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Q155P7

- Q155P7_MOUSE

UniProt

Q155P7 - Q155P7_MOUSE

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Protein
Submitted name:

LEK1

Gene

Cenpf

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. heart development Source: UniProtKB
  2. negative regulation of apoptotic process Source: UniProtKB
  3. positive regulation of cell cycle Source: UniProtKB
  4. positive regulation of cell proliferation Source: UniProtKB
  5. regulation of dendritic cell cytokine production Source: UniProtKB
  6. regulation of establishment of protein localization Source: UniProtKB
  7. regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  8. regulation of intracellular transport Source: UniProtKB
  9. regulation of microtubule-based process Source: UniProtKB
  10. regulation of myeloid dendritic cell activation Source: UniProtKB
  11. regulation of striated muscle tissue development Source: MGI
  12. regulation of T cell activation Source: UniProtKB
  13. regulation of T cell cytokine production Source: UniProtKB
  14. stem cell fate specification Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
LEK1Imported
Gene namesi
Name:CenpfImported
Synonyms:Lek1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1313302. Cenpf.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. chromosome, centromeric region Source: MGI
  3. cytoplasm Source: UniProtKB
  4. kinetochore Source: UniProtKB
  5. nucleus Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB
  7. pronucleus Source: MGI
  8. recycling endosome Source: UniProtKB
  9. trans-Golgi network Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ155P7.
PRIDEiQ155P7.

PTM databases

PhosphoSiteiQ155P7.

Expressioni

Gene expression databases

GenevestigatoriQ155P7.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Nde1Q9CZA68EBI-2211248,EBI-309934
RB1P064004EBI-2211248,EBI-491274From a different organism.
Rb1P134054EBI-2211248,EBI-971782
Rbl1Q647013EBI-2211248,EBI-1213109
Rbl2Q647003EBI-2211248,EBI-2271232
Snap25P6087913EBI-2211248,EBI-445270
Stx4P704529EBI-2211248,EBI-645716

Protein-protein interaction databases

IntActiQ155P7. 12 interactions.
STRINGi10090.ENSMUSP00000027900.

Structurei

3D structure databases

ProteinModelPortaliQ155P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000169807.
HOVERGENiHBG050893.

