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Q15619

- OR1C1_HUMAN

UniProt

Q15619 - OR1C1_HUMAN

Protein

Olfactory receptor 1C1

Gene

OR1C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 4 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1C1
    Alternative name(s):
    Olfactory receptor OR1-42
    Olfactory receptor TPCR27
    Gene namesi
    Name:OR1C1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8182. OR1C1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32056.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 1C1PRO_0000150417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ15619.

    PTM databases

    PhosphoSiteiQ15619.

    Expressioni

    Gene expression databases

    BgeeiQ15619.
    CleanExiHS_OR1C1.
    GenevestigatoriQ15619.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000386138.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15619.
    SMRiQ15619. Positions 27-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147455.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ15619.
    KOiK04257.
    OMAiMNLCLCV.
    OrthoDBiEOG7JT6WV.
    PhylomeDBiQ15619.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15619-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKRNLTVVR EFVLLGLPSS AEQQHLLSVL FLCMYLATTL GNMLIIATIG    50
    FDSHLHSPMY FFLSNLAFVD ICFTSTTVPQ MVVNILTGTK TISFAGCLTQ 100
    LFFFVSFVNM DSLLLCVMAY DRYVAICHPL HYTARMNLCL CVQLVAGLWL 150
    VTYLHALLHT VLIAQLSFCA SNIIHHFFCD LNPLLQLSCS DVSFNVMIIF 200
    AVGGLLALTP LVCILVSYGL IFSTVLKITS TQGKQRAVST CSCHLSVVVL 250
    FYGTAIAVYF SPSSPHMPES DTLSTIMYSM VAPMLNPFIY TLRNRDMKRG 300
    LQKMLLKCTV FQQQ 314
    Length:314
    Mass (Da):35,042
    Last modified:July 5, 2005 - v4
    Checksum:i65D28E304B2FFFC3
    GO

    Sequence cautioni

    The sequence DAA04763.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti178 – 1781F → L(PubMed:12213199)Curated
    Sequence conflicti178 – 1781F → L(PubMed:9119360)Curated
    Sequence conflicti204 – 2041G → D(PubMed:12213199)Curated
    Sequence conflicti204 – 2041G → D(PubMed:9119360)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti209 – 2091T → M.
    Corresponds to variant rs12068080 [ dbSNP | Ensembl ].
    VAR_053118

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065625 Genomic DNA. Translation: BAC05851.1.
    AL450999 Genomic DNA. Translation: CAH70622.1.
    CH471148 Genomic DNA. Translation: EAW77202.1.
    BC140914 mRNA. Translation: AAI40915.1.
    AF399560 Genomic DNA. Translation: AAK95045.1.
    X89674 mRNA. Translation: CAA61821.1.
    BK004365 Genomic DNA. Translation: DAA04763.1. Different initiation.
    CCDSiCCDS41481.1.
    PIRiS58002.
    RefSeqiNP_036485.2. NM_012353.2.
    UniGeneiHs.381306.

    Genome annotation databases

    EnsembliENST00000408896; ENSP00000386138; ENSG00000221888.
    GeneIDi26188.
    KEGGihsa:26188.
    UCSCiuc010pza.2. human.

    Polymorphism databases

    DMDMi68846933.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065625 Genomic DNA. Translation: BAC05851.1 .
    AL450999 Genomic DNA. Translation: CAH70622.1 .
    CH471148 Genomic DNA. Translation: EAW77202.1 .
    BC140914 mRNA. Translation: AAI40915.1 .
    AF399560 Genomic DNA. Translation: AAK95045.1 .
    X89674 mRNA. Translation: CAA61821.1 .
    BK004365 Genomic DNA. Translation: DAA04763.1 . Different initiation.
    CCDSi CCDS41481.1.
    PIRi S58002.
    RefSeqi NP_036485.2. NM_012353.2.
    UniGenei Hs.381306.

    3D structure databases

    ProteinModelPortali Q15619.
    SMRi Q15619. Positions 27-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000386138.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q15619.

    Polymorphism databases

    DMDMi 68846933.

    Proteomic databases

    PRIDEi Q15619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000408896 ; ENSP00000386138 ; ENSG00000221888 .
    GeneIDi 26188.
    KEGGi hsa:26188.
    UCSCi uc010pza.2. human.

    Organism-specific databases

    CTDi 26188.
    GeneCardsi GC01M247920.
    H-InvDB HIX0028945.
    HGNCi HGNC:8182. OR1C1.
    neXtProti NX_Q15619.
    PharmGKBi PA32056.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147455.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q15619.
    KOi K04257.
    OMAi MNLCLCV.
    OrthoDBi EOG7JT6WV.
    PhylomeDBi Q15619.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1C1.
    GenomeRNAii 26188.
    NextBioi 48314.
    PROi Q15619.

    Gene expression databases

    Bgeei Q15619.
    CleanExi HS_OR1C1.
    Genevestigatori Q15619.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    6. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
      Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
      Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
      Tissue: Testis.
    7. Cited for: IDENTIFICATION.
    8. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1C1_HUMAN
    AccessioniPrimary (citable) accession number: Q15619
    Secondary accession number(s): B9EIR9
    , Q5VVD2, Q6IF97, Q8NGZ1, Q96R83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 120 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3