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Protein

Olfactory receptor 8B8

Gene

OR8B8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B8
Alternative name(s):
Olfactory receptor TPCR85
Olfactory-like receptor JCG8
Gene namesi
Name:OR8B8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8477. OR8B8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31119CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32756.

Polymorphism and mutation databases

BioMutaiOR8B8.
DMDMi14423794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 8B8PRO_0000150657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15620.
PRIDEiQ15620.

Expressioni

Tissue specificityi

Expressed in the tongue and testis.

Gene expression databases

CleanExiHS_OR8B8.
GenevisibleiQ15620. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330280.

Structurei

3D structure databases

ProteinModelPortaliQ15620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV7V. Eukaryota.
ENOG41115S0. LUCA.
GeneTreeiENSGT00760000118817.
HOVERGENiHBG017625.
InParanoidiQ15620.
KOiK04257.
OMAiPLLECAC.
OrthoDBiEOG71K63J.
PhylomeDBiQ15620.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15620-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAENSSFVT QFILAGLTDQ PGVQIPLFFL FLGFYVVTVV GNLGLITLIR
60 70 80 90 100
LNSHLHTPMY FFLYNLSFID FCYSSVITPK MLMSFVLKKN SISYAGCMTQ
110 120 130 140 150
LFFFLFFVVS ESFILSAMAY DRYVAICNPL LYMVTMSPQV CFLLLLGVYG
160 170 180 190 200
MGFAGAMAHT ACMMGVTFCA NNLVNHYMCD ILPLLECACT STYVNELVVF
210 220 230 240 250
VVVGIDIGVP TVTIFISYAL ILSSIFHIDS TEGRSKAFST CSSHIIAVSL
260 270 280 290 300
FFGSGAFMYL KPFSLLAMNQ GKVSSLFYTT VVPMLNPLIY SLRNKDVKVA
310
LKKILNKNAF S
Length:311
Mass (Da):34,482
Last modified:June 20, 2001 - v2
Checksum:i9D8AAC4DA179ABE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041G → S in CAA61822 (PubMed:9119360).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238488 mRNA. Translation: AAL32997.1.
AB065832 Genomic DNA. Translation: BAC06051.1.
CH471065 Genomic DNA. Translation: EAW67583.1.
BC130393 mRNA. Translation: AAI30394.1.
BC130419 mRNA. Translation: AAI30420.1.
AF399510 Genomic DNA. Translation: AAK94995.1.
X89675 mRNA. Translation: CAA61822.1.
CCDSiCCDS8446.1.
PIRiS58007.
RefSeqiNP_036510.1. NM_012378.1.
UniGeneiHs.351822.

Genome annotation databases

EnsembliENST00000328064; ENSP00000330280; ENSG00000197125.
GeneIDi26493.
KEGGihsa:26493.
UCSCiuc010sal.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238488 mRNA. Translation: AAL32997.1.
AB065832 Genomic DNA. Translation: BAC06051.1.
CH471065 Genomic DNA. Translation: EAW67583.1.
BC130393 mRNA. Translation: AAI30394.1.
BC130419 mRNA. Translation: AAI30420.1.
AF399510 Genomic DNA. Translation: AAK94995.1.
X89675 mRNA. Translation: CAA61822.1.
CCDSiCCDS8446.1.
PIRiS58007.
RefSeqiNP_036510.1. NM_012378.1.
UniGeneiHs.351822.

3D structure databases

ProteinModelPortaliQ15620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330280.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8B8.
DMDMi14423794.

Proteomic databases

PaxDbiQ15620.
PRIDEiQ15620.

Protocols and materials databases

DNASUi26493.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328064; ENSP00000330280; ENSG00000197125.
GeneIDi26493.
KEGGihsa:26493.
UCSCiuc010sal.3. human.

Organism-specific databases

CTDi26493.
GeneCardsiOR8B8.
HGNCiHGNC:8477. OR8B8.
neXtProtiNX_Q15620.
PharmGKBiPA32756.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV7V. Eukaryota.
ENOG41115S0. LUCA.
GeneTreeiENSGT00760000118817.
HOVERGENiHBG017625.
InParanoidiQ15620.
KOiK04257.
OMAiPLLECAC.
OrthoDBiEOG71K63J.
PhylomeDBiQ15620.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8B8.
GenomeRNAii26493.
NextBioi48748.
PROiQ15620.

Gene expression databases

CleanExiHS_OR8B8.
GenevisibleiQ15620. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New GPCRs from a human lingual cDNA library."
    Gaudin J.-C., Breuils L., Haertle T.
    Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tongue.
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  6. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
    Tissue: Testis.

Entry informationi

Entry nameiOR8B8_HUMAN
AccessioniPrimary (citable) accession number: Q15620
Secondary accession number(s): A1L446, Q96RC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: March 16, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.