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Q155P7 (Q155P7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Cenpf MGI 1313302
Synonyms:Lek1 EMBL ABG25915.1
OrganismMus musculus (Mouse) EMBL ABG25915.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2997 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Gene Ontology (GO)
   Biological_processheart development

Inferred from mutant phenotype PubMed 15861132. Source: UniProtKB

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 14555653. Source: UniProtKB

positive regulation of cell cycle

Inferred from mutant phenotype PubMed 14555653. Source: UniProtKB

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 14555653. Source: UniProtKB

regulation of G2/M transition of mitotic cell cycle

Inferred from direct assay PubMed 17498689. Source: UniProtKB

regulation of T cell activation

Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB

regulation of T cell cytokine production

Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB

regulation of dendritic cell cytokine production

Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB

regulation of establishment of protein localization

Inferred from mutant phenotype PubMed 17498689. Source: UniProtKB

regulation of intracellular transport

Inferred from direct assay PubMed 18827011. Source: UniProtKB

regulation of microtubule-based process

Inferred from mutant phenotype Ref.1. Source: UniProtKB

regulation of myeloid dendritic cell activation

Inferred from mutant phenotype PubMed 18768859. Source: UniProtKB

regulation of striated muscle tissue development

Inferred from direct assay PubMed 10373470. Source: MGI

stem cell fate specification

Inferred from mutant phenotype PubMed 15861132. Source: UniProtKB

   Cellular_componentcentrosome

Inferred from direct assay Ref.2. Source: UniProtKB

chromosome, centromeric region

Inferred from sequence orthology PubMed 11084331. Source: MGI

cytoplasm

Inferred from mutant phenotype PubMed 17498689. Source: UniProtKB

kinetochore

Inferred from direct assay PubMed 12974617. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 17498689. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from direct assay PubMed 18827011. Source: UniProtKB

pronucleus

Inferred from direct assay PubMed 10373470. Source: MGI

recycling endosome

Inferred from direct assay Ref.2. Source: UniProtKB

trans-Golgi network

Inferred from direct assay PubMed 18827011. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 14555653Ref.1PubMed 18827011. Source: UniProtKB

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q155P7 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 3CB74C4F24537155

FASTA2,997342,452
        10         20         30         40         50         60 
MSWALEEWKE GLPSRALQKI QELEGQLEKL KKEKQQRQFQ LDSLEAALQK QKQKVEDGKT 

        70         80         90        100        110        120 
EGADLKRENQ RLMEICEHLE KSRQKLSHEL QVKESQVNLQ ESQLSSCKKQ IEKLEQELKR 

       130        140        150        160        170        180 
CKSEFERSQQ VAQSADVSLN PCSTPQKLFA TPLTPSSTYE DLKEKYNKEV EERKRLEEEV 

       190        200        210        220        230        240 
KALHAKKVSL PVSQATMNHR DIARHQASSS VFPWQQENTP SRLSSDALKT PLRRDGSAAH 

       250        260        270        280        290        300 
FLGEEVSPNK SSMKTGRGDC SSLPGEPHSA QLLHQAKAQN QDLKSKMTEL ELRLQGQEKE 

       310        320        330        340        350        360 
MRSQVNKCQD LQLQLEKTKV ELIEKERILN KTRDEVVRST AQYDQAAAKC TTLEQKLKTL 

       370        380        390        400        410        420 
TEELSCHRQN AESAKRSLEQ RIKEKEKELQ EELSRQHQSF QALDSEYTQM KTRLTQELQQ 

       430        440        450        460        470        480 
VKHLHSTLQL ELEKVTSVKQ QLERNLEEIR LKLSRAEQAL QASQVAENEL RRSSEEMKKE 

       490        500        510        520        530        540 
NSLIRSQSEQ RTREVCHLEE ELGKVKVSLS KSQNFAEEMK AKNTSQEIML RDLQEKLNQQ 

       550        560        570        580        590        600 
ENSLTLEKLK LALADLERQR NCSQDLLKKR EHHIDQLNNK LNKIEKEFET LLSALELKKK 

       610        620        630        640        650        660 
ECEELKEEKN QISFWKIDSE KLINQIESEK EILLGKINHL ETSLKTQQVS PDSNERIRTL 

       670        680        690        700        710        720 
EMERENFTVE IKNLQSMLDS KMVEIKTQKQ AYLELQQKSE SSDQKHQKEI ENMCLKANKL 

