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Q155P7

- Q155P7_MOUSE

UniProt

Q155P7 - Q155P7_MOUSE

Protein
Submitted name:

LEK1

Gene

Cenpf

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. heart development Source: UniProtKB
    2. negative regulation of apoptotic process Source: UniProtKB
    3. positive regulation of cell cycle Source: UniProtKB
    4. positive regulation of cell proliferation Source: UniProtKB
    5. regulation of dendritic cell cytokine production Source: UniProtKB
    6. regulation of establishment of protein localization Source: UniProtKB
    7. regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
    8. regulation of intracellular transport Source: UniProtKB
    9. regulation of microtubule-based process Source: UniProtKB
    10. regulation of myeloid dendritic cell activation Source: UniProtKB
    11. regulation of striated muscle tissue development Source: MGI
    12. regulation of T cell activation Source: UniProtKB
    13. regulation of T cell cytokine production Source: UniProtKB
    14. stem cell fate specification Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    LEK1Imported
    Gene namesi
    Name:CenpfImported
    Synonyms:Lek1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1313302. Cenpf.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. chromosome, centromeric region Source: MGI
    3. cytoplasm Source: UniProtKB
    4. kinetochore Source: UniProtKB
    5. nucleus Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. pronucleus Source: MGI
    8. recycling endosome Source: UniProtKB
    9. trans-Golgi network Source: UniProtKB

    PTM / Processingi

    Proteomic databases

    PaxDbiQ155P7.
    PRIDEiQ155P7.

    PTM databases

    PhosphoSiteiQ155P7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ155P7.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Nde1Q9CZA68EBI-2211248,EBI-309934
    RB1P064004EBI-2211248,EBI-491274From a different organism.
    Rb1P134054EBI-2211248,EBI-971782
    Rbl1Q647013EBI-2211248,EBI-1213109
    Rbl2Q647003EBI-2211248,EBI-2271232
    Snap25P6087913EBI-2211248,EBI-445270
    Stx4P704529EBI-2211248,EBI-645716

    Protein-protein interaction databases

    IntActiQ155P7. 12 interactions.
    STRINGi10090.ENSMUSP00000027900.

    Structurei

    3D structure databases

    ProteinModelPortaliQ155P7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000169807.
    HOVERGENiHBG050893.
    InParanoidiQ155P7.

