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Q155P7

- Q155P7_MOUSE

UniProt

Q155P7 - Q155P7_MOUSE

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Protein
Submitted name: LEK1
Gene
Cenpf, Lek1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. heart development Source: UniProtKB
  2. negative regulation of apoptotic process Source: UniProtKB
  3. positive regulation of cell cycle Source: UniProtKB
  4. positive regulation of cell proliferation Source: UniProtKB
  5. regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  6. regulation of T cell activation Source: UniProtKB
  7. regulation of T cell cytokine production Source: UniProtKB
  8. regulation of dendritic cell cytokine production Source: UniProtKB
  9. regulation of establishment of protein localization Source: UniProtKB
  10. regulation of intracellular transport Source: UniProtKB
  11. regulation of microtubule-based process Source: UniProtKB
  12. regulation of myeloid dendritic cell activation Source: UniProtKB
  13. regulation of striated muscle tissue development Source: MGI
  14. stem cell fate specification Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
LEK1Imported
Gene namesi
Name:CenpfImported
Synonyms:Lek1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1313302. Cenpf.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. chromosome, centromeric region Source: MGI
  3. cytoplasm Source: UniProtKB
  4. kinetochore Source: UniProtKB
  5. nucleus Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB
  7. pronucleus Source: MGI
  8. recycling endosome Source: UniProtKB
  9. trans-Golgi network Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ155P7.
PRIDEiQ155P7.

PTM databases

PhosphoSiteiQ155P7.

Expressioni

Gene expression databases

GenevestigatoriQ155P7.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Nde1Q9CZA68EBI-2211248,EBI-309934
RB1P064004EBI-2211248,EBI-491274From a different organism.
Rb1P134054EBI-2211248,EBI-971782
Rbl1Q647013EBI-2211248,EBI-1213109
Rbl2Q647003EBI-2211248,EBI-2271232
Snap25P6087913EBI-2211248,EBI-445270
Stx4P704529EBI-2211248,EBI-645716

Protein-protein interaction databases

IntActiQ155P7. 12 interactions.
STRINGi10090.ENSMUSP00000027900.

Structurei

3D structure databases

ProteinModelPortaliQ155P7.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000169807.
HOVERGENiHBG050893.
InParanoidiQ155P7.

Family and domain databases

InterProiIPR018302. CenpF/LEK1_Rb-prot-bd.
IPR019513. Centromere_CenpF_leu-rich_rpt.
IPR018463. Centromere_CenpF_N.
[Graphical view]
PfamiPF10490. CENP-F_C_Rb_bdg. 1 hit.
PF10473. CENP-F_leu_zip. 3 hits.
PF10481. CENP-F_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q155P7-1 [UniParc]FASTAAdd to Basket

