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Reviewed, UniProtKB/Swiss-Prot Q15643 (TRIPB_HUMAN)

Last modified November 25, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thyroid receptor-interacting protein 11
      Short name=TRIP-11
Alternative name(s):
    Golgi-associated microtubule-binding protein 210
    GMAP-210
    Trip230
    Clonal evolution-related gene on chromosome 14
Gene names
Name: TRIP11
Synonyms: CEV14
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1979 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Subunit structure

Binds RB1.

Subcellular location

Golgi apparatus › cis-Golgi network membrane; Peripheral membrane protein. Note= Associates with the ends of centrosome-nucleated microtubules.

Tissue specificity

Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung.

Domain

Extended rod-like protein with coiled-coil domains.

Involvement in disease

A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.

Sequence similarities

Contains 1 GRIP domain.

Sequence caution

The sequence AAB84386.1 differs from that shown. Reason: Frameshift at positions 1932 and 1955.

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Ontologies

Keywords

   Cellular componentGolgi apparatus
Membrane
   Coding sequence diversityChromosomal rearrangement
   DomainCoiled coil
   PTMPhosphoprotein

Gene Ontology (GO)

   Biological processtranscription from RNA polymerase II promoter Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from direct assay. Source: HPA

   Molecular functiontranscription coactivator activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19791979Thyroid receptor-interacting protein 11
PRO_0000190076

Regions

Domain1774 – 182350GRIP
Coiled coil52 – 17731722 Potential

Sites

Site1754 – 17552Breakpoint for translocation to form TRIP11-PDGFRB

Amino acid modifications

Modified residue4641Phosphoserine
Modified residue18421Phosphoserine
Modified residue18461Phosphothreonine
Modified residue18911Phosphoserine

Experimental info

Sequence conflict1211L → F in AAD09135. Ref.1
Sequence conflict3821A → G in AAD09135. Ref.1
Sequence conflict3911Q → R in AAD09135. Ref.1
Sequence conflict5161D → A in AAD09135. Ref.1
Sequence conflict561 – 5633KEK → FVL in AAD09135. Ref.1
Sequence conflict12021H → N Ref.1 Ref.4
Sequence conflict12371H → R in AAB84386. Ref.4
Sequence conflict1346 – 13472QQ → HE in AAB84386. Ref.4
Sequence conflict1658 – 16658QLSVSQEQ → RFCLSGT in AAD09135. Ref.1
Sequence conflict16701A → R in AAD09135. Ref.1
Sequence conflict18271S → G in AAD09135. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q15643-1 [UniParc].

Last modified July 25, 2003. Version 2.
Checksum: 83E46777D34D360D

FASTA1,979227,639
        10         20         30         40         50         60 
MSSWLGGLGS GLGQSLGQVG GSLASLTGQI SNFTKDMLME GTEEVEAELP DSRTKEIEAI 

        70         80         90        100        110        120 
HAILRSENER LKKLCTDLEE KHEASEIQIK QQSTSYRNQL QQKEVEISHL KARQIALQDQ 

       130        140        150        160        170        180 
LLKLQSAAQS VPSGAGVPAT TASSSFAYGI SHHPSAFHDD DMDFGDIISS QQEINRLSNE 

       190        200        210        220        230        240 
VSRLESEVGH WRHIAQTSKA QGTDNSDQSE ICKLQNIIKE LKQNRSQEID DHQHEMSVLQ 

       250        260        270        280        290        300 
NAHQQKLTEI SRRHREELSD YEERIEELEN LLQQGGSGVI ETDLSKIYEM QKTIQVLQIE 

       310        320        330        340        350        360 
KVESTKKMEQ LEDKIKDINK KLSSAENDRD ILRREQEQLN VEKRQIMEEC ENLKLECSKL 

       370        380        390        400        410        420 
QPSAVKQSDT MTEKERILAQ SASVEEVFRL QQALSDAENE IMRLSSLNQD NSLAEDNLKL 

