Q155P7 (Q155P7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LEK1 EMBL ABG25915.1

Gene names

Name:	Cenpf MGI 1313302
Synonyms:	Lek1 EMBL ABG25915.1

Organism

Mus musculus (Mouse) EMBL ABG25915.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2997 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Gene Ontology (GO)
Biological_process	heart development Inferred from mutant phenotype PubMed 15861132. Source: UniProtKB negative regulation of apoptotic process Inferred from mutant phenotype PubMed 14555653. Source: UniProtKB positive regulation of cell cycle Inferred from mutant phenotype PubMed 14555653. Source: UniProtKB positive regulation of cell proliferation Inferred from mutant phenotype PubMed 14555653. Source: UniProtKB regulation of G2/M transition of mitotic cell cycle Inferred from direct assay PubMed 17498689. Source: UniProtKB regulation of T cell activation Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB regulation of T cell cytokine production Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB regulation of dendritic cell cytokine production Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB regulation of establishment of protein localization Inferred from mutant phenotype PubMed 17498689. Source: UniProtKB regulation of intracellular transport Inferred from direct assay PubMed 18827011. Source: UniProtKB regulation of microtubule-based process Inferred from mutant phenotype Ref.1. Source: UniProtKB regulation of myeloid dendritic cell activation Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB regulation of striated muscle tissue development Inferred from direct assay PubMed 10373470. Source: MGI stem cell fate specification Inferred from mutant phenotype PubMed 15861132. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay Ref.2. Source: UniProtKB kinetochore Inferred from direct assay PubMed 12974617. Source: UniProtKB perinuclear region of cytoplasm Inferred from direct assay PubMed 18827011. Source: UniProtKB pronucleus Inferred from direct assay PubMed 10373470. Source: MGI recycling endosome Inferred from direct assay Ref.2. Source: UniProtKB trans-Golgi network Inferred from direct assay PubMed 18827011. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Nde1	Q9CZA6	8	EBI-2211248,EBI-309934
RB1	P06400	4	EBI-2211248,EBI-491274	From a different organism.
Rb1	P13405	4	EBI-2211248,EBI-971782
Rbl1	Q64701	3	EBI-2211248,EBI-1213109
Rbl2	Q64700	3	EBI-2211248,EBI-2271232
Snap25	P60879	13	EBI-2211248,EBI-445270
Stx4	P70452	9	EBI-2211248,EBI-645716

