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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit C

Gene

TAF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.2 Publications

GO - Molecular functioni

  • RNA polymerase I CORE element sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 110 kDa
Short name:
TAFI110
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
Gene namesi
Name:TAF1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11534. TAF1C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9013.
OpenTargetsiENSG00000103168.
PharmGKBiPA36309.

Polymorphism and mutation databases

BioMutaiTAF1C.
DMDMi313104019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188631 – 869TATA box-binding protein-associated factor RNA polymerase I subunit CAdd BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei834PhosphothreonineCombined sources1
Modified residuei848PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15572.
MaxQBiQ15572.
PaxDbiQ15572.
PeptideAtlasiQ15572.
PRIDEiQ15572.

PTM databases

iPTMnetiQ15572.
PhosphoSitePlusiQ15572.

Expressioni

Gene expression databases

BgeeiENSG00000103168.
CleanExiHS_TAF1C.
ExpressionAtlasiQ15572. baseline and differential.
GenevisibleiQ15572. HS.

Organism-specific databases

HPAiHPA026320.
HPA067377.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SETQ011054EBI-2510659,EBI-1053182
TAF12Q165142EBI-2510659,EBI-1034238
TBPP202263EBI-2510659,EBI-355371

Protein-protein interaction databases

BioGridi114482. 31 interactors.
DIPiDIP-269N.
IntActiQ15572. 13 interactors.
MINTiMINT-3031839.
STRINGi9606.ENSP00000367802.

Structurei

3D structure databases

ProteinModelPortaliQ15572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOVERGENiHBG079499.
InParanoidiQ15572.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG091G09D1.
PhylomeDBiQ15572.
TreeFamiTF351959.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15572-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL
60 70 80 90 100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV
110 120 130 140 150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL
160 170 180 190 200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL
210 220 230 240 250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG
260 270 280 290 300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP
310 320 330 340 350
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG
360 370 380 390 400
ELAICSRSGA VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL
410 420 430 440 450
TVGDRTGVKM LDTQGPPGCG LLLFRLGAEA SCQKGERVLL TQYLGHSSPK
460 470 480 490 500
CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW NHGLPSPLLL ARLLPPPRPS
510 520 530 540 550
CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI DSLPAFPLLE
560 570 580 590 600
PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR
610 620 630 640 650
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP
660 670 680 690 700
PVWTAPTFTH RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL
710 720 730 740 750
PAAEPPPAPE SGLEDKLSER LGEAWAGRGA AWWERQQGRT SEPGRQTRRP
760 770 780 790 800
KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW PPADALPLPP TTPPSQELTP
810 820 830 840 850
DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA SSVRATRSQQ
860
HTPVLSSSQP LRKKPRMGF
Length:869
Mass (Da):95,213
Last modified:November 30, 2010 - v2
Checksum:i6AAFAF296D98A5DB
GO
Isoform 2 (identifier: Q15572-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T
     521-521: Missing.

Note: No experimental confirmation available.
Show »
Length:775
Mass (Da):84,985
Checksum:i29B8C09D7F9228EF
GO
Isoform 4 (identifier: Q15572-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Note: No experimental confirmation available.
Show »
Length:537
Mass (Da):58,441
Checksum:i6C36809B5E6D2203
GO
Isoform 5 (identifier: Q15572-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):49,946
Checksum:iDBE3CAD1F8541D45
GO
Isoform 6 (identifier: Q15572-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T

Note: No experimental confirmation available.
Show »
Length:843
Mass (Da):92,284
Checksum:i75D245B40F7E9948
GO

