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Protein

Nuclear receptor coactivator 2

Gene

NCOA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140396-MONOMER.
ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-159418. Recycling of bile acids and salts.
R-HSA-192105. Synthesis of bile acids and bile salts.
R-HSA-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-HSA-193807. Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
R-HSA-211976. Endogenous sterols.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
R-HSA-3214847. HATs acetylate histones.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-400253. Circadian Clock.
R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
SignaLinkiQ15596.
SIGNORiQ15596.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 2
Short name:
NCoA-2
Alternative name(s):
Class E basic helix-loop-helix protein 75
Short name:
bHLHe75
Transcriptional intermediary factor 2
Short name:
hTIF2
Gene namesi
Name:NCOA2
Synonyms:BHLHE75, SRC2, TIF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7669. NCOA2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi644 – 645LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 693-A-A-694 and 748-A-A-749. 1 Publication2
Mutagenesisi693 – 694LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 748-A-A-749. 1 Publication2
Mutagenesisi748 – 749LL → AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 693-A-A-694. 1 Publication2
Mutagenesisi1079 – 1083LLDQL → AADQA: Reduces transcriptional coactivation and disrupts interaction with CREBBP/CBP. 1 Publication5
Mutagenesisi1081 – 1082DQ → AA: Has little effect on transcriptional coactivation. 1 Publication2

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei869 – 870Breakpoint for translocation to form KAT6A-NCOA23 Publications2

Organism-specific databases

DisGeNETi10499.
OpenTargetsiENSG00000140396.
PharmGKBiPA31471.

Polymorphism and mutation databases

BioMutaiNCOA2.
DMDMi13626594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000944022 – 1464Nuclear receptor coactivator 2Add BLAST1463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei338Asymmetric dimethylarginineBy similarity1
Modified residuei487PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei636N6-acetyllysineBy similarity1
Modified residuei640N6-acetyllysineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei771PhosphoserineCombined sources1
Modified residuei780N6-acetyllysineCombined sources1
Modified residuei785N6-acetyllysine; alternateCombined sources1
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei864Asymmetric dimethylarginineBy similarity1
Modified residuei874Asymmetric dimethylarginineBy similarity1
Modified residuei1173Asymmetric dimethylarginineCombined sources1
Modified residuei1177Asymmetric dimethylarginineCombined sources1
Modified residuei1190Asymmetric dimethylarginineCombined sources1
Modified residuei1196Asymmetric dimethylarginineCombined sources1
Modified residuei1203Asymmetric dimethylarginineCombined sources1
Modified residuei1221Asymmetric dimethylarginineCombined sources1
Modified residuei1240Asymmetric dimethylarginineBy similarity1
Modified residuei1261Omega-N-methylarginineCombined sources1
Modified residuei1266Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15596.
MaxQBiQ15596.
PaxDbiQ15596.
PeptideAtlasiQ15596.
PRIDEiQ15596.

PTM databases

iPTMnetiQ15596.
PhosphoSitePlusiQ15596.

Expressioni

Gene expression databases

BgeeiENSG00000140396.
CleanExiHS_NCOA2.
ExpressionAtlasiQ15596. baseline and differential.
GenevisibleiQ15596. HS.

Organism-specific databases

HPAiHPA060243.

Interactioni

Subunit structurei

Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity).By similarity9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-81236,EBI-608057
DDX17Q928412EBI-81236,EBI-746012
ESR1P033728EBI-81236,EBI-78473

GO - Molecular functioni

  • ligand-dependent nuclear receptor binding Source: UniProtKB
  • nuclear hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115761. 72 interactors.
DIPiDIP-5997N.
IntActiQ15596. 19 interactors.
MINTiMINT-122867.
STRINGi9606.ENSP00000399968.

Chemistry databases

BindingDBiQ15596.

