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Protein

High mobility group nucleosome-binding domain-containing protein 3

Gene

HMGN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).By similarity

GO - Molecular functioni

  • nucleosomal DNA binding Source: InterPro
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118418-MONOMER.
SignaLinkiQ15651.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 3
Alternative name(s):
Thyroid receptor-interacting protein 7
Short name:
TR-interacting protein 7
Short name:
TRIP-7
Gene namesi
Name:HMGN3
Synonyms:TRIP7
ORF Names:PNAS-24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12312. HMGN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118418.
PharmGKBiPA36990.

Polymorphism and mutation databases

BioMutaiHMGN3.
DMDMi23831169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325741 – 99High mobility group nucleosome-binding domain-containing protein 3Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15651.
MaxQBiQ15651.
PaxDbiQ15651.
PeptideAtlasiQ15651.
PRIDEiQ15651.
TopDownProteomicsiQ15651-1. [Q15651-1]
Q15651-2. [Q15651-2]

PTM databases

iPTMnetiQ15651.
PhosphoSitePlusiQ15651.

Expressioni

Tissue specificityi

Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.2 Publications

Inductioni

By estrogen.

Gene expression databases

BgeeiENSG00000118418.
CleanExiHS_HMGN3.
ExpressionAtlasiQ15651. baseline and differential.
GenevisibleiQ15651. HS.

Organism-specific databases

HPAiCAB018370.
HPA027971.

Interactioni

Subunit structurei

Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes.2 Publications

GO - Molecular functioni

  • thyroid hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114734. 10 interactors.
IntActiQ15651. 11 interactors.
STRINGi9606.ENSP00000341267.

Structurei

3D structure databases

ProteinModelPortaliQ15651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J0Z7. Eukaryota.
ENOG410YTHP. LUCA.
GeneTreeiENSGT00730000111287.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ15651.
KOiK11301.
PhylomeDBiQ15651.

Family and domain databases

InterProiIPR031073. HMGN3.
IPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087:SF2. PTHR23087:SF2. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15651-1) [UniParc]FASTAAdd to basket
Also known as: HMGN3a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPAPPKPE PKPRKTSAKK
60 70 80 90
EPGAKISRGA KGKKEEKQEA GKEGTAPSEN GETKAEEAQK TESVDNEGE
Length:99
Mass (Da):10,666
Last modified:October 10, 2002 - v2
Checksum:iACC44835523B9C21
GO
Isoform 2 (identifier: Q15651-2) [UniParc]FASTAAdd to basket
Also known as: HMGN3b

The sequence of this isoform differs from the canonical sequence as follows:
     76-77: AP → EN
     78-99: Missing.

Show »
Length:77
Mass (Da):8,378
Checksum:iB2650E1912B8828A
GO

Sequence cautioni

The sequence AAA73877 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01790776 – 77AP → EN in isoform 2. 3 Publications2
Alternative sequenceiVSP_01790878 – 99Missing in isoform 2. 3 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40357 mRNA. Translation: AAA73877.1. Different initiation.
AF401520 mRNA. Translation: AAK92012.1.
AF274949 mRNA. Translation: AAK07526.1.
AY043282 mRNA. Translation: AAK85736.1.
AK315391 mRNA. Translation: BAG37784.1.
AL355796 Genomic DNA. Translation: CAH74094.1.
AL355796 Genomic DNA. Translation: CAH74095.1.
CH471051 Genomic DNA. Translation: EAW48711.1.
BC009529 mRNA. Translation: AAH09529.1.
BK000003 mRNA. Translation: DAA00392.1.
BK000006 mRNA. Translation: DAA00395.1.
BX648085 Transcribed RNA. Translation: CAI46267.1.
CCDSiCCDS4988.1. [Q15651-1]
CCDS4989.1. [Q15651-2]
RefSeqiNP_001188291.1. NM_001201362.1.
NP_001188292.1. NM_001201363.1.
NP_001305813.1. NM_001318884.1.
NP_001305814.1. NM_001318885.1.
NP_001305815.1. NM_001318886.1.
NP_001305816.1. NM_001318887.1.
NP_001305817.1. NM_001318888.1.
NP_004233.1. NM_004242.3. [Q15651-1]
NP_620058.1. NM_138730.2. [Q15651-2]
UniGeneiHs.77558.

