 1060 1070 1080 AGGKVQESQK PPTLIPEPKD SQANFKSSSE QSLTEMWRPN NNLSKEKTEW HVEKSSGKLQ 1090 1100 1110 1120 1130 1140 AAMASVIVRP SSSTKTDSMP AMQLASKDRV SERSSAGAHK TDCLKLAEAG ETGRIILPNV 1150 1160 1170 1180 1190 1200 NSDSVHTKSE KNFQAVSQGS VPSSVMSAVN TMCNTKTDVI TSAADTTSVS SWGGSEVISS 1210 1220 1230 1240 1250 1260 LSNTILASTS SECVSSKSVS QPVAQKQECK VSTTAPVTLA SSKTGSVVQP SSGFSGTTDF 1270 1280 1290 1300 1310 1320 IHLKKHKAAL AAAQYKSSNA SETEPNAIKN QTLSASLPLD STVICSTINK ANSVGNGQAS 1330 1340 1350 1360 1370 1380 QTSQPNYHTK LKKAWLTRHS EEDKNTNKME NSGNSVSEII KPCSVNLIAS TSSDIQNSVD 1390 1400 1410 1420 1430 1440 SKIIVDKYVK DDKVNRRKAK RTYESGSESG DSDESESKSE QRTKRQPKPT YKKKQNDLQK 1450 1460 1470 1480 RKGEIEEDLK PNGVLSRSAK ERSKLKLQSN SNSCHLVKTE
	Isoform 3 (s-JMJD1C) [UniParc]. Checksum: 6005F440A38FC096	FASTA	2,358	263,157
	10 20 30 40 50 60 MQGPYSLNGY RVRVYRQDSA TQWFTGIITH HDLFTRTMIV MNDQVLEPQN VDPSMVQMTF 70 80 90 100 110 120 LDDVVHSLLK GENIGITSRR RSRANQNVNA VHSHYTRAQA NSPRPAMNSQ AAVPKQNTHQ 130 140 150 160 170 180 QQQQRSIRPN KRKGSDSSIP DEEKMKEEKY DYISRGENPK GKNKHLMNKR RKPEEDEKKL 190 200 210 220 230 240 NMKRLRTDNV SDFSESSDSE NSNKRIIDNS SEQKPENELK NKNTSKINGE EGKPHNNEKA 250 260 270 280 290 300 GEETLKNSQP PWDQIQEDKK HEEAEKRKSV DTQLQEDMII HSSEQSTVSD HNSNDLLPQE 310 320 330 340 350 360 CNMDKTHTME LLPKEKFVSR PPTPKCVIDI TNDTNLEKVA QENSSTFGLQ TLQKMDPNVS 370 380 390 400 410 420 DSKHSIANAK FLETAKKDSD QSWVSDVVKV DLTQSSVTNA SSGNDHLNME KEKYVSYISP 430 440 450 460 470 480 LSAVSVMEDK LHKRSPPPET IKSKLNTSVD THKIKSSPSP EVVKPKITHS PDSVKSKATY 490 500 510 520 530 540 VNSQATGERR LANKIEHELS RCSFHPIPTR SSTLETTKSP LIIDKNEHFT VYRDPALIGS 550 560 570 580 590 600 ETGANHISPF LSQHPFPLHS SSHRTCLNPG THHPALTPAP HLLAGSSSQT PLPTINTHPL 610 620 630 640 650 660 TSGPHHAVHH PHLLPTVLPG VPTASLLGGH PRLESAHASS LSHLALAHQQ QQQLLQHQSP 670 680 690 700 710 720 HLLGQAHPSA SYNQLGLYPI IWQYPNGTHA YSGLGLPSSK WVHPENAVNA EASLRRNSPS 730 740 750 760 770 780 PWLHQPTPVT SADGIGLLSH IPVRPSSAEP HRPLKITAHS SPPLTKTLVD HHKEELERKA 790 800 810 820 830 840 FMEPLRSVAS TSAKNDLDLN RSQTGKDCHL HRHFVDPVLN QLQRPPQETG ERLNKYKEEH 850 860 870 880 890 900 RRILQESIDV APFTTKIKGL EGERENYSRV ASSSSSPKSH IIKQDMDVER SVSDLYKMKH 910 920 930 940 950 960 SVPQSLPQSN YFTTLSNSVV NEPPRSYPSK EVSNIYGDKQ SNALAAAAAN PQTLTSFITS 970 980 990 1000 1010 1020 LSKPPPLIKH QPESEGLVGK IPEHLPHQIA SHSVTTFRND CRSPTHLTVS STNTLRSMPA 1030 1040 1050 1060 1070 1080 LHRAPVFHPP IHHSLERKEG SYSSLSPPTL TPVMPVNAGG KVQESQKPPT LIPEPKDSQA 1090 1100 1110 1120 1130 1140 NFKSSSEQSL TEMWRPNNNL SKEKTEWHVE KSSGKLQAAM ASVIVRPSSS TKTDSMPAMQ 1150 1160 1170 1180 1190 1200 LASKDRVSER SSAGAHKTDC LKLAEAGETG RIILPNVNSD SVHTKSEKNF QAVSQGSVPS 1210 1220 1230 1240 1250 1260 SVMSAVNTMC NTKTDVITSA ADTTSVSSWG GSEVISSLSN TILASTSSEC VSSKSVSQPV 1270 1280 1290 