       730        740        750        760        770        780 
TGQVESLECK LQLLSSEVVT KDQQYQDLRM EYETLRDLLK SRGSSLVTNE DNQRSSEDNQ 

       790        800        810        820        830        840 
RSSEDNQRGS LAFEQQPAVS DSFANVMGRK GSINSERSDC SVDGGRSPEH IAILQNRVTS 

       850        860        870        880        890        900 
LESSLESQNQ MNSDLQMRCE ELLQIKGEVE ENLSKAEQIH QNFVAETNQC ISKLQEDAAV 

       910        920        930        940        950        960 
HQNIVAETLA TLESKEKELQ LLKEKLEAQQ TEVQKLNKNN CLLEGTLKEL QLLSDTLSSE 

       970        980        990       1000       1010       1020 
KKEMNSIISL SKKNIEELTQ ANEALKEVNE ALEQEKMNLL QKHEKITSCI AEQERSIAEL 

      1030       1040       1050       1060       1070       1080 
SDQYKQERLQ LLQRCEETEA VLEDLRGNYK TAQENNAKLE CMLSECTALC ENRKNELEQL 

      1090       1100       1110       1120       1130       1140 
KETFAKEQQE FLTKLAFAEE QNRKLMLELE IEQQTVRSEI TNTNKHSMSA TDGLRQECLT 

      1150       1160       1170       1180       1190       1200 
LNEEQNEQQN EVSNLTHENE QLMELTQTKH DSYLAVEPVE NSVKATEDEI GKSSSQYQMD 

      1210       1220       1230       1240       1250       1260 
IDTKDISLDS YKAQLVHLEA LVRILEVQLD QSEEENKKLH LELQTIREEL ETKSSQDPQS 

      1270       1280       1290       1300       1310       1320 
QARTGLKDCD TAEEKYVSML QELSASQNEN AHLQCSLQTA VNKLNELGKM CDVLRVEKLQ 

      1330       1340       1350       1360       1370       1380 
LESELNDSRT ECITATSQMT AEVEKLVSEM KMLNHESALS QNELMKDTSG GEFHDKANHS 

      1390       1400       1410       1420       1430       1440 
SVFLTPLDSS NFCEQMTLSS KEVRVHFAEL QEKFSCLQSE HKILHDQHCE VSSKMSALRS 

      1450       1460       1470       1480       1490       1500 
YVDTLKAENS ALSMSLRTLQ GDLVKEGEPA AEGGHGLPLS FCGADSPSLT NFGETSFYKD 

      1510       1520       1530       1540       1550       1560 
VLEQTGDTCH LSLEGNASAN SCDLDEEFSS SLEEETLTEK ESPPAPGRTV EGLEVLCQVY 

      1570       1580       1590       1600       1610       1620 
LQSLKNLEEK TESQRIMKNK EIEELEQLLS SERKELSCLR KQYLSEKEQW QQKLTSVTLE 

      1630       1640       1650       1660       1670       1680 
MESKLAEEKQ QTKTLSLELE VARLQLQELD LSSRSLLGTD LESVVRCQND NYDIKESEVY 

      1690       1700       1710       1720       1730       1740 
ISETTEKTPK QDTDQTCDKD IQQDLGLETS VTESETTRLT GEGCEEQPPK TNCEAPAEDK 

      1750       1760       1770       1780       1790       1800 
TQDCSECISE LCSSSNVLVP MDVLEDQGSI QNLQLQKDTL NENLRLLPEV EDWDKKVESL 

      1810       1820       1830       1840       1850       1860 
LNEIMEADSK LSLQEVQLKM KIATCIQLEK IVKDLRKEKA DLSEKLESLP CNQEVCLRVE 

      1870       1880       1890       1900       1910       1920 
RSEEDLGFNL DMGANELLSK STKDNATNTE DNYKEKFLDM ERELTRIKSE KANIEHHILS 

      1930       1940       1950       1960       1970       1980 
VETNLEVVQA EKLCLERDTE SKQKVIIDLK EELFTVISER NRLREELDNV SKESKALDQM 

      1990       2000       2010       2020       2030       2040 
SKKMKEKIEE LESHQRESLR HIGAVESEVK DKADLIQTLS FNVGELTKDK AHLQEQLQNL 

      2050       2060       2070       2080       2090       2100 
QNDSQELSLA IGELEIQIGQ LNKEKESLVK ESQNFQIKLT ESECEKQTIS KALEVALKEK 