Family and domain databases

InterProiIPR018302. CenpF/LEK1_Rb-prot-bd.
IPR019513. Centromere_CenpF_leu-rich_rpt.
IPR018463. Centromere_CenpF_N.
[Graphical view]
PfamiPF10490. CENP-F_C_Rb_bdg. 1 hit.
PF10473. CENP-F_leu_zip. 3 hits.
PF10481. CENP-F_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q155P7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK
60 70 80 90 100
QKQKVEDGKT EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ
110 120 130 140 150
ESQLSSCKKQ IEKLEQELKR CKSEFERSQQ VAQSADVSLN PCSTPQKLFA
160 170 180 190 200
TPLTPSSTYE DLKEKYNKEV EERKRLEEEV KALHAKKVSL PVSQATMNHR
210 220 230 240 250
DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH FLGEEVSPNK
260 270 280 290 300
SSMKTGRGDC SSLPGEPHSA QLLHQAKAQN QDLKSKMTEL ELRLQGQEKE
310 320 330 340 350
MRSQVNKCQD LQLQLEKTKV ELIEKERILN KTRDEVVRST AQYDQAAAKC
360 370 380 390 400
TTLEQKLKTL TEELSCHRQN AESAKRSLEQ RIKEKEKELQ EELSRQHQSF
410 420 430 440 450
QALDSEYTQM KTRLTQELQQ VKHLHSTLQL ELEKVTSVKQ QLERNLEEIR
460 470 480 490 500
LKLSRAEQAL QASQVAENEL RRSSEEMKKE NSLIRSQSEQ RTREVCHLEE
510 520 530 540 550
ELGKVKVSLS KSQNFAEEMK AKNTSQEIML RDLQEKLNQQ ENSLTLEKLK
560 570 580 590 600
LALADLERQR NCSQDLLKKR EHHIDQLNNK LNKIEKEFET LLSALELKKK
610 620 630 640 650
ECEELKEEKN QISFWKIDSE KLINQIESEK EILLGKINHL ETSLKTQQVS
660 670 680 690 700
PDSNERIRTL EMERENFTVE IKNLQSMLDS KMVEIKTQKQ AYLELQQKSE
710 720 730 740 750
SSDQKHQKEI ENMCLKANKL TGQVESLECK LQLLSSEVVT KDQQYQDLRM
760 770 780 790 800
EYETLRDLLK SRGSSLVTNE DNQRSSEDNQ RSSEDNQRGS LAFEQQPAVS
810 820 830 840 850
DSFANVMGRK GSINSERSDC SVDGGRSPEH IAILQNRVTS LESSLESQNQ
860 870 880 890 900
MNSDLQMRCE ELLQIKGEVE ENLSKAEQIH QNFVAETNQC ISKLQEDAAV
910 920 930 940 950
HQNIVAETLA TLESKEKELQ LLKEKLEAQQ TEVQKLNKNN CLLEGTLKEL
960 970 980 990 1000
QLLSDTLSSE KKEMNSIISL SKKNIEELTQ ANEALKEVNE ALEQEKMNLL
1010 1020 1030 1040 1050
QKHEKITSCI AEQERSIAEL SDQYKQERLQ LLQRCEETEA VLEDLRGNYK
1060 1070 1080 1090 1100
TAQENNAKLE CMLSECTALC ENRKNELEQL KETFAKEQQE FLTKLAFAEE
1110 1120 1130 1140 1150
QNRKLMLELE IEQQTVRSEI TNTNKHSMSA TDGLRQECLT LNEEQNEQQN
1160 1170 1180 1190 1200
EVSNLTHENE QLMELTQTKH DSYLAVEPVE NSVKATEDEI GKSSSQYQMD
1210 1220 1230 1240 1250
IDTKDISLDS YKAQLVHLEA LVRILEVQLD QSEEENKKLH LELQTIREEL
1260 1270 1280 1290 1300
ETKSSQDPQS QARTGLKDCD TAEEKYVSML QELSASQNEN AHLQCSLQTA
1310 1320 1330 1340 1350
VNKLNELGKM CDVLRVEKLQ LESELNDSRT ECITATSQMT AEVEKLVSEM
1360 1370 1380 1390 1400
KMLNHESALS QNELMKDTSG GEFHDKANHS SVFLTPLDSS NFCEQMTLSS
1410 1420 1430 1440 1450
KEVRVHFAEL QEKFSCLQSE HKILHDQHCE VSSKMSALRS YVDTLKAENS
1460 1470 1480 1490 1500
ALSMSLRTLQ GDLVKEGEPA AEGGHGLPLS FCGADSPSLT NFGETSFYKD
1510 1520 1530 1540 1550
VLEQTGDTCH LSLEGNASAN SCDLDEEFSS SLEEETLTEK ESPPAPGRTV
1560 1570 1580 1590 1600
EGLEVLCQVY LQSLKNLEEK TESQRIMKNK EIEELEQLLS SERKELSCLR
1610 1620 1630 1640 1650
KQYLSEKEQW QQKLTSVTLE MESKLAEEKQ QTKTLSLELE VARLQLQELD
1660 1670 1680 1690 1700
LSSRSLLGTD LESVVRCQND NYDIKESEVY ISETTEKTPK QDTDQTCDKD
1710 1720 1730 1740 1750
IQQDLGLETS VTESETTRLT GEGCEEQPPK TNCEAPAEDK TQDCSECISE
1760 1770 1780 1790 1800
LCSSSNVLVP MDVLEDQGSI QNLQLQKDTL NENLRLLPEV EDWDKKVESL
1810 1820 1830 1840 1850
LNEIMEADSK LSLQEVQLKM KIATCIQLEK IVKDLRKEKA DLSEKLESLP
1860 1870 1880 1890 1900
CNQEVCLRVE RSEEDLGFNL DMGANELLSK STKDNATNTE DNYKEKFLDM
1910 1920 1930 1940 1950
ERELTRIKSE KANIEHHILS VETNLEVVQA EKLCLERDTE SKQKVIIDLK
1960 1970 1980 1990 2000
EELFTVISER NRLREELDNV SKESKALDQM SKKMKEKIEE LESHQRESLR
2010 2020 2030 2040 2050
HIGAVESEVK DKADLIQTLS FNVGELTKDK AHLQEQLQNL QNDSQELSLA
2060 2070 2080 2090 2100
IGELEIQIGQ LNKEKESLVK ESQNFQIKLT ESECEKQTIS KALEVALKEK
2110 2120 2130 2140 2150
GEFAVQLSSA QEEVHQLRRG IEKLSVRIEA DEKKHLSAVA KLKESQRESD
2160 2170 2180 2190 2200
SLKDTVETLE RELERSEENQ ELAILDSENL KAEVETLKAQ KDEMTKSLRI
2210 2220 2230 2240 2250
FELDLVTVRT ERENLAKQLQ EKQSRVSELD ERCSSLRRLL EEKEQARVQM
2260 2270 2280 2290 2300
EEDSKSAMLM LQMQLKELRE EVAALCNDQE TLKAQEQSLD QPGEEVHHLK
2310 2320 2330 2340 2350
SSIRKLKVHI DADEKKHQNI LEQLKESKHH ADLLKDRVEN LEQELILSEK
2360 2370 2380 2390 2400
NMIFQAEKSK AEIQTLKSEI QRMAQNLQDL QLELISTRSE NENLIKELKK
2410 2420 2430 2440 2450
EQERVSDLET INPSIENLLK DKEQEKVQMK EEAKITVEML QTQLKELNET
2460 2470 2480 2490 2500
VVSLCNDQEV SKTKEQNLGS QVQTLELEKA QLLQDLGEAK NKYIIFQSSV
2510 2520 2530 2540 2550
NALTQEVEAG KQKLEKGEKE IRTLKEQLKS QEQLVCKLAQ VEGEQELWQK
2560 2570 2580 2590 2600
QKLELRNVTM ALEQKVQVLQ SENNTLQSTY EALQNSHKSL ESELGLIKLE
2610 2620 2630 2640 2650
KVALVERVST ISGKEAELQR ELRDMLQKTT QLSEDYNKEK NRLTEEVEVL
2660 2670 2680 2690 2700
REELQNTKAA HLKSVNQLEK ELQRAQGKIK LMLKSCRQLE GEKEMLQKEL
2710 2720 2730 2740 2750
SQLEAAQQQR AGSLVDSNVD EVMTENKALK ETLEEKVKEA DKYLDKYCSL
2760 2770 2780 2790 2800
LISHEELEKA KEILEIEVAR LKSRQSRQDL QSSPLLNSSI PGPSPNTSVS
2810 2820 2830 2840 2850
EMKSASGQNK ASGKRQRSSG VWEHGKRAAP STAETFSKKS RKSDSKSTRP
2860 2870 2880 2890 2900
AEHEQETEFE PEGLPEVVKK GFADIPTGKT SPYILRRTTM ATRTSPRFAT
2910 2920 2930 2940 2950
QKLVGSSPSL GKENVVESSK PTAGGSRSQK VKVVQESSAD SHTAFQELPA
2960 2970 2980 2990
KSLTASNIPG RNSTESPREG LRAKRAYPAS SPAAGPDPTN NENCRVQ
Length:2,997
Mass (Da):342,452
Last modified:July 25, 2006 - v1
Checksum:i3CB74C4F24537155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ642022 mRNA. Translation: ABG25915.1.
UniGeneiMm.129746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ642022 mRNA. Translation: ABG25915.1 .
UniGenei Mm.129746.

