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Q15629

- TRAM1_HUMAN

UniProt

Q15629 - TRAM1_HUMAN

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Protein

Translocating chain-associated membrane protein 1

Gene
TRAM1, TRAM
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Stimulatory or required for the translocation of secretory proteins across the ER membrane.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. cotranslational protein targeting to membrane Source: ProtInc
  3. gene expression Source: Reactome
  4. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  5. translation Source: Reactome
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane protein 1
Gene namesi
Name:TRAM1
Synonyms:TRAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:20568. TRAM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2928Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei30 – 5021Helical; Reviewed predictionAdd
BLAST
Topological domaini51 – 7626Lumenal Reviewed predictionAdd
BLAST
Transmembranei77 – 9721Helical; Reviewed predictionAdd
BLAST
Topological domaini98 – 12124Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei122 – 14221Helical; Reviewed predictionAdd
BLAST
Topological domaini143 – 15917Lumenal Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Topological domaini181 – 19212Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei193 – 21321Helical; Reviewed predictionAdd
BLAST
Topological domaini214 – 2174Lumenal Reviewed prediction
Transmembranei218 – 23821Helical; Reviewed predictionAdd
BLAST
Topological domaini239 – 25113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei252 – 27221Helical; Reviewed predictionAdd
BLAST
Topological domaini273 – 29725Lumenal Reviewed predictionAdd
BLAST
Transmembranei298 – 31821Helical; Reviewed predictionAdd
BLAST
Topological domaini319 – 37456Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: ProtInc
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134955644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 374373Translocating chain-associated membrane protein 1PRO_0000185530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Inferred
Modified residuei365 – 3651Phosphoserine5 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ15629.
PaxDbiQ15629.
PRIDEiQ15629.

PTM databases

PhosphoSiteiQ15629.

Expressioni

Gene expression databases

ArrayExpressiQ15629.
BgeeiQ15629.
CleanExiHS_TRAM1.
GenevestigatoriQ15629.

Organism-specific databases

HPAiHPA023929.

Interactioni

Subunit structurei

Interacts with human cytomegalovirus/HHV-5 protein US2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCAP31P515725EBI-1788852,EBI-77683

Protein-protein interaction databases

BioGridi117032. 13 interactions.
DIPiDIP-45978N.
IntActiQ15629. 3 interactions.
MINTiMINT-4825850.
STRINGi9606.ENSP00000262213.

Structurei

3D structure databases

ProteinModelPortaliQ15629.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 326210TLCAdd
BLAST

Sequence similaritiesi

Belongs to the TRAM family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292300.
HOGENOMiHOG000007494.
HOVERGENiHBG054402.
InParanoidiQ15629.
KOiK14010.
OMAiLQLAYWF.
PhylomeDBiQ15629.
TreeFamiTF314319.

Family and domain databases

InterProiIPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view]
PfamiPF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15629-1 [UniParc]FASTAAdd to Basket

« Hide

MAIRKKSTKS PPVLSHEFVL QNHADIVSCV AMVFLLGLMF EITAKASIIF    50
VTLQYNVTLP ATEEQATESV SLYYYGIKDL ATVFFYMLVA IIIHAVIQEY 100
MLDKINRRMH FSKTKHSKFN ESGQLSAFYL FACVWGTFIL ISENYISDPT 150
ILWRAYPHNL MTFQMKFFYI SQLAYWLHAF PELYFQKTKK EDIPRQLVYI 200
GLYLFHIAGA YLLNLNHLGL VLLVLHYFVE FLFHISRLFY FSNEKYQKGF 250
SLWAVLFVLG RLLTLILSVL TVGFGLARAE NQKLDFSTGN FNVLAVRIAV 300
LASICVTQAF MMWKFINFQL RRWREHSAFQ APAVKKKPTV TKGRSSKKGT 350
ENGVNGTLTS NVADSPRNKK EKSS 374
Length:374
Mass (Da):43,072
Last modified:January 23, 2007 - v3
Checksum:i9232ADA33DE20076
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63679 mRNA. Translation: CAA45218.1.
BC000687 mRNA. Translation: AAH00687.1.
BC037738 mRNA. Translation: AAH37738.1.
CCDSiCCDS6207.1.
PIRiS30034.
RefSeqiNP_055109.1. NM_014294.5.
UniGeneiHs.491988.

Genome annotation databases

EnsembliENST00000262213; ENSP00000262213; ENSG00000067167.
GeneIDi23471.
KEGGihsa:23471.
UCSCiuc003xyo.2. human.

Polymorphism databases

DMDMi18202507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63679 mRNA. Translation: CAA45218.1 .
BC000687 mRNA. Translation: AAH00687.1 .
BC037738 mRNA. Translation: AAH37738.1 .
CCDSi CCDS6207.1.
PIRi S30034.
RefSeqi NP_055109.1. NM_014294.5.
UniGenei Hs.491988.

3D structure databases

ProteinModelPortali Q15629.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117032. 13 interactions.
DIPi DIP-45978N.
IntActi Q15629. 3 interactions.
MINTi MINT-4825850.
STRINGi 9606.ENSP00000262213.

PTM databases

PhosphoSitei Q15629.

Polymorphism databases

DMDMi 18202507.

Proteomic databases

MaxQBi Q15629.
PaxDbi Q15629.
PRIDEi Q15629.

Protocols and materials databases

DNASUi 23471.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262213 ; ENSP00000262213 ; ENSG00000067167 .
GeneIDi 23471.
KEGGi hsa:23471.
UCSCi uc003xyo.2. human.

Organism-specific databases

CTDi 23471.
GeneCardsi GC08M071535.
HGNCi HGNC:20568. TRAM1.
HPAi HPA023929.
MIMi 605190. gene.
neXtProti NX_Q15629.
PharmGKBi PA134955644.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292300.
HOGENOMi HOG000007494.
HOVERGENi HBG054402.
InParanoidi Q15629.
KOi K14010.
OMAi LQLAYWF.
PhylomeDBi Q15629.
TreeFami TF314319.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

ChiTaRSi TRAM1. human.
GenomeRNAii 23471.
NextBioi 45801.
PROi Q15629.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15629.
Bgeei Q15629.
CleanExi HS_TRAM1.
Genevestigatori Q15629.

Family and domain databases

InterProi IPR006634. TLC-dom.
IPR013599. TRAM1.
IPR016447. Translocation_assoc_membrane.
[Graphical view ]
Pfami PF08390. TRAM1. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view ]
PIRSFi PIRSF005449. Translocation_assoc_membrane. 1 hit.
SMARTi SM00724. TLC. 1 hit.
[Graphical view ]
PROSITEi PS50922. TLC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A protein of the endoplasmic reticulum involved early in polypeptide translocation."
    Goerlich D., Hartmann E., Prehn S., Rapoport T.A.
    Nature 357:47-52(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Kidney.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein."
    Oresic K., Ng C.L., Tortorella D.
    J. Biol. Chem. 284:5905-5914(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-5 PROTEIN US2.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRAM1_HUMAN
AccessioniPrimary (citable) accession number: Q15629
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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