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Q15643 (TRIPB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thyroid receptor-interacting protein 11

Short name=TR-interacting protein 11
Short name=TRIP-11
Alternative name(s):
Clonal evolution-related gene on chromosome 14 protein
Golgi-associated microtubule-binding protein 210
Short name=GMAP-210
Trip230
Gene names
Name:TRIP11
Synonyms:CEV14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1979 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. Ref.1 Ref.2

Subunit structure

Binds RB1.

Subcellular location

Golgi apparatuscis-Golgi network membrane; Peripheral membrane protein. Cytoplasmcytoskeleton. Note: Associates with the ends of centrosome-nucleated microtubules. Ref.2

Tissue specificity

Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung. Ref.2 Ref.4

Domain

Extended rod-like protein with coiled-coil domains.

Involvement in disease

A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.

Achondrogenesis 1A (ACG1A) [MIM:200600]: A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9

Sequence similarities

Contains 1 GRIP domain.

Sequence caution

The sequence AAB84386.1 differs from that shown. Reason: Frameshift at positions 1932 and 1955.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19791979Thyroid receptor-interacting protein 11
PRO_0000190076

Regions

Domain1774 – 182350GRIP
Coiled coil52 – 17731722 Potential

Sites

Site1754 – 17552Breakpoint for translocation to form TRIP11-PDGFRB

Amino acid modifications

Modified residue4641Phosphoserine Ref.7 Ref.10
Modified residue18421Phosphoserine Ref.7 Ref.8 Ref.10
Modified residue18461Phosphothreonine Ref.7 Ref.8
Modified residue18911Phosphoserine Ref.6

Natural variations

Natural variant391M → L.
Corresponds to variant rs17127898 [ dbSNP | Ensembl ].
VAR_055861
Natural variant5061E → A.
Corresponds to variant rs2273186 [ dbSNP | Ensembl ].
VAR_055862
Natural variant7951V → L.
Corresponds to variant rs34699762 [ dbSNP | Ensembl ].
VAR_055863
Natural variant8841D → G.
Corresponds to variant rs34967261 [ dbSNP | Ensembl ].
VAR_055864
Natural variant10401I → V.
Corresponds to variant rs34805848 [ dbSNP | Ensembl ].
VAR_055865
Natural variant11071E → D.
Corresponds to variant rs4619320 [ dbSNP | Ensembl ].
VAR_060344
Natural variant14131D → A.
Corresponds to variant rs12884523 [ dbSNP | Ensembl ].
VAR_060345
Natural variant15031M → V.
Corresponds to variant rs34839498 [ dbSNP | Ensembl ].
VAR_055866
Natural variant15761R → H.
Corresponds to variant rs35007347 [ dbSNP | Ensembl ].
VAR_055867
Natural variant17491E → A.
Corresponds to variant rs2273183 [ dbSNP | Ensembl ].
VAR_055868
Natural variant17521R → K.
Corresponds to variant rs11851376 [ dbSNP | Ensembl ].
VAR_055869
Natural variant18271G → S. Ref.2 Ref.4 Ref.5
Corresponds to variant rs1051340 [ dbSNP | Ensembl ].
VAR_060346
Natural variant18461T → I. Ref.12
VAR_054151

Experimental info

Sequence conflict1211L → F in AAD09135. Ref.1
Sequence conflict3821A → G in AAD09135. Ref.1
Sequence conflict3911Q → R in AAD09135. Ref.1
Sequence conflict5161D → A in AAD09135. Ref.1
Sequence conflict561 – 5633KEK → FVL in AAD09135. Ref.1
Sequence conflict12021N → H Ref.2
Sequence conflict12371H → R in AAB84386. Ref.4
Sequence conflict1346 – 13472QQ → HE in AAB84386. Ref.4
Sequence conflict1658 – 16658QLSVSQEQ → RFCLSGT in AAD09135. Ref.1
Sequence conflict16701A → R in AAD09135. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q15643 [UniParc].

Last modified March 23, 2010. Version 3.
Checksum: 437EB5F5966BB1AE

FASTA1,979227,586
        10         20         30         40         50         60 
MSSWLGGLGS GLGQSLGQVG GSLASLTGQI SNFTKDMLME GTEEVEAELP DSRTKEIEAI 

        70         80         90        100        110        120 
HAILRSENER LKKLCTDLEE KHEASEIQIK QQSTSYRNQL QQKEVEISHL KARQIALQDQ 

       130        140        150        160        170        180 
LLKLQSAAQS VPSGAGVPAT TASSSFAYGI SHHPSAFHDD DMDFGDIISS QQEINRLSNE 

       190        200        210        220        230        240 
VSRLESEVGH WRHIAQTSKA QGTDNSDQSE ICKLQNIIKE LKQNRSQEID DHQHEMSVLQ 

