Reviewed,
UniProtKB/Swiss-Prot Q15643 (TRIPB_HUMAN)
Last modified
November 25, 2008.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Thyroid receptor-interacting protein 11 Short name=TRIP-11 Alternative name(s): Golgi-associated microtubule-binding protein 210 GMAP-210 Trip230 Clonal evolution-related gene on chromosome 14 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1979 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. |
| Subunit structure | Binds RB1. |
| Subcellular location | Golgi apparatus › cis-Golgi network membrane; Peripheral membrane protein. Note= Associates with the ends of centrosome-nucleated microtubules. |
| Tissue specificity | Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung. |
| Domain | Extended rod-like protein with coiled-coil domains. |
| Involvement in disease | A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia. |
| Sequence similarities | Contains 1 GRIP domain. |
| Sequence caution | The sequence AAB84386.1 differs from that shown. Reason: Frameshift at positions 1932 and 1955. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Coding sequence diversity | Chromosomal rearrangement |
| Domain | Coiled coil |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW membraneInferred from electronic annotation. Source: UniProtKB-KW nucleusInferred from direct assay. Source: HPA |
| Molecular function | transcription coactivator activity Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1979 | 1979 | Thyroid receptor-interacting protein 11 | PRO_0000190076 | |||||
Regions | |||||||||
| Domain | 1774 – 1823 | 50 | GRIP | ||||||
| Coiled coil | 52 – 1773 | 1722 | Potential | ||||||
Sites | |||||||||
| Site | 1754 – 1755 | 2 | Breakpoint for translocation to form TRIP11-PDGFRB | ||||||
Amino acid modifications | |||||||||
| Modified residue | 464 | 1 | Phosphoserine | ||||||
| Modified residue | 1842 | 1 | Phosphoserine | ||||||
| Modified residue | 1846 | 1 | Phosphothreonine | ||||||
| Modified residue | 1891 | 1 | Phosphoserine | ||||||
Experimental info | |||||||||
| Sequence conflict | 121 | 1 | L → F in AAD09135. Ref.1 | ||||||
| Sequence conflict | 382 | 1 | A → G in AAD09135. Ref.1 | ||||||
| Sequence conflict | 391 | 1 | Q → R in AAD09135. Ref.1 | ||||||
| Sequence conflict | 516 | 1 | D → A in AAD09135. Ref.1 | ||||||
| Sequence conflict | 561 – 563 | 3 | KEK → FVL in AAD09135. Ref.1 | ||||||
| Sequence conflict | 1202 | 1 | H → N Ref.1 Ref.4 | ||||||
| Sequence conflict | 1237 | 1 | H → R in AAB84386. Ref.4 | ||||||
| Sequence conflict | 1346 – 1347 | 2 | QQ → HE in AAB84386. Ref.4 | ||||||
| Sequence conflict | 1658 – 1665 | 8 | QLSVSQEQ → RFCLSGT in AAD09135. Ref.1 | ||||||
| Sequence conflict | 1670 | 1 | A → R in AAD09135. Ref.1 | ||||||
| Sequence conflict | 1827 | 1 | S → G in AAD09135. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein." Chang K.-H., Chen Y., Chen T.-T., Chou W.-H., Chen P.-L., Ma Y.-T., Yang-Feng T.L., Leng L., Tsai M.-J., O'Malley B.W., Lee W.-H. Proc. Natl. Acad. Sci. U.S.A. 94:9040-9045(1997) [PubMed: 9256431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RB1 AND THRB. Tissue: Fibroblast. |
| [2] | "GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein." Infante C., Ramos-Morales F., Fedriani F., Bornens M., Rios R.M. J. Cell Biol. 145:83-98(1999) [PubMed: 10189370] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MICROTUBULES. Tissue: Cervix carcinoma. |
| [3] | "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J.Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution." Abe A., Emi N., Tanimoto M., Terasaki H., Marunouchi T., Saito H. Blood 90:4271-4277(1997) [PubMed: 9373237] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1188-1979, CHROMOSOMAL TRANSLOCATION WITH PDGFRB, TISSUE SPECIFICITY. Tissue: Leukemia. |
| [5] | "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor." Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D. Mol. Endocrinol. 9:243-254(1995) [PubMed: 7776974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1757-1944, INTERACTION WITH THRB. Tissue: Cervix carcinoma. |
| [6] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1891, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-1842 AND THR-1846, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF007217 mRNA. Translation: AAD09135.1. Y12490 mRNA. Translation: CAA73095.1. AL049872 Genomic DNA. No translation available. AF011368 mRNA. Translation: AAB84386.1. Frameshift. L40380 mRNA. Translation: AAC41730.1. Sequence problems. | |
| PIR | T03719. |
| RefSeq | NP_004230.2. |
| UniGene | Hs.632339 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IC2 based on UniProtKB P04268. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15643. |
PTM databases | |
| PhosphoSite | Q15643. |
Genome annotation databases | |
| Ensembl | ENSG00000100815. Homo sapiens. [Contig view] |
| GeneID | 9321. |
Organism-specific databases | |
| H-InvDB | HIX0022592. |
| HGNC | HGNC:12305. TRIP11. |
| HPA | HPA002570. |
| MIM | 604505. gene. |
| PharmGKB | PA36984. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q15643. |
| HOVERGEN | Q15643. |
Gene expression databases | |
| ArrayExpress | Q15643. |
| CleanEx | HS_TRIP11. |
| GermOnline | ENSG00000100815. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000237. GRIP. [Graphical view] |
| PROSITE | PS50913. GRIP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q15643. |
| SOURCE | Search... |
Entry information
| Entry name | TRIPB_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15643 Secondary accession number(s): O14689, O15154, O95949 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


