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Q15599

- NHRF2_HUMAN

UniProt

Q15599 - NHRF2_HUMAN

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Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Gene

SLC9A3R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.2 Publications

GO - Molecular functioni

  1. beta-catenin binding Source: UniProtKB
  2. phosphatase binding Source: UniProtKB
  3. protein C-terminus binding Source: UniProtKB
  4. receptor binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  2. protein complex assembly Source: ProtInc
Complete GO annotation...

Protein family/group databases

TCDBi8.A.24.1.2. the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Short name:
NHERF-2
Alternative name(s):
NHE3 kinase A regulatory protein E3KARP
SRY-interacting protein 1
Short name:
SIP-1
Sodium-hydrogen exchanger regulatory factor 2
Solute carrier family 9 isoform A3 regulatory factor 2
Tyrosine kinase activator protein 1
Short name:
TKA-1
Gene namesi
Name:SLC9A3R2
Synonyms:NHERF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11076. SLC9A3R2.

Subcellular locationi

Endomembrane system 1 Publication; Peripheral membrane protein 1 Publication. Nucleus 1 Publication. Apical cell membrane By similarity
Note: Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern.By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular vesicular exosome Source: UniProtKB
  4. focal adhesion Source: UniProtKB
  5. nucleus Source: ProtInc
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Na(+)/H(+) exchange regulatory cofactor NHE-RF2PRO_0000096805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphoserine1 Publication
Modified residuei254 – 2541Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15599.
PaxDbiQ15599.
PRIDEiQ15599.

PTM databases

PhosphoSiteiQ15599.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiQ15599.
CleanExiHS_SLC9A3R2.
ExpressionAtlasiQ15599. baseline and differential.
GenevestigatoriQ15599.

Organism-specific databases

HPAiHPA001672.

Interactioni

Subunit structurei

Homodimer, and heterodimer with SLC9A3R1. Binds PDZK1. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts (via the PDZ domains) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells (By similarity). Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2. Interacts with MCC and PODXL. Interacts with SGK1 and KCNJ1/ROMK1. Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5.By similarity10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CFTRP135697EBI-1149760,EBI-349854
LPAR2Q9HBW03EBI-1149760,EBI-765995
mGluR1aQ9R0W02EBI-1149760,EBI-8505383From a different organism.
PTENP604845EBI-1149760,EBI-696162
SLC26A3P408795EBI-1149760,EBI-8542350

Protein-protein interaction databases

BioGridi114754. 42 interactions.
DIPiDIP-29093N.
IntActiQ15599. 20 interactions.
MINTiMINT-126664.
STRINGi9606.ENSP00000408005.

Structurei

Secondary structure

1
337
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 156Combined sources
Beta strandi23 – 275Combined sources
Beta strandi34 – 396Combined sources
Helixi44 – 474Combined sources
Beta strandi55 – 595Combined sources
Helixi69 – 7810Combined sources
Beta strandi82 – 887Combined sources
Beta strandi150 – 1556Combined sources
Beta strandi163 – 1675Combined sources
Beta strandi169 – 17911Combined sources
Helixi184 – 1885Combined sources
Beta strandi195 – 1995Combined sources
Helixi209 – 2168Combined sources
Beta strandi219 – 22810Combined sources
Helixi327 – 33610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D11X-ray2.81E/F/G/H310-337[»]
2HE4X-ray1.45A147-228[»]
2OCSX-ray1.50A9-91[»]
4P0CX-ray1.34A9-90[»]
ProteinModelPortaliQ15599.
SMRiQ15599. Positions 9-91, 143-337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15599.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9080PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini150 – 23081PDZ 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG319972.
GeneTreeiENSGT00530000062999.
HOGENOMiHOG000089940.
HOVERGENiHBG052616.
InParanoidiQ15599.
KOiK13358.
OMAiRGEHGYG.
PhylomeDBiQ15599.
TreeFamiTF350449.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR015098. EBP50_C-term.
IPR017300. NaH_exchngr_reg_CF_NHE-RF.
IPR001478. PDZ.
[Graphical view]
PfamiPF09007. EBP50_C-term. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiPD283022. EBP50_C-term. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15599-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL
60 70 80 90 100
RAGDRLVEVN GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ
110 120 130 140 150
LTCTEEMAQR GLPPAHDPWE PKPDWAHTGS HSSEAGKKDV SGPLRELRPR
160 170 180 190 200
LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD PGSPAARSGL RAQDRLIEVN
210 220 230 240 250
GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR VTPTEEHVEG
260 270 280 290 300
PLPSPVTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KQDPFQESGL
310 320 330
HLSPTAAEAK EKARAMRVNK RAPQMDWNRK REIFSNF
Length:337
Mass (Da):37,414
Last modified:February 16, 2004 - v2
Checksum:i4F5D341590D22ED7
GO
Isoform 2 (identifier: Q15599-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-296: Missing.

Show »
Length:326
Mass (Da):36,153
Checksum:i59EB725D61D896DC
GO
Isoform 3 (identifier: Q15599-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAAPEPLRPRLCRLVRGEQGYGFHLHG → MARSGSATPPARAPGAPPRSPPQRLVQ
     28-138: Missing.

