Reviewed, UniProtKB/Swiss-Prot Q15645 (TRP13_HUMAN)

Names and origin

Protein names

Recommended name:
    Thyroid receptor-interacting protein 13
Alternative name(s):
    Thyroid hormone receptor interactor 13
      Short name=TRIP-13
    Human papillomavirus type 16 E1 protein-binding protein
      Short name=HPV16 E1 protein-binding protein
      Short name=16E1-BP

Gene names

Name:

TRIP13

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with HPV16 E1. Ref.1 Ref.4
Sequence similarities	Belongs to the AAA ATPase family.
Sequence caution	The sequence AAC41732.1 differs from that shown. Reason: Frameshift at positions 1 and 5.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transcription from RNA polymerase II promoter Ref.4 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Ref.1 Non-traceable author statement. Source: UniProtKB identical protein binding Inferred from physical interaction. Source: IntAct nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro transcription cofactor activity Ref.4 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-358993,EBI-358993
ARL11	Q969Q4	2	EBI-358993,EBI-751892
C11orf54	Q9H0W9	2	EBI-358993,EBI-740204
COMT	Q9BWC7	2	EBI-358993,EBI-743305
DDAH2	O95865	2	EBI-358993,EBI-749139
GLYCTK	Q8IVS8	2	EBI-358993,EBI-748515
HDHD3	Q9BSH5	2	EBI-358993,EBI-745201
KIAA1609	Q6P9B6	2	EBI-358993,EBI-746504
LASP1	Q14847	2	EBI-358993,EBI-742828
LOXL4	Q96JB6	2	EBI-358993,EBI-749562
MAD2L1BP	Q15013	4	EBI-358993,EBI-712181
NIF3L1	Q9GZT8	2	EBI-358993,EBI-740897
PARK2	O60260	2	EBI-358993,EBI-716346
PPP2CA	P67775	2	EBI-358993,EBI-712311
WDYHV1	Q96HA8	2	EBI-358993,EBI-741158

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15645-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15645-2)

The sequence of this isoform differs from the canonical sequence as follows:
     171-406: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Thyroid receptor-interacting protein 13		PRO_0000084782
Regions
	Nucleotide binding	179 – 186	8	ATP Potential
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine
	Modified residue	18	1	Phosphoserine Ref.6
	Modified residue	56	1	Phosphotyrosine Ref.5
Natural variations
	Alternative sequence	171 – 406	236	Missing in isoform 2.		VSP_016957

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: DFB0B37462D1D581	FASTA	432	48,551
	10 20 30 40 50 60 MDEAVGDLKQ ALPCVAESPT VHVEVHQRGS STAKKEDINL SVRKLLNRHN IVFGDYTWTE 70 80 90 100 110 120 FDEPFLTRNV QSVSIIDTEL KVKDSQPIDL SACTVALHIF QLNEDGPSSE NLEEETENII 130 140 150 160 170 180 AANHWVLPAA EFHGLWDSLV YDVEVKSHLL DYVMTTLLFS DKNVNSNLIT WNRVVLLHGP 190 200 210 220 230 240 PGTGKTSLCK ALAQKLTIRL SSRYRYGQLI EINSHSLFSK WFSESGKLVT KMFQKIQDLI 250 260 270 280 290 300 DDKDALVFVL IDEVESLTAA RNACRAGTEP SDAIRVVNAV LTQIDQIKRH SNVVILTTSN 310 320 330 340 350 360 ITEKIDVAFV DRADIKQYIG PPSAAAIFKI YLSCLEELMK CQIIYPRQQL LTLRELEMIG 370 380 390 400 410 420 FIENNVSKLS LLLNDISRKS EGLSGRVLRK LPFLAHALYV QAPTVTIEGF LQALSLAVDK 430 QFEERKKLAA YI
	Isoform 2. Checksum: 74AF9425508B518A	FASTA	196	22,084
	10 20 30 40 50 60 MDEAVGDLKQ ALPCVAESPT VHVEVHQRGS STAKKEDINL SVRKLLNRHN IVFGDYTWTE 70 80 90 100 110 120 FDEPFLTRNV QSVSIIDTEL KVKDSQPIDL SACTVALHIF QLNEDGPSSE NLEEETENII 130 140 150 160 170 180 AANHWVLPAA EFHGLWDSLV YDVEVKSHLL DYVMTTLLFS DKNVNSNLIT IEGFLQALSL 190 AVDKQFEERK KLAAYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins." Yasugi T., Vidal M., Sakai H., Howley P.M., Benson J.D. J. Virol. 71:5942-5951(1997) [PubMed: 9223484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH HPV16 E1.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[4]	"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor." Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D. Mol. Endocrinol. 9:243-254(1995) [PubMed: 7776974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-417 (ISOFORM 2), INTERACTION WITH THRA.
[5]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-56, MASS SPECTROMETRY.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U96131 mRNA. Translation: AAB64095.1. CR456744 mRNA. Translation: CAG33025.1. BC000404 mRNA. Translation: AAH00404.1. BC019294 mRNA. Translation: AAH19294.1. L40384 mRNA. Translation: AAC41732.1. Frameshift.
IPI	IPI00003505. IPI00847729.
RefSeq	NP_004228.1.
UniGene	Hs.436187
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15645. 50 interactions.
STRING	Q15645.
PTM databases
PhosphoSite	Q15645.
Proteomic databases
PeptideAtlas	Q15645.
PRIDE	Q15645.
Genome annotation databases
Ensembl	ENST00000166345; ENSP00000166345; ENSG00000071539; Homo sapiens. [Genome view]
GeneID	9319.
KEGG	hsa:9319.
UCSC	uc003jbr.1. human. uc010ite.1. human.
Organism-specific databases
CTD	9319.
GeneCards	GC05P000946.
H-InvDB	HIX0004712.
HGNC	HGNC:12307. TRIP13.
MIM	604507. gene.
PharmGKB	PA36986.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q15645.
HOVERGEN	Q15645.
OMA	LAHALYI
OrthoDB	EOG9Q87HT
Gene expression databases
ArrayExpress	Q15645.
Bgee	Q15645.
CleanEx	HS_TRIP13.
Genevestigator	Q15645.
GermOnline	ENSG00000071539. Homo sapiens.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR001270. Chaprnin_clpA/B. [Graphical view]
Pfam	PF00004. AAA. 1 hit. [Graphical view]
PRINTS	PR00300. CLPPROTEASEA.
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	34909.
SOURCE	Search...

Entry information

Entry name

TRP13_HUMAN

Accession

Primary (citable) accession number: Q15645
Secondary accession number(s): O15324

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 10, 2006
Last modified:	November 24, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.