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Protein

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Gene

TRADD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.By similarity

GO - Molecular functioni

  • binding, bridging Source: BHF-UCL
  • death domain binding Source: BHF-UCL
  • kinase binding Source: BHF-UCL
  • signal transducer activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102871-MONOMER.
ReactomeiR-HSA-140534. Ligand-dependent caspase activation.
R-HSA-3371378. Regulation by c-FLIP.
R-HSA-5213460. RIPK1-mediated regulated necrosis.
R-HSA-5218900. CASP8 activity is inhibited.
R-HSA-5357786. TNFR1-induced proapoptotic signaling.
R-HSA-5357905. Regulation of TNFR1 signaling.
R-HSA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-HSA-5675482. Regulation of necroptotic cell death.
R-HSA-69416. Dimerization of procaspase-8.
R-HSA-75893. TNF signaling.
SignaLinkiQ15628.
SIGNORiQ15628.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Short name:
TNFR1-associated DEATH domain protein
Alternative name(s):
TNFRSF1A-associated via death domain
Gene namesi
Name:TRADD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:12030. TRADD.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • death-inducing signaling complex Source: UniProtKB
  • membrane raft Source: Ensembl
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8717.
OpenTargetsiENSG00000102871.
PharmGKBiPA36707.

Polymorphism and mutation databases

BioMutaiTRADD.
DMDMi6094511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656021 – 312Tumor necrosis factor receptor type 1-associated DEATH domain proteinAdd BLAST312

Proteomic databases

EPDiQ15628.
MaxQBiQ15628.
PaxDbiQ15628.
PeptideAtlasiQ15628.
PRIDEiQ15628.

PTM databases

iPTMnetiQ15628.
PhosphoSitePlusiQ15628.

Expressioni

Tissue specificityi

Found in all examined tissues.

Gene expression databases

BgeeiENSG00000102871.
CleanExiHS_TRADD.
GenevisibleiQ15628. HS.

Organism-specific databases

HPAiCAB004602.

Interactioni

Subunit structurei

Interacts with TRIP12 (By similarity). Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-359215,EBI-359215
FADDQ131583EBI-359215,EBI-494804
KRT18P0578311EBI-359215,EBI-297888
TNFRSF1AP1943811EBI-359215,EBI-299451
TRAF2Q129335EBI-359215,EBI-355744

GO - Molecular functioni

  • death domain binding Source: BHF-UCL
  • kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114257. 43 interactors.
DIPiDIP-285N.
IntActiQ15628. 18 interactors.
MINTiMINT-99115.
STRINGi9606.ENSP00000341268.

Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 25Combined sources14
Helixi28 – 33Combined sources6
Turni35 – 37Combined sources3
Helixi38 – 52Combined sources15
Turni56 – 58Combined sources3
Beta strandi59 – 66Combined sources8
Beta strandi68 – 79Combined sources12
Helixi80 – 91Combined sources12
Helixi94 – 106Combined sources13
Beta strandi114 – 120Combined sources7
Helixi125 – 128Combined sources4
Helixi132 – 141Combined sources10
Helixi150 – 162Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F2HNMR-A1-169[»]
1F3VX-ray2.00A1-179[»]
ProteinModelPortaliQ15628.
SMRiQ15628.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15628.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 289DeathPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 289Interaction with KRT14 and KRT181 PublicationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi147 – 163Nuclear export signalBy similarityAdd BLAST17
Motifi231 – 244Nuclear localization signalBy similarityAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi192 – 198Poly-Pro7

Domaini

Requires the intact death domain to associate with TNFRSF1A/TNFR1.

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF81. Eukaryota.
ENOG4111IRA. LUCA.
GeneTreeiENSGT00390000002016.
HOGENOMiHOG000059664.
HOVERGENiHBG054083.
InParanoidiQ15628.
KOiK03171.
OMAiLRFCGRQ.
OrthoDBiEOG091G0DXR.
PhylomeDBiQ15628.
TreeFamiTF331882.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.30.70.680. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR009095. TRADD_N.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF09034. TRADD_N. 1 hit.
[Graphical view]
ProDomiPD182470. TRADD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF55044. SSF55044. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15628-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA
60 70 80 90 100
ESGGSPDVLQ MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ
110 120 130 140 150
RSLAAALAQH SVPLQLELRA GAERLDALLA DEERCLSCIL AQQPDRLRDE
160 170 180 190 200
ELAELEDALR NLKCGSGARG GDGEVASAPL QPPVPSLSEV KPPPPPPPAQ
210 220 230 240 250
TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG CRALRDPALD
260 270 280 290 300
SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED
310
LLGLTDPNGG LA
Length:312
Mass (Da):34,247
Last modified:July 15, 1999 - v2
Checksum:i5645D7E63E5FF05A
GO
Isoform 2 (identifier: Q15628-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):27,904
Checksum:i669B381D012B108A
GO