Structurei

Secondary structure

11464
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi689 – 693Combined sources5
Beta strandi739 – 741Combined sources3
Helixi743 – 750Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWQX-ray2.45C/D688-696[»]
1GWRX-ray2.40C/D742-750[»]
1M2ZX-ray2.50B/E734-754[»]
1MV9X-ray1.90B686-698[»]
1MVCX-ray1.90B686-698[»]
1MZNX-ray1.90B/D/F/H686-698[»]
1P93X-ray2.70E/F/G/H740-751[»]
1T63X-ray2.07B740-753[»]
1T65X-ray1.66B686-698[»]
1UHLX-ray2.90C/D687-696[»]
1YOKX-ray2.50B/C740-753[»]
1ZDTX-ray2.10P/Q741-752[»]
1ZDUX-ray2.50P/Q741-751[»]
1ZKYX-ray2.25C/D686-698[»]
2AO6X-ray1.89B740-753[»]
2B1VX-ray1.80C/D686-698[»]
2B1ZX-ray1.78C/D686-698[»]
2B23X-ray2.10C/D686-698[»]
2FAIX-ray2.10C/D686-698[»]
2G44X-ray2.65C/D686-698[»]
2G5OX-ray2.30C/D686-698[»]
2LDCNMR-A687-697[»]
2P15X-ray1.94C/D686-698[»]
2P1TX-ray1.80B686-698[»]
2P1UX-ray2.20B686-698[»]
2P1VX-ray2.20B686-698[»]
2Q7JX-ray1.90B740-753[»]
2Q7LX-ray1.92B740-753[»]
2YJDX-ray1.93C/D687-697[»]
2ZXZX-ray3.00B686-698[»]
2ZY0X-ray2.90B/D686-698[»]
3A9EX-ray2.75I686-698[»]
3CLDX-ray2.84C/H740-751[»]
3DZUX-ray3.20E/G685-697[»]
3DZYX-ray3.10E/G685-697[»]
3E00X-ray3.10E/G685-697[»]
3E7CX-ray2.15D/H741-751[»]
3E94X-ray1.90B686-698[»]
3ERDX-ray2.03C/D686-698[»]
3FUGX-ray2.00B686-698[»]
3GN8X-ray2.50C/E734-754[»]
3K22X-ray2.10D/H740-751[»]
3K23X-ray3.00D/E/F740-751[»]
3KWYX-ray2.30B686-698[»]
3KYTX-ray2.35C686-697[»]
3L0EX-ray2.30B740-751[»]
3L0JX-ray2.40C688-697[»]
3L0LX-ray1.74C/E685-697[»]
3O1DX-ray2.40B686-698[»]
3O1EX-ray2.50B686-698[»]
3OAPX-ray2.05B686-696[»]
3OZJX-ray2.10B/D686-696[»]
3PCUX-ray2.00B687-696[»]
3PLZX-ray1.75C/D740-753[»]
3Q95X-ray2.05C/D686-698[»]
3Q97X-ray2.10C/D686-698[»]
3R5MX-ray2.80B/D687-696[»]
3UP0X-ray1.60P/Q740-753[»]
3UP3X-ray1.25P741-754[»]
4CSJX-ray2.30B741-753[»]
4DOSX-ray2.00B/C740-753[»]
4E2JX-ray2.50C/E741-752[»]
4FHHX-ray2.33B686-698[»]
4FHIX-ray2.40B686-698[»]
4IA1X-ray2.44B686-698[»]
4IA2X-ray2.95B686-698[»]
4IA3X-ray2.70B686-698[»]
4IA7X-ray2.70B686-698[»]
4IQRX-ray2.90I/J/K/L685-697[»]
4IU7X-ray2.29C/D687-696[»]
4IUIX-ray2.30C/D687-696[»]
4IV2X-ray2.14C/D687-696[»]
4IV4X-ray2.30C/D687-696[»]
4IVWX-ray2.06C/D687-696[»]
4IVYX-ray1.95C/D687-696[»]
4IW6X-ray1.98C/D687-696[»]
4IW8X-ray2.04C/D687-696[»]
4IWCX-ray2.24C/D687-696[»]
4IWFX-ray1.93C/D687-696[»]
4K4JX-ray2.00B686-698[»]
4K6IX-ray2.10B686-698[»]
4M8EX-ray2.40B686-696[»]
4M8HX-ray2.20B686-696[»]
4NIEX-ray2.01C/D686-697[»]
4NQAX-ray3.10C/D/J/K686-698[»]
4OC7X-ray2.50B686-698[»]
4P6WX-ray1.95B741-752[»]
4P6XX-ray2.50B/D/F/H/J/L740-753[»]
4PLDX-ray1.75B740-753[»]
4PLEX-ray1.75B/D/F/H740-753[»]
4POHX-ray2.30B686-698[»]
4POJX-ray2.00B686-698[»]
4PP3X-ray2.00B686-698[»]
4PP5X-ray2.00B686-698[»]
4PP6X-ray2.20C/D688-696[»]
4PPPX-ray2.69C/D688-696[»]
4PPSX-ray1.93C/D687-698[»]
4PXMX-ray1.90C/D686-698[»]
