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Protein

Olfactory receptor 4D1

Gene

OR4D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D1
Alternative name(s):
Olfactory receptor 4D3
Olfactory receptor TPCR16
Gene namesi
Name:OR4D1
Synonyms:OR4D3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8293. OR4D1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 31021CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32267.

Polymorphism and mutation databases

BioMutaiOR4D1.
DMDMi290457670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 4D1PRO_0000150537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15615.
PaxDbiQ15615.
PeptideAtlasiQ15615.
PRIDEiQ15615.

PTM databases

iPTMnetiQ15615.

Expressioni

Gene expression databases

BgeeiQ15615.
CleanExiHS_OR4D1.
GenevisibleiQ15615. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365451.

Structurei

3D structure databases

ProteinModelPortaliQ15615.
SMRiQ15615. Positions 32-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFX. Eukaryota.
ENOG41119VH. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ15615.
KOiK04257.
OMAiFDCQLHT.
OrthoDBiEOG7KSX95.
PhylomeDBiQ15615.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQNTTQVS MFVLLGFSQT QELQKFLFLL FLLVYVTTIV GNLLIMVTVT
60 70 80 90 100
FDCRLHTPMY FLLRNLALID LCYSTVTSPK MLVDFLHETK TISYQGCMAQ
110 120 130 140 150
IFFFHLLGGG TVFFLSVMAY DRYIAISQPL RYVTIMNTQL CVGLVVAAWV
160 170 180 190 200
GGFVHSIVQL ALILPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLMI
210 220 230 240 250
SNSGLLVIIW FLLLLISYTV ILVMLRSHSG KARRKAASTC TTHIIVVSMI
260 270 280 290 300
FIPCIYIYTW PFTPFLMDKA VSISYTVMTP MLNPMIYTLR NQDMKAAMRR
310
LGKCLVICRE
Length:310
Mass (Da):35,240
Last modified:March 2, 2010 - v3
Checksum:i058A7B0E8A6CF672
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701G → D in AAK95052 (PubMed:16625196).Curated
Sequence conflicti170 – 1701G → D in CAA61817 (Ref. 3) Curated
Sequence conflicti201 – 2011S → F in AAK95052 (PubMed:16625196).Curated
Sequence conflicti201 – 2011S → F in CAA61817 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541R → Q.
Corresponds to variant rs12602205 [ dbSNP | Ensembl ].
VAR_057546
Natural varianti174 – 1741L → I.2 Publications
Corresponds to variant rs7218964 [ dbSNP | Ensembl ].
VAR_060479

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065913 Genomic DNA. Translation: BAC06128.1.
AC005962 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94482.1.
BC136589 mRNA. Translation: AAI36590.1.
BC136595 mRNA. Translation: AAI36596.1.
AF399567 Genomic DNA. Translation: AAK95052.1.
X89670 mRNA. Translation: CAA61817.1.
CCDSiCCDS42365.1.
PIRiS58015.
RefSeqiNP_036506.1. NM_012374.1.
UniGeneiHs.531188.

Genome annotation databases

EnsembliENST00000268912; ENSP00000365451; ENSG00000141194.
GeneIDi26689.
KEGGihsa:26689.
UCSCiuc010wno.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065913 Genomic DNA. Translation: BAC06128.1.
AC005962 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94482.1.
BC136589 mRNA. Translation: AAI36590.1.
BC136595 mRNA. Translation: AAI36596.1.
AF399567 Genomic DNA. Translation: AAK95052.1.
X89670 mRNA. Translation: CAA61817.1.
CCDSiCCDS42365.1.
PIRiS58015.
RefSeqiNP_036506.1. NM_012374.1.
UniGeneiHs.531188.

3D structure databases

ProteinModelPortaliQ15615.
SMRiQ15615. Positions 32-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365451.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15615.

Polymorphism and mutation databases

BioMutaiOR4D1.
DMDMi290457670.

Proteomic databases

EPDiQ15615.
PaxDbiQ15615.
PeptideAtlasiQ15615.
PRIDEiQ15615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268912; ENSP00000365451; ENSG00000141194.
GeneIDi26689.
KEGGihsa:26689.
UCSCiuc010wno.3. human.

Organism-specific databases

CTDi26689.
GeneCardsiOR4D1.
H-InvDBHIX0202548.
HGNCiHGNC:8293. OR4D1.
neXtProtiNX_Q15615.
PharmGKBiPA32267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEFX. Eukaryota.
ENOG41119VH. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ15615.
KOiK04257.
OMAiFDCQLHT.
OrthoDBiEOG7KSX95.
PhylomeDBiQ15615.
TreeFamiTF338273.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4D1.
GenomeRNAii26689.
PROiQ15615.

Gene expression databases

BgeeiQ15615.
CleanExiHS_OR4D1.
GenevisibleiQ15615. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280, VARIANT ILE-174.
  6. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-279, VARIANT ILE-174.
    Tissue: Testis.

Entry informationi

Entry nameiOR4D1_HUMAN
AccessioniPrimary (citable) accession number: Q15615
Secondary accession number(s): B2RN14, Q8NGB1, Q96R76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 2, 2010
Last modified: July 6, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.