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Protein

Dual specificity testis-specific protein kinase 1

Gene

TESK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:

Enzyme regulationi

Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86ATPPROSITE-ProRule annotation1
Active sitei175Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 71ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS02972-MONOMER.
BRENDAi2.7.10.2. 2681.
ReactomeiR-HSA-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiQ15569.
SIGNORiQ15569.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity testis-specific protein kinase 1 (EC:2.7.12.1)
Alternative name(s):
Testicular protein kinase 1
Gene namesi
Name:TESK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11731. TESK1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107140.
PharmGKBiPA36448.

Chemistry databases

ChEMBLiCHEMBL5604.
GuidetoPHARMACOLOGYi2239.

Polymorphism and mutation databases

BioMutaiTESK1.
DMDMi209572684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867461 – 626Dual specificity testis-specific protein kinase 1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220Phosphoserine; by autocatalysisBy similarity1
Modified residuei338Omega-N-methylarginineBy similarity1

Post-translational modificationi

Autophosphorylated on serine and tyrosine residues.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ15569.
PeptideAtlasiQ15569.
PRIDEiQ15569.

PTM databases

iPTMnetiQ15569.
PhosphoSitePlusiQ15569.

Expressioni

Gene expression databases

BgeeiENSG00000107140.
CleanExiHS_TESK1.
GenevisibleiQ15569. HS.

Organism-specific databases

HPAiHPA017064.

Interactioni

Subunit structurei

Interacts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit activity (By similarity). Interacts with SPRY4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPRY4Q9C0044EBI-354852,EBI-354861

Protein-protein interaction databases

BioGridi112875. 12 interactors.
IntActiQ15569. 6 interactors.
MINTiMINT-210342.
STRINGi9606.ENSP00000338127.

Chemistry databases

BindingDBiQ15569.

Structurei

3D structure databases

ProteinModelPortaliQ15569.
SMRiQ15569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 314Protein kinasePROSITE-ProRule annotationAdd BLAST258

Domaini

The extracatalytic C-terminal part is highly rich in proline residues.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF1S. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063025.
HOGENOMiHOG000231415.
HOVERGENiHBG058204.
InParanoidiQ15569.
KOiK08841.
OMAiKMECEGS.
OrthoDBiEOG091G0HLL.
PhylomeDBiQ15569.
TreeFamiTF318014.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR015782. TESK1.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF383. PTHR23257:SF383. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS
60 70 80 90 100
LARVDDFHCA EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE
110 120 130 140 150
VQLMNRLRHP NILRFMGVCV HQGQLHALTE YMNGGTLEQL LSSPEPLSWP
160 170 180 190 200
VRLHLALDIA RGLRYLHSKG VFHRDLTSKN CLVRREDRGF TAVVGDFGLA
210 220 230 240 250
EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV FAFGIVLCEL
260 270 280 290 300
IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST
310 320 330 340 350
RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP
360 370 380 390 400
RLSRSRSDLF LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK
410 420 430 440 450
PVLPLVPPSP FPSTQLPLVT TPETLVQPGT PARRCRSLPS SPELPRRMET
460 470 480 490 500
ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP GPAPQLPLAV ATDNFISTCS
510 520 530 540 550
SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS LPRAAALERT
560 570 580 590 600
EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE
610 620
AGSLLCHRGH HAKPPTPSLQ LPGARS
Length:626
Mass (Da):67,684
Last modified:October 14, 2008 - v2
Checksum:i32F78E5E6AEDB0E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43A → V in BAA09459 (PubMed:8537404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035638539H → Y in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications1
Natural variantiVAR_041213574G → S.1 PublicationCorresponds to variant rs55673450dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50863 mRNA. Translation: BAA09459.1.
AL357874 Genomic DNA. Translation: CAI13441.1.
CH471071 Genomic DNA. Translation: EAW58375.1.
BC038448 mRNA. Translation: AAH38448.1.
BC067130 mRNA. Translation: AAH67130.1.
CCDSiCCDS6580.1.
RefSeqiNP_001305159.1. NM_001318230.1.
NP_006276.2. NM_006285.2.
UniGeneiHs.708096.

Genome annotation databases

EnsembliENST00000336395; ENSP00000338127; ENSG00000107140.
ENST00000620767; ENSP00000481045; ENSG00000107140.
GeneIDi7016.
KEGGihsa:7016.
UCSCiuc003zxa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50863 mRNA. Translation: BAA09459.1.
AL357874 Genomic DNA. Translation: CAI13441.1.
CH471071 Genomic DNA. Translation: EAW58375.1.
BC038448 mRNA. Translation: AAH38448.1.
BC067130 mRNA. Translation: AAH67130.1.
CCDSiCCDS6580.1.
RefSeqiNP_001305159.1. NM_001318230.1.
NP_006276.2. NM_006285.2.
UniGeneiHs.708096.

3D structure databases

ProteinModelPortaliQ15569.
SMRiQ15569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112875. 12 interactors.
IntActiQ15569. 6 interactors.
MINTiMINT-210342.
STRINGi9606.ENSP00000338127.

Chemistry databases

BindingDBiQ15569.
ChEMBLiCHEMBL5604.
GuidetoPHARMACOLOGYi2239.

PTM databases

iPTMnetiQ15569.
PhosphoSitePlusiQ15569.

Polymorphism and mutation databases

BioMutaiTESK1.
DMDMi209572684.

Proteomic databases

PaxDbiQ15569.
PeptideAtlasiQ15569.
PRIDEiQ15569.

Protocols and materials databases

DNASUi7016.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336395; ENSP00000338127; ENSG00000107140.
ENST00000620767; ENSP00000481045; ENSG00000107140.
GeneIDi7016.
KEGGihsa:7016.
UCSCiuc003zxa.4. human.

Organism-specific databases

CTDi7016.
GeneCardsiTESK1.
HGNCiHGNC:11731. TESK1.
HPAiHPA017064.
MIMi601782. gene.
neXtProtiNX_Q15569.
OpenTargetsiENSG00000107140.
PharmGKBiPA36448.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF1S. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063025.
HOGENOMiHOG000231415.
HOVERGENiHBG058204.
InParanoidiQ15569.
KOiK08841.
OMAiKMECEGS.
OrthoDBiEOG091G0HLL.
PhylomeDBiQ15569.
TreeFamiTF318014.

Enzyme and pathway databases

BioCyciZFISH:HS02972-MONOMER.
BRENDAi2.7.10.2. 2681.
ReactomeiR-HSA-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiQ15569.
SIGNORiQ15569.

Miscellaneous databases

ChiTaRSiTESK1. human.
GeneWikiiTESK1.
GenomeRNAii7016.
PROiQ15569.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107140.
CleanExiHS_TESK1.
GenevisibleiQ15569. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR015782. TESK1.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF383. PTHR23257:SF383. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTESK1_HUMAN
AccessioniPrimary (citable) accession number: Q15569
Secondary accession number(s): Q8IXZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.