    Family and domain databases

    InterProiIPR018302. CenpF/LEK1_Rb-prot-bd.
    IPR019513. Centromere_CenpF_leu-rich_rpt.
    IPR018463. Centromere_CenpF_N.
    [Graphical view]
    PfamiPF10490. CENP-F_C_Rb_bdg. 1 hit.
    PF10473. CENP-F_leu_zip. 3 hits.
    PF10481. CENP-F_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q155P7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK     50
    QKQKVEDGKT EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ 100
    ESQLSSCKKQ IEKLEQELKR CKSEFERSQQ VAQSADVSLN PCSTPQKLFA 150
    TPLTPSSTYE DLKEKYNKEV EERKRLEEEV KALHAKKVSL PVSQATMNHR 200
    DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH FLGEEVSPNK 250
    SSMKTGRGDC SSLPGEPHSA QLLHQAKAQN QDLKSKMTEL ELRLQGQEKE 300
    MRSQVNKCQD LQLQLEKTKV ELIEKERILN KTRDEVVRST AQYDQAAAKC 350
    TTLEQKLKTL TEELSCHRQN AESAKRSLEQ RIKEKEKELQ EELSRQHQSF 400
    QALDSEYTQM KTRLTQELQQ VKHLHSTLQL ELEKVTSVKQ QLERNLEEIR 450
    LKLSRAEQAL QASQVAENEL RRSSEEMKKE NSLIRSQSEQ RTREVCHLEE 500
    ELGKVKVSLS KSQNFAEEMK AKNTSQEIML RDLQEKLNQQ ENSLTLEKLK 550
    LALADLERQR NCSQDLLKKR EHHIDQLNNK LNKIEKEFET LLSALELKKK 600
    ECEELKEEKN QISFWKIDSE KLINQIESEK EILLGKINHL ETSLKTQQVS 650
    PDSNERIRTL EMERENFTVE IKNLQSMLDS KMVEIKTQKQ AYLELQQKSE 700
    SSDQKHQKEI ENMCLKANKL TGQVESLECK LQLLSSEVVT KDQQYQDLRM 750
    EYETLRDLLK SRGSSLVTNE DNQRSSEDNQ RSSEDNQRGS LAFEQQPAVS 800
    DSFANVMGRK GSINSERSDC SVDGGRSPEH IAILQNRVTS LESSLESQNQ 850
    MNSDLQMRCE ELLQIKGEVE ENLSKAEQIH QNFVAETNQC ISKLQEDAAV 900
    HQNIVAETLA TLESKEKELQ LLKEKLEAQQ TEVQKLNKNN CLLEGTLKEL 950
    QLLSDTLSSE KKEMNSIISL SKKNIEELTQ ANEALKEVNE ALEQEKMNLL 1000
    QKHEKITSCI AEQERSIAEL SDQYKQERLQ LLQRCEETEA VLEDLRGNYK 1050
    TAQENNAKLE CMLSECTALC ENRKNELEQL KETFAKEQQE FLTKLAFAEE 1100
    QNRKLMLELE IEQQTVRSEI TNTNKHSMSA TDGLRQECLT LNEEQNEQQN 1150
    EVSNLTHENE QLMELTQTKH DSYLAVEPVE NSVKATEDEI GKSSSQYQMD 1200
    IDTKDISLDS YKAQLVHLEA LVRILEVQLD QSEEENKKLH LELQTIREEL 1250
    ETKSSQDPQS QARTGLKDCD TAEEKYVSML QELSASQNEN AHLQCSLQTA 1300
    VNKLNELGKM CDVLRVEKLQ LESELNDSRT ECITATSQMT AEVEKLVSEM 1350
    KMLNHESALS QNELMKDTSG GEFHDKANHS SVFLTPLDSS NFCEQMTLSS 1400
    KEVRVHFAEL QEKFSCLQSE HKILHDQHCE VSSKMSALRS YVDTLKAENS 1450
    ALSMSLRTLQ GDLVKEGEPA AEGGHGLPLS FCGADSPSLT NFGETSFYKD 1500
    VLEQTGDTCH LSLEGNASAN SCDLDEEFSS SLEEETLTEK ESPPAPGRTV 1550
    EGLEVLCQVY LQSLKNLEEK TESQRIMKNK EIEELEQLLS SERKELSCLR 1600
    KQYLSEKEQW QQKLTSVTLE MESKLAEEKQ QTKTLSLELE VARLQLQELD 1650
    LSSRSLLGTD LESVVRCQND NYDIKESEVY ISETTEKTPK QDTDQTCDKD 1700
    IQQDLGLETS VTESETTRLT GEGCEEQPPK TNCEAPAEDK TQDCSECISE 1750
    LCSSSNVLVP MDVLEDQGSI QNLQLQKDTL NENLRLLPEV EDWDKKVESL 1800
    LNEIMEADSK LSLQEVQLKM KIATCIQLEK IVKDLRKEKA DLSEKLESLP 1850
    CNQEVCLRVE RSEEDLGFNL DMGANELLSK STKDNATNTE DNYKEKFLDM 1900
    ERELTRIKSE KANIEHHILS VETNLEVVQA EKLCLERDTE SKQKVIIDLK 1950
    EELFTVISER NRLREELDNV SKESKALDQM SKKMKEKIEE LESHQRESLR 2000
    HIGAVESEVK DKADLIQTLS FNVGELTKDK AHLQEQLQNL QNDSQELSLA 2050
    IGELEIQIGQ LNKEKESLVK ESQNFQIKLT ESECEKQTIS KALEVALKEK 2100
    GEFAVQLSSA QEEVHQLRRG IEKLSVRIEA DEKKHLSAVA KLKESQRESD 2150
    SLKDTVETLE RELERSEENQ ELAILDSENL KAEVETLKAQ KDEMTKSLRI 2200
    FELDLVTVRT ERENLAKQLQ EKQSRVSELD ERCSSLRRLL EEKEQARVQM 2250
    EEDSKSAMLM LQMQLKELRE EVAALCNDQE TLKAQEQSLD QPGEEVHHLK 2300
    SSIRKLKVHI DADEKKHQNI LEQLKESKHH ADLLKDRVEN LEQELILSEK 2350
    NMIFQAEKSK AEIQTLKSEI QRMAQNLQDL QLELISTRSE NENLIKELKK 2400
    EQERVSDLET INPSIENLLK DKEQEKVQMK EEAKITVEML QTQLKELNET 2450
    VVSLCNDQEV SKTKEQNLGS QVQTLELEKA QLLQDLGEAK NKYIIFQSSV 2500
    NALTQEVEAG KQKLEKGEKE IRTLKEQLKS QEQLVCKLAQ VEGEQELWQK 2550
    QKLELRNVTM ALEQKVQVLQ SENNTLQSTY EALQNSHKSL ESELGLIKLE 2600
    KVALVERVST ISGKEAELQR ELRDMLQKTT QLSEDYNKEK NRLTEEVEVL 2650
    REELQNTKAA HLKSVNQLEK ELQRAQGKIK LMLKSCRQLE GEKEMLQKEL 2700
    SQLEAAQQQR AGSLVDSNVD EVMTENKALK ETLEEKVKEA DKYLDKYCSL 2750
    LISHEELEKA KEILEIEVAR LKSRQSRQDL QSSPLLNSSI PGPSPNTSVS 2800
    EMKSASGQNK ASGKRQRSSG VWEHGKRAAP STAETFSKKS RKSDSKSTRP 2850
    AEHEQETEFE PEGLPEVVKK GFADIPTGKT SPYILRRTTM ATRTSPRFAT 2900
    QKLVGSSPSL GKENVVESSK PTAGGSRSQK VKVVQESSAD SHTAFQELPA 2950
    KSLTASNIPG RNSTESPREG LRAKRAYPAS SPAAGPDPTN NENCRVQ 2997
    Length:2,997
    Mass (Da):342,452
    Last modified:July 25, 2006 - v1
    Checksum:i3CB74C4F24537155
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ642022 mRNA. Translation: ABG25915.1.
    UniGeneiMm.129746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ642022 mRNA. Translation: ABG25915.1 .
    UniGenei Mm.129746.

