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Q15633

- TRBP2_HUMAN

UniProt

Q15633 - TRBP2_HUMAN

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Protein

RISC-loading complex subunit TARBP2

Gene
TARBP2, TRBP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.9 Publications

GO - Molecular functioni

  1. double-stranded RNA binding Source: InterPro
  2. miRNA binding Source: UniProtKB-HAMAP
  3. protein binding Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. siRNA binding Source: UniProtKB

GO - Biological processi

  1. gene expression Source: Reactome
  2. miRNA loading onto RISC involved in gene silencing by miRNA Source: UniProtKB
  3. negative regulation of defense response to virus by host Source: UniProtKB
  4. negative regulation of protein kinase activity Source: UniProtKB
  5. positive regulation of viral genome replication Source: UniProtKB
  6. pre-miRNA processing Source: UniProtKB
  7. production of siRNA involved in RNA interference Source: UniProtKB
  8. regulation of transcription, DNA-templated Source: ProtInc
  9. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  10. regulation of translation Source: UniProtKB-KW
  11. regulation of viral transcription Source: UniProtKB
  12. targeting of mRNA for destruction involved in RNA interference Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_118560. Small interfering RNA (siRNA) biogenesis.
REACT_12417. MicroRNA (miRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
RISC-loading complex subunit TARBP2
Alternative name(s):
TAR RNA-binding protein 2
Trans-activation-responsive RNA-binding protein
Gene namesi
Name:TARBP2
Synonyms:TRBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:11569. TARBP2.

Subcellular locationi

Cytoplasm. Cytoplasmperinuclear region. Nucleus 3 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. nucleus Source: HPA
  4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  5. RISC complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366RISC-loading complex subunit TARBP2UniRule annotationPRO_0000065622Add
BLAST

Proteomic databases

MaxQBiQ15633.
PaxDbiQ15633.
PRIDEiQ15633.

PTM databases

PhosphoSiteiQ15633.

Expressioni

Gene expression databases

ArrayExpressiQ15633.
BgeeiQ15633.
CleanExiHS_TARBP2.
GenevestigatoriQ15633.

Organism-specific databases

HPAiHPA051181.

Interactioni

Subunit structurei

Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and PRKRA. Associates with the 60S ribosome.11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADARP55265-12EBI-978581,EBI-6913056
ADARP55265-53EBI-978581,EBI-6913210
AGO2Q9UKV85EBI-978581,EBI-528269
DICER1Q9UPY315EBI-978581,EBI-395506
EIF2AK2P195252EBI-978581,EBI-640775
PRKRAO755692EBI-978581,EBI-713955

Protein-protein interaction databases

BioGridi112758. 39 interactions.
DIPiDIP-29665N.
IntActiQ15633. 10 interactions.
MINTiMINT-92451.
STRINGi9606.ENSP00000266987.

Structurei

Secondary structure

1
366
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi31 – 4111
Beta strandi47 – 537
Beta strandi62 – 687
Beta strandi71 – 799
Helixi80 – 9516
Helixi161 – 17010
Beta strandi177 – 1859
Beta strandi187 – 1893
Beta strandi191 – 1988
Beta strandi201 – 2099
Helixi210 – 22617

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CPNNMR-A150-225[»]
3ADLX-ray2.20A161-231[»]
3LLHX-ray2.14A/B22-105[»]
ProteinModelPortaliQ15633.
SMRiQ15633. Positions 28-225, 293-360.

Miscellaneous databases

EvolutionaryTraceiQ15633.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9768DRBM 1Add
BLAST
Domaini159 – 22769DRBM 2Add
BLAST
Domaini293 – 36169DRBM 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 10584Sufficient for interaction with PRKRAUniRule annotationAdd
BLAST
Regioni152 – 23483Sufficient for interaction with PRKRAUniRule annotationAdd
BLAST
Regioni228 – 366139Sufficient for interaction with DICER1UniRule annotationAdd
BLAST
Regioni287 – 36680Sufficient for interaction with PRKRAUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TARBP2 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG245126.
HOGENOMiHOG000231919.
HOVERGENiHBG001700.
InParanoidiQ15633.
OMAiIEQMLAV.
PhylomeDBiQ15633.
TreeFamiTF315953.

Family and domain databases

Gene3Di3.30.160.20. 3 hits.
HAMAPiMF_03034. TRBP2.
InterProiIPR014720. dsRNA-bd_dom.
IPR028605. TRBP2.
[Graphical view]
PANTHERiPTHR10910:SF61. PTHR10910:SF61. 1 hit.
PfamiPF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00358. DSRM. 3 hits.
[Graphical view]
PROSITEiPS50137. DS_RBD. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 1 (identifier: Q15633-1) [UniParc]FASTAAdd to Basket