Note: No experimental confirmation available.

Show »
Length:226
Mass (Da):24,718
Checksum:i51D77F534CB2328A
GO

Sequence cautioni

The sequence AAH14513.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA90511.1 differs from that shown. Reason: Frameshift at position 309. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511Missing in CAA90511. (PubMed:9314537)Curated
Sequence conflicti180 – 1801D → Y in BM920873. (PubMed:15489334)Curated
Sequence conflicti334 – 3363FSN → LQH in BM920873. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MAAPE…FHLHG → MARSGSATPPARAPGAPPRS PPQRLVQ in isoform 3. 1 PublicationVSP_046849Add
BLAST
Alternative sequencei28 – 138111Missing in isoform 3. 1 PublicationVSP_046850Add
BLAST
Alternative sequencei286 – 29611Missing in isoform 2. 1 PublicationVSP_009378Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82108 mRNA. Translation: AAB53042.1.
Z50150 mRNA. Translation: CAA90511.1. Frameshift.
AF004900 mRNA. Translation: AAC63061.1.
AF035771 mRNA. Translation: AAC52090.1.
AB014460 Genomic DNA. Translation: BAA32696.1.
AB016243 Genomic DNA. Translation: BAA33216.1.
AC005600 Genomic DNA. Translation: AAC34208.1.
AC093513 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85563.1.
CH471112 Genomic DNA. Translation: EAW85564.1.
CH471112 Genomic DNA. Translation: EAW85565.1.
CH471112 Genomic DNA. Translation: EAW85566.1.
BC014513 mRNA. Translation: AAH14513.2. Different initiation.
BC106001 mRNA. Translation: AAI06002.1.
BM920873 mRNA. No translation available.
CCDSiCCDS45382.1. [Q15599-1]
CCDS45383.1. [Q15599-2]
CCDS58407.1. [Q15599-3]
PIRiG01158.
RefSeqiNP_001123484.1. NM_001130012.2. [Q15599-1]
NP_001239002.1. NM_001252073.1. [Q15599-3]
NP_004776.3. NM_004785.5. [Q15599-2]
UniGeneiHs.440896.

Genome annotation databases

EnsembliENST00000424542; ENSP00000408005; ENSG00000065054. [Q15599-1]
ENST00000432365; ENSP00000402857; ENSG00000065054. [Q15599-2]
ENST00000566198; ENSP00000456895; ENSG00000065054. [Q15599-3]
GeneIDi9351.
KEGGihsa:9351.
UCSCiuc002coi.3. human. [Q15599-1]
uc002coj.3. human.

Polymorphism databases

DMDMi42559433.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82108 mRNA. Translation: AAB53042.1 .
Z50150 mRNA. Translation: CAA90511.1 . Frameshift.
AF004900 mRNA. Translation: AAC63061.1 .
AF035771 mRNA. Translation: AAC52090.1 .
AB014460 Genomic DNA. Translation: BAA32696.1 .
AB016243 Genomic DNA. Translation: BAA33216.1 .
AC005600 Genomic DNA. Translation: AAC34208.1 .
AC093513 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85563.1 .
CH471112 Genomic DNA. Translation: EAW85564.1 .
CH471112 Genomic DNA. Translation: EAW85565.1 .
CH471112 Genomic DNA. Translation: EAW85566.1 .
BC014513 mRNA. Translation: AAH14513.2 . Different initiation.
BC106001 mRNA. Translation: AAI06002.1 .
BM920873 mRNA. No translation available.
CCDSi CCDS45382.1. [Q15599-1 ]
CCDS45383.1. [Q15599-2 ]
CCDS58407.1. [Q15599-3 ]
PIRi G01158.
RefSeqi NP_001123484.1. NM_001130012.2. [Q15599-1 ]
NP_001239002.1. NM_001252073.1. [Q15599-3 ]
NP_004776.3. NM_004785.5. [Q15599-2 ]
UniGenei Hs.440896.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D11 X-ray 2.81 E/F/G/H 310-337 [» ]
2HE4 X-ray 1.45 A 147-228 [» ]
2OCS X-ray 1.50 A 9-91 [» ]
4P0C X-ray 1.34 A 9-90 [» ]
ProteinModelPortali Q15599.
SMRi Q15599. Positions 9-91, 143-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114754. 42 interactions.
DIPi DIP-29093N.
IntActi Q15599. 20 interactions.
MINTi MINT-126664.
STRINGi 9606.ENSP00000408005.

Protein family/group databases

TCDBi 8.A.24.1.2. the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family.

PTM databases

PhosphoSitei Q15599.

Polymorphism databases

DMDMi 42559433.

Proteomic databases

MaxQBi Q15599.
PaxDbi Q15599.
PRIDEi Q15599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000424542 ; ENSP00000408005 ; ENSG00000065054 . [Q15599-1 ]
ENST00000432365 ; ENSP00000402857 ; ENSG00000065054 . [Q15599-2 ]
ENST00000566198 ; ENSP00000456895 ; ENSG00000065054 . [Q15599-3 ]
GeneIDi 9351.
KEGGi hsa:9351.
UCSCi uc002coi.3. human. [Q15599-1 ]
uc002coj.3. human.

