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Q15649

- ZNHI3_HUMAN

UniProt

Q15649 - ZNHI3_HUMAN

Protein

Zinc finger HIT domain-containing protein 3

Gene

ZNHIT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 4232HIT-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. thyroid hormone receptor binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger HIT domain-containing protein 3
    Alternative name(s):
    HNF-4a coactivator
    Thyroid hormone receptor interactor 3
    Thyroid receptor-interacting protein 3
    Short name:
    TR-interacting protein 3
    Short name:
    TRIP-3
    Gene namesi
    Name:ZNHIT3
    Synonyms:TRIP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:12309. ZNHIT3.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36987.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 155155Zinc finger HIT domain-containing protein 3PRO_0000173550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15649.
    PaxDbiQ15649.
    PRIDEiQ15649.

    PTM databases

    PhosphoSiteiQ15649.

    Expressioni

    Gene expression databases

    ArrayExpressiQ15649.
    BgeeiQ15649.
    CleanExiHS_ZNHIT3.
    GenevestigatoriQ15649.

    Organism-specific databases

    HPAiHPA022892.

    Interactioni

    Subunit structurei

    Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.

    Protein-protein interaction databases

    BioGridi114736. 14 interactions.
    IntActiQ15649. 4 interactions.
    STRINGi9606.ENSP00000225410.

    Structurei

    Secondary structure

    1
    155
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni12 – 143
    Beta strandi19 – 213
    Turni23 – 253
    Beta strandi28 – 314
    Helixi32 – 4110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YQQNMR-A4-46[»]
    ProteinModelPortaliQ15649.
    SMRiQ15649. Positions 2-46.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15649.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HIT-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 4232HIT-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG121021.
    HOGENOMiHOG000230732.
    HOVERGENiHBG055775.
    InParanoidiQ15649.
    OMAiNLDQGED.
    PhylomeDBiQ15649.
    TreeFamiTF324673.

    Family and domain databases

    InterProiIPR007529. Znf_HIT.
    [Graphical view]
    PfamiPF04438. zf-HIT. 1 hit.
    [Graphical view]
    PROSITEiPS51083. ZF_HIT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15649-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE    50
    KKIRSALPTK TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLGESAT 100
    LRSLLLNPHL RQLMVNLDQG EDKAKLMRAY MQEPLFVEFA DCCLGIVEPS 150
    QNEES 155
    Length:155
    Mass (Da):17,607
    Last modified:April 13, 2004 - v2
    Checksum:iA115FD0AA9321AB0
    GO
    Isoform 2 (identifier: Q15649-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         96-155: GESATLRSLL...IVEPSQNEES → DGLSSCHPGW...ATTPNQFLYF

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:148
    Mass (Da):16,453
    Checksum:iDBEB11E191297F8D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 15560GESAT…QNEES → DGLSSCHPGWSAAAQSRLTA TSPSQIQAILMPQPPEQLGL QAPATTPNQFLYF in isoform 2. CuratedVSP_055155Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF400652 mRNA. Translation: AAM82423.1.
    AK290858 mRNA. Translation: BAF83547.1.
    AC126327 Genomic DNA. No translation available.
    CH471199 Genomic DNA. Translation: EAW57552.1.
    BC017931 mRNA. Translation: AAH17931.1.
    L40410 mRNA. Translation: AAC41737.1.
    CCDSiCCDS11312.1. [Q15649-1]
    CCDS62156.1. [Q15649-2]
    RefSeqiNP_001268361.1. NM_001281432.1.
    NP_001268362.1. NM_001281433.1.
    NP_001268363.1. NM_001281434.1.
    NP_004764.1. NM_004773.3.
    UniGeneiHs.2210.

    Genome annotation databases

    GeneIDi9326.
    KEGGihsa:9326.
    UCSCiuc002hms.1. human. [Q15649-1]

    Polymorphism databases

    DMDMi46397898.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF400652 mRNA. Translation: AAM82423.1 .
    AK290858 mRNA. Translation: BAF83547.1 .
    AC126327 Genomic DNA. No translation available.
    CH471199 Genomic DNA. Translation: EAW57552.1 .
    BC017931 mRNA. Translation: AAH17931.1 .
    L40410 mRNA. Translation: AAC41737.1 .
    CCDSi CCDS11312.1. [Q15649-1 ]
    CCDS62156.1. [Q15649-2 ]
    RefSeqi NP_001268361.1. NM_001281432.1.
    NP_001268362.1. NM_001281433.1.
    NP_001268363.1. NM_001281434.1.
    NP_004764.1. NM_004773.3.
    UniGenei Hs.2210.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YQQ NMR - A 4-46 [» ]
    ProteinModelPortali Q15649.
    SMRi Q15649. Positions 2-46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114736. 14 interactions.
    IntActi Q15649. 4 interactions.
    STRINGi 9606.ENSP00000225410.

    PTM databases

    PhosphoSitei Q15649.

    Polymorphism databases

    DMDMi 46397898.

    Proteomic databases

    MaxQBi Q15649.
    PaxDbi Q15649.
    PRIDEi Q15649.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9326.
    KEGGi hsa:9326.
    UCSCi uc002hms.1. human. [Q15649-1 ]

    Organism-specific databases

    CTDi 9326.
    GeneCardsi GC17P034842.
    HGNCi HGNC:12309. ZNHIT3.
    HPAi HPA022892.
    MIMi 604500. gene.
    neXtProti NX_Q15649.
    PharmGKBi PA36987.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG121021.
    HOGENOMi HOG000230732.
    HOVERGENi HBG055775.
    InParanoidi Q15649.
    OMAi NLDQGED.
    PhylomeDBi Q15649.
    TreeFami TF324673.

    Miscellaneous databases

    EvolutionaryTracei Q15649.
    GenomeRNAii 9326.
    NextBioi 34935.
    PROi Q15649.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15649.
    Bgeei Q15649.
    CleanExi HS_ZNHIT3.
    Genevestigatori Q15649.

    Family and domain databases

    InterProi IPR007529. Znf_HIT.
    [Graphical view ]
    Pfami PF04438. zf-HIT. 1 hit.
    [Graphical view ]
    PROSITEi PS51083. ZF_HIT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha."
      Iwahashi H., Yamagata K., Yoshiuchi I., Terasaki J., Yang Q., Fukui K., Ihara A., Zhu Q., Asakura T., Cao Y., Imagawa A., Namba M., Hanafusa T., Miyagawa J., Matsuzawa Y.
      Diabetes 51:910-914(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    6. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
      Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
      Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-155, INTERACTION WITH THRA.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Solution structure of the ZF-HIT domain in zinc finger HIT domain-containing protein 3 (TRIP-3)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-46.

    Entry informationi

    Entry nameiZNHI3_HUMAN
    AccessioniPrimary (citable) accession number: Q15649
    Secondary accession number(s): A8K493, K7EQP1, Q8WVJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3