Reviewed,
UniProtKB/Swiss-Prot Q15569 (TESK1_HUMAN)
Last modified
November 25, 2008.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity testis-specific protein kinase 1 EC=2.7.12.1 Alternative name(s): Testicular protein kinase 1 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 626 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Magnesium By similarity. Manganese By similarity. |
| Enzyme regulation | Activated by autophosphorylation on Ser-220 By similarity. |
| Subunit structure | Interacts with SPRY4. |
| Domain | The extracatalytic C-terminal part is highly rich in proline residues. |
| Post-translational modification | Autophosphorylated on serine and tyrosine residues By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro spermatogenesis Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.5Inferred from physical interaction. Source: IntAct protein serine/threonine kinase activity Ref.1Traceable author statement. Source: ProtInc protein tyrosine kinase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 626 | 626 | Dual specificity testis-specific protein kinase 1 | PRO_0000086746 | |||||
Regions | |||||||||
| Domain | 57 – 314 | 258 | Protein kinase | ||||||
| Nucleotide binding | 63 – 71 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 175 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 86 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 220 | 1 | Phosphoserine; by autocatalysis By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 539 | 1 | H → Y in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. | VAR_035638 | |||||
| Natural variant | 574 | 1 | G → S: dbSNP rs55673450. | VAR_041213 | |||||
Experimental info | |||||||||
| Sequence conflict | 43 | 1 | A → V in BAA09459. Ref.1 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| D50863 mRNA. Translation: BAA09459.1. AL357874 Genomic DNA. Translation: CAI13441.1. CH471071 Genomic DNA. Translation: EAW58375.1. BC038448 mRNA. Translation: AAH38448.1. BC067130 mRNA. Translation: AAH67130.1. | |
| RefSeq | NP_006276.2. |
| UniGene | Hs.699324 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FVR based on UniProtKB Q02763. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15569. |
PTM databases | |
| PhosphoSite | Q15569. |
Genome annotation databases | |
| Ensembl | ENSG00000107140. Homo sapiens. [Contig view] |
| GeneID | 7016. |
| KEGG | hsa:7016. |
Organism-specific databases | |
| HGNC | HGNC:11731. TESK1. |
| HPA | HPA017064. |
| MIM | 601782. gene. |
| PharmGKB | PA36448. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q15569. |
| HOVERGEN | Q15569. |
Gene expression databases | |
| CleanEx | HS_TESK1. |
| GermOnline | ENSG00000107140. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR015782. TESK1. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view] |
| PANTHER | PTHR23257:SF10. TESK1. 1 hit. |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | TESK1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15569 Secondary accession number(s): Q8IXZ8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

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