Q15572 (TAF1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C

Alternative name(s):
RNA polymerase I-specific TBP-associated factor 110 kDa
Short name=TAFI110
TATA box-binding protein-associated factor 1C
Short name=TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C

Gene names

Name:

TAF1C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	869 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. Ref.8 Ref.9
Subunit structure	Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription. Ref.1 Ref.7 Ref.8 Ref.10
Subcellular location	Nucleus.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.11 Ref.12
Sequence caution	The sequence BAD92831.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW termination of RNA polymerase I transcription Traceable author statement. Source: Reactome transcription elongation from RNA polymerase I promoter Traceable author statement. Source: Reactome transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc transcription initiation from RNA polymerase I promoter Traceable author statement. Source: Reactome
Cellular component	nucleoplasm Traceable author statement. Source: Reactome
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15572-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15572-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T
     521-521: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q15572-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q15572-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q15572-6)

The sequence of this isoform differs from the canonical sequence as follows:
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 869	869	TATA box-binding protein-associated factor RNA polymerase I subunit C		PRO_0000118863
Amino acid modifications
	Modified residue	834	1	Phosphothreonine Ref.12
	Modified residue	848	1	Phosphoserine Ref.11
	Modified residue	858	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	1 – 409	409	Missing in isoform 5.		VSP_038086
	Alternative sequence	1 – 332	332	Missing in isoform 4.		VSP_038087
	Alternative sequence	1 – 67	67	Missing in isoform 2.		VSP_015153
	Alternative sequence	280 – 306	27	SKALI…HPSSA → T in isoform 2 and isoform 6.		VSP_015154
	Alternative sequence	521	1	Missing in isoform 2.		VSP_015156
	Natural variant	91	1	C → Y. Ref.1 Ref.2 Ref.4 Ref.6 Corresponds to variant rs4782591 [ dbSNP | Ensembl ].		VAR_058966
	Natural variant	304	1	S → F. Ref.4 Corresponds to variant rs4150145 [ dbSNP | Ensembl ].		VAR_023245
	Natural variant	357	1	R → H. Ref.4 Corresponds to variant rs4150147 [ dbSNP | Ensembl ].		VAR_023246
	Natural variant	387	1	S → L. Ref.4 Corresponds to variant rs4150151 [ dbSNP | Ensembl ].		VAR_023247
	Natural variant	518	1	H → Y. Ref.4 Corresponds to variant rs4150165 [ dbSNP | Ensembl ].		VAR_023248
	Natural variant	523	1	G → R. Corresponds to variant rs4150167 [ dbSNP | Ensembl ].		VAR_057261
	Natural variant	573	1	P → L. Ref.4 Corresponds to variant rs4150170 [ dbSNP | Ensembl ].		VAR_023249
	Natural variant	575	1	L → M. Ref.2 Ref.4 Ref.6 Corresponds to variant rs2230129 [ dbSNP | Ensembl ].		VAR_023250
	Natural variant	591	1	A → G. Ref.4 Corresponds to variant rs4150172 [ dbSNP | Ensembl ].		VAR_023251
	Natural variant	635	1	G → S. Ref.4 Corresponds to variant rs4150173 [ dbSNP | Ensembl ].		VAR_023252
	Natural variant	791	1	T → M. Ref.4 Corresponds to variant rs4150175 [ dbSNP | Ensembl ].		VAR_023253
