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Protein

High mobility group nucleosome-binding domain-containing protein 3

Gene

HMGN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ15651.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 3
Alternative name(s):
Thyroid receptor-interacting protein 7
Short name:
TR-interacting protein 7
Short name:
TRIP-7
Gene namesi
Name:HMGN3
Synonyms:TRIP7
ORF Names:PNAS-24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12312. HMGN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36990.

Polymorphism and mutation databases

BioMutaiHMGN3.
DMDMi23831169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999High mobility group nucleosome-binding domain-containing protein 3PRO_0000232574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61Phosphoserine2 Publications
Modified residuei10 – 101Phosphothreonine3 Publications
Modified residuei78 – 781Phosphoserine2 Publications
Modified residuei93 – 931Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15651.
PaxDbiQ15651.
PRIDEiQ15651.

PTM databases

PhosphoSiteiQ15651.

Expressioni

Tissue specificityi

Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.2 Publications

Inductioni

By estrogen.

Gene expression databases

BgeeiQ15651.
CleanExiHS_HMGN3.
ExpressionAtlasiQ15651. baseline and differential.
GenevisibleiQ15651. HS.

Organism-specific databases

HPAiCAB018370.
HPA027971.

Interactioni

Subunit structurei

Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629931EBI-1758705,EBI-401755

Protein-protein interaction databases

BioGridi114734. 8 interactions.
IntActiQ15651. 6 interactions.
STRINGi9606.ENSP00000341267.

Structurei

3D structure databases

ProteinModelPortaliQ15651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiNOG70460.
GeneTreeiENSGT00730000111287.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ15651.
KOiK11301.
OrthoDBiEOG7HXCTV.
PhylomeDBiQ15651.

Family and domain databases

InterProiIPR031073. HMGN3.
IPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087. PTHR23087. 1 hit.
PTHR23087:SF2. PTHR23087:SF2. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15651-1) [UniParc]FASTAAdd to basket

Also known as: HMGN3a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPAPPKPE PKPRKTSAKK
60 70 80 90
EPGAKISRGA KGKKEEKQEA GKEGTAPSEN GETKAEEAQK TESVDNEGE
Length:99
Mass (Da):10,666
Last modified:October 10, 2002 - v2
Checksum:iACC44835523B9C21
GO
Isoform 2 (identifier: Q15651-2) [UniParc]FASTAAdd to basket

Also known as: HMGN3b

The sequence of this isoform differs from the canonical sequence as follows:
     76-77: AP → EN
     78-99: Missing.

Show »
Length:77
Mass (Da):8,378
Checksum:iB2650E1912B8828A
GO

Sequence cautioni

The sequence AAA73877.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 772AP → EN in isoform 2. 3 PublicationsVSP_017907
Alternative sequencei78 – 9922Missing in isoform 2. 3 PublicationsVSP_017908Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40357 mRNA. Translation: AAA73877.1. Different initiation.
AF401520 mRNA. Translation: AAK92012.1.
AF274949 mRNA. Translation: AAK07526.1.
AY043282 mRNA. Translation: AAK85736.1.
AK315391 mRNA. Translation: BAG37784.1.
AL355796 Genomic DNA. Translation: CAH74094.1.
AL355796 Genomic DNA. Translation: CAH74095.1.
CH471051 Genomic DNA. Translation: EAW48711.1.
BC009529 mRNA. Translation: AAH09529.1.
BK000003 mRNA. Translation: DAA00392.1.
BK000006 mRNA. Translation: DAA00395.1.
BX648085 Transcribed RNA. Translation: CAI46267.1.
CCDSiCCDS4988.1. [Q15651-1]
CCDS4989.1. [Q15651-2]
RefSeqiNP_001188291.1. NM_001201362.1.
NP_001188292.1. NM_001201363.1.
NP_004233.1. NM_004242.3. [Q15651-1]
NP_620058.1. NM_138730.2. [Q15651-2]
UniGeneiHs.77558.

