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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit A

Gene

TAF1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit A
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 48 kDa
Short name:
TAFI48
TATA box-binding protein-associated factor 1A
Short name:
TBP-associated factor 1A
Transcription factor SL1
Transcription initiation factor SL1/TIF-IB subunit A
Gene namesi
Name:TAF1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11532. TAF1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36307.

Polymorphism and mutation databases

BioMutaiTAF1A.
DMDMi74739864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450TATA box-binding protein-associated factor RNA polymerase I subunit APRO_0000227987Add
BLAST

Proteomic databases

EPDiQ15573.
MaxQBiQ15573.
PaxDbiQ15573.
PeptideAtlasiQ15573.
PRIDEiQ15573.

PTM databases

iPTMnetiQ15573.
PhosphoSiteiQ15573.

Expressioni

Gene expression databases

BgeeiENSG00000143498.
CleanExiHS_TAF1A.
ExpressionAtlasiQ15573. baseline and differential.
GenevisibleiQ15573. HS.

Organism-specific databases

HPAiHPA053101.
HPA054334.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT. Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
C11orf57Q6ZUT13EBI-2510647,EBI-3920396
C11orf57Q6ZUT1-23EBI-2510647,EBI-10180231
SETQ011052EBI-2510647,EBI-1053182
TBPP202262EBI-2510647,EBI-355371

Protein-protein interaction databases

BioGridi114484. 37 interactions.
IntActiQ15573. 11 interactions.
MINTiMINT-4329083.
STRINGi9606.ENSP00000327072.

Structurei

3D structure databases

ProteinModelPortaliQ15573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEFS. Eukaryota.
ENOG410YWVA. LUCA.
GeneTreeiENSGT00390000011405.
HOGENOMiHOG000059667.
HOVERGENiHBG053462.
InParanoidiQ15573.
KOiK15212.
OMAiKDDYAYN.
OrthoDBiEOG091G072C.
PhylomeDBiQ15573.
TreeFamiTF330958.

Family and domain databases

InterProiIPR016629. RNA_pol_I_TAF1A/TAFI48.
[Graphical view]
PIRSFiPIRSF015161. TAFI48. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15573-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDFSEELKG PVTDDEEVET SVLSGAGMHF PWLQTYVETV AIGGKRRKDF
60 70 80 90 100
AQTTSACLSF IQEALLKHQW QQAAEYMYSY FQTLEDSDSY KRQAAPEIIW
110 120 130 140 150
KLGSEILFYH PKSNMESFNT FANRMKNIGV MNYLKISLQH ALYLLHHGML
160 170 180 190 200
KDAKRNLSEA ETWRHGENTS SREILINLIQ AYKGLLQYYT WSEKKMELSK
210 220 230 240 250
LDKDDYAYNA VAQDVFNHSW KTSANISALI KIPGVWDPFV KSYVEMLEFY
260 270 280 290 300
GDRDGAQEVL TNYAYDEKFP SNPNAHIYLY NFLKRQKAPR SKLISVLKIL
310 320 330 340 350
YQIVPSHKLM LEFHTLLRKS EKEEHRKLGL EVLFGVLDFA GCTKNITAWK
360 370 380 390 400
YLAKYLKNIL MGNHLAWVQE EWNSRKNWWP GFHFSYFWAK SDWKEDTALA
410 420 430 440 450
CEKAFVAGLL LGKGCRYFRY ILKQDHQILG KKIKRMKRSV KKYSIVNPRL
Length:450
Mass (Da):52,676
Last modified:November 1, 1996 - v1
Checksum:i130330D78493C4D8
GO
Isoform 2 (identifier: Q15573-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):39,615
Checksum:i16966A610BFC1078
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981I → M.
Corresponds to variant rs17163271 [ dbSNP | Ensembl ].
VAR_052253

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 114114Missing in isoform 2. 1 PublicationVSP_017635Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39060 mRNA. Translation: AAA62862.1.
AK001054 mRNA. Translation: BAA91482.1.
AK315740 mRNA. Translation: BAG38095.1.
AL592148 Genomic DNA. Translation: CAI40466.1.
AL592148 Genomic DNA. Translation: CAI40467.1.
CH471100 Genomic DNA. Translation: EAW93271.1.
CH471100 Genomic DNA. Translation: EAW93272.1.
BC013808 mRNA. Translation: AAH13808.1.
CCDSiCCDS1531.1. [Q15573-1]
CCDS1532.1. [Q15573-2]
PIRiI61580.
RefSeqiNP_001188465.1. NM_001201536.1. [Q15573-1]
NP_005672.1. NM_005681.3. [Q15573-1]
NP_647603.1. NM_139352.2. [Q15573-2]
XP_006711676.1. XM_006711613.3. [Q15573-2]
UniGeneiHs.153088.