    3D structure databases

    ProteinModelPortali Q155P7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q155P7. 12 interactions.
    STRINGi 10090.ENSMUSP00000027900.

    PTM databases

    PhosphoSitei Q155P7.

    Proteomic databases

    PaxDbi Q155P7.
    PRIDEi Q155P7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1313302. Cenpf.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000169807.
    HOVERGENi HBG050893.
    InParanoidi Q155P7.

    Miscellaneous databases

    ChiTaRSi CENPF. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q155P7.

    Family and domain databases

    InterProi IPR018302. CenpF/LEK1_Rb-prot-bd.
    IPR019513. Centromere_CenpF_leu-rich_rpt.
    IPR018463. Centromere_CenpF_N.
    [Graphical view ]
    Pfami PF10490. CENP-F_C_Rb_bdg. 1 hit.
    PF10473. CENP-F_leu_zip. 3 hits.
    PF10481. CENP-F_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway."
      Soukoulis V., Reddy S., Pooley R.D., Feng Y., Walsh C.A., Bader D.M.
      Proc. Natl. Acad. Sci. U.S.A. 102:8549-8554(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ICRImported.
    2. "CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25."
      Pooley R.D., Reddy S., Soukoulis V., Roland J.T., Goldenring J.R., Bader D.M.
      Mol. Biol. Cell 17:3176-3186(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ICRImported.

    Entry informationi

    Entry nameiQ155P7_MOUSE
    AccessioniPrimary (citable) accession number: Q155P7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)