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Protein

Olfactory receptor 8G1

Gene

OR8G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31167-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8G1
Alternative name(s):
Olfactory receptor OR11-281
Olfactory receptor TPCR25
Gene namesi
Name:OR8G1
Synonyms:OR8G1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8484. OR8G1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197849.
PharmGKBiPA32764.

Polymorphism and mutation databases

DMDMi82592515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506621 – 311Olfactory receptor 8G1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ15617.

PTM databases

iPTMnetiQ15617.
PhosphoSitePlusiQ15617.

Expressioni

Gene expression databases

ExpressionAtlasiQ15617. baseline and differential.
GenevisibleiQ15617. HS.

Structurei

3D structure databases

ProteinModelPortaliQ15617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15617.
KOiK04257.
OMAiCVGAFNI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ15617.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGENNSSVT EFILAGLSEQ PELQLPLFLL FLGIYVVTVV GNLGMTTLIW
60 70 80 90 100
LSSHLHTPMY YFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ
110 120 130 140 150
LYFFLVFAIA ECHMLAAMAY DRYMAICSPL LYSVIISNKA CFSLILGVYI
160 170 180 190 200
IGLVCASVHT GCMFRVQFCK FDLINHYFCD LLPLLKLSCS SIYVNKLLIL
210 220 230 240 250
CVGAFNILVP SLTILCSYIF IIASILHIRS TEGRSKAFST CSSHMLAVVI
260 270 280 290 300
FFGSAAFMYL QPSSISSMDQ GKVSSVFYTI IVPMLNPLIY SLRNKDVHVS
310
LKKMLQRRTL L
Length:311
Mass (Da):34,904
Last modified:November 22, 2005 - v2
Checksum:i0E28F95C37960C3E
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity thus producing thus a pseudogene.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034260247A → V.Corresponds to variant rs4482039dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065946 Genomic DNA. Translation: BAC06159.1.
X89672 mRNA. Translation: CAA61819.1.
AF399507 Genomic DNA. Translation: AAK94992.1.
BK004423 Genomic DNA. Translation: DAA04821.1.
CCDSiCCDS73407.1.
PIRiS58017.
RefSeqiNP_001002905.1. NM_001002905.1.
UniGeneiHs.448172.

Genome annotation databases

EnsembliENST00000341493; ENSP00000476313; ENSG00000197849.
GeneIDi26494.
KEGGihsa:26494.
UCSCiuc031yin.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065946 Genomic DNA. Translation: BAC06159.1.
X89672 mRNA. Translation: CAA61819.1.
AF399507 Genomic DNA. Translation: AAK94992.1.
BK004423 Genomic DNA. Translation: DAA04821.1.
CCDSiCCDS73407.1.
PIRiS58017.
RefSeqiNP_001002905.1. NM_001002905.1.
UniGeneiHs.448172.

3D structure databases

ProteinModelPortaliQ15617.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15617.
PhosphoSitePlusiQ15617.

Polymorphism and mutation databases

DMDMi82592515.

Proteomic databases

PRIDEiQ15617.

Protocols and materials databases

DNASUi26494.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341493; ENSP00000476313; ENSG00000197849.
GeneIDi26494.
KEGGihsa:26494.
UCSCiuc031yin.1. human.

Organism-specific databases

CTDi26494.
GeneCardsiOR8G1.
HGNCiHGNC:8484. OR8G1.
neXtProtiNX_Q15617.
OpenTargetsiENSG00000197849.
PharmGKBiPA32764.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15617.
KOiK04257.
OMAiCVGAFNI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ15617.

Enzyme and pathway databases

BioCyciZFISH:G66-31167-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8G1.
GenomeRNAii26494.
PROiQ15617.

Gene expression databases

ExpressionAtlasiQ15617. baseline and differential.
GenevisibleiQ15617. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8G1_HUMAN
AccessioniPrimary (citable) accession number: Q15617
Secondary accession number(s): Q8NG88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 22, 2005
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.