Q15649 (ZNHI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger HIT domain-containing protein 3

Alternative name(s):
HNF-4a coactivator
Thyroid hormone receptor interactor 3
Thyroid receptor-interacting protein 3
Short name=TR-interacting protein 3
Short name=TRIP-3

Gene names

Name:	ZNHIT3
Synonyms:	TRIP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
Sequence similarities	Contains 1 HIT-type zinc finger.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Traceable author statement Ref.5. Source: UniProtKB
Cellular_component	intracellular Non-traceable author statement Ref.5. Source: UniProtKB
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thyroid hormone receptor binding Traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 155

155

Zinc finger HIT domain-containing protein 3

PRO_0000173550

Regions

Zinc finger

11 – 42

32

HIT-type

Amino acid modifications

Modified residue

80

1

Phosphoserine Ref.6 Ref.7 Ref.8 Ref.9

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

155

Helix Strand Turn

Details...

Turn

12 – 14

3

Beta strand

19 – 21

3

Turn

23 – 25

3

Beta strand

28 – 31

4

Helix

32 – 41

10

Sequences

	Sequence		Length	Mass (Da)
	Q15649 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: A115FD0AA9321AB0	FASTA	155	17,607
	10 20 30 40 50 60 MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE KKIRSALPTK 70 80 90 100 110 120 TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLGESAT LRSLLLNPHL RQLMVNLDQG 130 140 150 EDKAKLMRAY MQEPLFVEFA DCCLGIVEPS QNEES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha." Iwahashi H., Yamagata K., Yoshiuchi I., Terasaki J., Yang Q., Fukui K., Ihara A., Zhu Q., Asakura T., Cao Y., Imagawa A., Namba M., Hanafusa T., Miyagawa J., Matsuzawa Y. Diabetes 51:910-914(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor." Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D. Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-155, INTERACTION WITH THRA.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, MASS SPECTROMETRY.
[10]	"Solution structure of the ZF-HIT domain in zinc finger HIT domain-containing protein 3 (TRIP-3)." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-46.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF400652 mRNA. Translation: AAM82423.1.
AK290858 mRNA. Translation: BAF83547.1.
CH471199 Genomic DNA. Translation: EAW57552.1.
BC017931 mRNA. Translation: AAH17931.1.
L40410 mRNA. Translation: AAC41737.1.

IPI

IPI00178888.

RefSeq

NP_004764.1. NM_004773.2.

UniGene

Hs.2210.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YQQ	NMR	-	A	4-46	[»]

ProteinModelPortal

Q15649.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15649. 4 interactions.

STRING

9606.ENSP00000225410.

PTM databases

PhosphoSite

Q15649.

Polymorphism databases

DMDM

46397898.

Proteomic databases

PaxDb

Q15649.

PRIDE

Q15649.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000225410; ENSP00000225410; ENSG00000108278.
ENST00000562164; ENSP00000456878; ENSG00000260952.

GeneID

9326.

KEGG

hsa:9326.

UCSC

uc002hms.1. human.

Organism-specific databases

CTD

9326.

GeneCards

GC17P034842.

HGNC

HGNC:12309. ZNHIT3.

HPA

HPA022892.

MIM

604500. gene.

neXtProt

NX_Q15649.

PharmGKB

PA36987.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG121021.

HOGENOM

HOG000230732.

HOVERGEN

HBG055775.

InParanoid

Q15649.

OMA

DDSIADF.

OrthoDB

EOG4JHCGW.

PhylomeDB

Q15649.

Gene expression databases

Bgee

Q15649.

CleanEx

HS_ZNHIT3.

Genevestigator

Q15649.

GermOnline

ENSG00000108278. Homo sapiens.

Family and domain databases

InterPro

IPR007529. Znf_HIT.
[Graphical view]

Pfam

PF04438. zf-HIT. 1 hit.
[Graphical view]

PROSITE

PS51083. ZF_HIT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q15649.

GenomeRNAi

9326.

NextBio

34935.

SOURCE

Search...

Entry information

Entry name

ZNHI3_HUMAN

Accession

Primary (citable) accession number: Q15649
Secondary accession number(s): A8K493, Q8WVJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.