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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit A

Gene

TAF1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit A
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 48 kDa
Short name:
TAFI48
TATA box-binding protein-associated factor 1A
Short name:
TBP-associated factor 1A
Transcription factor SL1
Transcription initiation factor SL1/TIF-IB subunit A
Gene namesi
Name:TAF1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143498.17
HGNCiHGNC:11532 TAF1A
MIMi604903 gene
neXtProtiNX_Q15573

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

MalaCardsiTAF1A
OpenTargetsiENSG00000143498
PharmGKBiPA36307

Polymorphism and mutation databases

BioMutaiTAF1A
DMDMi74739864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279871 – 450TATA box-binding protein-associated factor RNA polymerase I subunit AAdd BLAST450

Proteomic databases

EPDiQ15573
MaxQBiQ15573
PaxDbiQ15573
PeptideAtlasiQ15573
PRIDEiQ15573

PTM databases

iPTMnetiQ15573
PhosphoSitePlusiQ15573

Expressioni

Gene expression databases

BgeeiENSG00000143498
CleanExiHS_TAF1A
ExpressionAtlasiQ15573 baseline and differential
GenevisibleiQ15573 HS

Organism-specific databases

HPAiHPA053101
HPA054334

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT. Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868).3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114484, 40 interactors
CORUMiQ15573
IntActiQ15573, 11 interactors
MINTiQ15573
STRINGi9606.ENSP00000327072

Structurei

3D structure databases

ProteinModelPortaliQ15573
SMRiQ15573
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEFS Eukaryota
ENOG410YWVA LUCA
GeneTreeiENSGT00390000011405
HOGENOMiHOG000059667
HOVERGENiHBG053462
InParanoidiQ15573
KOiK15212
OMAiLQYYTWS
OrthoDBiEOG091G072C
PhylomeDBiQ15573
TreeFamiTF330958

Family and domain databases

InterProiView protein in InterPro
IPR016629 RNA_pol_I_TAF1A/TAFI48
PIRSFiPIRSF015161 TAFI48, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15573-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDFSEELKG PVTDDEEVET SVLSGAGMHF PWLQTYVETV AIGGKRRKDF
60 70 80 90 100
AQTTSACLSF IQEALLKHQW QQAAEYMYSY FQTLEDSDSY KRQAAPEIIW
110 120 130 140 150
KLGSEILFYH PKSNMESFNT FANRMKNIGV MNYLKISLQH ALYLLHHGML
160 170 180 190 200
KDAKRNLSEA ETWRHGENTS SREILINLIQ AYKGLLQYYT WSEKKMELSK
210 220 230 240 250
LDKDDYAYNA VAQDVFNHSW KTSANISALI KIPGVWDPFV KSYVEMLEFY
260 270 280 290 300
GDRDGAQEVL TNYAYDEKFP SNPNAHIYLY NFLKRQKAPR SKLISVLKIL
310 320 330 340 350
YQIVPSHKLM LEFHTLLRKS EKEEHRKLGL EVLFGVLDFA GCTKNITAWK
360 370 380 390 400
YLAKYLKNIL MGNHLAWVQE EWNSRKNWWP GFHFSYFWAK SDWKEDTALA
410 420 430 440 450
CEKAFVAGLL LGKGCRYFRY ILKQDHQILG KKIKRMKRSV KKYSIVNPRL
Length:450
Mass (Da):52,676
Last modified:November 1, 1996 - v1
Checksum:i130330D78493C4D8
GO
Isoform 2 (identifier: Q15573-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):39,615
Checksum:i16966A610BFC1078
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05225398I → M. Corresponds to variant dbSNP:rs17163271Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0176351 – 114Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39060 mRNA Translation: AAA62862.1
AK001054 mRNA Translation: BAA91482.1
AK315740 mRNA Translation: BAG38095.1
AL592148 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93271.1
CH471100 Genomic DNA Translation: EAW93272.1
BC013808 mRNA Translation: AAH13808.1
CCDSiCCDS1531.1 [Q15573-1]
CCDS1532.1 [Q15573-2]
PIRiI61580
RefSeqiNP_001188465.1, NM_001201536.1 [Q15573-1]
NP_005672.1, NM_005681.3 [Q15573-1]
NP_647603.1, NM_139352.2 [Q15573-2]
XP_006711676.1, XM_006711613.3 [Q15573-2]
XP_016858248.1, XM_017002759.1 [Q15573-2]
XP_016858249.1, XM_017002760.1 [Q15573-2]
UniGeneiHs.153088

Genome annotation databases

EnsembliENST00000350027; ENSP00000339976; ENSG00000143498 [Q15573-1]
ENST00000352967; ENSP00000327072; ENSG00000143498 [Q15573-1]
ENST00000366890; ENSP00000355856; ENSG00000143498 [Q15573-2]
GeneIDi9015
KEGGihsa:9015
UCSCiuc001hni.3 human [Q15573-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAF1A_HUMAN
AccessioniPrimary (citable) accession number: Q15573
Secondary accession number(s): B2RDZ8, D3DTB7, Q9NWA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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