Sequences

	Sequence		Length	Mass (Da)
	Q155P7 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 3CB74C4F24537155	FASTA	2,997	342,452
	10 20 30 40 50 60 MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK QKQKVEDGKT 70 80 90 100 110 120 EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ ESQLSSCKKQ IEKLEQELKR 130 140 150 160 170 180 CKSEFERSQQ VAQSADVSLN PCSTPQKLFA TPLTPSSTYE DLKEKYNKEV EERKRLEEEV 190 200 210 220 230 240 KALHAKKVSL PVSQATMNHR DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH 250 260 270 280 290 300 FLGEEVSPNK SSMKTGRGDC SSLPGEPHSA QLLHQAKAQN QDLKSKMTEL ELRLQGQEKE 310 320 330 340 350 360 MRSQVNKCQD LQLQLEKTKV ELIEKERILN KTRDEVVRST AQYDQAAAKC TTLEQKLKTL 370 380 390 400 410 420 TEELSCHRQN AESAKRSLEQ RIKEKEKELQ EELSRQHQSF QALDSEYTQM KTRLTQELQQ 430 440 450 460 470 480 VKHLHSTLQL ELEKVTSVKQ QLERNLEEIR LKLSRAEQAL QASQVAENEL RRSSEEMKKE 490 500 510 520 530 540 NSLIRSQSEQ RTREVCHLEE ELGKVKVSLS KSQNFAEEMK AKNTSQEIML RDLQEKLNQQ 550 560 570 580 590 600 ENSLTLEKLK LALADLERQR NCSQDLLKKR EHHIDQLNNK LNKIEKEFET LLSALELKKK 610 620 630 640 650 660 ECEELKEEKN QISFWKIDSE KLINQIESEK EILLGKINHL ETSLKTQQVS PDSNERIRTL 670 680 690 700 710 720 EMERENFTVE IKNLQSMLDS KMVEIKTQKQ AYLELQQKSE SSDQKHQKEI ENMCLKANKL 730 740 750 760 770 780 TGQVESLECK LQLLSSEVVT KDQQYQDLRM EYETLRDLLK SRGSSLVTNE DNQRSSEDNQ 790 800 810 820 830 840 RSSEDNQRGS LAFEQQPAVS DSFANVMGRK GSINSERSDC SVDGGRSPEH IAILQNRVTS 850 860 870 880 890 900 LESSLESQNQ MNSDLQMRCE ELLQIKGEVE ENLSKAEQIH QNFVAETNQC ISKLQEDAAV 910 920 930 940 950 960 HQNIVAETLA TLESKEKELQ LLKEKLEAQQ TEVQKLNKNN CLLEGTLKEL QLLSDTLSSE 970 980 990 1000 1010 1020 KKEMNSIISL SKKNIEELTQ ANEALKEVNE ALEQEKMNLL QKHEKITSCI AEQERSIAEL 1030 1040 1050 1060 1070 1080 SDQYKQERLQ LLQRCEETEA VLEDLRGNYK TAQENNAKLE CMLSECTALC ENRKNELEQL 1090 1100 1110 1120 1130 1140 KETFAKEQQE FLTKLAFAEE QNRKLMLELE IEQQTVRSEI TNTNKHSMSA TDGLRQECLT 1150 1160 1170 1180 1190 1200 LNEEQNEQQN EVSNLTHENE QLMELTQTKH DSYLAVEPVE NSVKATEDEI GKSSSQYQMD 1210 1220 1230 1240 1250 1260 IDTKDISLDS YKAQLVHLEA LVRILEVQLD QSEEENKKLH LELQTIREEL ETKSSQDPQS 1270 1280 1290 1300 1310 1320 QARTGLKDCD TAEEKYVSML QELSASQNEN AHLQCSLQTA VNKLNELGKM CDVLRVEKLQ 1330 1340 1350 1360 1370 1380 LESELNDSRT ECITATSQMT AEVEKLVSEM KMLNHESALS QNELMKDTSG GEFHDKANHS 1390 1400 1410 1420 1430 1440 SVFLTPLDSS NFCEQMTLSS KEVRVHFAEL QEKFSCLQSE HKILHDQHCE VSSKMSALRS 1450 1460 1470 1480 1490 1500 YVDTLKAENS ALSMSLRTLQ GDLVKEGEPA AEGGHGLPLS FCGADSPSLT NFGETSFYKD 1510 1520 1530 1540 1550 1560 VLEQTGDTCH LSLEGNASAN SCDLDEEFSS SLEEETLTEK ESPPAPGRTV EGLEVLCQVY 1570 1580 1590 1600 1610 1620 LQSLKNLEEK TESQRIMKNK EIEELEQLLS SERKELSCLR KQYLSEKEQW QQKLTSVTLE 1630 1640 1650 1660 1670 1680 MESKLAEEKQ QTKTLSLELE VARLQLQELD LSSRSLLGTD LESVVRCQND NYDIKESEVY 1690 1700 1710 1720 1730 1740 ISETTEKTPK QDTDQTCDKD IQQDLGLETS VTESETTRLT GEGCEEQPPK TNCEAPAEDK 1750 1760 1770 1780 1790 1800 TQDCSECISE LCSSSNVLVP MDVLEDQGSI QNLQLQKDTL NENLRLLPEV EDWDKKVESL 1810 1820 1830 1840 1850 1860 LNEIMEADSK LSLQEVQLKM KIATCIQLEK IVKDLRKEKA DLSEKLESLP CNQEVCLRVE 1870 1880 1890 1900 1910 1920 RSEEDLGFNL DMGANELLSK STKDNATNTE DNYKEKFLDM ERELTRIKSE KANIEHHILS 1930 1940 1950 1960 1970 1980 VETNLEVVQA EKLCLERDTE SKQKVIIDLK EELFTVISER NRLREELDNV SKESKALDQM 1990 2000 2010 2020 2030 2040 SKKMKEKIEE LESHQRESLR HIGAVESEVK DKADLIQTLS FNVGELTKDK AHLQEQLQNL 2050 2060 2070 2080 2090 2100 QNDSQELSLA IGELEIQIGQ LNKEKESLVK ESQNFQIKLT ESECEKQTIS KALEVALKEK 2110 2120 2130 2140 2150 2160 GEFAVQLSSA QEEVHQLRRG IEKLSVRIEA DEKKHLSAVA KLKESQRESD SLKDTVETLE 2170 2180 2190 2200 2210 2220 RELERSEENQ ELAILDSENL KAEVETLKAQ KDEMTKSLRI FELDLVTVRT ERENLAKQLQ 2230 2240 2250 2260 2270 2280 EKQSRVSELD ERCSSLRRLL EEKEQARVQM EEDSKSAMLM LQMQLKELRE EVAALCNDQE 2290 2300 2310 2320 2330 2340 TLKAQEQSLD QPGEEVHHLK SSIRKLKVHI DADEKKHQNI LEQLKESKHH ADLLKDRVEN 2350 2360 2370 2380 2390 2400 LEQELILSEK NMIFQAEKSK AEIQTLKSEI QRMAQNLQDL QLELISTRSE NENLIKELKK 2410 2420 2430 2440 2450 2460 EQERVSDLET INPSIENLLK DKEQEKVQMK EEAKITVEML QTQLKELNET VVSLCNDQEV 2470 2480 2490 2500 2510 2520 SKTKEQNLGS QVQTLELEKA QLLQDLGEAK NKYIIFQSSV NALTQEVEAG KQKLEKGEKE 2530 2540 2550 2560 2570 2580 IRTLKEQLKS QEQLVCKLAQ VEGEQELWQK QKLELRNVTM ALEQKVQVLQ SENNTLQSTY 2590 2600 2610 2620 2630 2640 EALQNSHKSL ESELGLIKLE KVALVERVST ISGKEAELQR ELRDMLQKTT QLSEDYNKEK 2650 2660 2670 2680 2690 2700 NRLTEEVEVL REELQNTKAA HLKSVNQLEK ELQRAQGKIK LMLKSCRQLE GEKEMLQKEL 2710 2720 2730 2740 2750 2760 SQLEAAQQQR AGSLVDSNVD EVMTENKALK ETLEEKVKEA DKYLDKYCSL LISHEELEKA 2770 2780 2790 2800 2810 2820 KEILEIEVAR LKSRQSRQDL QSSPLLNSSI PGPSPNTSVS EMKSASGQNK ASGKRQRSSG 2830 2840 2850 2860 2870 2880 VWEHGKRAAP STAETFSKKS RKSDSKSTRP AEHEQETEFE PEGLPEVVKK GFADIPTGKT 2890 2900 2910 2920 2930 2940 SPYILRRTTM ATRTSPRFAT QKLVGSSPSL GKENVVESSK PTAGGSRSQK VKVVQESSAD 2950 2960 2970 2980 2990 SHTAFQELPA KSLTASNIPG RNSTESPREG LRAKRAYPAS SPAAGPDPTN NENCRVQ