Genome annotation databases

EnsembliENST00000275036; ENSP00000275036; ENSG00000118418. [Q15651-2]
ENST00000344726; ENSP00000341267; ENSG00000118418. [Q15651-1]
GeneIDi9324.
KEGGihsa:9324.
UCSCiuc003pis.4. human. [Q15651-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40357 mRNA. Translation: AAA73877.1. Different initiation.
AF401520 mRNA. Translation: AAK92012.1.
AF274949 mRNA. Translation: AAK07526.1.
AY043282 mRNA. Translation: AAK85736.1.
AK315391 mRNA. Translation: BAG37784.1.
AL355796 Genomic DNA. Translation: CAH74094.1.
AL355796 Genomic DNA. Translation: CAH74095.1.
CH471051 Genomic DNA. Translation: EAW48711.1.
BC009529 mRNA. Translation: AAH09529.1.
BK000003 mRNA. Translation: DAA00392.1.
BK000006 mRNA. Translation: DAA00395.1.
BX648085 Transcribed RNA. Translation: CAI46267.1.
CCDSiCCDS4988.1. [Q15651-1]
CCDS4989.1. [Q15651-2]
RefSeqiNP_001188291.1. NM_001201362.1.
NP_001188292.1. NM_001201363.1.
NP_001305813.1. NM_001318884.1.
NP_001305814.1. NM_001318885.1.
NP_001305815.1. NM_001318886.1.
NP_001305816.1. NM_001318887.1.
NP_001305817.1. NM_001318888.1.
NP_004233.1. NM_004242.3. [Q15651-1]
NP_620058.1. NM_138730.2. [Q15651-2]
UniGeneiHs.77558.

3D structure databases

ProteinModelPortaliQ15651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114734. 10 interactors.
IntActiQ15651. 11 interactors.
STRINGi9606.ENSP00000341267.

PTM databases

iPTMnetiQ15651.
PhosphoSitePlusiQ15651.

Polymorphism and mutation databases

BioMutaiHMGN3.
DMDMi23831169.

Proteomic databases

EPDiQ15651.
MaxQBiQ15651.
PaxDbiQ15651.
PeptideAtlasiQ15651.
PRIDEiQ15651.
TopDownProteomicsiQ15651-1. [Q15651-1]
Q15651-2. [Q15651-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275036; ENSP00000275036; ENSG00000118418. [Q15651-2]
ENST00000344726; ENSP00000341267; ENSG00000118418. [Q15651-1]
GeneIDi9324.
KEGGihsa:9324.
UCSCiuc003pis.4. human. [Q15651-1]

Organism-specific databases

CTDi9324.
GeneCardsiHMGN3.
HGNCiHGNC:12312. HMGN3.
HPAiCAB018370.
HPA027971.
MIMi604502. gene.
neXtProtiNX_Q15651.
OpenTargetsiENSG00000118418.
PharmGKBiPA36990.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0Z7. Eukaryota.
ENOG410YTHP. LUCA.
GeneTreeiENSGT00730000111287.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ15651.
KOiK11301.
PhylomeDBiQ15651.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118418-MONOMER.
SignaLinkiQ15651.

Miscellaneous databases

ChiTaRSiHMGN3. human.
GeneWikiiHMGN3.
GenomeRNAii9324.
PROiQ15651.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118418.
CleanExiHS_HMGN3.
ExpressionAtlasiQ15651. baseline and differential.
GenevisibleiQ15651. HS.

Family and domain databases

InterProiIPR031073. HMGN3.
IPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087:SF2. PTHR23087:SF2. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN3_HUMAN
AccessioniPrimary (citable) accession number: Q15651
Secondary accession number(s): B2RD37
, Q5HYD3, Q7RTT0, Q969M5, Q9BZT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.