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Protein

Olfactory receptor 7A5

Gene

OR7A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7A5
Alternative name(s):
Olfactory receptor OR19-17
Olfactory receptor TPCR92
Gene namesi
Name:OR7A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8368. OR7A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31927CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32622.

Polymorphism and mutation databases

BioMutaiOR7A5.
DMDMi14423795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Olfactory receptor 7A5PRO_0000150643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15622.
PRIDEiQ15622.

Expressioni

Gene expression databases

BgeeiQ15622.
GenevisibleiQ15622. HS.

Organism-specific databases

HPAiHPA053823.

Interactioni

Protein-protein interaction databases

BioGridi117777. 1 interaction.
STRINGi9606.ENSP00000316955.

Structurei

3D structure databases

ProteinModelPortaliQ15622.
SMRiQ15622. Positions 27-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15622.
KOiK04257.
OMAiGQFFKKC.
OrthoDBiEOG7HXCR6.
PhylomeDBiQ15622.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGNDTQIS EFLLLGFSQE PGLQPFLFGL FLSMYLVTVL GNLLIILATI
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD ICVTSTTIPK MLMNIQTQNK VITYIACLMQ
110 120 130 140 150
MYFFILFAGF ENFLLSVMAY DRFVAICHPL HYMVIMNPHL CGLLVLASWT
160 170 180 190 200
MSALYSLLQI LMVVRLSFCT ALEIPHFFCE LNQVIQLACS DSFLNHMVIY
210 220 230 240 250
FTVALLGGGP LTGILYSYSK IISSIHAISS AQGKYKAFST CASHLSVVSL
260 270 280 290 300
FYGAILGVYL SSAATRNSHS SATASVMYTV VTPMLNPFIY SLRNKDIKRA
310
LGIHLLWGTM KGQFFKKCP
Length:319
Mass (Da):35,579
Last modified:November 1, 1998 - v2
Checksum:iB024A0B6E703189A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10530 Genomic DNA. Translation: CAA71558.1.
AK312475 mRNA. Translation: BAG35379.1.
AC005255 Genomic DNA. Translation: AAC25626.1.
AF399543 Genomic DNA. Translation: AAK95028.1.
CH471106 Genomic DNA. Translation: EAW84450.1.
BC104809 mRNA. Translation: AAI04810.1.
X89677 mRNA. Translation: CAA61824.1.
BK004221 Genomic DNA. Translation: DAA04619.1.
CCDSiCCDS12318.1.
PIRiJC5624.
RefSeqiNP_059976.1. NM_017506.1.
XP_011526214.1. XM_011527912.1.
XP_011526215.1. XM_011527913.1.
XP_011526216.1. XM_011527914.1.
UniGeneiHs.137573.
Hs.690626.

Genome annotation databases

EnsembliENST00000322301; ENSP00000316955; ENSG00000188269.
ENST00000594432; ENSP00000471977; ENSG00000188269.
GeneIDi26659.
KEGGihsa:26659.
UCSCiuc002mzw.4. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10530 Genomic DNA. Translation: CAA71558.1.
AK312475 mRNA. Translation: BAG35379.1.
AC005255 Genomic DNA. Translation: AAC25626.1.
AF399543 Genomic DNA. Translation: AAK95028.1.
CH471106 Genomic DNA. Translation: EAW84450.1.
BC104809 mRNA. Translation: AAI04810.1.
X89677 mRNA. Translation: CAA61824.1.
BK004221 Genomic DNA. Translation: DAA04619.1.
CCDSiCCDS12318.1.
PIRiJC5624.
RefSeqiNP_059976.1. NM_017506.1.
XP_011526214.1. XM_011527912.1.
XP_011526215.1. XM_011527913.1.
XP_011526216.1. XM_011527914.1.
UniGeneiHs.137573.
Hs.690626.

3D structure databases

ProteinModelPortaliQ15622.
SMRiQ15622. Positions 27-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117777. 1 interaction.
STRINGi9606.ENSP00000316955.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7A5.
DMDMi14423795.

Proteomic databases

PaxDbiQ15622.
PRIDEiQ15622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322301; ENSP00000316955; ENSG00000188269.
ENST00000594432; ENSP00000471977; ENSG00000188269.
GeneIDi26659.
KEGGihsa:26659.
UCSCiuc002mzw.4. human.

Organism-specific databases

CTDi26659.
GeneCardsiOR7A5.
HGNCiHGNC:8368. OR7A5.
HPAiHPA053823.
neXtProtiNX_Q15622.
PharmGKBiPA32622.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15622.
KOiK04257.
OMAiGQFFKKC.
OrthoDBiEOG7HXCR6.
PhylomeDBiQ15622.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7A5.
GenomeRNAii26659.
NextBioi49017.
PROiQ15622.

Gene expression databases

BgeeiQ15622.
GenevisibleiQ15622. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Biochem. Biophys. Res. Commun. 237:283-287(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Sperm.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
    Tissue: Testis.
  8. Cited for: IDENTIFICATION.
  9. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR7A5_HUMAN
AccessioniPrimary (citable) accession number: Q15622
Secondary accession number(s): B2R682, Q6IFP1, Q96R96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.