4Q0AX-ray1.90D687-695[»]
4QE6X-ray1.65B740-752[»]
4QE8X-ray2.62C/D740-752[»]
4RFWX-ray2.40G686-698[»]
4RMCX-ray2.70B686-698[»]
4RMDX-ray1.90B686-698[»]
4RMEX-ray2.30B686-698[»]
4RUOX-ray2.81B686-698[»]
4UDCX-ray2.50B740-753[»]
4UDDX-ray1.80B740-753[»]
4WG0X-ray1.82A/B/C/D/E/F/G/H/I/J/K/L/M742-752[»]
4ZN7X-ray1.93C/D686-698[»]
4ZN9X-ray2.21C/D686-698[»]
4ZNHX-ray1.93C/D686-698[»]
4ZNSX-ray1.86C/D686-698[»]
4ZNTX-ray1.90C/D686-698[»]
4ZNUX-ray2.40C/D686-698[»]
4ZNVX-ray1.77C/D686-698[»]
4ZNWX-ray2.31C/D686-698[»]
4ZO1X-ray3.22A686-694[»]
4ZSHX-ray1.80B686-698[»]
4ZUBX-ray2.39C/D687-697[»]
4ZUCX-ray1.82C/D687-696[»]
4ZWHX-ray1.85C/D687-696[»]
4ZWKX-ray2.07C/D687-696[»]
5APHX-ray1.54C686-697[»]
5APJX-ray2.08C686-697[»]
5BNUX-ray1.60C/D687-696[»]
5BP6X-ray2.03C/D687-696[»]
5BPRX-ray1.91C/D687-696[»]
5BQ4X-ray1.78C/D687-696[»]
5DI7X-ray2.24C/D686-699[»]
5DIDX-ray2.24C/D686-699[»]
5DIEX-ray2.24C/D686-699[»]
5DIGX-ray2.24C/D686-699[»]
5DK9X-ray2.28C/D686-699[»]
5DKBX-ray2.40C/D686-699[»]
5DKEX-ray2.60C/D686-699[»]
5DKGX-ray2.15C/D686-699[»]
5DKSX-ray2.60C/D686-699[»]
5DL4X-ray2.10C/D686-699[»]
5DLRX-ray2.26C/D686-699[»]
5DMCX-ray2.40C/D686-699[»]
5DMFX-ray2.40C/D686-699[»]
5DP0X-ray2.38C/D686-699[»]
5DRJX-ray2.07C/D686-699[»]
5DRMX-ray2.24C/D686-699[»]
5DTVX-ray2.29C/D686-699[»]
5DU5X-ray2.19C/D686-699[»]
5DUEX-ray2.09C/D686-699[»]
5DUGX-ray2.25C/D686-699[»]
5DUHX-ray2.24C/D686-699[»]
5DVSX-ray2.28C/D686-699[»]
5DVVX-ray2.50C/D686-699[»]
5DWEX-ray1.92C/D686-699[»]
5DWGX-ray2.30C/D686-699[»]
5DWIX-ray2.43C/D686-699[»]
5DWJX-ray2.00C/D686-699[»]
5DX3X-ray2.09C/D687-697[»]
5DXBX-ray2.08D/E687-697[»]
5DXEX-ray1.50C/D687-697[»]
5DXKX-ray2.23C/D686-699[»]
5DXMX-ray2.37C/D686-699[»]
5DXPX-ray2.20C/D686-699[»]
5DXQX-ray2.40C/D686-699[»]
5DXRX-ray2.28C/D686-699[»]
5DY8X-ray2.03C/D686-699[»]
5DYBX-ray2.27C/D686-699[»]
5DYDX-ray2.48C/D686-699[»]
5DZ0X-ray2.24C/D686-699[»]
5DZ1X-ray2.20C/D686-699[»]
5DZ3X-ray2.15C/D686-699[»]
5DZHX-ray2.11C/D686-699[»]
5DZIX-ray1.90C/D686-699[»]
5E0WX-ray2.00C/D686-699[»]
5E0XX-ray2.01C/D686-699[»]
5E14X-ray2.22C/D686-699[»]
5E15X-ray2.10C/D686-699[»]
5E19X-ray2.24C/D686-699[»]
5E1CX-ray1.98C/D686-699[»]
5EC9X-ray2.30B686-696[»]
5EGVX-ray2.86C/D686-699[»]
5EHJX-ray2.50C/D686-699[»]
5EI1X-ray2.40C/D686-699[»]
5EITX-ray2.68C/D686-699[»]
5G42X-ray1.72C688-697[»]
5G43X-ray2.58C686-697[»]
5G44X-ray1.84C686-697[»]
5G45X-ray2.07C688-697[»]
5G46X-ray1.76C688-697[»]
5HYRX-ray2.27F/G687-697[»]
5I4VX-ray2.61A/B/E/F687-699[»]
5SYZX-ray1.93C740-754[»]
ProteinModelPortaliQ15596.
SMRiQ15596.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 83bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini119 – 183PASPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni691 – 743CASP8AP2-bindingBy similarityAdd BLAST53
Regioni730 – 1121Interaction with ARNTLBy similarityAdd BLAST392