      2110       2120       2130       2140       2150       2160 
GEFAVQLSSA QEEVHQLRRG IEKLSVRIEA DEKKHLSAVA KLKESQRESD SLKDTVETLE 

      2170       2180       2190       2200       2210       2220 
RELERSEENQ ELAILDSENL KAEVETLKAQ KDEMTKSLRI FELDLVTVRT ERENLAKQLQ 

      2230       2240       2250       2260       2270       2280 
EKQSRVSELD ERCSSLRRLL EEKEQARVQM EEDSKSAMLM LQMQLKELRE EVAALCNDQE 

      2290       2300       2310       2320       2330       2340 
TLKAQEQSLD QPGEEVHHLK SSIRKLKVHI DADEKKHQNI LEQLKESKHH ADLLKDRVEN 

      2350       2360       2370       2380       2390       2400 
LEQELILSEK NMIFQAEKSK AEIQTLKSEI QRMAQNLQDL QLELISTRSE NENLIKELKK 

      2410       2420       2430       2440       2450       2460 
EQERVSDLET INPSIENLLK DKEQEKVQMK EEAKITVEML QTQLKELNET VVSLCNDQEV 

      2470       2480       2490       2500       2510       2520 
SKTKEQNLGS QVQTLELEKA QLLQDLGEAK NKYIIFQSSV NALTQEVEAG KQKLEKGEKE 

      2530       2540       2550       2560       2570       2580 
IRTLKEQLKS QEQLVCKLAQ VEGEQELWQK QKLELRNVTM ALEQKVQVLQ SENNTLQSTY 

      2590       2600       2610       2620       2630       2640 
EALQNSHKSL ESELGLIKLE KVALVERVST ISGKEAELQR ELRDMLQKTT QLSEDYNKEK 

      2650       2660       2670       2680       2690       2700 
NRLTEEVEVL REELQNTKAA HLKSVNQLEK ELQRAQGKIK LMLKSCRQLE GEKEMLQKEL 

      2710       2720       2730       2740       2750       2760 
SQLEAAQQQR AGSLVDSNVD EVMTENKALK ETLEEKVKEA DKYLDKYCSL LISHEELEKA 

      2770       2780       2790       2800       2810       2820 
KEILEIEVAR LKSRQSRQDL QSSPLLNSSI PGPSPNTSVS EMKSASGQNK ASGKRQRSSG 

      2830       2840       2850       2860       2870       2880 
VWEHGKRAAP STAETFSKKS RKSDSKSTRP AEHEQETEFE PEGLPEVVKK GFADIPTGKT 

      2890       2900       2910       2920       2930       2940 
SPYILRRTTM ATRTSPRFAT QKLVGSSPSL GKENVVESSK PTAGGSRSQK VKVVQESSAD 

      2950       2960       2970       2980       2990 
SHTAFQELPA KSLTASNIPG RNSTESPREG LRAKRAYPAS SPAAGPDPTN NENCRVQ 

« Hide

References

[1]"Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway."
Soukoulis V., Reddy S., Pooley R.D., Feng Y., Walsh C.A., Bader D.M.
Proc. Natl. Acad. Sci. U.S.A. 102:8549-8554(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ICR EMBL ABG25915.1.
[2]"CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25."
Pooley R.D., Reddy S., Soukoulis V., Roland J.T., Goldenring J.R., Bader D.M.
Mol. Biol. Cell 17:3176-3186(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ICR EMBL ABG25915.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ642022 mRNA. Translation: ABG25915.1.
UniGeneMm.129746.

3D structure databases

ProteinModelPortalQ155P7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ155P7. 12 interactions.
STRING10090.ENSMUSP00000027900.

PTM databases

PhosphoSiteQ155P7.

Proteomic databases

PaxDbQ155P7.
PRIDEQ155P7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1313302. Cenpf.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000169807.
HOVERGENHBG050893.
InParanoidQ155P7.

Gene expression databases

GenevestigatorQ155P7.

Family and domain databases

InterProIPR018302. CenpF/LEK1_Rb-prot-bd.
IPR019513. Centromere_CenpF_leu-rich_rpt.
IPR018463. Centromere_CenpF_N.
[Graphical view]
PfamPF10490. CENP-F_C_Rb_bdg. 1 hit.
PF10473. CENP-F_leu_zip. 3 hits.
PF10481. CENP-F_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCENPF. mouse.
SOURCESearch...

Entry information

Entry nameQ155P7_MOUSE
AccessionPrimary (citable) accession number: Q155P7
Entry history
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)