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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit C

Gene

TAF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.2 Publications

GO - Molecular functioni

  • RNA polymerase I CORE element sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 110 kDa
Short name:
TAFI110
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
Gene namesi
Name:TAF1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11534. TAF1C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36309.

Polymorphism and mutation databases

BioMutaiTAF1C.
DMDMi313104019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869TATA box-binding protein-associated factor RNA polymerase I subunit CPRO_0000118863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei848 – 8481PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15572.
MaxQBiQ15572.
PaxDbiQ15572.
PRIDEiQ15572.

PTM databases

iPTMnetiQ15572.
PhosphoSiteiQ15572.

Expressioni

Gene expression databases

BgeeiQ15572.
CleanExiHS_TAF1C.
ExpressionAtlasiQ15572. baseline and differential.
GenevisibleiQ15572. HS.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SETQ011054EBI-2510659,EBI-1053182
TAF12Q165142EBI-2510659,EBI-1034238
TBPP202263EBI-2510659,EBI-355371

Protein-protein interaction databases

BioGridi114482. 31 interactions.
DIPiDIP-269N.
IntActiQ15572. 13 interactions.
MINTiMINT-3031839.
STRINGi9606.ENSP00000367802.

Structurei

3D structure databases

ProteinModelPortaliQ15572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOVERGENiHBG079499.
InParanoidiQ15572.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG7SBNPC.
PhylomeDBiQ15572.
TreeFamiTF351959.

Family and domain databases

InterProiIPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15572-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL
60 70 80 90 100
HVTKDLLWEP ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV
110 120 130 140 150
LDVTEQISRF LLDHGDVAFA PLGKLMLENF KLEGAGSRTK KKTVVSVKKL
160 170 180 190 200
LQDLGGHQPW GCPWAYLSNR QRRFSILGGP ILGTSVASHL AELLHEELVL
210 220 230 240 250
RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL HFQEVVLTPG
260 270 280 290 300
DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP
310 320 330 340 350
FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG
360 370 380 390 400
ELAICSRSGA VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL
410 420 430 440 450
TVGDRTGVKM LDTQGPPGCG LLLFRLGAEA SCQKGERVLL TQYLGHSSPK
460 470 480 490 500
CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW NHGLPSPLLL ARLLPPPRPS
510 520 530 540 550
CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI DSLPAFPLLE
560 570 580 590 600
PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR
610 620 630 640 650
PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP
660 670 680 690 700
PVWTAPTFTH RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL
710 720 730 740 750
PAAEPPPAPE SGLEDKLSER LGEAWAGRGA AWWERQQGRT SEPGRQTRRP
760 770 780 790 800
KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW PPADALPLPP TTPPSQELTP
810 820 830 840 850
DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA SSVRATRSQQ
860
HTPVLSSSQP LRKKPRMGF
Length:869
Mass (Da):95,213
Last modified:November 30, 2010 - v2
Checksum:i6AAFAF296D98A5DB
GO
Isoform 2 (identifier: Q15572-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T
     521-521: Missing.

Note: No experimental confirmation available.
Show »
Length:775
Mass (Da):84,985
Checksum:i29B8C09D7F9228EF
GO
Isoform 4 (identifier: Q15572-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.

Note: No experimental confirmation available.
Show »
Length:537
Mass (Da):58,441
Checksum:i6C36809B5E6D2203
GO
Isoform 5 (identifier: Q15572-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):49,946
Checksum:iDBE3CAD1F8541D45
GO
Isoform 6 (identifier: Q15572-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-306: SKALIYTFLPHWLTCYLTPGPFHPSSA → T

Note: No experimental confirmation available.
Show »
Length:843
Mass (Da):92,284
Checksum:i75D245B40F7E9948
GO