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi641 – 645LXXLL motif 15
Motifi690 – 694LXXLL motif 25
Motifi745 – 749LXXLL motif 35
Motifi878 – 882LXXLL motif 45
Motifi1079 – 1087LLXXLXXXL motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1254 – 1260Poly-Gln7

Domaini

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.1 Publication
The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.1 Publication
Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.1 Publication

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5S. Eukaryota.
ENOG410XPF9. LUCA.
GeneTreeiENSGT00530000063109.
HOGENOMiHOG000230947.
HOVERGENiHBG052583.
InParanoidiQ15596.
KOiK11255.
OMAiPSDMNGW.
OrthoDBiEOG091G00US.
PhylomeDBiQ15596.
TreeFamiTF332652.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR032565. DUF4927.
IPR028822. NCOA2.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 2 hits.
PTHR10684:SF2. PTHR10684:SF2. 2 hits.
PfamiPF07469. DUF1518. 1 hit.
PF16279. DUF4927. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiSM01151. DUF1518. 1 hit.
SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRNTEKRNRE QENKYIEELA
60 70 80 90 100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS
110 120 130 140 150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN
160 170 180 190 200
QEELMNKSVY SILHVGDHTE FVKNLLPKSI VNGGSWSGEP PRRNSHTFNC
210 220 230 240 250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDLQSCLI
260 270 280 290 300
CVARRVPMKE RPVLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV
310 320 330 340 350
RRCIQKFHAQ HEGESVSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ
360 370 380 390 400
TKSKLIRSQT TNEPQLVISL HMLHREQNVC VMNPDLTGQT MGKPLNPISS
410 420 430 440 450
NSPAHQALCS GNPGQDMTLS SNINFPINGP KEQMGMPMGR FGGSGGMNHV
460 470 480 490 500
SGMQATTPQG SNYALKMNSP SQSSPGMNPG QPTSMLSPRH RMSPGVAGSP
510 520 530 540 550
RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGS
560 570 580 590 600
SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA
610 620 630 640 650
ESSCHPGEQK ETNDPNLPPA VSSERADGQS RLHDSKGQTK LLQLLTTKSD
660 670 680 690 700
QMEPSPLASS LSDTNKDSTG SLPGSGSTHG TSLKEKHKIL HRLLQDSSSP
710 720 730 740 750
VDLAKLTAEA TGKDLSQESS STAPGSEVTI KQEPVSPKKK ENALLRYLLD
760 770 780 790 800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTEKEE MSFEPGDQPG
810 820 830 840 850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP AGSVDKQAII NDLMQLTAEN
860 870 880 890 900
SPVTPVGAQK TALRISQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG
910 920 930 940 950
PFPPIRNSSP YSVIPQPGMM GNQGMIGNQG NLGNSSTGMI GNSASRPTMP
960 970 980 990 1000
SGEWAPQSSA VRVTCAATTS AMNRPVQGGM IRNPAASIPM RPSSQPGQRQ
1010 1020 1030 1040 1050
TLQSQVMNIG PSELEMNMGG PQYSQQQAPP NQTAPWPESI LPIDQASFAS
1060 1070 1080 1090 1100
QNRQPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL
1110 1120 1130 1140 1150
GIPELVSQSQ AVDPEQFSSQ DSNIMLEQKA PVFPQQYASQ AQMAQGSYSP
1160 1170 1180 1190 1200
MQDPNFHTMG QRPSYATLRM QPRPGLRPTG LVQNQPNQLR LQLQHRLQAQ
1210 1220 1230 1240 1250
QNRQPLMNQI SNVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR
1260 1270 1280 1290 1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPS GMPATMSNPR IPQANAQQFP
1310 1320 1330 1340 1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQAP
1360 1370 1380 1390 1400
SDINGWAQGN MGGNSMFSQQ SPPHFGQQAN TSMYSNNMNI NVSMATNTGG
1410 1420 1430 1440 1450
MSSMNQMTGQ ISMTSVTSVP TSGLSSMGPE QVNDPALRGG NLFPNQLPGM
1460
DMIKQEGDTT RKYC
Length:1,464
Mass (Da):159,157
Last modified:May 1, 1997 - v2
Checksum:i0A61AA5D1878304B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0245461282M → I.1 PublicationCorresponds to variant rs2228591dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97674 mRNA. Translation: CAA66263.1.
BC114383 mRNA. Translation: AAI14384.1.
CCDSiCCDS47872.1.
RefSeqiNP_001308632.1. NM_001321703.1.
NP_001308636.1. NM_001321707.1.
NP_001308640.1. NM_001321711.1.
NP_001308641.1. NM_001321712.1.
NP_001308642.1. NM_001321713.1.
NP_006531.1. NM_006540.3.
UniGeneiHs.446678.
Hs.595378.