       250        260        270        280        290        300 
NAHQQKLTEI SRRHREELSD YEERIEELEN LLQQGGSGVI ETDLSKIYEM QKTIQVLQIE 

       310        320        330        340        350        360 
KVESTKKMEQ LEDKIKDINK KLSSAENDRD ILRREQEQLN VEKRQIMEEC ENLKLECSKL 

       370        380        390        400        410        420 
QPSAVKQSDT MTEKERILAQ SASVEEVFRL QQALSDAENE IMRLSSLNQD NSLAEDNLKL 

       430        440        450        460        470        480 
KMRIEVLEKE KSLLSQEKEE LQMSLLKLNN EYEVIKSTAT RDISLDSELH DLRLNLEAKE 

       490        500        510        520        530        540 
QELNQSISEK ETLIAEIEEL DRQNQEATKH MILIKDQLSK QQNEGDSIIS KLKQDLNDEK 

       550        560        570        580        590        600 
KRVHQLEDDK MDITKELDVQ KEKLIQSEVA LNDLHLTKQK LEDKVENLVD QLNKSQESNV 

       610        620        630        640        650        660 
SIQKENLELK EHIRQNEEEL SRIRNELMQS LNQDSNSNFK DTLLKEREAE VRNLKQNLSE 

       670        680        690        700        710        720 
LEQLNENLKK VAFDVKMENE KLVLACEDVR HQLEECLAGN NQLSLEKNTI VETLKMEKGE 

       730        740        750        760        770        780 
IEAELCWAKK RLLEEANKYE KTIEELSNAR NLNTSALQLE HEHLIKLNQK KDMEIAELKK 

       790        800        810        820        830        840 
NIEQMDTDHK ETKDVLSSSL EEQKQLTQLI NKKEIFIEKL KERSSKLQEE LDKYSQALRK 

       850        860        870        880        890        900 
NEILRQTIEE KDRSLGSMKE ENNHLQEELE RLREEQSRTA PVADPKTLDS VTELASEVSQ 

       910        920        930        940        950        960 
LNTIKEHLEE EIKHHQKIIE DQNQSKMQLL QSLQEQKKEM DEFRYQHEQM NATHTQLFLE 

       970        980        990       1000       1010       1020 
KDEEIKSLQK TIEQIKTQLH EERQDIQTDN SDIFQETKVQ SLNIENGSEK HDLSKAETER 

      1030       1040       1050       1060       1070       1080 
LVKGIKEREL EIKLLNEKNI SLTKQIDQLS KDEVGKLTQI IQQKDLEIQA LHARISSTSH 

      1090       1100       1110       1120       1130       1140 
TQDVVYLQQQ LQAYAMEREK VFAVLNEKTR ENSHLKTEYH KMMDIVAAKE AALIKLQDEN 

      1150       1160       1170       1180       1190       1200 
KKLSTRFESS GQDMFRETIQ NLSRIIREKD IEIDALSQKC QTLLAVLQTS STGNEAGGVN 

      1210       1220       1230       1240       1250       1260 
SNQFEELLQE RDKLKQQVKK MEEWKQQVMT TVQNMQHESA QLQEELHQLQ AQVLVDSDNN 

      1270       1280       1290       1300       1310       1320 
SKLQVDYTGL IQSYEQNETK LKNFGQELAQ VQHSIGQLCN TKDLLLGKLD IISPQLSSAS 

      1330       1340       1350       1360       1370       1380 
LLTPQSAECL RASKSEVLSE SSELLQQELE ELRKSLQEKD ATIRTLQENN HRLSDSIAAT 

      1390       1400       1410       1420       1430       1440 
SELERKEHEQ TDSEIKQLKE KQDVLQKLLK EKDLLIKAKS DQLLSSNENF TNKVNENELL 

      1450       1460       1470       1480       1490       1500 
RQAVTNLKER ILILEMDIGK LKGENEKIVE TYRGKETEYQ ALQETNMKFS MMLREKEFEC 

      1510       1520       1530       1540       1550       1560 
HSMKEKALAF EQLLKEKEQG KTGELNQLLN AVKSMQEKTV VFQQERDQVM LALKQKQMEN 

      1570       1580       1590       1600       1610       1620 
TALQNEVQRL RDKEFRSNQE LERLRNHLLE SEDSYTREAL AAEDREAKLR KKVTVLEEKL 

      1630       1640       1650       1660       1670       1680 
VSSSNAMENA SHQASVQVES LQEQLNVVSK QRDETALQLS VSQEQVKQYA LSLANLQMVL 

      1690       1700       1710       1720       1730       1740 
EHFQQEEKAM YSAELEKQKQ LIAEWKKNAE NLEGKVISLQ ECLDEANAAL DSASRLTEQL 