Sequence cautioni

The sequence BAD92831 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244E → K in BAH13010 (PubMed:14702039).Curated1
Sequence conflicti481N → S in BAH14353 (PubMed:14702039).Curated1
Sequence conflicti777S → G in BAH14144 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05896691C → Y.4 PublicationsCorresponds to variant rs4782591dbSNPEnsembl.1
Natural variantiVAR_023245304S → F.1 PublicationCorresponds to variant rs4150145dbSNPEnsembl.1
Natural variantiVAR_023246357R → H.1 PublicationCorresponds to variant rs4150147dbSNPEnsembl.1
Natural variantiVAR_023247387S → L.1 PublicationCorresponds to variant rs4150151dbSNPEnsembl.1
Natural variantiVAR_023248518H → Y.1 PublicationCorresponds to variant rs4150165dbSNPEnsembl.1
Natural variantiVAR_057261523G → R.Corresponds to variant rs4150167dbSNPEnsembl.1
Natural variantiVAR_023249573P → L.1 PublicationCorresponds to variant rs4150170dbSNPEnsembl.1
Natural variantiVAR_023250575L → M.3 PublicationsCorresponds to variant rs2230129dbSNPEnsembl.1
Natural variantiVAR_023251591A → G.1 PublicationCorresponds to variant rs4150172dbSNPEnsembl.1
Natural variantiVAR_023252635G → S.1 PublicationCorresponds to variant rs4150173dbSNPEnsembl.1
Natural variantiVAR_023253791T → M.1 PublicationCorresponds to variant rs4150175dbSNPEnsembl.1
Natural variantiVAR_023254793P → L.2 PublicationsCorresponds to variant rs2230131dbSNPEnsembl.1
Natural variantiVAR_057262808P → S.Corresponds to variant rs3743640dbSNPEnsembl.1
Natural variantiVAR_023255816R → H.1 PublicationCorresponds to variant rs4150176dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380861 – 409Missing in isoform 5. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_0380871 – 332Missing in isoform 4. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_0151531 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_015154280 – 306SKALI…HPSSA → T in isoform 2 and isoform 6. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_015156521Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA. Translation: AAA62861.1.
AK299060 mRNA. Translation: BAH12941.1.
AK299347 mRNA. Translation: BAH13010.1.
AK304261 mRNA. Translation: BAH14144.1.
AK315982 mRNA. Translation: BAH14353.1.
AB209594 mRNA. Translation: BAD92831.1. Sequence problems.
AY158985 Genomic DNA. Translation: AAN38818.1.
AC009123 Genomic DNA. No translation available.
BC028131 mRNA. Translation: AAH28131.1.
CCDSiCCDS32496.1. [Q15572-1]
CCDS45535.1. [Q15572-2]
CCDS58488.1. [Q15572-4]
CCDS58489.1. [Q15572-6]
PIRiA55384.
RefSeqiNP_001230085.1. NM_001243156.1.
NP_001230086.1. NM_001243157.1. [Q15572-4]
NP_001230087.1. NM_001243158.1. [Q15572-4]
NP_001230088.1. NM_001243159.1. [Q15572-5]
NP_005670.3. NM_005679.3.
NP_647610.2. NM_139353.2.
XP_005256283.1. XM_005256226.3. [Q15572-1]
XP_016879334.1. XM_017023845.1. [Q15572-6]
XP_016879337.1. XM_017023848.1. [Q15572-4]
UniGeneiHs.153022.

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168. [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168. [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168. [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168. [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168. [Q15572-4]
GeneIDi9013.
KEGGihsa:9013.
UCSCiuc002fhm.4. human. [Q15572-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA. Translation: AAA62861.1.
AK299060 mRNA. Translation: BAH12941.1.
AK299347 mRNA. Translation: BAH13010.1.
AK304261 mRNA. Translation: BAH14144.1.
AK315982 mRNA. Translation: BAH14353.1.
AB209594 mRNA. Translation: BAD92831.1. Sequence problems.
AY158985 Genomic DNA. Translation: AAN38818.1.
AC009123 Genomic DNA. No translation available.
BC028131 mRNA. Translation: AAH28131.1.
CCDSiCCDS32496.1. [Q15572-1]
CCDS45535.1. [Q15572-2]
CCDS58488.1. [Q15572-4]
CCDS58489.1. [Q15572-6]
PIRiA55384.
RefSeqiNP_001230085.1. NM_001243156.1.
NP_001230086.1. NM_001243157.1. [Q15572-4]
NP_001230087.1. NM_001243158.1. [Q15572-4]
NP_001230088.1. NM_001243159.1. [Q15572-5]
NP_005670.3. NM_005679.3.
NP_647610.2. NM_139353.2.
XP_005256283.1. XM_005256226.3. [Q15572-1]
XP_016879334.1. XM_017023845.1. [Q15572-6]
XP_016879337.1. XM_017023848.1. [Q15572-4]
UniGeneiHs.153022.

3D structure databases

ProteinModelPortaliQ15572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114482. 31 interactors.
DIPiDIP-269N.
IntActiQ15572. 13 interactors.
MINTiMINT-3031839.
STRINGi9606.ENSP00000367802.

PTM databases

iPTMnetiQ15572.
PhosphoSitePlusiQ15572.

Polymorphism and mutation databases

BioMutaiTAF1C.
DMDMi313104019.

Proteomic databases

EPDiQ15572.
MaxQBiQ15572.
PaxDbiQ15572.
PeptideAtlasiQ15572.
PRIDEiQ15572.

Protocols and materials databases

DNASUi9013.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168. [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168. [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168. [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168. [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168. [Q15572-4]
GeneIDi9013.
KEGGihsa:9013.
UCSCiuc002fhm.4. human. [Q15572-1]

Organism-specific databases

CTDi9013.
DisGeNETi9013.
GeneCardsiTAF1C.
H-InvDBHIX0013290.
HGNCiHGNC:11534. TAF1C.
HPAiHPA026320.
HPA067377.
MIMi604905. gene.
neXtProtiNX_Q15572.
OpenTargetsiENSG00000103168.
PharmGKBiPA36309.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOVERGENiHBG079499.
InParanoidiQ15572.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG091G09D1.
PhylomeDBiQ15572.
TreeFamiTF351959.

Enzyme and pathway databases

ReactomeiR-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.

Miscellaneous databases

GeneWikiiTAF1C.
GenomeRNAii9013.
PROiQ15572.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103168.
CleanExiHS_TAF1C.
ExpressionAtlasiQ15572. baseline and differential.
GenevisibleiQ15572. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF1C_HUMAN
AccessioniPrimary (citable) accession number: Q15572
Secondary accession number(s): B7Z5K5
, B7Z5S4, B7Z908, B7Z9L7, Q59F67, Q8N6V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.