       430        440        450        460        470        480 
KMRIEVLEKE KSLLSQEKEE LQMSLLKLNN EYEVIKSTAT RDISLDSELH DLRLNLEAKE 

       490        500        510        520        530        540 
QELNQSISEK ETLIAEIEEL DRQNQEATKH MILIKDQLSK QQNEGDSIIS KLKQDLNDEK 

       550        560        570        580        590        600 
KRVHQLEDDK MDITKELDVQ KEKLIQSEVA LNDLHLTKQK LEDKVENLVD QLNKSQESNV 

       610        620        630        640        650        660 
SIQKENLELK EHIRQNEEEL SRIRNELMQS LNQDSNSNFK DTLLKEREAE VRNLKQNLSE 

       670        680        690        700        710        720 
LEQLNENLKK VAFDVKMENE KLVLACEDVR HQLEECLAGN NQLSLEKNTI VETLKMEKGE 

       730        740        750        760        770        780 
IEAELCWAKK RLLEEANKYE KTIEELSNAR NLNTSALQLE HEHLIKLNQK KDMEIAELKK 

       790        800        810        820        830        840 
NIEQMDTDHK ETKDVLSSSL EEQKQLTQLI NKKEIFIEKL KERSSKLQEE LDKYSQALRK 

       850        860        870        880        890        900 
NEILRQTIEE KDRSLGSMKE ENNHLQEELE RLREEQSRTA PVADPKTLDS VTELASEVSQ 

       910        920        930        940        950        960 
LNTIKEHLEE EIKHHQKIIE DQNQSKMQLL QSLQEQKKEM DEFRYQHEQM NATHTQLFLE 

       970        980        990       1000       1010       1020 
KDEEIKSLQK TIEQIKTQLH EERQDIQTDN SDIFQETKVQ SLNIENGSEK HDLSKAETER 

      1030       1040       1050       1060       1070       1080 
LVKGIKEREL EIKLLNEKNI SLTKQIDQLS KDEVGKLTQI IQQKDLEIQA LHARISSTSH 

      1090       1100       1110       1120       1130       1140 
TQDVVYLQQQ LQAYAMEREK VFAVLNEKTR ENSHLKTEYH KMMDIVAAKE AALIKLQDEN 

      1150       1160       1170       1180       1190       1200 
KKLSTRFESS GQDMFRETIQ NLSRIIREKD IEIDALSQKC QTLLAVLQTS STGNEAGGVN 

      1210       1220       1230       1240       1250       1260 
SHQFEELLQE RDKLKQQVKK MEEWKQQVMT TVQNMQHESA QLQEELHQLQ AQVLVDSDNN 

      1270       1280       1290       1300       1310       1320 
SKLQVDYTGL IQSYEQNETK LKNFGQELAQ VQHSIGQLCN TKDLLLGKLD IISPQLSSAS 

      1330       1340       1350       1360       1370       1380 
LLTPQSAECL RASKSEVLSE SSELLQQELE ELRKSLQEKD ATIRTLQENN HRLSDSIAAT 

      1390       1400       1410       1420       1430       1440 
SELERKEHEQ TDSEIKQLKE KQDVLQKLLK EKDLLIKAKS DQLLSSNENF TNKVNENELL 

      1450       1460       1470       1480       1490       1500 
RQAVTNLKER ILILEMDIGK LKGENEKIVE TYRGKETEYQ ALQETNMKFS MMLREKEFEC 

      1510       1520       1530       1540       1550       1560 
HSMKEKALAF EQLLKEKEQG KTGELNQLLN AVKSMQEKTV VFQQERDQVM LALKQKQMEN 

      1570       1580       1590       1600       1610       1620 
TALQNEVQRL RDKEFRSNQE LERLRNHLLE SEDSYTREAL AAEDREAKLR KKVTVLEEKL 