Sequence cautioni

The sequence AAA98482 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565261 – 60Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41690 mRNA. Translation: AAA98482.1. Different initiation.
AJ311614, AJ311615, AJ311616 Genomic DNA. Translation: CAC38018.2.
AY995114 Genomic DNA. Translation: AAX89407.1.
BT006934 mRNA. Translation: AAP35580.1.
AY575851 Genomic DNA. Translation: AAS68637.1.
AK090673 mRNA. Translation: BAG52211.1.
AK315654 mRNA. Translation: BAG38020.1.
AC074143 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83081.1.
BC004491 mRNA. Translation: AAH04491.1.
CCDSiCCDS10829.1. [Q15628-1]
PIRiA56911.
RefSeqiNP_001310481.1. NM_001323552.1. [Q15628-1]
NP_003780.1. NM_003789.3. [Q15628-1]
XP_005256270.1. XM_005256213.3. [Q15628-2]
XP_016879304.1. XM_017023815.1. [Q15628-1]
UniGeneiHs.460996.

Genome annotation databases

EnsembliENST00000345057; ENSP00000341268; ENSG00000102871. [Q15628-1]
ENST00000486556; ENSP00000462591; ENSG00000102871. [Q15628-2]
GeneIDi8717.
KEGGihsa:8717.
UCSCiuc002erh.2. human. [Q15628-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41690 mRNA. Translation: AAA98482.1. Different initiation.
AJ311614, AJ311615, AJ311616 Genomic DNA. Translation: CAC38018.2.
AY995114 Genomic DNA. Translation: AAX89407.1.
BT006934 mRNA. Translation: AAP35580.1.
AY575851 Genomic DNA. Translation: AAS68637.1.
AK090673 mRNA. Translation: BAG52211.1.
AK315654 mRNA. Translation: BAG38020.1.
AC074143 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83081.1.
BC004491 mRNA. Translation: AAH04491.1.
CCDSiCCDS10829.1. [Q15628-1]
PIRiA56911.
RefSeqiNP_001310481.1. NM_001323552.1. [Q15628-1]
NP_003780.1. NM_003789.3. [Q15628-1]
XP_005256270.1. XM_005256213.3. [Q15628-2]
XP_016879304.1. XM_017023815.1. [Q15628-1]
UniGeneiHs.460996.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F2HNMR-A1-169[»]
1F3VX-ray2.00A1-179[»]
ProteinModelPortaliQ15628.
SMRiQ15628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114257. 43 interactors.
DIPiDIP-285N.
IntActiQ15628. 18 interactors.
MINTiMINT-99115.
STRINGi9606.ENSP00000341268.

PTM databases

iPTMnetiQ15628.
PhosphoSitePlusiQ15628.

Polymorphism and mutation databases

BioMutaiTRADD.
DMDMi6094511.

Proteomic databases

EPDiQ15628.
MaxQBiQ15628.
PaxDbiQ15628.
PeptideAtlasiQ15628.
PRIDEiQ15628.

Protocols and materials databases

DNASUi8717.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345057; ENSP00000341268; ENSG00000102871. [Q15628-1]
ENST00000486556; ENSP00000462591; ENSG00000102871. [Q15628-2]
GeneIDi8717.
KEGGihsa:8717.
UCSCiuc002erh.2. human. [Q15628-1]

Organism-specific databases

CTDi8717.
DisGeNETi8717.
GeneCardsiTRADD.
HGNCiHGNC:12030. TRADD.
HPAiCAB004602.
MIMi603500. gene.
neXtProtiNX_Q15628.
OpenTargetsiENSG00000102871.
PharmGKBiPA36707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF81. Eukaryota.
ENOG4111IRA. LUCA.
GeneTreeiENSGT00390000002016.
HOGENOMiHOG000059664.
HOVERGENiHBG054083.
InParanoidiQ15628.
KOiK03171.
OMAiLRFCGRQ.
OrthoDBiEOG091G0DXR.
PhylomeDBiQ15628.
TreeFamiTF331882.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102871-MONOMER.
ReactomeiR-HSA-140534. Ligand-dependent caspase activation.
R-HSA-3371378. Regulation by c-FLIP.
R-HSA-5213460. RIPK1-mediated regulated necrosis.
R-HSA-5218900. CASP8 activity is inhibited.
R-HSA-5357786. TNFR1-induced proapoptotic signaling.
R-HSA-5357905. Regulation of TNFR1 signaling.
R-HSA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-HSA-5675482. Regulation of necroptotic cell death.
R-HSA-69416. Dimerization of procaspase-8.
R-HSA-75893. TNF signaling.
SignaLinkiQ15628.
SIGNORiQ15628.

Miscellaneous databases

EvolutionaryTraceiQ15628.
GeneWikiiTRADD.
GenomeRNAii8717.
PROiQ15628.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102871.
CleanExiHS_TRADD.
GenevisibleiQ15628. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.30.70.680. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR009095. TRADD_N.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF09034. TRADD_N. 1 hit.
[Graphical view]
ProDomiPD182470. TRADD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF55044. SSF55044. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRADD_HUMAN
AccessioniPrimary (citable) accession number: Q15628
Secondary accession number(s): B2RDS3, B3KQZ9, Q52NZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: November 30, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.