	Natural variant	793	1	P → L. Ref.2 Ref.4 Corresponds to variant rs2230131 [ dbSNP | Ensembl ].		VAR_023254
	Natural variant	808	1	P → S. Corresponds to variant rs3743640 [ dbSNP | Ensembl ].		VAR_057262
	Natural variant	816	1	R → H. Ref.4 Corresponds to variant rs4150176 [ dbSNP | Ensembl ].		VAR_023255
Experimental info
	Sequence conflict	244	1	E → K in BAH13010. Ref.2
	Sequence conflict	481	1	N → S in BAH14353. Ref.2
	Sequence conflict	777	1	S → G in BAH14144. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 6AAFAF296D98A5DB	FASTA	869	95,213
	10 20 30 40 50 60 MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL HVTKDLLWEP 70 80 90 100 110 120 ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV LDVTEQISRF LLDHGDVAFA 130 140 150 160 170 180 PLGKLMLENF KLEGAGSRTK KKTVVSVKKL LQDLGGHQPW GCPWAYLSNR QRRFSILGGP 190 200 210 220 230 240 ILGTSVASHL AELLHEELVL RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL 250 260 270 280 290 300 HFQEVVLTPG DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP 310 320 330 340 350 360 FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG ELAICSRSGA 370 380 390 400 410 420 VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL TVGDRTGVKM LDTQGPPGCG 430 440 450 460 470 480 LLLFRLGAEA SCQKGERVLL TQYLGHSSPK CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW 490 500 510 520 530 540 NHGLPSPLLL ARLLPPPRPS CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI 550 560 570 580 590 600 DSLPAFPLLE PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR 610 620 630 640 650 660 PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP PVWTAPTFTH 670 680 690 700 710 720 RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL PAAEPPPAPE SGLEDKLSER 730 740 750 760 770 780 LGEAWAGRGA AWWERQQGRT SEPGRQTRRP KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW 790 800 810 820 830 840 PPADALPLPP TTPPSQELTP DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA 850 860 SSVRATRSQQ HTPVLSSSQP LRKKPRMGF
	Isoform 2 [UniParc]. Checksum: 29B8C09D7F9228EF	FASTA	775	84,985
	10 20 30 40 50 60 MLPPLIDPWD PGLTARDLLF RGGCRYRKRP RVVLDVTEQI SRFLLDHGDV AFAPLGKLML 70 80 90 100 110 120 ENFKLEGAGS RTKKKTVVSV KKLLQDLGGH QPWGCPWAYL SNRQRRFSIL GGPILGTSVA 130 140 150 160 170 180 SHLAELLHEE LVLRWEQLLL DEACTGGALA WVPGRTPQFG QLVYPAGGAQ DRLHFQEVVL 190 200 210 220 230 240 TPGDNPQFLG KPGRIQLQGP VRQVVTCTVQ GETLLAVRSD YHCAVWKFGK QWQPTLLQAM 250 260 270 280 290 300 QVEKGATGIS LSPHLPGELA ICSRSGAVCL WSPEDGLRQI YRDPETLVFR DSSSWRWADF 310 320 330 340 350 360 TAHPRVLTVG DRTGVKMLDT QGPPGCGLLL FRLGAEASCQ KGERVLLTQY LGHSSPKCLP 370 380 390 400 410 420 PTLHLVCTQF SLYLVDERLP LVPMLKWNHG LPSPLLLARL LPPPRPSCVQ PLLLGGQGGQ 430 440 450 460 470 480 LQLLHLAEGA SVPRLAGPPQ SLPSRIDSLP AFPLLEPKIQ WRLQERLKAP TIGLAAVVPP 490 500 510 520 530 540 LPSAPTPGLV LFQLSAAGDV FYQQLRPQVD SSLRRDAGPP GDTQPDCHAP TASWTSQDTA 550 560 570 580 590 600 GCSQWLKALL KVPLAPPVWT APTFTHRQML GSTELRREEE EGQRLGVLRK AMARGQLLLQ 610 620 630 640 650 660 RDLGSLPAAE PPPAPESGLE DKLSERLGEA WAGRGAAWWE RQQGRTSEPG RQTRRPKRRT 670 680 690 700 710 720 QLSSSFSLSG HVDPSEDTSS PHSPEWPPAD ALPLPPTTPP SQELTPDACA QGVPSEQRQM 730 740 750 760 770 LRDYMAKLPP QRDTPGCATT PPHSQASSVR ATRSQQHTPV LSSSQPLRKK PRMGF
	Isoform 4 [UniParc]. Checksum: 6C36809B5E6D2203	FASTA	537	58,441
