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Protein

Olfactory receptor 7A5

Gene

OR7A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33136-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7A5
Alternative name(s):
Olfactory receptor OR19-17
Olfactory receptor TPCR92
Gene namesi
Name:OR7A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8368. OR7A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 319CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188269.
PharmGKBiPA32622.

Polymorphism and mutation databases

BioMutaiOR7A5.
DMDMi14423795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506431 – 319Olfactory receptor 7A5Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15622.
PRIDEiQ15622.

Expressioni

Gene expression databases

BgeeiENSG00000188269.
ExpressionAtlasiQ15622. baseline and differential.
GenevisibleiQ15622. HS.

Organism-specific databases

HPAiHPA053823.

Interactioni

Protein-protein interaction databases

BioGridi117777. 1 interactor.
STRINGi9606.ENSP00000316955.

Structurei

3D structure databases

ProteinModelPortaliQ15622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15622.
KOiK04257.
OMAiGQFFKKC.
OrthoDBiEOG091G0B53.
PhylomeDBiQ15622.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGNDTQIS EFLLLGFSQE PGLQPFLFGL FLSMYLVTVL GNLLIILATI
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD ICVTSTTIPK MLMNIQTQNK VITYIACLMQ
110 120 130 140 150
MYFFILFAGF ENFLLSVMAY DRFVAICHPL HYMVIMNPHL CGLLVLASWT
160 170 180 190 200
MSALYSLLQI LMVVRLSFCT ALEIPHFFCE LNQVIQLACS DSFLNHMVIY
210 220 230 240 250
FTVALLGGGP LTGILYSYSK IISSIHAISS AQGKYKAFST CASHLSVVSL
260 270 280 290 300
FYGAILGVYL SSAATRNSHS SATASVMYTV VTPMLNPFIY SLRNKDIKRA
310
LGIHLLWGTM KGQFFKKCP
Length:319
Mass (Da):35,579
Last modified:November 1, 1998 - v2
Checksum:iB024A0B6E703189A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10530 Genomic DNA. Translation: CAA71558.1.
AK312475 mRNA. Translation: BAG35379.1.
AC005255 Genomic DNA. Translation: AAC25626.1.
AF399543 Genomic DNA. Translation: AAK95028.1.
CH471106 Genomic DNA. Translation: EAW84450.1.
BC104809 mRNA. Translation: AAI04810.1.
X89677 mRNA. Translation: CAA61824.1.
BK004221 Genomic DNA. Translation: DAA04619.1.
CCDSiCCDS12318.1.
PIRiJC5624.
RefSeqiNP_059976.1. NM_017506.1.
XP_011526214.1. XM_011527912.2.
XP_011526215.1. XM_011527913.2.
UniGeneiHs.137573.
Hs.690626.

Genome annotation databases

EnsembliENST00000322301; ENSP00000316955; ENSG00000188269.
ENST00000594432; ENSP00000471977; ENSG00000188269.
GeneIDi26659.
KEGGihsa:26659.
UCSCiuc002mzw.4. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10530 Genomic DNA. Translation: CAA71558.1.
AK312475 mRNA. Translation: BAG35379.1.
AC005255 Genomic DNA. Translation: AAC25626.1.
AF399543 Genomic DNA. Translation: AAK95028.1.
CH471106 Genomic DNA. Translation: EAW84450.1.
BC104809 mRNA. Translation: AAI04810.1.
X89677 mRNA. Translation: CAA61824.1.
BK004221 Genomic DNA. Translation: DAA04619.1.
CCDSiCCDS12318.1.
PIRiJC5624.
RefSeqiNP_059976.1. NM_017506.1.
XP_011526214.1. XM_011527912.2.
XP_011526215.1. XM_011527913.2.
UniGeneiHs.137573.
Hs.690626.

3D structure databases

ProteinModelPortaliQ15622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117777. 1 interactor.
STRINGi9606.ENSP00000316955.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7A5.
DMDMi14423795.

Proteomic databases

PaxDbiQ15622.
PRIDEiQ15622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322301; ENSP00000316955; ENSG00000188269.
ENST00000594432; ENSP00000471977; ENSG00000188269.
GeneIDi26659.
KEGGihsa:26659.
UCSCiuc002mzw.4. human.

Organism-specific databases

CTDi26659.
GeneCardsiOR7A5.
HGNCiHGNC:8368. OR7A5.
HPAiHPA053823.
neXtProtiNX_Q15622.
OpenTargetsiENSG00000188269.
PharmGKBiPA32622.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15622.
KOiK04257.
OMAiGQFFKKC.
OrthoDBiEOG091G0B53.
PhylomeDBiQ15622.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:G66-33136-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7A5.
GenomeRNAii26659.
PROiQ15622.

Gene expression databases

BgeeiENSG00000188269.
ExpressionAtlasiQ15622. baseline and differential.
GenevisibleiQ15622. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR7A5_HUMAN
AccessioniPrimary (citable) accession number: Q15622
Secondary accession number(s): B2R682, Q6IFP1, Q96R96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.