« Hide

MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK     50
QKQKVEDGKT EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ 100
ESQLSSCKKQ IEKLEQELKR CKSEFERSQQ VAQSADVSLN PCSTPQKLFA 150
TPLTPSSTYE DLKEKYNKEV EERKRLEEEV KALHAKKVSL PVSQATMNHR 200
DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH FLGEEVSPNK 250
SSMKTGRGDC SSLPGEPHSA QLLHQAKAQN QDLKSKMTEL ELRLQGQEKE 300
MRSQVNKCQD LQLQLEKTKV ELIEKERILN KTRDEVVRST AQYDQAAAKC 350
TTLEQKLKTL TEELSCHRQN AESAKRSLEQ RIKEKEKELQ EELSRQHQSF 400
QALDSEYTQM KTRLTQELQQ VKHLHSTLQL ELEKVTSVKQ QLERNLEEIR 450
LKLSRAEQAL QASQVAENEL RRSSEEMKKE NSLIRSQSEQ RTREVCHLEE 500
ELGKVKVSLS KSQNFAEEMK AKNTSQEIML RDLQEKLNQQ ENSLTLEKLK 550
LALADLERQR NCSQDLLKKR EHHIDQLNNK LNKIEKEFET LLSALELKKK 600
ECEELKEEKN QISFWKIDSE KLINQIESEK EILLGKINHL ETSLKTQQVS 650
PDSNERIRTL EMERENFTVE IKNLQSMLDS KMVEIKTQKQ AYLELQQKSE 700
SSDQKHQKEI ENMCLKANKL TGQVESLECK LQLLSSEVVT KDQQYQDLRM 750
EYETLRDLLK SRGSSLVTNE DNQRSSEDNQ RSSEDNQRGS LAFEQQPAVS 800
DSFANVMGRK GSINSERSDC SVDGGRSPEH IAILQNRVTS LESSLESQNQ 850
MNSDLQMRCE ELLQIKGEVE ENLSKAEQIH QNFVAETNQC ISKLQEDAAV 900
HQNIVAETLA TLESKEKELQ LLKEKLEAQQ TEVQKLNKNN CLLEGTLKEL 950
QLLSDTLSSE KKEMNSIISL SKKNIEELTQ ANEALKEVNE ALEQEKMNLL 1000
QKHEKITSCI AEQERSIAEL SDQYKQERLQ LLQRCEETEA VLEDLRGNYK 1050
TAQENNAKLE CMLSECTALC ENRKNELEQL KETFAKEQQE FLTKLAFAEE 1100
QNRKLMLELE IEQQTVRSEI TNTNKHSMSA TDGLRQECLT LNEEQNEQQN 1150
EVSNLTHENE QLMELTQTKH DSYLAVEPVE NSVKATEDEI GKSSSQYQMD 1200
IDTKDISLDS YKAQLVHLEA LVRILEVQLD QSEEENKKLH LELQTIREEL 1250
ETKSSQDPQS QARTGLKDCD TAEEKYVSML QELSASQNEN AHLQCSLQTA 1300
VNKLNELGKM CDVLRVEKLQ LESELNDSRT ECITATSQMT AEVEKLVSEM 1350
KMLNHESALS QNELMKDTSG GEFHDKANHS SVFLTPLDSS NFCEQMTLSS 1400
KEVRVHFAEL QEKFSCLQSE HKILHDQHCE VSSKMSALRS YVDTLKAENS 1450
ALSMSLRTLQ GDLVKEGEPA AEGGHGLPLS FCGADSPSLT NFGETSFYKD 1500
VLEQTGDTCH LSLEGNASAN SCDLDEEFSS SLEEETLTEK ESPPAPGRTV 1550
EGLEVLCQVY LQSLKNLEEK TESQRIMKNK EIEELEQLLS SERKELSCLR 1600
KQYLSEKEQW QQKLTSVTLE MESKLAEEKQ QTKTLSLELE VARLQLQELD 1650
LSSRSLLGTD LESVVRCQND NYDIKESEVY ISETTEKTPK QDTDQTCDKD 1700
IQQDLGLETS VTESETTRLT GEGCEEQPPK TNCEAPAEDK TQDCSECISE 1750
LCSSSNVLVP MDVLEDQGSI QNLQLQKDTL NENLRLLPEV EDWDKKVESL 1800
LNEIMEADSK LSLQEVQLKM KIATCIQLEK IVKDLRKEKA DLSEKLESLP 1850
CNQEVCLRVE RSEEDLGFNL DMGANELLSK STKDNATNTE DNYKEKFLDM 1900
ERELTRIKSE KANIEHHILS VETNLEVVQA EKLCLERDTE SKQKVIIDLK 1950
EELFTVISER NRLREELDNV SKESKALDQM SKKMKEKIEE LESHQRESLR 2000
HIGAVESEVK DKADLIQTLS FNVGELTKDK AHLQEQLQNL QNDSQELSLA 2050
IGELEIQIGQ LNKEKESLVK ESQNFQIKLT ESECEKQTIS KALEVALKEK 2100
GEFAVQLSSA QEEVHQLRRG IEKLSVRIEA DEKKHLSAVA KLKESQRESD 2150
SLKDTVETLE RELERSEENQ ELAILDSENL KAEVETLKAQ KDEMTKSLRI 2200
FELDLVTVRT ERENLAKQLQ EKQSRVSELD ERCSSLRRLL EEKEQARVQM 2250
EEDSKSAMLM LQMQLKELRE EVAALCNDQE TLKAQEQSLD QPGEEVHHLK 2300
SSIRKLKVHI DADEKKHQNI LEQLKESKHH ADLLKDRVEN LEQELILSEK 2350
NMIFQAEKSK AEIQTLKSEI QRMAQNLQDL QLELISTRSE NENLIKELKK 2400
EQERVSDLET INPSIENLLK DKEQEKVQMK EEAKITVEML QTQLKELNET 2450
VVSLCNDQEV SKTKEQNLGS QVQTLELEKA QLLQDLGEAK NKYIIFQSSV 2500
NALTQEVEAG KQKLEKGEKE IRTLKEQLKS QEQLVCKLAQ VEGEQELWQK 2550
QKLELRNVTM ALEQKVQVLQ SENNTLQSTY EALQNSHKSL ESELGLIKLE 2600
KVALVERVST ISGKEAELQR ELRDMLQKTT QLSEDYNKEK NRLTEEVEVL 2650
REELQNTKAA HLKSVNQLEK ELQRAQGKIK LMLKSCRQLE GEKEMLQKEL 2700
SQLEAAQQQR AGSLVDSNVD EVMTENKALK ETLEEKVKEA DKYLDKYCSL 2750
LISHEELEKA KEILEIEVAR LKSRQSRQDL QSSPLLNSSI PGPSPNTSVS 2800
EMKSASGQNK ASGKRQRSSG VWEHGKRAAP STAETFSKKS RKSDSKSTRP 2850
AEHEQETEFE PEGLPEVVKK GFADIPTGKT SPYILRRTTM ATRTSPRFAT 2900
QKLVGSSPSL GKENVVESSK PTAGGSRSQK VKVVQESSAD SHTAFQELPA 2950
KSLTASNIPG RNSTESPREG LRAKRAYPAS SPAAGPDPTN NENCRVQ 2997
Length:2,997
Mass (Da):342,452
Last modified:July 25, 2006 - v1
Checksum:i3CB74C4F24537155
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ642022 mRNA. Translation: ABG25915.1.
UniGeneiMm.129746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ642022 mRNA. Translation: ABG25915.1 .
UniGenei Mm.129746.

