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Protein

Olfactory receptor 1Q1

Gene

OR1Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.IKR:

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1Q1
Alternative name(s):
OST226
Olfactory receptor 1Q2
Olfactory receptor 1Q3
Olfactory receptor 9-A
Short name:
OR9-A
Olfactory receptor OR9-25
Olfactory receptor TPCR106
Gene namesi
Name:OR1Q1
Synonyms:OR1Q2, OR1Q3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165202.3.
HGNCiHGNC:8223. OR1Q1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularIEP:Add BLAST25
Transmembranei26 – 49Helical; Name=1IEP:Add BLAST24
Topological domaini50 – 57CytoplasmicIEP:8
Transmembranei58 – 79Helical; Name=2IEP:Add BLAST22
Topological domaini80 – 100ExtracellularIEP:Add BLAST21
Transmembranei101 – 120Helical; Name=3IEP:Add BLAST20
Topological domaini121 – 139CytoplasmicIEP:Add BLAST19
Transmembranei140 – 158Helical; Name=4IEP:Add BLAST19
Topological domaini159 – 195ExtracellularIEP:Add BLAST37
Transmembranei196 – 219Helical; Name=5IEP:Add BLAST24
Topological domaini220 – 236CytoplasmicIEP:Add BLAST17
Transmembranei237 – 259Helical; Name=6IEP:Add BLAST23
Topological domaini260 – 272ExtracellularIEP:Add BLAST13
Transmembranei273 – 292Helical; Name=7IEP:Add BLAST20
Topological domaini293 – 314CytoplasmicIEP:Add BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32094.

Polymorphism and mutation databases

BioMutaiOR1Q1.
DMDMi85681882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504501 – 314Olfactory receptor 1Q1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineIEP:1
Disulfide bondi97 ↔ 189IEP:

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15612.
PRIDEiQ15612.

PTM databases

iPTMnetiQ15612.
PhosphoSitePlusiQ15612.

Expressioni

Gene expression databases

BgeeiENSG00000165202.
CleanExiHS_OR1Q1.
GenevisibleiQ15612. HS.

Organism-specific databases

HPAiHPA044828.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297913.

Structurei

3D structure databases

ProteinModelPortaliQ15612.
SMRiQ15612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.IEP:

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJBA. Eukaryota.
ENOG41117G0. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ15612.
KOiK04257.
OMAiQTYFFIC.
OrthoDBiEOG091G0B53.
PhylomeDBiQ15612.
TreeFamiTF337210.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSNWTSVS HFVLLGISTH PEEQIPLFLV FSLMYAINIS GNLAIITLIL
60 70 80 90 100
SAPRLHIPMY IFLSNLALTD ICFTSTTVPK MLQIIFSPTK VISYTGCLAQ
110 120 130 140 150
TYFFICFAVM ENFILAVMAY DRYIAICHPF HYTMILTRML CVKMVVMCHA
160 170 180 190 200
LSHLHAMLHT FLIGQLIFCA DNRIPHFFCD LYALMKISCT STYLNTLMIH
210 220 230 240 250
TEGAVVISGA LAFITASYAC IILVVLRIPS AKGRWKTFST CGSHLTVVAI
260 270 280 290 300
FYGTLSWVYF RPLSSYSVTK GRIITVVYTV VTPMLNPFIY SLRNGDVKGG
310
FMKWMSRMQT FFFR
Length:314
Mass (Da):35,598
Last modified:January 10, 2006 - v3
Checksum:i6CFA2B4C946F0EBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126I → F in CAA61814 (PubMed:9119360).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05312624Q → R. Corresponds to variant dbSNP:rs972925Ensembl.1
Natural variantiVAR_024768163I → M2 PublicationsCorresponds to variant dbSNP:rs1329957Ensembl.1
Natural variantiVAR_053127240T → A. Corresponds to variant dbSNP:rs727913Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065722 Genomic DNA. Translation: BAC05943.1.
AL162254 Genomic DNA. No translation available.
AF399561 Genomic DNA. Translation: AAK95046.1.
X89667 mRNA. Translation: CAA61814.1.
BK004228 Genomic DNA. Translation: DAA04626.1.
CCDSiCCDS35125.1.
PIRiS58012.
RefSeqiNP_036496.1. NM_012364.1.
UniGeneiHs.684864.

Genome annotation databases

EnsembliENST00000297913; ENSP00000297913; ENSG00000165202.
GeneIDi158131.
KEGGihsa:158131.
UCSCiuc011lyy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1Q1_HUMAN
AccessioniPrimary (citable) accession number: Q15612
Secondary accession number(s): Q6IFN4, Q8NGR7, Q96R82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 10, 2006
Last modified: September 27, 2017
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families