Also known as: TRBP2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSEEEQGSGT TTGCGLPSIE QMLAANPGKT PISLLQEYGT RIGKTPVYDL    50
LKAEGQAHQP NFTFRVTVGD TSCTGQGPSK KAAKHKAAEV ALKHLKGGSM 100
LEPALEDSSS FSPLDSSLPE DIPVFTAAAA ATPVPSVVLT RSPPMELQPP 150
VSPQQSECNP VGALQELVVQ KGWRLPEYTV TQESGPAHRK EFTMTCRVER 200
FIEIGSGTSK KLAKRNAAAK MLLRVHTVPL DARDGNEVEP DDDHFSIGVG 250
SRLDGLRNRG PGCTWDSLRN SVGEKILSLR SCSLGSLGAL GPACCRVLSE 300
LSEEQAFHVS YLDIEELSLS GLCQCLVELS TQPATVCHGS ATTREAARGE 350
AARRALQYLK IMAGSK 366
Length:366
Mass (Da):39,039
Last modified:October 14, 2008 - v3
Checksum:i768BA11751DA4912
GO
Isoform 2 (identifier: Q15633-2) [UniParc]FASTAAdd to Basket

Also known as: TRBP1

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:345
Mass (Da):36,916
Checksum:i7506A9324E9D0596
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511S → F.2 Publications
Corresponds to variant rs1126500 [ dbSNP | Ensembl ].
VAR_046992

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform 2. VSP_035584Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441P → A in AAA36765. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60801 mRNA. Translation: AAA36765.1.
U08998 mRNA. Translation: AAB50581.2.
BT007140 mRNA. Translation: AAP35804.1.
CH471054 Genomic DNA. Translation: EAW96720.1.
BC005860 mRNA. Translation: AAH05860.1.
AF281068 Genomic DNA. Translation: AAL55730.1.
AF281068 Genomic DNA. Translation: AAL55731.1.
CCDSiCCDS41791.1. [Q15633-2]
CCDS8861.1. [Q15633-1]
PIRiG01420.
RefSeqiNP_004169.3. NM_004178.4. [Q15633-2]
NP_599150.1. NM_134323.1. [Q15633-1]
NP_599151.2. NM_134324.2. [Q15633-2]
XP_005269171.1. XM_005269114.1. [Q15633-2]
XP_005269172.1. XM_005269115.2. [Q15633-2]
UniGeneiHs.326.
Hs.604255.

Genome annotation databases

EnsembliENST00000266987; ENSP00000266987; ENSG00000139546. [Q15633-1]
ENST00000394357; ENSP00000377885; ENSG00000139546. [Q15633-2]
ENST00000456234; ENSP00000416077; ENSG00000139546. [Q15633-2]
GeneIDi6895.
KEGGihsa:6895.
UCSCiuc001sdo.3. human. [Q15633-1]

Polymorphism databases

DMDMi209572714.

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60801 mRNA. Translation: AAA36765.1 .
U08998 mRNA. Translation: AAB50581.2 .
BT007140 mRNA. Translation: AAP35804.1 .
CH471054 Genomic DNA. Translation: EAW96720.1 .
BC005860 mRNA. Translation: AAH05860.1 .
AF281068 Genomic DNA. Translation: AAL55730.1 .
AF281068 Genomic DNA. Translation: AAL55731.1 .
CCDSi CCDS41791.1. [Q15633-2 ]
CCDS8861.1. [Q15633-1 ]
PIRi G01420.
RefSeqi NP_004169.3. NM_004178.4. [Q15633-2 ]
NP_599150.1. NM_134323.1. [Q15633-1 ]
NP_599151.2. NM_134324.2. [Q15633-2 ]
XP_005269171.1. XM_005269114.1. [Q15633-2 ]
XP_005269172.1. XM_005269115.2. [Q15633-2 ]
UniGenei Hs.326.
Hs.604255.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CPN NMR - A 150-225 [» ]
3ADL X-ray 2.20 A 161-231 [» ]
3LLH X-ray 2.14 A/B 22-105 [» ]
ProteinModelPortali Q15633.
SMRi Q15633. Positions 28-225, 293-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112758. 39 interactions.
DIPi DIP-29665N.
IntActi Q15633. 10 interactions.
MINTi MINT-92451.
STRINGi 9606.ENSP00000266987.

Chemistry

BindingDBi Q15633.

PTM databases

PhosphoSitei Q15633.

Polymorphism databases

DMDMi 209572714.

Proteomic databases

MaxQBi Q15633.
PaxDbi Q15633.
PRIDEi Q15633.

Protocols and materials databases

DNASUi 6895.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266987 ; ENSP00000266987 ; ENSG00000139546 . [Q15633-1 ]
ENST00000394357 ; ENSP00000377885 ; ENSG00000139546 . [Q15633-2 ]
ENST00000456234 ; ENSP00000416077 ; ENSG00000139546 . [Q15633-2 ]
GeneIDi 6895.
KEGGi hsa:6895.
UCSCi uc001sdo.3. human. [Q15633-1 ]

Organism-specific databases

CTDi 6895.
GeneCardsi GC12P053890.
HGNCi HGNC:11569. TARBP2.
HPAi HPA051181.
MIMi 605053. gene.
neXtProti NX_Q15633.
PharmGKBi PA36334.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245126.
HOGENOMi HOG000231919.
HOVERGENi HBG001700.
InParanoidi Q15633.
OMAi IEQMLAV.
PhylomeDBi Q15633.
TreeFami TF315953.