3D structure databases

ProteinModelPortali Q155P7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q155P7. 12 interactions.
STRINGi 10090.ENSMUSP00000027900.

PTM databases

PhosphoSitei Q155P7.

Proteomic databases

PaxDbi Q155P7.
PRIDEi Q155P7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1313302. Cenpf.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000169807.
HOVERGENi HBG050893.

Miscellaneous databases

ChiTaRSi Cenpf. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q155P7.

Family and domain databases

InterProi IPR018302. CenpF/LEK1_Rb-prot-bd.
IPR019513. Centromere_CenpF_leu-rich_rpt.
IPR018463. Centromere_CenpF_N.
[Graphical view ]
Pfami PF10490. CENP-F_C_Rb_bdg. 1 hit.
PF10473. CENP-F_leu_zip. 3 hits.
PF10481. CENP-F_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway."
    Soukoulis V., Reddy S., Pooley R.D., Feng Y., Walsh C.A., Bader D.M.
    Proc. Natl. Acad. Sci. U.S.A. 102:8549-8554(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRImported.
  2. "CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25."
    Pooley R.D., Reddy S., Soukoulis V., Roland J.T., Goldenring J.R., Bader D.M.
    Mol. Biol. Cell 17:3176-3186(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRImported.

Entry informationi

Entry nameiQ155P7_MOUSE
AccessioniPrimary (citable) accession number: Q155P7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)