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Protein

Olfactory receptor 4D1

Gene

OR4D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141194-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D1
Alternative name(s):
Olfactory receptor 4D3
Olfactory receptor TPCR16
Gene namesi
Name:OR4D1
Synonyms:OR4D3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8293. OR4D1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 310CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26689.
OpenTargetsiENSG00000141194.
PharmGKBiPA32267.

Polymorphism and mutation databases

BioMutaiOR4D1.
DMDMi290457670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505371 – 310Olfactory receptor 4D1Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15615.
PeptideAtlasiQ15615.
PRIDEiQ15615.

PTM databases

iPTMnetiQ15615.
PhosphoSitePlusiQ15615.

Expressioni

Gene expression databases

BgeeiENSG00000141194.
CleanExiHS_OR4D1.
GenevisibleiQ15615. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365451.

Structurei

3D structure databases

ProteinModelPortaliQ15615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFX. Eukaryota.
ENOG41119VH. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ15615.
KOiK04257.
OMAiMKRLGKH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ15615.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQNTTQVS MFVLLGFSQT QELQKFLFLL FLLVYVTTIV GNLLIMVTVT
60 70 80 90 100
FDCRLHTPMY FLLRNLALID LCYSTVTSPK MLVDFLHETK TISYQGCMAQ
110 120 130 140 150
IFFFHLLGGG TVFFLSVMAY DRYIAISQPL RYVTIMNTQL CVGLVVAAWV
160 170 180 190 200
GGFVHSIVQL ALILPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLMI
210 220 230 240 250
SNSGLLVIIW FLLLLISYTV ILVMLRSHSG KARRKAASTC TTHIIVVSMI
260 270 280 290 300
FIPCIYIYTW PFTPFLMDKA VSISYTVMTP MLNPMIYTLR NQDMKAAMRR
310
LGKCLVICRE
Length:310
Mass (Da):35,240
Last modified:March 2, 2010 - v3
Checksum:i058A7B0E8A6CF672
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170G → D in AAK95052 (PubMed:16625196).Curated1
Sequence conflicti170G → D in CAA61817 (Ref. 3) Curated1
Sequence conflicti201S → F in AAK95052 (PubMed:16625196).Curated1
Sequence conflicti201S → F in CAA61817 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754654R → Q.Corresponds to variant rs12602205dbSNPEnsembl.1
Natural variantiVAR_060479174L → I.2 PublicationsCorresponds to variant rs7218964dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065913 Genomic DNA. Translation: BAC06128.1.
AC005962 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94482.1.
BC136589 mRNA. Translation: AAI36590.1.
BC136595 mRNA. Translation: AAI36596.1.
AF399567 Genomic DNA. Translation: AAK95052.1.
X89670 mRNA. Translation: CAA61817.1.
CCDSiCCDS42365.1.
PIRiS58015.
RefSeqiNP_036506.1. NM_012374.1.
UniGeneiHs.531188.

Genome annotation databases

EnsembliENST00000268912; ENSP00000365451; ENSG00000141194.
GeneIDi26689.
KEGGihsa:26689.
UCSCiuc010wno.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065913 Genomic DNA. Translation: BAC06128.1.
AC005962 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94482.1.
BC136589 mRNA. Translation: AAI36590.1.
BC136595 mRNA. Translation: AAI36596.1.
AF399567 Genomic DNA. Translation: AAK95052.1.
X89670 mRNA. Translation: CAA61817.1.
CCDSiCCDS42365.1.
PIRiS58015.
RefSeqiNP_036506.1. NM_012374.1.
UniGeneiHs.531188.

3D structure databases

ProteinModelPortaliQ15615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365451.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15615.
PhosphoSitePlusiQ15615.

Polymorphism and mutation databases

BioMutaiOR4D1.
DMDMi290457670.

Proteomic databases

PaxDbiQ15615.
PeptideAtlasiQ15615.
PRIDEiQ15615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268912; ENSP00000365451; ENSG00000141194.
GeneIDi26689.
KEGGihsa:26689.
UCSCiuc010wno.3. human.

Organism-specific databases

CTDi26689.
DisGeNETi26689.
GeneCardsiOR4D1.
H-InvDBHIX0202548.
HGNCiHGNC:8293. OR4D1.
neXtProtiNX_Q15615.
OpenTargetsiENSG00000141194.
PharmGKBiPA32267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEFX. Eukaryota.
ENOG41119VH. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ15615.
KOiK04257.
OMAiMKRLGKH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ15615.
TreeFamiTF338273.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141194-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4D1.
GenomeRNAii26689.
PROiQ15615.

Gene expression databases

BgeeiENSG00000141194.
CleanExiHS_OR4D1.
GenevisibleiQ15615. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4D1_HUMAN
AccessioniPrimary (citable) accession number: Q15615
Secondary accession number(s): B2RN14, Q8NGB1, Q96R76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.