Genome annotation databases

EnsembliENST00000452400; ENSP00000399968; ENSG00000140396.
GeneIDi10499.
KEGGihsa:10499.
UCSCiuc003xyn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97674 mRNA. Translation: CAA66263.1.
BC114383 mRNA. Translation: AAI14384.1.
CCDSiCCDS47872.1.
RefSeqiNP_001308632.1. NM_001321703.1.
NP_001308636.1. NM_001321707.1.
NP_001308640.1. NM_001321711.1.
NP_001308641.1. NM_001321712.1.
NP_001308642.1. NM_001321713.1.
NP_006531.1. NM_006540.3.
UniGeneiHs.446678.
Hs.595378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWQX-ray2.45C/D688-696[»]
1GWRX-ray2.40C/D742-750[»]
1M2ZX-ray2.50B/E734-754[»]
1MV9X-ray1.90B686-698[»]
1MVCX-ray1.90B686-698[»]
1MZNX-ray1.90B/D/F/H686-698[»]
1P93X-ray2.70E/F/G/H740-751[»]
1T63X-ray2.07B740-753[»]
1T65X-ray1.66B686-698[»]
1UHLX-ray2.90C/D687-696[»]
1YOKX-ray2.50B/C740-753[»]
1ZDTX-ray2.10P/Q741-752[»]
1ZDUX-ray2.50P/Q741-751[»]
1ZKYX-ray2.25C/D686-698[»]
2AO6X-ray1.89B740-753[»]
2B1VX-ray1.80C/D686-698[»]
2B1ZX-ray1.78C/D686-698[»]
2B23X-ray2.10C/D686-698[»]
2FAIX-ray2.10C/D686-698[»]
2G44X-ray2.65C/D686-698[»]
2G5OX-ray2.30C/D686-698[»]
2LDCNMR-A687-697[»]
2P15X-ray1.94C/D686-698[»]
2P1TX-ray1.80B686-698[»]
2P1UX-ray2.20B686-698[»]
2P1VX-ray2.20B686-698[»]
2Q7JX-ray1.90B740-753[»]
2Q7LX-ray1.92B740-753[»]
2YJDX-ray1.93C/D687-697[»]
2ZXZX-ray3.00B686-698[»]
2ZY0X-ray2.90B/D686-698[»]
3A9EX-ray2.75I686-698[»]
3CLDX-ray2.84C/H740-751[»]
3DZUX-ray3.20E/G685-697[»]
3DZYX-ray3.10E/G685-697[»]
3E00X-ray3.10E/G685-697[»]
3E7CX-ray2.15D/H741-751[»]
3E94X-ray1.90B686-698[»]
3ERDX-ray2.03C/D686-698[»]
3FUGX-ray2.00B686-698[»]
3GN8X-ray2.50C/E734-754[»]
3K22X-ray2.10D/H740-751[»]
3K23X-ray3.00D/E/F740-751[»]
3KWYX-ray2.30B686-698[»]
3KYTX-ray2.35C686-697[»]
3L0EX-ray2.30B740-751[»]
3L0JX-ray2.40C688-697[»]
3L0LX-ray1.74C/E685-697[»]
3O1DX-ray2.40B686-698[»]
3O1EX-ray2.50B686-698[»]
3OAPX-ray2.05B686-696[»]
3OZJX-ray2.10B/D686-696[»]
3PCUX-ray2.00B687-696[»]