1300 1310 1320 AQKQECKVST TAPVTLASSK TGSVVQPSSG FSGTTDFIHL KKHKAALAAA QYKSSNASET 1330 1340 1350 1360 1370 1380 EPNAIKNQTL SASLPLDSTV ICSTINKANS VGNGQASQTS QPNYHTKLKK AWLTRHSEED 1390 1400 1410 1420 1430 1440 KNTNKMENSG NSVSEIIKPC SVNLIASTSS DIQNSVDSKI IVDKYVKDDK VNRRKAKRTY 1450 1460 1470 1480 1490 1500 ESGSESGDSD ESESKSEQRT KRQPKPTYKK KQNDLQKRKG EIEEDLKPNG VLSRSAKERS 1510 1520 1530 1540 1550 1560 KLKLQSNSNT GIPRSVLKDW RKVKKLKQTG ESFLQDDSCC EIGPNLQKCR ECRLIRSKKG 1570 1580 1590 1600 1610 1620 EEPAHSPVFC RFYYFRRLSF SKNGVVRIDG FSSPDQYDDE AMSLWTHENF EDDELDIETS 1630 1640 1650 1660 1670 1680 KYILDIIGDK FCQLVTSEKT ALSWVKKDAK IAWKRAVRGV REMCDACEAT LFNIHWVCQK 1690 1700 1710 1720 1730 1740 CGFVVCLDCY KAKERKSSRD KELYAWMKCV KGQPHDHKHL MPTQIIPGSV LTDLLDAMHT 1750 1760 1770 1780 1790 1800 LREKYGIKSH CHCTNKQNLQ VGNFPTMNGV SQVLQNVLNH SNKISLCMPE SQQQNTPPKS 1810 1820 1830 1840 1850 1860 EKNGGSSPES DVGTDNKLTP PESQSPLHWL ADLAEQKARE EKKENKELTL ENQIKEEREQ 1870 1880 1890 1900 1910 1920 DNSESPNGRT SPLVSQNNEQ GSTLRDLLTT TAGKLRVGST DAGIAFAPVY SMGAPSSKSG 1930 1940 1950 1960 1970 1980 RTMPNILDDI IASVVENKIP PSKTSKINVK PELKEEPEES IISAVDENNK LYSDIPHSWI 1990 2000 2010 2020 2030 2040 CEKHILWLKD YKNSSNWKLF KECWKQGQPA VVSGVHKKMN ISLWKAESIS LDFGDHQADL 2050 2060 2070 2080 2090 2100 LNCKDSIISN ANVKEFWDGF EEVSKRQKNK SGETVVLKLK DWPSGEDFKT MMPARYEDLL 2110 2120 2130 2140 2150 2160 KSLPLPEYCN PEGKFNLASH LPGFFVRPDL GPRLCSAYGV VAAKDHDIGT TNLHIEVSDV 2170 2180 2190 2200 2210 2220 VNILVYVGIA KGNGILSKAG ILKKFEEEDL DDILRKRLKD SSEIPGALWH IYAGKDVDKI 2230 2240 2250 2260 2270 2280 REFLQKISKE QGLEVLPEHD PIRDQSWYVN KKLRQRLLEE YGVRTCTLIQ FLGDAIVLPA 2290 2300 2310 2320 2330 2340 GALHQVQNFH SCIQVTEDFV SPEHLVESFH LTQELRLLKE EINYDDKLQV KNILYHAVKE 2350 MVRALKIHED EVEDMEEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR." Wolf S.S., Patchev V.K., Obendorf M. Arch. Biochem. Biophys. 460:56-66(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-2540, VARIANTS THR-464 AND ASP-2535. Tissue: Amygdala and Cervix.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427. Tissue: Embryo.
[5]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1275-2540. Tissue: Brain.
[6]	"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor." Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D. Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR.
[7]	"Identification and characterization of TRIP8 gene in silico." Katoh M., Katoh M. Int. J. Mol. Med. 12:817-821(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF THE GENE.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376 AND SER-641, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-373; SER-617; SER-638; SER-641; SER-652 AND SER-1989, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

