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Protein

Transcriptional enhancer factor TEF-4

Gene

TEAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 114TEAPROSITE-ProRule annotationAdd BLAST77

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SIGNORiQ15562

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-4
Alternative name(s):
TEA domain family member 2
Short name:
TEAD-2
Gene namesi
Name:TEAD2
Synonyms:TEF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000074219.13
HGNCiHGNC:11715 TEAD2
MIMi601729 gene
neXtProtiNX_Q15562

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8463
OpenTargetsiENSG00000074219
PharmGKBiPA36433

Polymorphism and mutation databases

BioMutaiTEAD2
DMDMi21264529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059321 – 447Transcriptional enhancer factor TEF-4Add BLAST447

Proteomic databases

EPDiQ15562
MaxQBiQ15562
PaxDbiQ15562
PeptideAtlasiQ15562
PRIDEiQ15562
ProteomicsDBi60636

PTM databases

iPTMnetiQ15562
PhosphoSitePlusiQ15562
SwissPalmiQ15562

Expressioni

Gene expression databases

BgeeiENSG00000074219
CleanExiHS_TEAD2
ExpressionAtlasiQ15562 baseline and differential
GenevisibleiQ15562 HS

Organism-specific databases

HPAiHPA066292
HPA069963

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • disordered domain specific binding Source: CAFA
  • protein heterodimerization activity Source: CAFA
  • RNA polymerase II transcription factor binding Source: GO_Central
  • transcription coactivator binding Source: CAFA

Protein-protein interaction databases

BioGridi114041, 83 interactors
DIPiDIP-59318N
IntActiQ15562, 77 interactors
MINTiQ15562
STRINGi9606.ENSP00000310701

Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi229 – 238Combined sources10
Helixi240 – 243Combined sources4
Beta strandi249 – 255Combined sources7
Beta strandi268 – 270Combined sources3
Helixi271 – 277Combined sources7
Beta strandi280 – 284Combined sources5
Helixi285 – 291Combined sources7
Helixi294 – 296Combined sources3
Beta strandi297 – 304Combined sources8
Beta strandi326 – 337Combined sources12
Beta strandi340 – 349Combined sources10
Beta strandi352 – 362Combined sources11
Beta strandi364 – 366Combined sources3
Beta strandi369 – 378Combined sources10
Helixi381 – 390Combined sources10
Helixi396 – 403Combined sources8
Beta strandi406 – 414Combined sources9
Turni415 – 417Combined sources3
Beta strandi420 – 430Combined sources11
Beta strandi433 – 435Combined sources3
Beta strandi438 – 445Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L15X-ray2.00A/B217-447[»]
5DQ8X-ray2.31A/B217-447[»]
5DQEX-ray2.18A/B217-447[»]
5EMVX-ray2.00A/B218-446[»]
5HGUX-ray2.05A/B217-447[»]
ProteinModelPortaliQ15562
SMRiQ15562
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15562

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 447Transcriptional activationSequence analysisAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 216Pro-richAdd BLAST65

Phylogenomic databases

eggNOGiKOG3841 Eukaryota
ENOG410XQMP LUCA
GeneTreeiENSGT00390000008670
HOGENOMiHOG000253933
HOVERGENiHBG056905
InParanoidiQ15562
KOiK09448
OMAiQMGEPRA
OrthoDBiEOG091G08YE
PhylomeDBiQ15562
TreeFamiTF313443

