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Q15619

- OR1C1_HUMAN

UniProt

Q15619 - OR1C1_HUMAN

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Protein

Olfactory receptor 1C1

Gene

OR1C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1C1
Alternative name(s):
Olfactory receptor OR1-42
Olfactory receptor TPCR27
Gene namesi
Name:OR1C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8182. OR1C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 1C1PRO_0000150417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ15619.

PTM databases

PhosphoSiteiQ15619.

Expressioni

Gene expression databases

BgeeiQ15619.
CleanExiHS_OR1C1.
GenevestigatoriQ15619.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386138.

Structurei

3D structure databases

ProteinModelPortaliQ15619.
SMRiQ15619. Positions 27-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147455.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ15619.
KOiK04257.
OMAiMNLCLCV.
OrthoDBiEOG7JT6WV.
PhylomeDBiQ15619.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15619-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKRNLTVVR EFVLLGLPSS AEQQHLLSVL FLCMYLATTL GNMLIIATIG
60 70 80 90 100
FDSHLHSPMY FFLSNLAFVD ICFTSTTVPQ MVVNILTGTK TISFAGCLTQ
110 120 130 140 150
LFFFVSFVNM DSLLLCVMAY DRYVAICHPL HYTARMNLCL CVQLVAGLWL
160 170 180 190 200
VTYLHALLHT VLIAQLSFCA SNIIHHFFCD LNPLLQLSCS DVSFNVMIIF
210 220 230 240 250
AVGGLLALTP LVCILVSYGL IFSTVLKITS TQGKQRAVST CSCHLSVVVL
260 270 280 290 300
FYGTAIAVYF SPSSPHMPES DTLSTIMYSM VAPMLNPFIY TLRNRDMKRG
310
LQKMLLKCTV FQQQ
Length:314
Mass (Da):35,042
Last modified:July 5, 2005 - v4
Checksum:i65D28E304B2FFFC3
GO

Sequence cautioni

The sequence DAA04763.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781F → L(PubMed:12213199)Curated
Sequence conflicti178 – 1781F → L(PubMed:9119360)Curated
Sequence conflicti204 – 2041G → D(PubMed:12213199)Curated
Sequence conflicti204 – 2041G → D(PubMed:9119360)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti209 – 2091T → M.
Corresponds to variant rs12068080 [ dbSNP | Ensembl ].
VAR_053118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065625 Genomic DNA. Translation: BAC05851.1.
AL450999 Genomic DNA. Translation: CAH70622.1.
CH471148 Genomic DNA. Translation: EAW77202.1.
BC140914 mRNA. Translation: AAI40915.1.
AF399560 Genomic DNA. Translation: AAK95045.1.
X89674 mRNA. Translation: CAA61821.1.
BK004365 Genomic DNA. Translation: DAA04763.1. Different initiation.
CCDSiCCDS41481.1.
PIRiS58002.
RefSeqiNP_036485.2. NM_012353.2.
UniGeneiHs.381306.

Genome annotation databases

EnsembliENST00000408896; ENSP00000386138; ENSG00000221888.
GeneIDi26188.
KEGGihsa:26188.
UCSCiuc010pza.2. human.

Polymorphism databases

DMDMi68846933.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065625 Genomic DNA. Translation: BAC05851.1 .
AL450999 Genomic DNA. Translation: CAH70622.1 .
CH471148 Genomic DNA. Translation: EAW77202.1 .
BC140914 mRNA. Translation: AAI40915.1 .
AF399560 Genomic DNA. Translation: AAK95045.1 .
X89674 mRNA. Translation: CAA61821.1 .
BK004365 Genomic DNA. Translation: DAA04763.1 . Different initiation.
CCDSi CCDS41481.1.
PIRi S58002.
RefSeqi NP_036485.2. NM_012353.2.
UniGenei Hs.381306.

3D structure databases

ProteinModelPortali Q15619.
SMRi Q15619. Positions 27-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386138.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q15619.

Polymorphism databases

DMDMi 68846933.

Proteomic databases

PRIDEi Q15619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000408896 ; ENSP00000386138 ; ENSG00000221888 .
GeneIDi 26188.
KEGGi hsa:26188.
UCSCi uc010pza.2. human.

Organism-specific databases

CTDi 26188.
GeneCardsi GC01M247920.
H-InvDB HIX0028945.
HGNCi HGNC:8182. OR1C1.
neXtProti NX_Q15619.
PharmGKBi PA32056.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147455.
GeneTreei ENSGT00760000118845.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q15619.
KOi K04257.
OMAi MNLCLCV.
OrthoDBi EOG7JT6WV.
PhylomeDBi Q15619.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1C1.
GenomeRNAii 26188.
NextBioi 48314.
PROi Q15619.

Gene expression databases

Bgeei Q15619.
CleanExi HS_OR1C1.
Genevestigatori Q15619.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  6. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
    Tissue: Testis.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1C1_HUMAN
AccessioniPrimary (citable) accession number: Q15619
Secondary accession number(s): B9EIR9
, Q5VVD2, Q6IF97, Q8NGZ1, Q96R83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3