3PLZX-ray1.75C/D740-753[»]
3Q95X-ray2.05C/D686-698[»]
3Q97X-ray2.10C/D686-698[»]
3R5MX-ray2.80B/D687-696[»]
3UP0X-ray1.60P/Q740-753[»]
3UP3X-ray1.25P741-754[»]
4CSJX-ray2.30B741-753[»]
4DOSX-ray2.00B/C740-753[»]
4E2JX-ray2.50C/E741-752[»]
4FHHX-ray2.33B686-698[»]
4FHIX-ray2.40B686-698[»]
4IA1X-ray2.44B686-698[»]
4IA2X-ray2.95B686-698[»]
4IA3X-ray2.70B686-698[»]
4IA7X-ray2.70B686-698[»]
4IQRX-ray2.90I/J/K/L685-697[»]
4IU7X-ray2.29C/D687-696[»]
4IUIX-ray2.30C/D687-696[»]
4IV2X-ray2.14C/D687-696[»]
4IV4X-ray2.30C/D687-696[»]
4IVWX-ray2.06C/D687-696[»]
4IVYX-ray1.95C/D687-696[»]
4IW6X-ray1.98C/D687-696[»]
4IW8X-ray2.04C/D687-696[»]
4IWCX-ray2.24C/D687-696[»]
4IWFX-ray1.93C/D687-696[»]
4K4JX-ray2.00B686-698[»]
4K6IX-ray2.10B686-698[»]
4M8EX-ray2.40B686-696[»]
4M8HX-ray2.20B686-696[»]
4NIEX-ray2.01C/D686-697[»]
4NQAX-ray3.10C/D/J/K686-698[»]
4OC7X-ray2.50B686-698[»]
4P6WX-ray1.95B741-752[»]
4P6XX-ray2.50B/D/F/H/J/L740-753[»]
4PLDX-ray1.75B740-753[»]
4PLEX-ray1.75B/D/F/H740-753[»]
4POHX-ray2.30B686-698[»]
4POJX-ray2.00B686-698[»]
4PP3X-ray2.00B686-698[»]
4PP5X-ray2.00B686-698[»]
4PP6X-ray2.20C/D688-696[»]
4PPPX-ray2.69C/D688-696[»]
4PPSX-ray1.93C/D687-698[»]
4PXMX-ray1.90C/D686-698[»]
4Q0AX-ray1.90D687-695[»]
4QE6X-ray1.65B740-752[»]
4QE8X-ray2.62C/D740-752[»]
4RFWX-ray2.40G686-698[»]
4RMCX-ray2.70B686-698[»]
4RMDX-ray1.90B686-698[»]
4RMEX-ray2.30B686-698[»]
4RUOX-ray2.81B686-698[»]
4UDCX-ray2.50B740-753[»]
4UDDX-ray1.80B740-753[»]
4WG0X-ray1.82A/B/C/D/E/F/G/H/I/J/K/L/M742-752[»]
4ZN7X-ray1.93C/D686-698[»]
4ZN9X-ray2.21C/D686-698[»]
4ZNHX-ray1.93C/D686-698[»]
4ZNSX-ray1.86C/D686-698[»]
4ZNTX-ray1.90C/D686-698[»]
4ZNUX-ray2.40C/D686-698[»]
4ZNVX-ray1.77C/D686-698[»]
4ZNWX-ray2.31C/D686-698[»]
4ZO1X-ray3.22A686-694[»]
4ZSHX-ray1.80B686-698[»]
4ZUBX-ray2.39C/D687-697[»]
4ZUCX-ray1.82C/D687-696[»]
4ZWHX-ray1.85C/D687-696[»]
4ZWKX-ray2.07C/D687-696[»]
5APHX-ray1.54C686-697[»]
5APJX-ray2.08C686-697[»]
5BNUX-ray1.60C/D687-696[»]