EF068222 mRNA. Translation: ABK64187.1.
BX537954 mRNA. Translation: CAD97921.1. Frameshift.
AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems.
AL713895, AL590502 Genomic DNA. Translation: CAI10948.1.
AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1.
AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1.
AK027280 mRNA. No translation available.
AL831917 mRNA. Translation: CAD38578.1.
AB037801 mRNA. Translation: BAA92618.1.
L40411 mRNA. Translation: AAC41741.1. Frameshift.

IPI

IPI00384202.
IPI00902772.
IPI01012411.

RefSeq

NP_004232.2. NM_004241.2.
NP_116165.1. NM_032776.1.

UniGene

Hs.413416.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YPD	X-ray	2.10	A/B	2157-2540	[»]

ProteinModelPortal

Q15652.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15652. 2 interactions.

STRING

9606.ENSP00000382204.

PTM databases

PhosphoSite

Q15652.

Polymorphism databases

DMDM

85541650.

Proteomic databases

PaxDb

Q15652.

PRIDE

Q15652.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000399251; ENSP00000382195; ENSG00000171988.
ENST00000399262; ENSP00000382204; ENSG00000171988.
ENST00000542921; ENSP00000444682; ENSG00000171988.

GeneID

221037.

KEGG

hsa:221037.

UCSC

uc001jml.3. human.

Organism-specific databases

CTD

221037.

GeneCards

GC10M064926.

HGNC

HGNC:12313. JMJD1C.

MIM

604503. gene.

neXtProt

NX_Q15652.

PharmGKB

PA128394767.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG305537.

HOVERGEN

HBG079631.

InParanoid

Q15652.

KO

K11449.

OMA

YKMKHSV.

OrthoDB

EOG447FS9.

Enzyme and pathway databases

Reactome

REACT_604. Hemostasis.

Gene expression databases

ArrayExpress

Q15652.

Bgee

Q15652.

CleanEx

HS_JMJD1C.

Genevestigator

Q15652.

GermOnline

ENSG00000171988. Homo sapiens.

Family and domain databases

InterPro

IPR003347. JmjC_dom.
[Graphical view]

Pfam

PF02373. JmjC. 1 hit.
[Graphical view]

SMART

SM00558. JmjC. 1 hit.
[Graphical view]

PROSITE

PS51184. JMJC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

JMJD1C. human.

GenomeRNAi

221037.

NextBio

91161.

SOURCE

Search...

Entry information

Entry name

JHD2C_HUMAN

Accession

Primary (citable) accession number: Q15652
Secondary accession number(s): A0T124 , Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 10, 2006
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.