      1750       1760       1770       1780       1790       1800 
DVKEEQIEEL KRQNELRQEM LDDVQKKLMS LANSSEGKVD KVLMRNLFIG HFHTPKNQRH 

      1810       1820       1830       1840       1850       1860 
EVLRLMGSIL GVRREEMEQL FHDDQGGVTR WMTGWLGGGS KSVPNTPLRP NQQSVVNSSF 

      1870       1880       1890       1900       1910       1920 
SELFVKFLET ESHPSIPPPK LSVHDMKPLD SPGRRKRDTN APESFKDTAE SRSGRRTDVN 

      1930       1940       1950       1960       1970 
PFLAPRSAAV PLINPAGLGP GGPGHLLLKP ISDVLPTFTP LPALPDNSAG VVLKDLLKQ 

« Hide

References

« Hide 'large scale' references
[1]"A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein."
Chang K.-H., Chen Y., Chen T.-T., Chou W.-H., Chen P.-L., Ma Y.-T., Yang-Feng T.L., Leng L., Tsai M.-J., O'Malley B.W., Lee W.-H.
Proc. Natl. Acad. Sci. U.S.A. 94:9040-9045(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RB1 AND THRB.
Tissue: Fibroblast.
[2]"GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein."
Infante C., Ramos-Morales F., Fedriani F., Bornens M., Rios R.M.
J. Cell Biol. 145:83-98(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MICROTUBULES, VARIANT SER-1827.
Tissue: Cervix carcinoma.
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution."
Abe A., Emi N., Tanimoto M., Terasaki H., Marunouchi T., Saito H.
Blood 90:4271-4277(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1188-1979, CHROMOSOMAL TRANSLOCATION WITH PDGFRB, TISSUE SPECIFICITY, VARIANT SER-1827.
Tissue: Leukemia.
[5]"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1757-1944, INTERACTION WITH THRB, VARIANT SER-1827.
Tissue: Cervix carcinoma.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1891, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-1842 AND THR-1846, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1842 AND THR-1846, MASS SPECTROMETRY.
Tissue: Leukemic T-cell.
[9]"Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210."
Smits P., Bolton A.D., Funari V., Hong M., Boyden E.D., Lu L., Manning D.K., Dwyer N.D., Moran J.L., Prysak M., Merriman B., Nelson S.F., Bonafe L., Superti-Furga A., Ikegawa S., Krakow D., Cohn D.H., Kirchhausen T., Warman M.L., Beier D.R.
N. Engl. J. Med. 362:206-216(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN ACG1A.
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464 AND SER-1842, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. expand/collapse author list , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K.
Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-1846.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007217 mRNA. Translation: AAD09135.1.
Y12490 mRNA. Translation: CAA73095.1.
AL049872 Genomic DNA. No translation available.
AF011368 mRNA. Translation: AAB84386.1. Frameshift.
L40380 mRNA. Translation: AAC41730.1. Sequence problems.
IPIIPI00003515.
PIRT03719.
RefSeqNP_004230.2. NM_004239.3.
UniGeneHs.632339.
Hs.741740.

3D structure databases

ProteinModelPortalQ15643.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-40357N.
IntActQ15643. 8 interactions.
MINTMINT-2866314.
STRING9606.ENSP00000267622.

PTM databases

PhosphoSiteQ15643.

Polymorphism databases

DMDM292495059.

Proteomic databases

PaxDbQ15643.
PRIDEQ15643.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267622; ENSP00000267622; ENSG00000100815.
GeneID9321.
KEGGhsa:9321.
UCSCuc001xzy.3. human.

Organism-specific databases

CTD9321.
GeneCardsGC14M092435.
H-InvDBHIX0202079.
HGNCHGNC:12305. TRIP11.
HPAHPA002570.
MIM200600. phenotype.
604505. gene.
neXtProtNX_Q15643.
Orphanet93299. Achondrogenesis type 1A.
PharmGKBPA36984.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000168282.
HOVERGENHBG079281.
InParanoidQ15643.
OMAIEAELCW.
OrthoDBEOG4229HV.
PhylomeDBQ15643.

Gene expression databases

ArrayExpressQ15643.
BgeeQ15643.
CleanExHS_TRIP11.
GenevestigatorQ15643.
GermOnlineENSG00000100815. Homo sapiens.

Family and domain databases

InterProIPR000237. GRIP.
[Graphical view]
PROSITEPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9321.
NextBio34917.
SOURCESearch...

Entry information

Entry nameTRIPB_HUMAN
AccessionPrimary (citable) accession number: Q15643
Secondary accession number(s): O14689, O15154, O95949
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: May 1, 2013
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families