5BP6X-ray2.03C/D687-696[»]
5BPRX-ray1.91C/D687-696[»]
5BQ4X-ray1.78C/D687-696[»]
5DI7X-ray2.24C/D686-699[»]
5DIDX-ray2.24C/D686-699[»]
5DIEX-ray2.24C/D686-699[»]
5DIGX-ray2.24C/D686-699[»]
5DK9X-ray2.28C/D686-699[»]
5DKBX-ray2.40C/D686-699[»]
5DKEX-ray2.60C/D686-699[»]
5DKGX-ray2.15C/D686-699[»]
5DKSX-ray2.60C/D686-699[»]
5DL4X-ray2.10C/D686-699[»]
5DLRX-ray2.26C/D686-699[»]
5DMCX-ray2.40C/D686-699[»]
5DMFX-ray2.40C/D686-699[»]
5DP0X-ray2.38C/D686-699[»]
5DRJX-ray2.07C/D686-699[»]
5DRMX-ray2.24C/D686-699[»]
5DTVX-ray2.29C/D686-699[»]
5DU5X-ray2.19C/D686-699[»]
5DUEX-ray2.09C/D686-699[»]
5DUGX-ray2.25C/D686-699[»]
5DUHX-ray2.24C/D686-699[»]
5DVSX-ray2.28C/D686-699[»]
5DVVX-ray2.50C/D686-699[»]
5DWEX-ray1.92C/D686-699[»]
5DWGX-ray2.30C/D686-699[»]
5DWIX-ray2.43C/D686-699[»]
5DWJX-ray2.00C/D686-699[»]
5DX3X-ray2.09C/D687-697[»]
5DXBX-ray2.08D/E687-697[»]
5DXEX-ray1.50C/D687-697[»]
5DXKX-ray2.23C/D686-699[»]
5DXMX-ray2.37C/D686-699[»]
5DXPX-ray2.20C/D686-699[»]
5DXQX-ray2.40C/D686-699[»]
5DXRX-ray2.28C/D686-699[»]
5DY8X-ray2.03C/D686-699[»]
5DYBX-ray2.27C/D686-699[»]
5DYDX-ray2.48C/D686-699[»]
5DZ0X-ray2.24C/D686-699[»]
5DZ1X-ray2.20C/D686-699[»]
5DZ3X-ray2.15C/D686-699[»]
5DZHX-ray2.11C/D686-699[»]
5DZIX-ray1.90C/D686-699[»]
5E0WX-ray2.00C/D686-699[»]
5E0XX-ray2.01C/D686-699[»]
5E14X-ray2.22C/D686-699[»]
5E15X-ray2.10C/D686-699[»]
5E19X-ray2.24C/D686-699[»]
5E1CX-ray1.98C/D686-699[»]
5EC9X-ray2.30B686-696[»]
5EGVX-ray2.86C/D686-699[»]
5EHJX-ray2.50C/D686-699[»]
5EI1X-ray2.40C/D686-699[»]
5EITX-ray2.68C/D686-699[»]
5G42X-ray1.72C688-697[»]
5G43X-ray2.58C686-697[»]
5G44X-ray1.84C686-697[»]
5G45X-ray2.07C688-697[»]
5G46X-ray1.76C688-697[»]
5HYRX-ray2.27F/G687-697[»]
5I4VX-ray2.61A/B/E/F687-699[»]
5SYZX-ray1.93C740-754[»]
ProteinModelPortaliQ15596.
SMRiQ15596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115761. 72 interactors.
DIPiDIP-5997N.
IntActiQ15596. 19 interactors.
MINTiMINT-122867.
STRINGi9606.ENSP00000399968.

