Q15619 (OR1C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1C1

Alternative name(s):
Olfactory receptor OR1-42
Olfactory receptor TPCR27

Gene names

Name:

OR1C1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence DAA04763.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Non-traceable author statement Ref.6. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 1C1		PRO_0000150417
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 236	17	Cytoplasmic Potential
	Transmembrane	237 – 259	23	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 292	20	Helical; Name=7; Potential
	Topological domain	293 – 314	22	Cytoplasmic Potential
Amino acid modifications
	Modified residue	7	1	Phosphothreonine Ref.9
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	209	1	T → M. Corresponds to variant rs12068080 [ dbSNP | Ensembl ].		VAR_053118
Experimental info
	Sequence conflict	178	1	F → L Ref.5
	Sequence conflict	178	1	F → L Ref.6
	Sequence conflict	204	1	G → D Ref.5
	Sequence conflict	204	1	G → D Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q15619 [UniParc]. Last modified July 5, 2005. Version 4. Checksum: 65D28E304B2FFFC3	FASTA	314	35,042
	10 20 30 40 50 60 MEKRNLTVVR EFVLLGLPSS AEQQHLLSVL FLCMYLATTL GNMLIIATIG FDSHLHSPMY 70 80 90 100 110 120 FFLSNLAFVD ICFTSTTVPQ MVVNILTGTK TISFAGCLTQ LFFFVSFVNM DSLLLCVMAY 130 140 150 160 170 180 DRYVAICHPL HYTARMNLCL CVQLVAGLWL VTYLHALLHT VLIAQLSFCA SNIIHHFFCD 190 200 210 220 230 240 LNPLLQLSCS DVSFNVMIIF AVGGLLALTP LVCILVSYGL IFSTVLKITS TQGKQRAVST 250 260 270 280 290 300 CSCHLSVVVL FYGTAIAVYF SPSSPHMPES DTLSTIMYSM VAPMLNPFIY TLRNRDMKRG 310 LQKMLLKCTV FQQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed: 12213199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[6]	"Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species." Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M. Genomics 39:239-246(1997) [PubMed: 9119360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282. Tissue: Testis.
[7]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed: 14983052] [Abstract] Cited for: IDENTIFICATION.
[8]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065625 Genomic DNA. Translation: BAC05851.1. AL450999 Genomic DNA. Translation: CAH70622.1. CH471148 Genomic DNA. Translation: EAW77202.1. BC140914 mRNA. Translation: AAI40915.1. AF399560 Genomic DNA. Translation: AAK95045.1. X89674 mRNA. Translation: CAA61821.1. BK004365 Genomic DNA. Translation: DAA04763.1. Different initiation.
IPI	IPI00419369.
PIR	S58002.
RefSeq	NP_036485.2. NM_012353.2.
UniGene	Hs.381306.
3D structure databases
ProteinModelPortal	Q15619.
SMR	Q15619. Positions 109-140, 277-308.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15619.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q15619.
Polymorphism databases
DMDM	68846933.
Proteomic databases
PRIDE	Q15619.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000408896; ENSP00000386138; ENSG00000221888.
GeneID	26188.
KEGG	hsa:26188.
UCSC	uc001idl.1. human.
Organism-specific databases
CTD	26188.
GeneCards	GC01M247920.
HGNC	HGNC:8182. OR1C1.
neXtProt	NX_Q15619.
PharmGKB	PA32056.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17671.
GeneTree	ENSGT00580000081307.
HOGENOM	HBG755317.
HOVERGEN	HBG017625.
InParanoid	Q15619.
OMA	WLVTYLH.
OrthoDB	EOG44TP87.
PhylomeDB	Q15619.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q15619.
Bgee	Q15619.
CleanEx	HS_OR1C1.
Genevestigator	Q15619.
GermOnline	ENSG00000196079. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
KO	K04257.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	48314.

Entry information

Entry name

OR1C1_HUMAN

Accession

Primary (citable) accession number: Q15619
Secondary accession number(s): B9EIR9 , Q5VVD2, Q6IF97, Q8NGZ1, Q96R83

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	July 5, 2005
Last modified:	December 14, 2011
This is version 98 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.