Q15617 (OR8G1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 8G1

Alternative name(s):
Olfactory receptor OR11-281
Olfactory receptor TPCR25

Gene names

Name:	OR8G1
Synonyms:	OR8G1P

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity thus producing thus a pseudogene.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Non-traceable author statement Ref.2. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 8G1		PRO_0000150662
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 311	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	247	1	A → V. Corresponds to variant rs4482039 [ dbSNP | Ensembl ].		VAR_034260

Sequences

	Sequence		Length	Mass (Da)
	Q15617 [UniParc]. Last modified November 22, 2005. Version 2. Checksum: 0E28F95C37960C3E	FASTA	311	34,904
	10 20 30 40 50 60 MSGENNSSVT EFILAGLSEQ PELQLPLFLL FLGIYVVTVV GNLGMTTLIW LSSHLHTPMY 70 80 90 100 110 120 YFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY 130 140 150 160 170 180 DRYMAICSPL LYSVIISNKA CFSLILGVYI IGLVCASVHT GCMFRVQFCK FDLINHYFCD 190 200 210 220 230 240 LLPLLKLSCS SIYVNKLLIL CVGAFNILVP SLTILCSYIF IIASILHIRS TEGRSKAFST 250 260 270 280 290 300 CSSHMLAVVI FFGSAAFMYL QPSSISSMDQ GKVSSVFYTI IVPMLNPLIY SLRNKDVHVS 310 LKKMLQRRTL L

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species." Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M. Genomics 39:239-246(1997) [PubMed: 9119360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282. Tissue: Testis.
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed: 12213199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-282.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed: 14983052] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[6]	"Genetic elucidation of human hyperosmia to isovaleric acid." Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W., Lancet D. PLoS Biol. 5:2462-2468(2007) [PubMed: 17973576] [Abstract] Cited for: POLYMORPHISM.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065946 Genomic DNA. Translation: BAC06159.1. X89672 mRNA. Translation: CAA61819.1. AF399507 Genomic DNA. Translation: AAK94992.1. BK004423 Genomic DNA. Translation: DAA04821.1.
IPI	IPI00099998.
PIR	S58017.
RefSeq	NP_001002905.1. NM_001002905.1.
UniGene	Hs.448172.
3D structure databases
ProteinModelPortal	Q15617.
SMR	Q15617. Positions 109-140, 277-307.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15617.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	82592515.
Proteomic databases
PRIDE	Q15617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341493; ENSP00000344453; ENSG00000197849.
GeneID	26494.
KEGG	hsa:26494.
Organism-specific databases
CTD	26494.
GeneCards	GC11P124122.
HGNC	HGNC:8484. OR8G1.
neXtProt	NX_Q15617.
PharmGKB	PA32764.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18264.
GeneTree	ENSGT00600000084009.
HOGENOM	HBG755317.
HOVERGEN	HBG017625.
InParanoid	Q15617.
OrthoDB	EOG480HXC.
Gene expression databases
ArrayExpress	Q15617.
Genevestigator	Q15617.
GermOnline	ENSG00000197849. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
KO	K04257.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	48752.

Entry information

Entry name

OR8G1_HUMAN

Accession

Primary (citable) accession number: Q15617
Secondary accession number(s): Q8NG88

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 22, 2005
Last modified:	January 25, 2012
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.