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Protein

Olfactory receptor 8G1

Gene

OR8G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8G1
Alternative name(s):
Olfactory receptor OR11-281
Olfactory receptor TPCR25
Gene namesi
Name:OR8G1
Synonyms:OR8G1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8484. OR8G1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32764.

Polymorphism and mutation databases

DMDMi82592515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506621 – 311Olfactory receptor 8G1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ15617.
PRIDEiQ15617.

PTM databases

iPTMnetiQ15617.
PhosphoSitePlusiQ15617.

Expressioni

Gene expression databases

BgeeiENSG00000197849.
ExpressionAtlasiQ15617. baseline and differential.
GenevisibleiQ15617. HS.

Structurei

3D structure databases

ProteinModelPortaliQ15617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15617.
KOiK04257.
OMAiCVGAFNI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ15617.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGENNSSVT EFILAGLSEQ PELQLPLFLL FLGIYVVTVV GNLGMTTLIW
60 70 80 90 100
LSSHLHTPMY YFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ
110 120 130 140 150
LYFFLVFAIA ECHMLAAMAY DRYMAICSPL LYSVIISNKA CFSLILGVYI
160 170 180 190 200
IGLVCASVHT GCMFRVQFCK FDLINHYFCD LLPLLKLSCS SIYVNKLLIL
210 220 230 240 250
CVGAFNILVP SLTILCSYIF IIASILHIRS TEGRSKAFST CSSHMLAVVI
260 270 280 290 300
FFGSAAFMYL QPSSISSMDQ GKVSSVFYTI IVPMLNPLIY SLRNKDVHVS
310
LKKMLQRRTL L
Length:311
Mass (Da):34,904
Last modified:November 22, 2005 - v2
Checksum:i0E28F95C37960C3E
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity thus producing thus a pseudogene.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034260247A → V. Corresponds to variant dbSNP:rs4482039Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065946 Genomic DNA. Translation: BAC06159.1.
X89672 mRNA. Translation: CAA61819.1.
AF399507 Genomic DNA. Translation: AAK94992.1.
BK004423 Genomic DNA. Translation: DAA04821.1.
CCDSiCCDS73407.1.
PIRiS58017.
RefSeqiNP_001002905.1. NM_001002905.1.
UniGeneiHs.448172.

Genome annotation databases

EnsembliENST00000341493; ENSP00000476313; ENSG00000197849.
GeneIDi26494.
KEGGihsa:26494.
UCSCiuc031yin.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR8G1_HUMAN
AccessioniPrimary (citable) accession number: Q15617
Secondary accession number(s): Q8NG88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 22, 2005
Last modified: August 30, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families