      1630       1640       1650       1660       1670       1680 
VSSSNAMENA SHQASVQVES LQEQLNVVSK QRDETALQLS VSQEQVKQYA LSLANLQMVL 

      1690       1700       1710       1720       1730       1740 
EHFQQEEKAM YSAELEKQKQ LIAEWKKNAE NLEGKVISLQ ECLDEANAAL DSASRLTEQL 

      1750       1760       1770       1780       1790       1800 
DVKEEQIEEL KRQNELRQEM LDDVQKKLMS LANSSEGKVD KVLMRNLFIG HFHTPKNQRH 

      1810       1820       1830       1840       1850       1860 
EVLRLMGSIL GVRREEMEQL FHDDQGSVTR WMTGWLGGGS KSVPNTPLRP NQQSVVNSSF 

      1870       1880       1890       1900       1910       1920 
SELFVKFLET ESHPSIPPPK LSVHDMKPLD SPGRRKRDTN APESFKDTAE SRSGRRTDVN 

      1930       1940       1950       1960       1970 
PFLAPRSAAV PLINPAGLGP GGPGHLLLKP ISDVLPTFTP LPALPDNSAG VVLKDLLKQ

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References

« Hide 'large scale' references
[1]"A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein."
Chang K.-H., Chen Y., Chen T.-T., Chou W.-H., Chen P.-L., Ma Y.-T., Yang-Feng T.L., Leng L., Tsai M.-J., O'Malley B.W., Lee W.-H.
Proc. Natl. Acad. Sci. U.S.A. 94:9040-9045(1997) [PubMed: 9256431] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RB1 AND THRB.
Tissue: Fibroblast.
[2]"GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein."
Infante C., Ramos-Morales F., Fedriani F., Bornens M., Rios R.M.
J. Cell Biol. 145:83-98(1999) [PubMed: 10189370] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH MICROTUBULES.
Tissue: Cervix carcinoma.
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution."
Abe A., Emi N., Tanimoto M., Terasaki H., Marunouchi T., Saito H.
Blood 90:4271-4277(1997) [PubMed: 9373237] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1188-1979, CHROMOSOMAL TRANSLOCATION WITH PDGFRB, TISSUE SPECIFICITY.
Tissue: Leukemia.
[5]"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.
Mol. Endocrinol. 9:243-254(1995) [PubMed: 7776974] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1757-1944, INTERACTION WITH THRB.
Tissue: Cervix carcinoma.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1891, MASS SPECTROMETRY.
Tissue: Epithelium.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-1842 AND THR-1846, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF007217 mRNA. Translation: AAD09135.1.
Y12490 mRNA. Translation: CAA73095.1.
AL049872 Genomic DNA. No translation available.
AF011368 mRNA. Translation: AAB84386.1. Frameshift.
L40380 mRNA. Translation: AAC41730.1. Sequence problems.
PIRT03719.
RefSeqNP_004230.2.
UniGeneHs.632339

3D structure databases

HSSPHSSP built from PDB template 1IC2 based on UniProtKB P04268.
ModBaseSearch...

Protein-protein interaction databases

IntActQ15643.

PTM databases

PhosphoSiteQ15643.

Genome annotation databases

EnsemblENSG00000100815. Homo sapiens. [Contig view]
GeneID9321.

Organism-specific databases

H-InvDBHIX0022592.
HGNCHGNC:12305. TRIP11.
HPAHPA002570.
MIM604505. gene.
PharmGKBPA36984.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ15643.
HOVERGENQ15643.

Gene expression databases

ArrayExpressQ15643.
CleanExHS_TRIP11.
GermOnlineENSG00000100815. Homo sapiens.

Family and domain databases

InterProIPR000237. GRIP.
[Graphical view]
PROSITEPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubQ15643.
SOURCESearch...

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Entry information

Entry nameTRIPB_HUMAN
AccessionPrimary (citable) accession number: Q15643
Secondary accession number(s): O14689, O15154, O95949
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 25, 2003
Last modified: November 25, 2008
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents