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Q15652

- JHD2C_HUMAN

UniProt

Q15652 - JHD2C_HUMAN

Protein

Probable JmjC domain-containing histone demethylation protein 2C

Gene

JMJD1C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes By similarity.By similarity

    Cofactori

    Binds 1 Fe2+ ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi2336 – 23361Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi2338 – 23381Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi2466 – 24661Iron; catalyticPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1846 – 187126C6-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. dioxygenase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. thyroid hormone receptor binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. chromatin modification Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable JmjC domain-containing histone demethylation protein 2C (EC:1.14.11.-)
    Alternative name(s):
    Jumonji domain-containing protein 1C
    Thyroid receptor-interacting protein 8
    Short name:
    TR-interacting protein 8
    Short name:
    TRIP-8
    Gene namesi
    Name:JMJD1C
    Synonyms:JHDM2C, KIAA1380, TRIP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:12313. JMJD1C.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. intracellular Source: UniProtKB
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394767.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 25402540Probable JmjC domain-containing histone demethylation protein 2CPRO_0000084284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei317 – 3171Phosphoserine1 Publication
    Modified residuei373 – 3731Phosphoserine2 Publications
    Modified residuei376 – 3761Phosphoserine1 Publication
    Modified residuei617 – 6171Phosphoserine1 Publication
    Modified residuei638 – 6381Phosphoserine1 Publication
    Modified residuei641 – 6411Phosphoserine2 Publications
    Modified residuei652 – 6521Phosphoserine1 Publication
    Modified residuei1989 – 19891Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15652.
    PaxDbiQ15652.
    PRIDEiQ15652.

    PTM databases

    PhosphoSiteiQ15652.

    Expressioni

    Gene expression databases

    BgeeiQ15652.
    CleanExiHS_JMJD1C.
    GenevestigatoriQ15652.

    Organism-specific databases

    HPAiHPA056175.

    Interactioni

    Subunit structurei

    Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARP102752EBI-1224969,EBI-608057

    Protein-protein interaction databases

    BioGridi128677. 13 interactions.
    DIPiDIP-38114N.
    IntActiQ15652. 7 interactions.
    MINTiMINT-8247476.
    STRINGi9606.ENSP00000382204.

    Structurei

    Secondary structure

    1
    2540
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2159 – 21624
    Turni2163 – 21664
    Beta strandi2167 – 21704
    Helixi2178 – 21869
    Turni2187 – 21893
    Beta strandi2192 – 21943
    Helixi2197 – 22004
    Helixi2203 – 22064
    Helixi2208 – 22158
    Turni2225 – 22273
    Helixi2235 – 22406
    Beta strandi2242 – 22443
    Helixi2245 – 22473
    Beta strandi2259 – 22613
    Beta strandi2263 – 22664
    Helixi2268 – 22736
    Helixi2275 – 228410
    Helixi2288 – 22914
    Turni2300 – 23023
    Helixi2305 – 23073
    Beta strandi2315 – 23195
    Turni2323 – 23264
    Beta strandi2332 – 23376
    Beta strandi2339 – 235012
    Helixi2360 – 23689
    Helixi2374 – 23807
    Beta strandi2387 – 23948
    Helixi2396 – 23983
    Helixi2399 – 241315
    Helixi2423 – 24264
    Helixi2433 – 244311
    Beta strandi2448 – 24536
    Beta strandi2457 – 24604
    Beta strandi2465 – 248117
    Helixi2484 – 24863
    Helixi2487 – 249610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YPDX-ray2.10A/B2157-2540[»]
    ProteinModelPortaliQ15652.
    SMRiQ15652. Positions 2157-2497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2274 – 2498225JmjCPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi2066 – 20705LXXLL motif

    Domaini

    Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

    Sequence similaritiesi

    Belongs to the JHDM2 histone demethylase family.Curated
    Contains 1 JmjC domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1846 – 187126C6-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG305537.
    HOVERGENiHBG079631.
    InParanoidiQ15652.
    KOiK11449.
    OMAiFTGIITH.
    OrthoDBiEOG7B5WVG.
    PhylomeDBiQ15652.
    TreeFamiTF324723.

    Family and domain databases

    InterProiIPR003347. JmjC_dom.
    [Graphical view]
    PfamiPF02373. JmjC. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15652-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVETRAELV GKRFLCVAVG DEARSERWES GRGWRSWRAG VIRAVSHRDS     50
    RNPDLAVYVE FDDLEWDKRE WVKVYEDFST FLVEYHLIWA KRNDPSQTQG 100
    SKSKQIQWPA LTFKPLVERN IPSSVTAVEF LVDKQLDFLT EDSAFQPYQD 150
    DIDSLNPVLR DNPQLHEEVK VWVKEQKVQE IFMQGPYSLN GYRVRVYRQD 200
    SATQWFTGII THHDLFTRTM IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL 250
    LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT 300
    HQQQQQRSIR PNKRKGSDSS IPDEEKMKEE KYDYISRGEN PKGKNKHLMN 350
    KRRKPEEDEK KLNMKRLRTD NVSDFSESSD SENSNKRIID NSSEQKPENE 400
    LKNKNTSKIN GEEGKPHNNE KAGEETLKNS QPPWDQIQED KKHEEAEKRK 450
    SVDTQLQEDM IIHSSEQSTV SDHNSNDLLP QECNMDKTHT MELLPKEKFV 500
    SRPPTPKCVI DITNDTNLEK VAQENSSTFG LQTLQKMDPN VSDSKHSIAN 550
    AKFLETAKKD SDQSWVSDVV KVDLTQSSVT NASSGNDHLN MEKEKYVSYI 600
    SPLSAVSVME DKLHKRSPPP ETIKSKLNTS VDTHKIKSSP SPEVVKPKIT 650
    HSPDSVKSKA TYVNSQATGE RRLANKIEHE LSRCSFHPIP TRSSTLETTK 700
    SPLIIDKNEH FTVYRDPALI GSETGANHIS PFLSQHPFPL HSSSHRTCLN 750
    PGTHHPALTP APHLLAGSSS QTPLPTINTH PLTSGPHHAV HHPHLLPTVL 800
    PGVPTASLLG GHPRLESAHA SSLSHLALAH QQQQQLLQHQ SPHLLGQAHP 850
    SASYNQLGLY PIIWQYPNGT HAYSGLGLPS SKWVHPENAV NAEASLRRNS 900
    PSPWLHQPTP VTSADGIGLL SHIPVRPSSA EPHRPLKITA HSSPPLTKTL 950
    VDHHKEELER KAFMEPLRSV ASTSAKNDLD LNRSQTGKDC HLHRHFVDPV 1000
    LNQLQRPPQE TGERLNKYKE EHRRILQESI DVAPFTTKIK GLEGERENYS 1050
    RVASSSSSPK SHIIKQDMDV ERSVSDLYKM KHSVPQSLPQ SNYFTTLSNS 1100
    VVNEPPRSYP SKEVSNIYGD KQSNALAAAA ANPQTLTSFI TSLSKPPPLI 1150
    KHQPESEGLV GKIPEHLPHQ IASHSVTTFR NDCRSPTHLT VSSTNTLRSM 1200
    PALHRAPVFH PPIHHSLERK EGSYSSLSPP TLTPVMPVNA GGKVQESQKP 1250
    PTLIPEPKDS QANFKSSSEQ SLTEMWRPNN NLSKEKTEWH VEKSSGKLQA 1300
    AMASVIVRPS SSTKTDSMPA MQLASKDRVS ERSSAGAHKT DCLKLAEAGE 1350
    TGRIILPNVN SDSVHTKSEK NFQAVSQGSV PSSVMSAVNT MCNTKTDVIT 1400
    SAADTTSVSS WGGSEVISSL SNTILASTSS ECVSSKSVSQ PVAQKQECKV 1450
    STTAPVTLAS SKTGSVVQPS SGFSGTTDFI HLKKHKAALA AAQYKSSNAS 1500
    ETEPNAIKNQ TLSASLPLDS TVICSTINKA NSVGNGQASQ TSQPNYHTKL 1550
    KKAWLTRHSE EDKNTNKMEN SGNSVSEIIK PCSVNLIAST SSDIQNSVDS 1600
    KIIVDKYVKD DKVNRRKAKR TYESGSESGD SDESESKSEQ RTKRQPKPTY 1650
    KKKQNDLQKR KGEIEEDLKP NGVLSRSAKE RSKLKLQSNS NTGIPRSVLK 1700
    DWRKVKKLKQ TGESFLQDDS CCEIGPNLQK CRECRLIRSK KGEEPAHSPV 1750
    FCRFYYFRRL SFSKNGVVRI DGFSSPDQYD DEAMSLWTHE NFEDDELDIE 1800
    TSKYILDIIG DKFCQLVTSE KTALSWVKKD AKIAWKRAVR GVREMCDACE 1850
    ATLFNIHWVC QKCGFVVCLD CYKAKERKSS RDKELYAWMK CVKGQPHDHK 1900
    HLMPTQIIPG SVLTDLLDAM HTLREKYGIK SHCHCTNKQN LQVGNFPTMN 1950
    GVSQVLQNVL NHSNKISLCM PESQQQNTPP KSEKNGGSSP ESDVGTDNKL 2000
    TPPESQSPLH WLADLAEQKA REEKKENKEL TLENQIKEER EQDNSESPNG 2050
    RTSPLVSQNN EQGSTLRDLL TTTAGKLRVG STDAGIAFAP VYSMGAPSSK 2100
    SGRTMPNILD DIIASVVENK IPPSKTSKIN VKPELKEEPE ESIISAVDEN 2150
    NKLYSDIPHS WICEKHILWL KDYKNSSNWK LFKECWKQGQ PAVVSGVHKK 2200
    MNISLWKAES ISLDFGDHQA DLLNCKDSII SNANVKEFWD GFEEVSKRQK 2250
    NKSGETVVLK LKDWPSGEDF KTMMPARYED LLKSLPLPEY CNPEGKFNLA 2300
    SHLPGFFVRP DLGPRLCSAY GVVAAKDHDI GTTNLHIEVS DVVNILVYVG 2350
    IAKGNGILSK AGILKKFEEE DLDDILRKRL KDSSEIPGAL WHIYAGKDVD 2400
    KIREFLQKIS KEQGLEVLPE HDPIRDQSWY VNKKLRQRLL EEYGVRTCTL 2450
    IQFLGDAIVL PAGALHQVQN FHSCIQVTED FVSPEHLVES FHLTQELRLL 2500
    KEEINYDDKL QVKNILYHAV KEMVRALKIH EDEVEDMEEN 2540
    Length:2,540
    Mass (Da):284,525
    Last modified:January 10, 2006 - v2
    Checksum:i8B1727414D6B677F
    GO
    Isoform 2 (identifier: Q15652-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-219: Missing.
         1692-1699: TGIPRSVL → SCHLVKTE
         1700-2540: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,480
    Mass (Da):163,133
    Checksum:i72DB291B3FAB25B7
    GO
    Isoform 3 (identifier: Q15652-3) [UniParc]FASTAAdd to Basket

    Also known as: s-JMJD1C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-182: Missing.

    Note: May function as a tumor suppressor, reduced expression in breast cancer tumors.

    Show »
    Length:2,358
    Mass (Da):263,157
    Checksum:i6005F440A38FC096
    GO

    Sequence cautioni

    The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171.
    The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697.
    The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti488 – 4881T → A in CAD97921. (PubMed:17974005)Curated
    Sequence conflicti779 – 7791T → A in CAD97921. (PubMed:17974005)Curated
    Sequence conflicti783 – 7831T → P in CAD97921. (PubMed:17974005)Curated
    Sequence conflicti2093 – 20931S → A in AAC41741. (PubMed:7776974)Curated
    Sequence conflicti2148 – 21481Missing in BAA92618. (PubMed:10718198)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti272 – 2721A → T.
    Corresponds to variant rs34798625 [ dbSNP | Ensembl ].
    VAR_049654
    Natural varianti394 – 3941E → D.
    Corresponds to variant rs35380596 [ dbSNP | Ensembl ].
    VAR_049655
    Natural varianti464 – 4641S → T.1 Publication
    Corresponds to variant rs10761725 [ dbSNP | Ensembl ].
    VAR_049656
    Natural varianti591 – 5911M → V.
    Corresponds to variant rs41274072 [ dbSNP | Ensembl ].
    VAR_061277
    Natural varianti1393 – 13931N → Y.
    Corresponds to variant rs9703886 [ dbSNP | Ensembl ].
    VAR_049657
    Natural varianti2400 – 24001D → E.
    Corresponds to variant rs34491125 [ dbSNP | Ensembl ].
    VAR_049658
    Natural varianti2535 – 25351E → D.1 Publication
    Corresponds to variant rs1935 [ dbSNP | Ensembl ].
    VAR_049659

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 219219Missing in isoform 2. 1 PublicationVSP_018303Add
    BLAST
    Alternative sequencei1 – 182182Missing in isoform 3. 1 PublicationVSP_043909Add
    BLAST
    Alternative sequencei1692 – 16998TGIPRSVL → SCHLVKTE in isoform 2. 1 PublicationVSP_018304
    Alternative sequencei1700 – 2540841Missing in isoform 2. 1 PublicationVSP_018305Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF068222 mRNA. Translation: ABK64187.1.
    BX537954 mRNA. Translation: CAD97921.1. Frameshift.
    AL713895 Genomic DNA. Translation: CAI10947.1. Sequence problems.
    AL713895, AL590502 Genomic DNA. Translation: CAI10948.1.
    AL713895, AL607128, AC022022 Genomic DNA. Translation: CAI10950.1.
    AL607128, AL713895, AC022022 Genomic DNA. Translation: CAI14188.1.
    AK027280 mRNA. No translation available.
    AL831917 mRNA. Translation: CAD38578.1.
    AB037801 mRNA. Translation: BAA92618.1.
    L40411 mRNA. Translation: AAC41741.1. Frameshift.
    CCDSiCCDS41532.1. [Q15652-1]
    CCDS60538.1. [Q15652-3]
    RefSeqiNP_001269877.1. NM_001282948.1. [Q15652-3]
    NP_116165.1. NM_032776.2. [Q15652-1]
    XP_006717770.1. XM_006717707.1. [Q15652-3]
    UniGeneiHs.413416.

    Genome annotation databases

    EnsembliENST00000399262; ENSP00000382204; ENSG00000171988. [Q15652-1]
    ENST00000542921; ENSP00000444682; ENSG00000171988. [Q15652-3]
    GeneIDi221037.
    KEGGihsa:221037.
    UCSCiuc001jml.3. human. [Q15652-1]

    Polymorphism databases

    DMDMi85541650.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF068222 mRNA. Translation: ABK64187.1 .
    BX537954 mRNA. Translation: CAD97921.1 . Frameshift.
    AL713895 Genomic DNA. Translation: CAI10947.1 . Sequence problems.
    AL713895 , AL590502 Genomic DNA. Translation: CAI10948.1 .
    AL713895 , AL607128 , AC022022 Genomic DNA. Translation: CAI10950.1 .
    AL607128 , AL713895 , AC022022 Genomic DNA. Translation: CAI14188.1 .
    AK027280 mRNA. No translation available.
    AL831917 mRNA. Translation: CAD38578.1 .
    AB037801 mRNA. Translation: BAA92618.1 .
    L40411 mRNA. Translation: AAC41741.1 . Frameshift.
    CCDSi CCDS41532.1. [Q15652-1 ]
    CCDS60538.1. [Q15652-3 ]
    RefSeqi NP_001269877.1. NM_001282948.1. [Q15652-3 ]
    NP_116165.1. NM_032776.2. [Q15652-1 ]
    XP_006717770.1. XM_006717707.1. [Q15652-3 ]
    UniGenei Hs.413416.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YPD X-ray 2.10 A/B 2157-2540 [» ]
    ProteinModelPortali Q15652.
    SMRi Q15652. Positions 2157-2497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128677. 13 interactions.
    DIPi DIP-38114N.
    IntActi Q15652. 7 interactions.
    MINTi MINT-8247476.
    STRINGi 9606.ENSP00000382204.

    PTM databases

    PhosphoSitei Q15652.

    Polymorphism databases

    DMDMi 85541650.

    Proteomic databases

    MaxQBi Q15652.
    PaxDbi Q15652.
    PRIDEi Q15652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399262 ; ENSP00000382204 ; ENSG00000171988 . [Q15652-1 ]
    ENST00000542921 ; ENSP00000444682 ; ENSG00000171988 . [Q15652-3 ]
    GeneIDi 221037.
    KEGGi hsa:221037.
    UCSCi uc001jml.3. human. [Q15652-1 ]

    Organism-specific databases

    CTDi 221037.
    GeneCardsi GC10M064926.
    HGNCi HGNC:12313. JMJD1C.
    HPAi HPA056175.
    MIMi 604503. gene.
    neXtProti NX_Q15652.
    PharmGKBi PA128394767.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305537.
    HOVERGENi HBG079631.
    InParanoidi Q15652.
    KOi K11449.
    OMAi FTGIITH.
    OrthoDBi EOG7B5WVG.
    PhylomeDBi Q15652.
    TreeFami TF324723.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi JMJD1C. human.
    GenomeRNAii 221037.
    NextBioi 91161.
    PROi Q15652.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15652.
    CleanExi HS_JMJD1C.
    Genevestigatori Q15652.

    Family and domain databases

    InterProi IPR003347. JmjC_dom.
    [Graphical view ]
    Pfami PF02373. JmjC. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR."
      Wolf S.S., Patchev V.K., Obendorf M.
      Arch. Biochem. Biophys. 460:56-66(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-2540, VARIANTS THR-464 AND ASP-2535.
      Tissue: Amygdala and Cervix.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427.
      Tissue: Embryo.
    5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1275-2540.
      Tissue: Brain.
    6. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
      Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
      Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212, INTERACTION WITH THYROID RECEPTOR.
    7. "Identification and characterization of TRIP8 gene in silico."
      Katoh M., Katoh M.
      Int. J. Mol. Med. 12:817-821(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF THE GENE.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376 AND SER-641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-373; SER-617; SER-638; SER-641; SER-652 AND SER-1989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiJHD2C_HUMAN
    AccessioniPrimary (citable) accession number: Q15652
    Secondary accession number(s): A0T124
    , Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3