Sequence cautioni

The sequence BAD92831.1 differs from that shown.Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441E → K in BAH13010 (PubMed:14702039).Curated
Sequence conflicti481 – 4811N → S in BAH14353 (PubMed:14702039).Curated
Sequence conflicti777 – 7771S → G in BAH14144 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911C → Y.4 Publications
Corresponds to variant rs4782591 [ dbSNP | Ensembl ].
VAR_058966
Natural varianti304 – 3041S → F.1 Publication
Corresponds to variant rs4150145 [ dbSNP | Ensembl ].
VAR_023245
Natural varianti357 – 3571R → H.1 Publication
Corresponds to variant rs4150147 [ dbSNP | Ensembl ].
VAR_023246
Natural varianti387 – 3871S → L.1 Publication
Corresponds to variant rs4150151 [ dbSNP | Ensembl ].
VAR_023247
Natural varianti518 – 5181H → Y.1 Publication
Corresponds to variant rs4150165 [ dbSNP | Ensembl ].
VAR_023248
Natural varianti523 – 5231G → R.
Corresponds to variant rs4150167 [ dbSNP | Ensembl ].
VAR_057261
Natural varianti573 – 5731P → L.1 Publication
Corresponds to variant rs4150170 [ dbSNP | Ensembl ].
VAR_023249
Natural varianti575 – 5751L → M.3 Publications
Corresponds to variant rs2230129 [ dbSNP | Ensembl ].
VAR_023250
Natural varianti591 – 5911A → G.1 Publication
Corresponds to variant rs4150172 [ dbSNP | Ensembl ].
VAR_023251
Natural varianti635 – 6351G → S.1 Publication
Corresponds to variant rs4150173 [ dbSNP | Ensembl ].
VAR_023252
Natural varianti791 – 7911T → M.1 Publication
Corresponds to variant rs4150175 [ dbSNP | Ensembl ].
VAR_023253
Natural varianti793 – 7931P → L.2 Publications
Corresponds to variant rs2230131 [ dbSNP | Ensembl ].
VAR_023254
Natural varianti808 – 8081P → S.
Corresponds to variant rs3743640 [ dbSNP | Ensembl ].
VAR_057262
Natural varianti816 – 8161R → H.1 Publication
Corresponds to variant rs4150176 [ dbSNP | Ensembl ].
VAR_023255

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 409409Missing in isoform 5. 1 PublicationVSP_038086Add
BLAST
Alternative sequencei1 – 332332Missing in isoform 4. 1 PublicationVSP_038087Add
BLAST
Alternative sequencei1 – 6767Missing in isoform 2. 1 PublicationVSP_015153Add
BLAST
Alternative sequencei280 – 30627SKALI…HPSSA → T in isoform 2 and isoform 6. 2 PublicationsVSP_015154Add
BLAST
Alternative sequencei521 – 5211Missing in isoform 2. 1 PublicationVSP_015156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA. Translation: AAA62861.1.
AK299060 mRNA. Translation: BAH12941.1.
AK299347 mRNA. Translation: BAH13010.1.
AK304261 mRNA. Translation: BAH14144.1.
AK315982 mRNA. Translation: BAH14353.1.
AB209594 mRNA. Translation: BAD92831.1. Sequence problems.
AY158985 Genomic DNA. Translation: AAN38818.1.
AC009123 Genomic DNA. No translation available.
BC028131 mRNA. Translation: AAH28131.1.
CCDSiCCDS32496.1. [Q15572-1]
CCDS45535.1. [Q15572-2]
CCDS58488.1. [Q15572-4]
CCDS58489.1. [Q15572-6]
PIRiA55384.
RefSeqiNP_001230085.1. NM_001243156.1.
NP_001230086.1. NM_001243157.1. [Q15572-4]
NP_001230087.1. NM_001243158.1. [Q15572-4]
NP_001230088.1. NM_001243159.1. [Q15572-5]
NP_005670.3. NM_005679.3.
NP_647610.2. NM_139353.2.
XP_005256283.1. XM_005256226.2. [Q15572-1]
XP_006721388.1. XM_006721325.2.
UniGeneiHs.153022.

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168. [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168. [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168. [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168. [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168. [Q15572-4]
GeneIDi9013.
KEGGihsa:9013.
UCSCiuc002fhm.4. human. [Q15572-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39059 mRNA. Translation: AAA62861.1.
AK299060 mRNA. Translation: BAH12941.1.
AK299347 mRNA. Translation: BAH13010.1.
AK304261 mRNA. Translation: BAH14144.1.
AK315982 mRNA. Translation: BAH14353.1.
AB209594 mRNA. Translation: BAD92831.1. Sequence problems.
AY158985 Genomic DNA. Translation: AAN38818.1.
AC009123 Genomic DNA. No translation available.
BC028131 mRNA. Translation: AAH28131.1.
CCDSiCCDS32496.1. [Q15572-1]
CCDS45535.1. [Q15572-2]
CCDS58488.1. [Q15572-4]
CCDS58489.1. [Q15572-6]
PIRiA55384.
RefSeqiNP_001230085.1. NM_001243156.1.
NP_001230086.1. NM_001243157.1. [Q15572-4]
NP_001230087.1. NM_001243158.1. [Q15572-4]
NP_001230088.1. NM_001243159.1. [Q15572-5]
NP_005670.3. NM_005679.3.
NP_647610.2. NM_139353.2.
XP_005256283.1. XM_005256226.2. [Q15572-1]
XP_006721388.1. XM_006721325.2.
UniGeneiHs.153022.