Genome annotation databases

EnsembliENST00000275036; ENSP00000275036; ENSG00000118418. [Q15651-2]
ENST00000344726; ENSP00000341267; ENSG00000118418.
GeneIDi9324.
KEGGihsa:9324.
UCSCiuc003pis.3. human. [Q15651-2]
uc003pit.3. human. [Q15651-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40357 mRNA. Translation: AAA73877.1. Different initiation.
AF401520 mRNA. Translation: AAK92012.1.
AF274949 mRNA. Translation: AAK07526.1.
AY043282 mRNA. Translation: AAK85736.1.
AK315391 mRNA. Translation: BAG37784.1.
AL355796 Genomic DNA. Translation: CAH74094.1.
AL355796 Genomic DNA. Translation: CAH74095.1.
CH471051 Genomic DNA. Translation: EAW48711.1.
BC009529 mRNA. Translation: AAH09529.1.
BK000003 mRNA. Translation: DAA00392.1.
BK000006 mRNA. Translation: DAA00395.1.
BX648085 Transcribed RNA. Translation: CAI46267.1.
CCDSiCCDS4988.1. [Q15651-1]
CCDS4989.1. [Q15651-2]
RefSeqiNP_001188291.1. NM_001201362.1.
NP_001188292.1. NM_001201363.1.
NP_004233.1. NM_004242.3. [Q15651-1]
NP_620058.1. NM_138730.2. [Q15651-2]
UniGeneiHs.77558.

3D structure databases

ProteinModelPortaliQ15651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114734. 8 interactions.
IntActiQ15651. 6 interactions.
STRINGi9606.ENSP00000341267.

PTM databases

PhosphoSiteiQ15651.

Polymorphism and mutation databases

BioMutaiHMGN3.
DMDMi23831169.

Proteomic databases

MaxQBiQ15651.
PaxDbiQ15651.
PRIDEiQ15651.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275036; ENSP00000275036; ENSG00000118418. [Q15651-2]
ENST00000344726; ENSP00000341267; ENSG00000118418.
GeneIDi9324.
KEGGihsa:9324.
UCSCiuc003pis.3. human. [Q15651-2]
uc003pit.3. human. [Q15651-1]

Organism-specific databases

CTDi9324.
GeneCardsiGC06M079967.
HGNCiHGNC:12312. HMGN3.
HPAiCAB018370.
HPA027971.
MIMi604502. gene.
neXtProtiNX_Q15651.
PharmGKBiPA36990.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70460.
GeneTreeiENSGT00730000111287.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ15651.
KOiK11301.
OrthoDBiEOG7HXCTV.
PhylomeDBiQ15651.

Enzyme and pathway databases

SignaLinkiQ15651.

Miscellaneous databases

ChiTaRSiHMGN3. human.
GeneWikiiHMGN3.
GenomeRNAii9324.
NextBioi34925.
PROiQ15651.
SOURCEiSearch...

Gene expression databases

BgeeiQ15651.
CleanExiHS_HMGN3.
ExpressionAtlasiQ15651. baseline and differential.
GenevisibleiQ15651. HS.

Family and domain databases

InterProiIPR031073. HMGN3.
IPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087. PTHR23087. 1 hit.
PTHR23087:SF2. PTHR23087:SF2. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
    Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
    Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH THYROID RECEPTOR, TISSUE SPECIFICITY.
  2. "Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions."
    Leong P.W., Liew K., Lim W., Chow V.T.K.
    Virology 295:147-159(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Promyelocytic leukemia.
  4. "Identification and characterization of an estrogen inducible TRIP7-like mRNA isolated by differential display."
    Go V.S., Pogo B.G.T.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-99 (ISOFORM 1).
    Tissue: Small intestine.
  10. "HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins."
    West K.L., Ito Y., Birger Y., Postnikov Y., Shirakawa H., Bustin M.
    J. Biol. Chem. 276:25959-25969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, INTERACTION WITH NUCLEOSOMES, TISSUE SPECIFICITY.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-10 AND SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; THR-10 AND SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMGN3_HUMAN
AccessioniPrimary (citable) accession number: Q15651
Secondary accession number(s): B2RD37
, Q5HYD3, Q7RTT0, Q969M5, Q9BZT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: July 22, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.