Enzyme and pathway databases

Reactomei REACT_118560. Small interfering RNA (siRNA) biogenesis.
REACT_12417. MicroRNA (miRNA) biogenesis.

Miscellaneous databases

EvolutionaryTracei Q15633.
GeneWikii TARBP2.
GenomeRNAii 6895.
NextBioi 26949.
PROi Q15633.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15633.
Bgeei Q15633.
CleanExi HS_TARBP2.
Genevestigatori Q15633.

Family and domain databases

Gene3Di 3.30.160.20. 3 hits.
HAMAPi MF_03034. TRBP2.
InterProi IPR014720. dsRNA-bd_dom.
IPR028605. TRBP2.
[Graphical view ]
PANTHERi PTHR10910:SF61. PTHR10910:SF61. 1 hit.
Pfami PF00035. dsrm. 2 hits.
[Graphical view ]
SMARTi SM00358. DSRM. 3 hits.
[Graphical view ]
PROSITEi PS50137. DS_RBD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR."
    Gatignol A., Buckler-White A.J., Berkhout B., Jeang K.T.
    Science 251:1597-1600(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT PHE-251.
  2. Gatignol A., Duarte M.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)."
    Kozak C.A., Gatignol A., Graham K., Jeang K.T., McBride O.W.
    Genomics 25:66-72(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-251.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.
  7. "Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line."
    Bannwarth S., Talakoub L., Letourneur F., Duarte M., Purcell D.F., Hiscott J., Gatignol A.
    J. Biol. Chem. 276:48803-48813(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74, ALTERNATIVE PROMOTER USAGE.
  8. "Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen."
    Gatignol A., Buckler C., Jeang K.T.
    Mol. Cell. Biol. 13:2193-2202(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF RNA-BINDING.
  9. "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression."
    Daher A., Longuet M., Dorin D., Bois F., Segeral E., Bannwarth S., Battisti P.-L., Purcell D.F., Benarous R., Vaquero C., Meurs E.F., Gatignol A.
    J. Biol. Chem. 276:33899-33905(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SELF-ASSOCIATION, INTERACTION WITH EIF2AK2.
  10. "The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR."
    Dorin D., Bonnet M.C., Bannwarth S., Gatignol A., Meurs E.F., Vaquero C.
    J. Biol. Chem. 278:4440-4448(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing."
    Gregory R.I., Chendrimada T.P., Cooch N., Shiekhattar R.
    Cell 123:631-640(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DICER1 AND AGO2.
  12. "TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing."
    Haase A.D., Jaskiewicz L., Zhang H., Laine S., Sack R., Gatignol A., Filipowicz W.
    EMBO Rep. 6:961-967(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SELF-ASSOCIATION, INTERACTION WITH DICER1.
  13. "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA."
    Maniataki E., Mourelatos Z.
    Genes Dev. 19:2979-2990(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DICER1 AND AGO2.
  14. "TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing."
    Chendrimada T.P., Gregory R.I., Kumaraswamy E., Norman J., Cooch N., Nishikura K., Shiekhattar R.
    Nature 436:740-744(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH DICER1 AND AGO2, RNA-BINDING.
  15. "The role of PACT in the RNA silencing pathway."
    Lee Y., Hur I., Park S.-Y., Kim Y.-K., Suh M.R., Kim V.N.
    EMBO J. 25:522-532(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DICER1; AGO2 AND PRKRA, SUBCELLULAR LOCATION.
  16. "Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."
    Kok K.H., Ng M.-H., Ching Y.-P., Jin D.-Y.
    J. Biol. Chem. 282:17649-17657(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH DICER1 AND PRKRA, SUBCELLULAR LOCATION.
  17. "RNA helicase A interacts with RISC in human cells and functions in RISC loading."
    Robb G.B., Rana T.M.
    Mol. Cell 26:523-537(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DHX9.
  18. Cited for: INTERACTION WITH DICER1; AGO2; EIF6 AND MOV10, ASSOCIATION WITH THE 60S RIBOSOME.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH DICER1 AND AGO2.
  21. "Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions."
    Laraki G., Clerzius G., Daher A., Melendez-Pena C., Daniels S., Gatignol A.
    RNA Biol. 5:92-103(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SELF-ASSOCIATION, INTERACTION WITH EIF2AK2 AND PRKRA, SUBCELLULAR LOCATION.
  22. Cited for: FUNCTION.
  23. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  24. "Solution structure of the second DSRBD of TAR RNA-binding protein 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 150-225.

Entry informationi

Entry nameiTRBP2_HUMAN
AccessioniPrimary (citable) accession number: Q15633
Secondary accession number(s): Q12878
, Q8WY32, Q8WY33, Q9BRY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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