3D structure databases

ProteinModelPortaliQ15572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114482. 31 interactions.
DIPiDIP-269N.
IntActiQ15572. 13 interactions.
MINTiMINT-3031839.
STRINGi9606.ENSP00000367802.

PTM databases

iPTMnetiQ15572.
PhosphoSiteiQ15572.

Polymorphism and mutation databases

BioMutaiTAF1C.
DMDMi313104019.

Proteomic databases

EPDiQ15572.
MaxQBiQ15572.
PaxDbiQ15572.
PRIDEiQ15572.

Protocols and materials databases

DNASUi9013.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341690; ENSP00000345305; ENSG00000103168. [Q15572-2]
ENST00000541676; ENSP00000437900; ENSG00000103168. [Q15572-4]
ENST00000566732; ENSP00000455933; ENSG00000103168. [Q15572-6]
ENST00000567759; ENSP00000455265; ENSG00000103168. [Q15572-1]
ENST00000570117; ENSP00000455247; ENSG00000103168. [Q15572-4]
GeneIDi9013.
KEGGihsa:9013.
UCSCiuc002fhm.4. human. [Q15572-1]

Organism-specific databases

CTDi9013.
GeneCardsiTAF1C.
H-InvDBHIX0013290.
HGNCiHGNC:11534. TAF1C.
MIMi604905. gene.
neXtProtiNX_Q15572.
PharmGKBiPA36309.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOVERGENiHBG079499.
InParanoidiQ15572.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG7SBNPC.
PhylomeDBiQ15572.
TreeFamiTF351959.

Enzyme and pathway databases

ReactomeiR-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.

Miscellaneous databases

GeneWikiiTAF1C.
GenomeRNAii9013.
NextBioi33765.
PROiQ15572.
SOURCEiSearch...

Gene expression databases

BgeeiQ15572.
CleanExiHS_TAF1C.
ExpressionAtlasiQ15572. baseline and differential.
GenevisibleiQ15572. HS.

Family and domain databases

InterProiIPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits."
    Comai L., Zomerdijk J.C.B.M., Beckmann H., Zhou S., Admon A., Tjian R.
    Science 266:1966-1972(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 55-65; 96-112; 125-131; 324-337; 338-354; 553-561; 563-582 AND 646-659, INTERACTION WITH TBP; TAF1A AND TAF1B, IDENTIFICATION IN THE SL1 COMPLEX, VARIANT TYR-91.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6), VARIANTS TYR-91; MET-575 AND LEU-793.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  4. NIEHS SNPs program
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-91; PHE-304; HIS-357; LEU-387; TYR-518; LEU-573; MET-575; GLY-591; SER-635; MET-791; LEU-793 AND HIS-816.
  5. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS TYR-91 AND MET-575.
    Tissue: Lung.
  7. "Repression of RNA polymerase I transcription by the tumor suppressor p53."
    Zhai W., Comai L.
    Mol. Cell. Biol. 20:5930-5938(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53.
  8. "hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters."
    Miller G., Panov K.I., Friedrich J.K., Trinkle-Mulcahy L., Lamond A.I., Zomerdijk J.C.B.M.
    EMBO J. 20:1373-1382(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RRN3.
  9. "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."
    Friedrich J.K., Panov K.I., Cabart P., Russell J., Zomerdijk J.C.B.M.
    J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE SL1 COMPLEX.
  10. "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I."
    Grandori C., Gomez-Roman N., Felton-Edkins Z.A., Ngouenet C., Galloway D.A., Eisenman R.N., White R.J.
    Nat. Cell Biol. 7:311-318(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYC.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-848, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTAF1C_HUMAN
AccessioniPrimary (citable) accession number: Q15572
Secondary accession number(s): B7Z5K5
, B7Z5S4, B7Z908, B7Z9L7, Q59F67, Q8N6V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 30, 2010
Last modified: April 13, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.