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Protein

Transcriptional enhancer factor TEF-4

Gene

TEAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 107TEAPROSITE-ProRule annotationAdd BLAST68

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074219-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SIGNORiQ15562.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-4
Alternative name(s):
TEA domain family member 2
Short name:
TEAD-2
Gene namesi
Name:TEAD2
Synonyms:TEF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11715. TEAD2.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8463.
OpenTargetsiENSG00000074219.
PharmGKBiPA36433.

Polymorphism and mutation databases

BioMutaiTEAD2.
DMDMi21264529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059321 – 447Transcriptional enhancer factor TEF-4Add BLAST447

Proteomic databases

EPDiQ15562.
MaxQBiQ15562.
PaxDbiQ15562.
PeptideAtlasiQ15562.
PRIDEiQ15562.

PTM databases

iPTMnetiQ15562.
PhosphoSitePlusiQ15562.
SwissPalmiQ15562.

Expressioni

Gene expression databases

BgeeiENSG00000074219.
CleanExiHS_TEAD2.
ExpressionAtlasiQ15562. baseline and differential.
GenevisibleiQ15562. HS.

Organism-specific databases

HPAiCAB018614.
CAB069394.

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L15Q5TBC74EBI-6427252,EBI-10247136
TRIM3O753824EBI-9370956,EBI-2129889
USF2Q158533EBI-6427252,EBI-1055994
VGLL3A8MV65-24EBI-9370956,EBI-11957216

Protein-protein interaction databases

BioGridi114041. 83 interactors.
DIPiDIP-59318N.
IntActiQ15562. 74 interactors.
STRINGi9606.ENSP00000310701.

Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi229 – 238Combined sources10
Helixi240 – 243Combined sources4
Beta strandi249 – 255Combined sources7
Beta strandi268 – 270Combined sources3
Helixi271 – 277Combined sources7
Beta strandi280 – 284Combined sources5
Helixi285 – 291Combined sources7
Helixi294 – 296Combined sources3
Beta strandi297 – 304Combined sources8
Beta strandi326 – 337Combined sources12
Beta strandi340 – 349Combined sources10
Beta strandi352 – 362Combined sources11
Beta strandi364 – 366Combined sources3
Beta strandi369 – 378Combined sources10
Helixi381 – 390Combined sources10
Helixi396 – 403Combined sources8
Beta strandi406 – 414Combined sources9
Turni415 – 417Combined sources3
Beta strandi420 – 430Combined sources11
Beta strandi433 – 435Combined sources3
Beta strandi438 – 445Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L15X-ray2.00A/B217-447[»]
5DQ8X-ray2.31A/B217-447[»]
5DQEX-ray2.18A/B217-447[»]
5EMVX-ray2.00A/B218-446[»]
5HGUX-ray2.05A/B217-447[»]
ProteinModelPortaliQ15562.
SMRiQ15562.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15562.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 447Transcriptional activationSequence analysisAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 216Pro-richAdd BLAST65

Sequence similaritiesi

Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3841. Eukaryota.
ENOG410XQMP. LUCA.
GeneTreeiENSGT00390000008670.
HOGENOMiHOG000253933.
HOVERGENiHBG056905.
InParanoidiQ15562.
KOiK09448.
OMAiTPWNVPD.
OrthoDBiEOG091G08YE.
PhylomeDBiQ15562.
TreeFamiTF313443.

Family and domain databases

InterProiIPR000818. TEA/ATTS_dom.
IPR016361. TEF_metazoa.
[Graphical view]
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15562-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEPRAGAAL DDGSGWTGSE EGSEEGTGGS EGAGGDGGPD AEGVWSPDIE
60 70 80 90 100
QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV
110 120 130 140 150
SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL
160 170 180 190 200
GPTGPQASEL FQFWSGGSGP PWNVPDVKPF SQTPFTLSLT PPSTDLPGYE
210 220 230 240 250
PPQALSPLPP PTPSPPAWQA RGLGTARLQL VEFSAFVEPP DAVDSYQRHL
260 270 280 290 300
FVHISQHCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV
310 320 330 340 350
KFWADLNWGP SGEEAGAGGS ISSGGFYGVS SQYESLEHMT LTCSSKVCSF
360 370 380 390 400
GKQVVEKVET ERAQLEDGRF VYRLLRSPMC EYLVNFLHKL RQLPERYMMN
410 420 430 440
SVLENFTILQ VVTNRDTQEL LLCTAYVFEV STSERGAQHH IYRLVRD
Length:447
Mass (Da):49,243
Last modified:May 27, 2002 - v2
Checksum:iA9077F55638A3AC7
GO
Isoform 2 (identifier: Q15562-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-155: P → PQVV

Show »
Length:450
Mass (Da):49,569
Checksum:iF90CF8D5E42E20E6
GO
Isoform 3 (identifier: Q15562-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     155-155: P → PQVV

Show »
Length:319
Mass (Da):35,403
Checksum:i91BCE65CE4E8A7D1
GO
Isoform 4 (identifier: Q15562-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: K → KALNV

