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Protein

Dual specificity testis-specific protein kinase 1

Gene

TESK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:

Enzyme regulationi

Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86ATPPROSITE-ProRule annotation1
Active sitei175Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 71ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • negative regulation of protein autophosphorylation Source: ARUK-UCL
  • negative regulation of protein serine/threonine kinase activity Source: ARUK-UCL
  • positive regulation of stress fiber assembly Source: ARUK-UCL
  • regulation of protein localization Source: ARUK-UCL
  • spermatogenesis Source: ProtInc

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
SignaLinkiQ15569
SIGNORiQ15569

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity testis-specific protein kinase 1 (EC:2.7.12.1)
Alternative name(s):
Testicular protein kinase 1
Gene namesi
Name:TESK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107140.15
HGNCiHGNC:11731 TESK1
MIMi601782 gene
neXtProtiNX_Q15569

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107140
PharmGKBiPA36448

Chemistry databases

ChEMBLiCHEMBL5604
GuidetoPHARMACOLOGYi2239

Polymorphism and mutation databases

BioMutaiTESK1
DMDMi209572684

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867461 – 626Dual specificity testis-specific protein kinase 1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220Phosphoserine; by autocatalysisBy similarity1
Modified residuei338Omega-N-methylarginineBy similarity1

Post-translational modificationi

Autophosphorylated on serine and tyrosine residues.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ15569
PeptideAtlasiQ15569
PRIDEiQ15569
ProteomicsDBi60637

PTM databases

iPTMnetiQ15569
PhosphoSitePlusiQ15569

Expressioni

Gene expression databases

BgeeiENSG00000107140
CleanExiHS_TESK1
GenevisibleiQ15569 HS

Interactioni

Subunit structurei

Interacts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit activity (By similarity). Interacts with SPRY4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPRY4Q9C0044EBI-354852,EBI-354861

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112875, 13 interactors
IntActiQ15569, 6 interactors
MINTiQ15569
STRINGi9606.ENSP00000338127

Chemistry databases

BindingDBiQ15569

Structurei

3D structure databases

ProteinModelPortaliQ15569
SMRiQ15569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 314Protein kinasePROSITE-ProRule annotationAdd BLAST258

Domaini

The extracatalytic C-terminal part is highly rich in proline residues.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF1S Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063025
HOGENOMiHOG000231415
HOVERGENiHBG058204
InParanoidiQ15569
KOiK08841
OMAiKMECEGS
OrthoDBiEOG091G0HLL
PhylomeDBiQ15569
TreeFamiTF318014

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR015782 TESK1
IPR008266 Tyr_kinase_AS
PANTHERiPTHR44164:SF3 PTHR44164:SF3, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Q15569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS
60 70 80 90 100
LARVDDFHCA EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE
110 120 130 140 150
VQLMNRLRHP NILRFMGVCV HQGQLHALTE YMNGGTLEQL LSSPEPLSWP
160 170 180 190 200
VRLHLALDIA RGLRYLHSKG VFHRDLTSKN CLVRREDRGF TAVVGDFGLA
210 220 230 240 250
EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV FAFGIVLCEL
260 270 280 290 300
IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST
310 320 330 340 350
RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP
360 370 380 390 400
RLSRSRSDLF LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK
410 420 430 440 450
PVLPLVPPSP FPSTQLPLVT TPETLVQPGT PARRCRSLPS SPELPRRMET
460 470 480 490 500
ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP GPAPQLPLAV ATDNFISTCS
510 520 530 540 550
SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS LPRAAALERT
560 570 580 590 600
EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE
610 620
AGSLLCHRGH HAKPPTPSLQ LPGARS
Length:626
Mass (Da):67,684
Last modified:October 14, 2008 - v2
Checksum:i32F78E5E6AEDB0E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43A → V in BAA09459 (PubMed:8537404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035638539H → Y in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications1
Natural variantiVAR_041213574G → S1 PublicationCorresponds to variant dbSNP:rs55673450Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50863 mRNA Translation: BAA09459.1
AL357874 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58375.1
BC038448 mRNA Translation: AAH38448.1
BC067130 mRNA Translation: AAH67130.1
CCDSiCCDS6580.1
RefSeqiNP_001305159.1, NM_001318230.1
NP_006276.2, NM_006285.2
UniGeneiHs.708096

Genome annotation databases

EnsembliENST00000336395; ENSP00000338127; ENSG00000107140
ENST00000620767; ENSP00000481045; ENSG00000107140
GeneIDi7016
KEGGihsa:7016
UCSCiuc003zxa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTESK1_HUMAN
AccessioniPrimary (citable) accession number: Q15569
Secondary accession number(s): Q8IXZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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