Genome annotation databases

EnsembliENST00000350027; ENSP00000339976; ENSG00000143498. [Q15573-1]
ENST00000352967; ENSP00000327072; ENSG00000143498. [Q15573-1]
ENST00000366890; ENSP00000355856; ENSG00000143498. [Q15573-2]
GeneIDi9015.
KEGGihsa:9015.
UCSCiuc001hni.3. human. [Q15573-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39060 mRNA. Translation: AAA62862.1.
AK001054 mRNA. Translation: BAA91482.1.
AK315740 mRNA. Translation: BAG38095.1.
AL592148 Genomic DNA. Translation: CAI40466.1.
AL592148 Genomic DNA. Translation: CAI40467.1.
CH471100 Genomic DNA. Translation: EAW93271.1.
CH471100 Genomic DNA. Translation: EAW93272.1.
BC013808 mRNA. Translation: AAH13808.1.
CCDSiCCDS1531.1. [Q15573-1]
CCDS1532.1. [Q15573-2]
PIRiI61580.
RefSeqiNP_001188465.1. NM_001201536.1. [Q15573-1]
NP_005672.1. NM_005681.3. [Q15573-1]
NP_647603.1. NM_139352.2. [Q15573-2]
XP_006711676.1. XM_006711613.3. [Q15573-2]
UniGeneiHs.153088.

3D structure databases

ProteinModelPortaliQ15573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114484. 37 interactions.
IntActiQ15573. 11 interactions.
MINTiMINT-4329083.
STRINGi9606.ENSP00000327072.

PTM databases

iPTMnetiQ15573.
PhosphoSiteiQ15573.

Polymorphism and mutation databases

BioMutaiTAF1A.
DMDMi74739864.

Proteomic databases

EPDiQ15573.
MaxQBiQ15573.
PaxDbiQ15573.
PeptideAtlasiQ15573.
PRIDEiQ15573.

Protocols and materials databases

DNASUi9015.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350027; ENSP00000339976; ENSG00000143498. [Q15573-1]
ENST00000352967; ENSP00000327072; ENSG00000143498. [Q15573-1]
ENST00000366890; ENSP00000355856; ENSG00000143498. [Q15573-2]
GeneIDi9015.
KEGGihsa:9015.
UCSCiuc001hni.3. human. [Q15573-1]

Organism-specific databases

CTDi9015.
GeneCardsiTAF1A.
HGNCiHGNC:11532. TAF1A.
HPAiHPA053101.
HPA054334.
MIMi604903. gene.
neXtProtiNX_Q15573.
PharmGKBiPA36307.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEFS. Eukaryota.
ENOG410YWVA. LUCA.
GeneTreeiENSGT00390000011405.
HOGENOMiHOG000059667.
HOVERGENiHBG053462.
InParanoidiQ15573.
KOiK15212.
OMAiKDDYAYN.
OrthoDBiEOG091G072C.
PhylomeDBiQ15573.
TreeFamiTF330958.

Enzyme and pathway databases

ReactomeiR-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.

Miscellaneous databases

GeneWikiiTAF1A.
GenomeRNAii9015.
PROiQ15573.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143498.
CleanExiHS_TAF1A.
ExpressionAtlasiQ15573. baseline and differential.
GenevisibleiQ15573. HS.

Family and domain databases

InterProiIPR016629. RNA_pol_I_TAF1A/TAFI48.
[Graphical view]
PIRSFiPIRSF015161. TAFI48. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF1A_HUMAN
AccessioniPrimary (citable) accession number: Q15573
Secondary accession number(s): B2RDZ8, D3DTB7, Q9NWA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.