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Protein

Olfactory receptor 1Q1

Gene

OR1Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165202-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1Q1
Alternative name(s):
OST226
Olfactory receptor 1Q2
Olfactory receptor 1Q3
Olfactory receptor 9-A
Short name:
OR9-A
Olfactory receptor OR9-25
Olfactory receptor TPCR106
Gene namesi
Name:OR1Q1
Synonyms:OR1Q2, OR1Q3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8223. OR1Q1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165202.
PharmGKBiPA32094.

Polymorphism and mutation databases

BioMutaiOR1Q1.
DMDMi85681882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504501 – 314Olfactory receptor 1Q1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15612.
PRIDEiQ15612.

PTM databases

iPTMnetiQ15612.
PhosphoSitePlusiQ15612.

Expressioni

Gene expression databases

CleanExiHS_OR1Q1.
GenevisibleiQ15612. HS.

Organism-specific databases

HPAiHPA044828.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297913.

Structurei

3D structure databases

ProteinModelPortaliQ15612.
SMRiQ15612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJBA. Eukaryota.
ENOG41117G0. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15612.
KOiK04257.
OMAiRMQTFFF.
OrthoDBiEOG091G0B53.
PhylomeDBiQ15612.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSNWTSVS HFVLLGISTH PEEQIPLFLV FSLMYAINIS GNLAIITLIL
60 70 80 90 100
SAPRLHIPMY IFLSNLALTD ICFTSTTVPK MLQIIFSPTK VISYTGCLAQ
110 120 130 140 150
TYFFICFAVM ENFILAVMAY DRYIAICHPF HYTMILTRML CVKMVVMCHA
160 170 180 190 200
LSHLHAMLHT FLIGQLIFCA DNRIPHFFCD LYALMKISCT STYLNTLMIH
210 220 230 240 250
TEGAVVISGA LAFITASYAC IILVVLRIPS AKGRWKTFST CGSHLTVVAI
260 270 280 290 300
FYGTLSWVYF RPLSSYSVTK GRIITVVYTV VTPMLNPFIY SLRNGDVKGG
310
FMKWMSRMQT FFFR
Length:314
Mass (Da):35,598
Last modified:January 10, 2006 - v3
Checksum:i6CFA2B4C946F0EBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126I → F in CAA61814 (PubMed:9119360).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05312624Q → R.Corresponds to variant rs972925dbSNPEnsembl.1
Natural variantiVAR_024768163I → M.2 PublicationsCorresponds to variant rs1329957dbSNPEnsembl.1
Natural variantiVAR_053127240T → A.Corresponds to variant rs727913dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065722 Genomic DNA. Translation: BAC05943.1.
AL162254 Genomic DNA. Translation: CAI16288.1.
AF399561 Genomic DNA. Translation: AAK95046.1.
X89667 mRNA. Translation: CAA61814.1.
BK004228 Genomic DNA. Translation: DAA04626.1.
CCDSiCCDS35125.1.
PIRiS58012.
RefSeqiNP_036496.1. NM_012364.1.
UniGeneiHs.684864.

Genome annotation databases

EnsembliENST00000297913; ENSP00000297913; ENSG00000165202.
GeneIDi158131.
KEGGihsa:158131.
UCSCiuc011lyy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065722 Genomic DNA. Translation: BAC05943.1.
AL162254 Genomic DNA. Translation: CAI16288.1.
AF399561 Genomic DNA. Translation: AAK95046.1.
X89667 mRNA. Translation: CAA61814.1.
BK004228 Genomic DNA. Translation: DAA04626.1.
CCDSiCCDS35125.1.
PIRiS58012.
RefSeqiNP_036496.1. NM_012364.1.
UniGeneiHs.684864.

3D structure databases

ProteinModelPortaliQ15612.
SMRiQ15612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297913.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15612.
PhosphoSitePlusiQ15612.

Polymorphism and mutation databases

BioMutaiOR1Q1.
DMDMi85681882.

Proteomic databases

PaxDbiQ15612.
PRIDEiQ15612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297913; ENSP00000297913; ENSG00000165202.
GeneIDi158131.
KEGGihsa:158131.
UCSCiuc011lyy.2. human.

Organism-specific databases

CTDi158131.
GeneCardsiOR1Q1.
HGNCiHGNC:8223. OR1Q1.
HPAiHPA044828.
neXtProtiNX_Q15612.
OpenTargetsiENSG00000165202.
PharmGKBiPA32094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJBA. Eukaryota.
ENOG41117G0. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15612.
KOiK04257.
OMAiRMQTFFF.
OrthoDBiEOG091G0B53.
PhylomeDBiQ15612.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165202-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1Q1.
GenomeRNAii158131.
PROiQ15612.

Gene expression databases

CleanExiHS_OR1Q1.
GenevisibleiQ15612. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1Q1_HUMAN
AccessioniPrimary (citable) accession number: Q15612
Secondary accession number(s): Q6IFN4, Q8NGR7, Q96R82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.