Family and domain databases

Gene3Di1.10.10.1610, 1 hit
InterProiView protein in InterPro
IPR000818 TEA/ATTS_dom
IPR038096 TEA/ATTS_sf
IPR016361 TEF_metazoa
PfamiView protein in Pfam
PF01285 TEA, 1 hit
PIRSFiPIRSF002603 TEF, 1 hit
PRINTSiPR00065 TEADOMAIN
SMARTiView protein in SMART
SM00426 TEA, 1 hit
PROSITEiView protein in PROSITE
PS00554 TEA_1, 1 hit
PS51088 TEA_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15562-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEPRAGAAL DDGSGWTGSE EGSEEGTGGS EGAGGDGGPD AEGVWSPDIE
60 70 80 90 100
QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV
110 120 130 140 150
SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL
160 170 180 190 200
GPTGPQASEL FQFWSGGSGP PWNVPDVKPF SQTPFTLSLT PPSTDLPGYE
210 220 230 240 250
PPQALSPLPP PTPSPPAWQA RGLGTARLQL VEFSAFVEPP DAVDSYQRHL
260 270 280 290 300
FVHISQHCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV
310 320 330 340 350
KFWADLNWGP SGEEAGAGGS ISSGGFYGVS SQYESLEHMT LTCSSKVCSF
360 370 380 390 400
GKQVVEKVET ERAQLEDGRF VYRLLRSPMC EYLVNFLHKL RQLPERYMMN
410 420 430 440
SVLENFTILQ VVTNRDTQEL LLCTAYVFEV STSERGAQHH IYRLVRD
Length:447
Mass (Da):49,243
Last modified:May 27, 2002 - v2
Checksum:iA9077F55638A3AC7
GO
Isoform 2 (identifier: Q15562-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-155: P → PQVV

Show »
Length:450
Mass (Da):49,569
Checksum:iF90CF8D5E42E20E6
GO
Isoform 3 (identifier: Q15562-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     155-155: P → PQVV

Show »
Length:319
Mass (Da):35,403
Checksum:i91BCE65CE4E8A7D1
GO
Isoform 4 (identifier: Q15562-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: K → KALNV

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,640
Checksum:i8DB857BAE7F47CF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144P → L in CAA64214 (PubMed:8702974).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451261 – 131Missing in isoform 3. 2 PublicationsAdd BLAST131
Alternative sequenceiVSP_055673120K → KALNV in isoform 4. Curated1
Alternative sequenceiVSP_045127155P → PQVV in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093236 mRNA Translation: BAC04104.1
AK290736 mRNA Translation: BAF83425.1
AK300241 mRNA Translation: BAG62008.1
AC010524 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52469.1
BC051301 mRNA Translation: AAH51301.1
BC007556 mRNA Translation: AAH07556.1
BC018803 mRNA No translation available.
X94440 mRNA Translation: CAA64214.1
CCDSiCCDS12761.1 [Q15562-1]
CCDS58670.1 [Q15562-3]
CCDS58671.1 [Q15562-2]
CCDS59406.1 [Q15562-4]
PIRiG01116
RefSeqiNP_001243587.1, NM_001256658.1 [Q15562-2]
NP_001243588.1, NM_001256659.1 [Q15562-2]
NP_001243589.1, NM_001256660.1 [Q15562-4]
NP_001243590.1, NM_001256661.1 [Q15562-4]
NP_001243591.1, NM_001256662.1 [Q15562-3]
NP_003589.1, NM_003598.1 [Q15562-1]
XP_006723487.1, XM_006723424.1 [Q15562-4]
XP_011525705.1, XM_011527403.1 [Q15562-2]
UniGeneiHs.515534

Genome annotation databases

EnsembliENST00000311227; ENSP00000310701; ENSG00000074219 [Q15562-1]
ENST00000377214; ENSP00000366419; ENSG00000074219 [Q15562-2]
ENST00000539846; ENSP00000437928; ENSG00000074219 [Q15562-3]
ENST00000593945; ENSP00000469640; ENSG00000074219 [Q15562-4]
ENST00000598810; ENSP00000472109; ENSG00000074219 [Q15562-4]
ENST00000601519; ENSP00000469672; ENSG00000074219 [Q15562-2]
GeneIDi8463
KEGGihsa:8463
UCSCiuc002png.5 human [Q15562-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTEAD2_HUMAN
AccessioniPrimary (citable) accession number: Q15562
Secondary accession number(s): B4DTJ6
, M0R1T9, Q8NA25, Q96IG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: June 20, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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