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,640
Checksum:i8DB857BAE7F47CF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144P → L in CAA64214 (PubMed:8702974).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451261 – 131Missing in isoform 3. 2 PublicationsAdd BLAST131
Alternative sequenceiVSP_055673120K → KALNV in isoform 4. Curated1
Alternative sequenceiVSP_045127155P → PQVV in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093236 mRNA. Translation: BAC04104.1.
AK290736 mRNA. Translation: BAF83425.1.
AK300241 mRNA. Translation: BAG62008.1.
AC010524 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52469.1.
BC051301 mRNA. Translation: AAH51301.1.
BC007556 mRNA. Translation: AAH07556.1.
BC018803 mRNA. No translation available.
X94440 mRNA. Translation: CAA64214.1.
CCDSiCCDS12761.1. [Q15562-1]
CCDS58670.1. [Q15562-3]
CCDS58671.1. [Q15562-2]
CCDS59406.1. [Q15562-4]
PIRiG01116.
RefSeqiNP_001243587.1. NM_001256658.1. [Q15562-2]
NP_001243588.1. NM_001256659.1. [Q15562-2]
NP_001243589.1. NM_001256660.1. [Q15562-4]
NP_001243590.1. NM_001256661.1. [Q15562-4]
NP_001243591.1. NM_001256662.1. [Q15562-3]
NP_003589.1. NM_003598.1. [Q15562-1]
XP_006723487.1. XM_006723424.1. [Q15562-4]
XP_011525705.1. XM_011527403.1. [Q15562-2]
UniGeneiHs.515534.

Genome annotation databases

EnsembliENST00000311227; ENSP00000310701; ENSG00000074219. [Q15562-1]
ENST00000377214; ENSP00000366419; ENSG00000074219. [Q15562-2]
ENST00000539846; ENSP00000437928; ENSG00000074219. [Q15562-3]
ENST00000593945; ENSP00000469640; ENSG00000074219. [Q15562-4]
ENST00000598810; ENSP00000472109; ENSG00000074219. [Q15562-4]
ENST00000601519; ENSP00000469672; ENSG00000074219. [Q15562-2]
GeneIDi8463.
KEGGihsa:8463.
UCSCiuc002png.5. human. [Q15562-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093236 mRNA. Translation: BAC04104.1.
AK290736 mRNA. Translation: BAF83425.1.
AK300241 mRNA. Translation: BAG62008.1.
AC010524 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52469.1.
BC051301 mRNA. Translation: AAH51301.1.
BC007556 mRNA. Translation: AAH07556.1.
BC018803 mRNA. No translation available.
X94440 mRNA. Translation: CAA64214.1.
CCDSiCCDS12761.1. [Q15562-1]
CCDS58670.1. [Q15562-3]
CCDS58671.1. [Q15562-2]
CCDS59406.1. [Q15562-4]
PIRiG01116.
RefSeqiNP_001243587.1. NM_001256658.1. [Q15562-2]
NP_001243588.1. NM_001256659.1. [Q15562-2]
NP_001243589.1. NM_001256660.1. [Q15562-4]
NP_001243590.1. NM_001256661.1. [Q15562-4]
NP_001243591.1. NM_001256662.1. [Q15562-3]
NP_003589.1. NM_003598.1. [Q15562-1]
XP_006723487.1. XM_006723424.1. [Q15562-4]
XP_011525705.1. XM_011527403.1. [Q15562-2]
UniGeneiHs.515534.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L15X-ray2.00A/B217-447[»]
5DQ8X-ray2.31A/B217-447[»]
5DQEX-ray2.18A/B217-447[»]
5EMVX-ray2.00A/B218-446[»]
5HGUX-ray2.05A/B217-447[»]
ProteinModelPortaliQ15562.
SMRiQ15562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114041. 83 interactors.
DIPiDIP-59318N.
IntActiQ15562. 74 interactors.
STRINGi9606.ENSP00000310701.

PTM databases

iPTMnetiQ15562.
PhosphoSitePlusiQ15562.
SwissPalmiQ15562.

Polymorphism and mutation databases

BioMutaiTEAD2.
DMDMi21264529.

Proteomic databases

EPDiQ15562.
MaxQBiQ15562.
PaxDbiQ15562.
PeptideAtlasiQ15562.
PRIDEiQ15562.

Protocols and materials databases

DNASUi8463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311227; ENSP00000310701; ENSG00000074219. [Q15562-1]
ENST00000377214; ENSP00000366419; ENSG00000074219. [Q15562-2]
ENST00000539846; ENSP00000437928; ENSG00000074219. [Q15562-3]
ENST00000593945; ENSP00000469640; ENSG00000074219. [Q15562-4]
ENST00000598810; ENSP00000472109; ENSG00000074219. [Q15562-4]
ENST00000601519; ENSP00000469672; ENSG00000074219. [Q15562-2]
GeneIDi8463.
KEGGihsa:8463.
UCSCiuc002png.5. human. [Q15562-1]

Organism-specific databases

CTDi8463.
DisGeNETi8463.
GeneCardsiTEAD2.
HGNCiHGNC:11715. TEAD2.
HPAiCAB018614.
CAB069394.
MIMi601729. gene.
neXtProtiNX_Q15562.
OpenTargetsiENSG00000074219.
PharmGKBiPA36433.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3841. Eukaryota.
ENOG410XQMP. LUCA.
GeneTreeiENSGT00390000008670.
HOGENOMiHOG000253933.
HOVERGENiHBG056905.
InParanoidiQ15562.
KOiK09448.
OMAiTPWNVPD.
OrthoDBiEOG091G08YE.
PhylomeDBiQ15562.
TreeFamiTF313443.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074219-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SIGNORiQ15562.

Miscellaneous databases

ChiTaRSiTEAD2. human.
EvolutionaryTraceiQ15562.
GeneWikiiTEAD2.
GenomeRNAii8463.
PROiQ15562.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074219.
CleanExiHS_TEAD2.
ExpressionAtlasiQ15562. baseline and differential.
GenevisibleiQ15562. HS.

Family and domain databases

InterProiIPR000818. TEA/ATTS_dom.
IPR016361. TEF_metazoa.
[Graphical view]
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEAD2_HUMAN
AccessioniPrimary (citable) accession number: Q15562
Secondary accession number(s): B4DTJ6
, M0R1T9, Q8NA25, Q96IG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.