3D structure databases

ProteinModelPortali Q155P7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q155P7. 12 interactions.
STRINGi 10090.ENSMUSP00000027900.

PTM databases

PhosphoSitei Q155P7.

Proteomic databases

PaxDbi Q155P7.
PRIDEi Q155P7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1313302. Cenpf.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000169807.
HOVERGENi HBG050893.
InParanoidi Q155P7.

Miscellaneous databases

ChiTaRSi CENPF. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q155P7.

Family and domain databases

InterProi IPR018302. CenpF/LEK1_Rb-prot-bd.
IPR019513. Centromere_CenpF_leu-rich_rpt.
IPR018463. Centromere_CenpF_N.
[Graphical view ]
Pfami PF10490. CENP-F_C_Rb_bdg. 1 hit.
PF10473. CENP-F_leu_zip. 3 hits.
PF10481. CENP-F_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway."
    Soukoulis V., Reddy S., Pooley R.D., Feng Y., Walsh C.A., Bader D.M.
    Proc. Natl. Acad. Sci. U.S.A. 102:8549-8554(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRImported.
  2. "CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25."
    Pooley R.D., Reddy S., Soukoulis V., Roland J.T., Goldenring J.R., Bader D.M.
    Mol. Biol. Cell 17:3176-3186(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRImported.

Entry informationi

Entry nameiQ155P7_MOUSE
AccessioniPrimary (citable) accession number: Q155P7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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