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Protein

Translin

Gene

TSN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • endonuclease activity Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • mRNA binding Source: Ensembl
  • sequence-specific DNA binding Source: InterPro
  • single-stranded DNA binding Source: InterPro

GO - Biological processi

  • DNA recombination Source: ProtInc
  • production of siRNA involved in RNA interference Source: Reactome

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-426486 Small interfering RNA (siRNA) biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translin (EC:3.1.-.-)
Alternative name(s):
Component 3 of promoter of RISC
Short name:
C3PO
Gene namesi
Name:TSN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000211460.11
HGNCiHGNC:12379 TSN
MIMi600575 gene
neXtProtiNX_Q15631

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7247
OpenTargetsiENSG00000211460
PharmGKBiPA37047

Polymorphism and mutation databases

BioMutaiTSN
DMDMi6136060

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916831 – 228TranslinAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187N6-acetyllysineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15631
MaxQBiQ15631
PaxDbiQ15631
PeptideAtlasiQ15631
PRIDEiQ15631
TopDownProteomicsiQ15631-1 [Q15631-1]

PTM databases

iPTMnetiQ15631
PhosphoSitePlusiQ15631

Expressioni

Gene expression databases

BgeeiENSG00000211460
CleanExiHS_TSN
ExpressionAtlasiQ15631 baseline and differential
GenevisibleiQ15631 HS

Organism-specific databases

HPAiHPA059561

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi113098, 32 interactors
DIPiDIP-42216N
IntActiQ15631, 22 interactors
MINTiQ15631
STRINGi9606.ENSP00000374332

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 42Combined sources40
Helixi43 – 46Combined sources4
Beta strandi47 – 51Combined sources5
Helixi54 – 77Combined sources24
Helixi81 – 83Combined sources3
Helixi84 – 87Combined sources4
Helixi88 – 90Combined sources3
Helixi92 – 110Combined sources19
Helixi116 – 123Combined sources8
Beta strandi128 – 133Combined sources6
Helixi137 – 160Combined sources24
Helixi166 – 181Combined sources16
Helixi189 – 195Combined sources7
Helixi198 – 213Combined sources16
Turni214 – 216Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J1JX-ray2.20A/B/C/D1-228[»]
3PJAX-ray3.00A/B/C/D/E/F/G/H/I1-228[»]
3QB5X-ray2.95A/B/C1-228[»]
4WYVX-ray3.00A/B/C/D/E/F/G/H1-228[»]
ProteinModelPortaliQ15631
SMRiQ15631
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15631

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 90DNA/RNA binding5
Regioni177 – 198Leucine-zipperSequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiKOG3067 Eukaryota
ENOG410XR87 LUCA
GeneTreeiENSGT00390000014517
HOGENOMiHOG000198374
HOVERGENiHBG000373
InParanoidiQ15631
OMAiCAWLGGL
OrthoDBiEOG091G0NRN
PhylomeDBiQ15631
TreeFamiTF323690

Family and domain databases

CDDicd14819 Translin, 1 hit
Gene3Di1.20.58.190, 1 hit
1.20.58.200, 1 hit
InterProiView protein in InterPro
IPR033956 Translin
IPR016069 Translin_C
IPR002848 Translin_fam
IPR016068 Translin_N
IPR036081 Translin_sf
PANTHERiPTHR10741 PTHR10741, 1 hit
PTHR10741:SF2 PTHR10741:SF2, 1 hit
PfamiView protein in Pfam
PF01997 Translin, 1 hit
SUPFAMiSSF74784 SSF74784, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSEIFVEL QGFLAAEQDI REEIRKVVQS LEQTAREILT LLQGVHQGAG
60 70 80 90 100
FQDIPKRCLK AREHFGTVKT HLTSLKTKFP AEQYYRFHEH WRFVLQRLVF
110 120 130 140 150
LAAFVVYLET ETLVTREAVT EILGIEPDRE KGFHLDVEDY LSGVLILASE
160 170 180 190 200
LSRLSVNSVT AGDYSRPLHI STFINELDSG FRLLNLKNDS LRKRYDGLKY
210 220
DVKKVEEVVY DLSIRGFNKE TAAACVEK
Length:228
Mass (Da):26,183
Last modified:November 1, 1996 - v1
Checksum:i3CAAF20BED7C4939
GO
Isoform 2 (identifier: Q15631-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-148: PDREKGFHLDVEDYLSGVLILA → AVCQQRDCWRLLPTPPHLHLHQ
     149-228: Missing.

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):17,279
Checksum:i475F177A67256825
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044937127 – 148PDREK…VLILA → AVCQQRDCWRLLPTPPHLHL HQ in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_044938149 – 228Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78627 mRNA Translation: CAA55341.1
BT019490 mRNA Translation: AAV38297.1
BT019491 mRNA Translation: AAV38298.1
AK296469 mRNA Translation: BAH12364.1
AC018737 Genomic DNA Translation: AAY14831.1
BC002359 mRNA Translation: AAH02359.1
Y12563
, Y12564, Y12565, Y12566, Y12567 Genomic DNA Translation: CAA73150.1
CCDSiCCDS33284.1 [Q15631-1]
CCDS58723.1 [Q15631-2]
PIRiS51738
RefSeqiNP_001248330.1, NM_001261401.1 [Q15631-2]
NP_004613.1, NM_004622.2 [Q15631-1]
UniGeneiHs.75066

Genome annotation databases

EnsembliENST00000389682; ENSP00000374332; ENSG00000211460 [Q15631-1]
ENST00000536142; ENSP00000437728; ENSG00000211460 [Q15631-2]
GeneIDi7247
KEGGihsa:7247
UCSCiuc002tnl.4 human [Q15631-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTSN_HUMAN
AccessioniPrimary (citable) accession number: Q15631
Secondary accession number(s): B7Z3X8, Q5U0K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health