References

[1]	"Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway." Soukoulis V., Reddy S., Pooley R.D., Feng Y., Walsh C.A., Bader D.M. Proc. Natl. Acad. Sci. U.S.A. 102:8549-8554(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ICR EMBL ABG25915.1.
[2]	"CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25." Pooley R.D., Reddy S., Soukoulis V., Roland J.T., Goldenring J.R., Bader D.M. Mol. Biol. Cell 17:3176-3186(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ICR EMBL ABG25915.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ642022 mRNA. Translation: ABG25915.1.
IPI	IPI00404359.
UniGene	Mm.129746.
3D structure databases
ProteinModelPortal	Q155P7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q155P7. 12 interactions.
STRING	10090.ENSMUSP00000027900.
PTM databases
PhosphoSite	Q155P7.
Proteomic databases
PaxDb	Q155P7.
PRIDE	Q155P7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1313302. Cenpf.
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000169807.
HOVERGEN	HBG050893.
InParanoid	Q155P7.
OrthoDB	EOG4Z36D0.
Gene expression databases
ArrayExpress	Q155P7.
Genevestigator	Q155P7.
Family and domain databases
InterPro	IPR019513. Centromere_CenpF_leu-rich_rpt. IPR018463. Centromere_CenpF_N. IPR018302. Centromere_CenpF_Rb-prot-bd. [Graphical view]
Pfam	PF10473. Cenp-F_leu_zip. 2 hits. PF10481. Cenp-F_N. 1 hit. PF10490. Rb-bdg_C_Cenp-F. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CENPF. mouse.
SOURCE	Search...

Entry information

Entry name

Q155P7_MOUSE

Accession

Primary (citable) accession number: Q155P7

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)