	10 20 30 40 50 60 MQVEKGATGI SLSPHLPGEL AICSRSGAVC LWSPEDGLRQ IYRDPETLVF RDSSSWRWAD 70 80 90 100 110 120 FTAHPRVLTV GDRTGVKMLD TQGPPGCGLL LFRLGAEASC QKGERVLLTQ YLGHSSPKCL 130 140 150 160 170 180 PPTLHLVCTQ FSLYLVDERL PLVPMLKWNH GLPSPLLLAR LLPPPRPSCV QPLLLGGQGG 190 200 210 220 230 240 QLQLLHLAGE GASVPRLAGP PQSLPSRIDS LPAFPLLEPK IQWRLQERLK APTIGLAAVV 250 260 270 280 290 300 PPLPSAPTPG LVLFQLSAAG DVFYQQLRPQ VDSSLRRDAG PPGDTQPDCH APTASWTSQD 310 320 330 340 350 360 TAGCSQWLKA LLKVPLAPPV WTAPTFTHRQ MLGSTELRRE EEEGQRLGVL RKAMARGQLL 370 380 390 400 410 420 LQRDLGSLPA AEPPPAPESG LEDKLSERLG EAWAGRGAAW WERQQGRTSE PGRQTRRPKR 430 440 450 460 470 480 RTQLSSSFSL SGHVDPSEDT SSPHSPEWPP ADALPLPPTT PPSQELTPDA CAQGVPSEQR 490 500 510 520 530 QMLRDYMAKL PPQRDTPGCA TTPPHSQASS VRATRSQQHT PVLSSSQPLR KKPRMGF
	Isoform 5 [UniParc]. Checksum: DBE3CAD1F8541D45	FASTA	460	49,946
	10 20 30 40 50 60 MLDTQGPPGC GLLLFRLGAE ASCQKGERVL LTQYLGHSSP KCLPPTLHLV CTQFSLYLVD 70 80 90 100 110 120 ERLPLVPMLK WNHGLPSPLL LARLLPPPRP SCVQPLLLGG QGGQLQLLHL AGEGASVPRL 130 140 150 160 170 180 AGPPQSLPSR IDSLPAFPLL EPKIQWRLQE RLKAPTIGLA AVVPPLPSAP TPGLVLFQLS 190 200 210 220 230 240 AAGDVFYQQL RPQVDSSLRR DAGPPGDTQP DCHAPTASWT SQDTAGCSQW LKALLKVPLA 250 260 270 280 290 300 PPVWTAPTFT HRQMLGSTEL RREEEEGQRL GVLRKAMARG QLLLQRDLGS LPAAEPPPAP 310 320 330 340 350 360 ESGLEDKLSE RLGEAWAGRG AAWWERQQGR TSEPGRQTRR PKRRTQLSSS FSLSGHVDPS 370 380 390 400 410 420 EDTSSPHSPE WPPADALPLP PTTPPSQELT PDACAQGVPS EQRQMLRDYM AKLPPQRDTP 430 440 450 460 GCATTPPHSQ ASSVRATRSQ QHTPVLSSSQ PLRKKPRMGF
	Isoform 6 [UniParc]. Checksum: 75D245B40F7E9948	FASTA	843	92,284
	10 20 30 40 50 60 MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL HVTKDLLWEP 70 80 90 100 110 120 ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV LDVTEQISRF LLDHGDVAFA 130 140 150 160 170 180 PLGKLMLENF KLEGAGSRTK KKTVVSVKKL LQDLGGHQPW GCPWAYLSNR QRRFSILGGP 190 200 210 220 230 240 ILGTSVASHL AELLHEELVL RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL 250 260 270 280 290 300 HFQEVVLTPG DNPQFLGKPG RIQLQGPVRQ VVTCTVQGET LLAVRSDYHC AVWKFGKQWQ 310 320 330 340 350 360 PTLLQAMQVE KGATGISLSP HLPGELAICS RSGAVCLWSP EDGLRQIYRD PETLVFRDSS 370 380 390 400 410 420 SWRWADFTAH PRVLTVGDRT GVKMLDTQGP PGCGLLLFRL GAEASCQKGE RVLLTQYLGH 430 440 450 460 470 480 SSPKCLPPTL HLVCTQFSLY LVDERLPLVP MLKWNHGLPS PLLLARLLPP PRPSCVQPLL 490 500 510 520 530 540 LGGQGGQLQL LHLAGEGASV PRLAGPPQSL PSRIDSLPAF PLLEPKIQWR LQERLKAPTI 550 560 570 580 590 600 GLAAVVPPLP SAPTPGLVLF QLSAAGDVFY QQLRPQVDSS LRRDAGPPGD TQPDCHAPTA 610 620 630 640 650 660 SWTSQDTAGC SQWLKALLKV PLAPPVWTAP TFTHRQMLGS TELRREEEEG QRLGVLRKAM 670 680 690 700 710 720 ARGQLLLQRD LGSLPAAEPP PAPESGLEDK LSERLGEAWA GRGAAWWERQ QGRTSEPGRQ 730 740 750 760 770 780 TRRPKRRTQL SSSFSLSGHV DPSEDTSSPH SPEWPPADAL PLPPTTPPSQ ELTPDACAQG 790 800 810 820 830 840 VPSEQRQMLR DYMAKLPPQR DTPGCATTPP HSQASSVRAT RSQQHTPVLS SSQPLRKKPR MGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits." Comai L., Zomerdijk J.C.B.M., Beckmann H., Zhou S., Admon A., Tjian R. Science 266:1966-1972(1994) [PubMed: 7801123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 55-65; 96-112; 125-131; 324-337; 338-354; 553-561; 563-582 AND 646-659, INTERACTION WITH TBP; TAF1A AND TAF1B, IDENTIFICATION IN THE SL1 COMPLEX, VARIANT TYR-91.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6), VARIANTS TYR-91; MET-575 AND LEU-793.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Spleen.
[4]	NIEHS SNPs program Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-91; PHE-304; HIS-357; LEU-387; TYR-518; LEU-573; MET-575; GLY-591; SER-635; MET-791; LEU-793 AND HIS-816.