Chemistry databases

BindingDBiQ15596.

PTM databases

iPTMnetiQ15596.
PhosphoSitePlusiQ15596.

Polymorphism and mutation databases

BioMutaiNCOA2.
DMDMi13626594.

Proteomic databases

EPDiQ15596.
MaxQBiQ15596.
PaxDbiQ15596.
PeptideAtlasiQ15596.
PRIDEiQ15596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452400; ENSP00000399968; ENSG00000140396.
GeneIDi10499.
KEGGihsa:10499.
UCSCiuc003xyn.2. human.

Organism-specific databases

CTDi10499.
DisGeNETi10499.
GeneCardsiNCOA2.
HGNCiHGNC:7669. NCOA2.
HPAiHPA060243.
MIMi601993. gene.
neXtProtiNX_Q15596.
OpenTargetsiENSG00000140396.
PharmGKBiPA31471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ5S. Eukaryota.
ENOG410XPF9. LUCA.
GeneTreeiENSGT00530000063109.
HOGENOMiHOG000230947.
HOVERGENiHBG052583.
InParanoidiQ15596.
KOiK11255.
OMAiPSDMNGW.
OrthoDBiEOG091G00US.
PhylomeDBiQ15596.
TreeFamiTF332652.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140396-MONOMER.
ReactomeiR-HSA-1368082. RORA activates gene expression.
R-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-159418. Recycling of bile acids and salts.
R-HSA-192105. Synthesis of bile acids and bile salts.
R-HSA-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-HSA-193807. Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
R-HSA-211976. Endogenous sterols.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
R-HSA-3214847. HATs acetylate histones.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
R-HSA-400253. Circadian Clock.
R-HSA-5625886. Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
SignaLinkiQ15596.
SIGNORiQ15596.

Miscellaneous databases

ChiTaRSiNCOA2. human.
EvolutionaryTraceiQ15596.
GeneWikiiNuclear_receptor_coactivator_2.
GenomeRNAii10499.
PROiQ15596.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140396.
CleanExiHS_NCOA2.
ExpressionAtlasiQ15596. baseline and differential.
GenevisibleiQ15596. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR032565. DUF4927.
IPR028822. NCOA2.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 2 hits.
PTHR10684:SF2. PTHR10684:SF2. 2 hits.
PfamiPF07469. DUF1518. 1 hit.
PF16279. DUF4927. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiSM01151. DUF1518. 1 hit.
SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCOA2_HUMAN
AccessioniPrimary (citable) accession number: Q15596
Secondary accession number(s): Q14CD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 187 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.