Organism-specific databases

CTDi 9351.
GeneCardsi GC16P002075.
HGNCi HGNC:11076. SLC9A3R2.
HPAi HPA001672.
MIMi 606553. gene.
neXtProti NX_Q15599.
PharmGKBi PA35932.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319972.
GeneTreei ENSGT00530000062999.
HOGENOMi HOG000089940.
HOVERGENi HBG052616.
InParanoidi Q15599.
KOi K13358.
OMAi RGEHGYG.
PhylomeDBi Q15599.
TreeFami TF350449.

Miscellaneous databases

EvolutionaryTracei Q15599.
GenomeRNAii 9351.
NextBioi 35017.
PROi Q15599.
SOURCEi Search...

Gene expression databases

Bgeei Q15599.
CleanExi HS_SLC9A3R2.
ExpressionAtlasi Q15599. baseline and differential.
Genevestigatori Q15599.

Family and domain databases

Gene3Di 2.30.42.10. 2 hits.
InterProi IPR015098. EBP50_C-term.
IPR017300. NaH_exchngr_reg_CF_NHE-RF.
IPR001478. PDZ.
[Graphical view ]
Pfami PF09007. EBP50_C-term. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view ]
PIRSFi PIRSF037866. EBP50. 1 hit.
ProDomi PD283022. EBP50_C-term. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00228. PDZ. 2 hits.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 2 hits.
PROSITEi PS50106. PDZ. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains."
    Poulat F., de Santa Barbara P., Desclozeaux M., Soullier S., Moniot B., Bonneaud N., Boizet B., Berta P.
    J. Biol. Chem. 272:7167-7172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH SRY, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Cervix carcinoma, Fetal brain and Testis.
  2. "Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family."
    Reczek D., Berryman M., Bretscher A.
    J. Cell Biol. 139:169-179(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein."
    Yun C.H.C., Oh S., Zizak M., Steplock D., Tsao S., Tse C.-M., Weinman E.J., Donowitz M.
    Proc. Natl. Acad. Sci. U.S.A. 94:3010-3015(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH SLC9A3, TISSUE SPECIFICITY.
    Tissue: Embryo.
  4. "Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes."
    Imai K., Sarker A.H., Akiyama K., Ikeda S., Yao M., Tsutsui K., Shohmori T., Seki S.
    Gene 222:287-295(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins."
    Hall R.A., Ostedgaard L.S., Premont R.T., Blitzer J.T., Rahman N., Welsh M.J., Lefkowitz R.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:8496-8501(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ADRB2; P2RY1 AND P2YR2.
    Tissue: Lung.
  6. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Kidney and Testis.
  9. "cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor."
    Zizak M., Lamprecht G., Steplock D., Tariq N., Shenolikar S., Donowitz M., Yun C.H.C., Weinman E.J.
    J. Biol. Chem. 274:24753-24758(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLC9A3.
  10. "Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains."
    Lohi H., Lamprecht G., Markovich D., Heil A., Kujala M., Seidler U., Kere J.
    Am. J. Physiol. 284:C769-C779(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLC26A6.
  11. "Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1."
    Palmada M., Embark H.M., Yun C., Bohmer C., Lang F.
    Biochem. Biophys. Res. Commun. 311:629-634(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SGK1 AND KCNJ1/ROMK1.
  12. "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation."
    Oh Y.-S., Jo N.W., Choi J.W., Kim H.S., Seo S.-W., Kang K.-O., Hwang J.-I., Heo K., Kim S.-H., Kim Y.-H., Kim I.-H., Kim J.H., Banno Y., Ryu S.H., Suh P.-G.
    Mol. Cell. Biol. 24:5069-5079(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LPAR2.
  13. "Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells."
    Meder D., Shevchenko A., Simons K., Fuellekrug J.
    J. Cell Biol. 168:303-313(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PODXL.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-254, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells."
    Arnaud C., Sebbagh M., Nola S., Audebert S., Bidaut G., Hermant A., Gayet O., Dusetti N.J., Ollendorff V., Santoni M.J., Borg J.P., Lecine P.
    FEBS Lett. 583:2326-2332(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MCC.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Structural basis for NHERF recognition by ERM proteins."
    Terawaki S., Maesaki R., Hakoshima T.
    Structure 14:777-789(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 310-337 IN COMPLEX WITH RDX.
  18. "The crystal structure of the first and second PDZ domain of human NHERF-2 (SLC9A3R2) interacting with a mode 1 PDZ binding motif."
    Structural genomics consortium (SGC)
    Submitted (JAN-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 9-232.

Entry informationi

Entry nameiNHRF2_HUMAN
AccessioniPrimary (citable) accession number: Q15599
Secondary accession number(s): D3DU84
, D3DU85, H3BSV6, O00272, O00556, Q3KQY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 26, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3