[5]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TYR-91 AND MET-575. Tissue: Lung.
[7]	"Repression of RNA polymerase I transcription by the tumor suppressor p53." Zhai W., Comai L. Mol. Cell. Biol. 20:5930-5938(2000) [PubMed: 10913176] [Abstract] Cited for: INTERACTION WITH TP53.
[8]	"hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters." Miller G., Panov K.I., Friedrich J.K., Trinkle-Mulcahy L., Lamond A.I., Zomerdijk J.C.B.M. EMBO J. 20:1373-1382(2001) [PubMed: 11250903] [Abstract] Cited for: FUNCTION, INTERACTION WITH RRN3.
[9]	"TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter." Friedrich J.K., Panov K.I., Cabart P., Russell J., Zomerdijk J.C.B.M. J. Biol. Chem. 280:29551-29558(2005) [PubMed: 15970593] [Abstract] Cited for: FUNCTION OF THE SL1 COMPLEX.
[10]	"c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I." Grandori C., Gomez-Roman N., Felton-Edkins Z.A., Ngouenet C., Galloway D.A., Eisenman R.N., White R.J. Nat. Cell Biol. 7:311-318(2005) [PubMed: 15723054] [Abstract] Cited for: INTERACTION WITH MYC.
[11]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-848 AND SER-858, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[12]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-834, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	L39059 mRNA. Translation: AAA62861.1. AK299060 mRNA. Translation: BAH12941.1. AK299347 mRNA. Translation: BAH13010.1. AK304261 mRNA. Translation: BAH14144.1. AK315982 mRNA. Translation: BAH14353.1. AB209594 mRNA. Translation: BAD92831.1. Sequence problems. AY158985 Genomic DNA. Translation: AAN38818.1. AC009123 Genomic DNA. No translation available. BC028131 mRNA. Translation: AAH28131.1.
IPI	IPI00246842. IPI00328322. IPI00944587. IPI00944609. IPI00944618.
PIR	A55384.
RefSeq	NP_001230085.1. NM_001243156.1. NP_001230086.1. NM_001243157.1. NP_001230087.1. NM_001243158.1. NP_001230088.1. NM_001243159.1. NP_005670.3. NM_005679.3. NP_647610.2. NM_139353.2.
UniGene	Hs.153022.
3D structure databases
ProteinModelPortal	Q15572.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-269N.
IntAct	Q15572. 1 interaction.
MINT	MINT-3031839.
STRING	Q15572.
PTM databases
PhosphoSite	Q15572.
Polymorphism databases
DMDM	73621973.
Proteomic databases
PRIDE	Q15572.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341690; ENSP00000345305; ENSG00000103168. ENST00000378541; ENSP00000367802; ENSG00000103168.
GeneID	9013.
KEGG	hsa:9013.
UCSC	uc002fhm.1. human. uc002fhn.1. human. uc002fho.1. human.
Organism-specific databases
CTD	9013.
GeneCards	GC16M084211.
H-InvDB	HIX0013290.
HGNC	HGNC:11534. TAF1C.
MIM	604905. gene.
neXtProt	NX_Q15572.
PharmGKB	PA36309.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04639.
GeneTree	ENSGT00390000010767.
HOGENOM	HBG283428.
HOVERGEN	HBG079499.
InParanoid	Q15572.
OMA	KKPRMGF.
OrthoDB	EOG4X97GS.
Enzyme and pathway databases
Reactome	REACT_1788. Transcription.
Gene expression databases
ArrayExpress	Q15572.
Bgee	Q15572.
CleanEx	HS_TAF1C.
Genevestigator	Q15572.
GermOnline	ENSG00000103168. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K15214.
ProtoNet	Search...
Other
NextBio	33765.
SOURCE	Search...

Entry information

Entry name

TAF1C_HUMAN

Accession

Primary (citable) accession number: Q15572
Secondary accession number(s): B7Z5K5 , B7Z5S4, B7Z908, B7Z9L7, Q59F67, Q8N6V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.