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Q15560

- TCEA2_HUMAN

UniProt

Q15560 - TCEA2_HUMAN

Protein

Transcription elongation factor A protein 2

Gene

TCEA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri257 – 29741TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, elongation Source: UniProtKB
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. regulation of DNA-templated transcription, elongation Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor A protein 2
    Alternative name(s):
    Testis-specific S-II
    Transcription elongation factor S-II protein 2
    Transcription elongation factor TFIIS.l
    Gene namesi
    Name:TCEA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11614. TCEA2.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: HPA
    2. nucleus Source: HPA
    3. transcription elongation factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36373.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Transcription elongation factor A protein 2PRO_0000121449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki58 – 58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ15560.
    PaxDbiQ15560.
    PRIDEiQ15560.

    PTM databases

    PhosphoSiteiQ15560.

    Expressioni

    Tissue specificityi

    Testis and ovary specific.1 Publication

    Gene expression databases

    ArrayExpressiQ15560.
    BgeeiQ15560.
    CleanExiHS_TCEA2.
    GenevestigatoriQ15560.

    Organism-specific databases

    HPAiHPA043836.

    Interactioni

    Subunit structurei

    Interacts with the basal transcription factor GTF2B. Interacts with REXO1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAGEA11P433642EBI-710310,EBI-739552
    MARK3P274482EBI-710310,EBI-707595

    Protein-protein interaction databases

    BioGridi112781. 32 interactions.
    IntActiQ15560. 16 interactions.
    STRINGi9606.ENSP00000343515.

    Structurei

    Secondary structure

    1
    299
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi139 – 15113
    Helixi155 – 1595
    Helixi163 – 17816
    Turni181 – 1833
    Helixi184 – 19714
    Beta strandi199 – 2024
    Helixi203 – 2097
    Helixi215 – 2206
    Helixi223 – 2275
    Turni229 – 2335
    Beta strandi235 – 2373

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LW4NMR-A130-239[»]
    ProteinModelPortaliQ15560.
    SMRiQ15560. Positions 2-86, 130-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 8378TFIIS N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 254117TFIIS centralPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TFS-II family.Curated
    Contains 1 TFIIS central domain.PROSITE-ProRule annotation
    Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TFIIS-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri257 – 29741TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1594.
    HOGENOMiHOG000195015.
    HOVERGENiHBG055022.
    KOiK03145.
    OMAiGADCEHI.
    OrthoDBiEOG7GQXWQ.
    PhylomeDBiQ15560.
    TreeFamiTF314970.

    Family and domain databases

    Gene3Di1.10.472.30. 1 hit.
    1.20.930.10. 1 hit.
    InterProiIPR016492. TF_IIS-rel.
    IPR003617. TFIIS/CRSP70_N_sub.
    IPR003618. TFIIS_cen_dom.
    IPR017923. TFIIS_N.
    IPR017890. TFS2M.
    IPR006289. TFSII.
    IPR001222. Znf_TFIIS.
    [Graphical view]
    PfamiPF08711. Med26. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006704. TF_IIS. 1 hit.
    SMARTiSM00510. TFS2M. 1 hit.
    SM00509. TFS2N. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF46942. SSF46942. 1 hit.
    SSF47676. SSF47676. 1 hit.
    TIGRFAMsiTIGR01385. TFSII. 1 hit.
    PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
    PS51319. TFIIS_N. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15560-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG    50
    MSVNALRKQS SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS 100
    RDASEAPDPS RKRPELPRAP STPRITTFPP VPVTCDAVRN KCREMLTAAL 150
    QTDHDHVAIG ADCERLSAQI EECIFRDVGN TDMKYKNRVR SRISNLKDAK 200
    NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR 250
    TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC 299
    Length:299
    Mass (Da):33,601
    Last modified:November 1, 1996 - v1
    Checksum:iFF0EAE8EDC7BCBE9
    GO
    Isoform 2 (identifier: Q15560-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:272
    Mass (Da):30,569
    Checksum:iB0023436A8268207
    GO

    Sequence cautioni

    The sequence CAD11900.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAD11901.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551A → T in BAG51383. (PubMed:14702039)Curated
    Sequence conflicti164 – 1641E → V in BAG51383. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2727Missing in isoform 2. 1 PublicationVSP_047345Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50495 mRNA. Translation: BAA09089.1.
    AK027824 mRNA. Translation: BAG51383.1.
    AL590548 Genomic DNA. Translation: CAD11900.1. Sequence problems.
    AL590548 Genomic DNA. Translation: CAD11901.1. Sequence problems.
    BC018896 mRNA. Translation: AAH18896.1.
    U86749 Genomic DNA. Translation: AAC39553.1.
    CCDSiCCDS13553.1. [Q15560-1]
    CCDS13554.1. [Q15560-2]
    PIRiJC4577.
    RefSeqiNP_003186.1. NM_003195.4. [Q15560-1]
    NP_942016.1. NM_198723.1. [Q15560-2]
    XP_006723937.1. XM_006723874.1. [Q15560-2]
    UniGeneiHs.505004.
    Hs.736326.

    Genome annotation databases

    EnsembliENST00000343484; ENSP00000343515; ENSG00000171703. [Q15560-1]
    ENST00000361317; ENSP00000354552; ENSG00000171703. [Q15560-2]
    GeneIDi6919.
    KEGGihsa:6919.
    UCSCiuc021wgp.1. human. [Q15560-1]

    Polymorphism databases

    DMDMi28380177.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50495 mRNA. Translation: BAA09089.1 .
    AK027824 mRNA. Translation: BAG51383.1 .
    AL590548 Genomic DNA. Translation: CAD11900.1 . Sequence problems.
    AL590548 Genomic DNA. Translation: CAD11901.1 . Sequence problems.
    BC018896 mRNA. Translation: AAH18896.1 .
    U86749 Genomic DNA. Translation: AAC39553.1 .
    CCDSi CCDS13553.1. [Q15560-1 ]
    CCDS13554.1. [Q15560-2 ]
    PIRi JC4577.
    RefSeqi NP_003186.1. NM_003195.4. [Q15560-1 ]
    NP_942016.1. NM_198723.1. [Q15560-2 ]
    XP_006723937.1. XM_006723874.1. [Q15560-2 ]
    UniGenei Hs.505004.
    Hs.736326.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LW4 NMR - A 130-239 [» ]
    ProteinModelPortali Q15560.
    SMRi Q15560. Positions 2-86, 130-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112781. 32 interactions.
    IntActi Q15560. 16 interactions.
    STRINGi 9606.ENSP00000343515.

    PTM databases

    PhosphoSitei Q15560.

    Polymorphism databases

    DMDMi 28380177.

    Proteomic databases

    MaxQBi Q15560.
    PaxDbi Q15560.
    PRIDEi Q15560.

    Protocols and materials databases

    DNASUi 6919.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343484 ; ENSP00000343515 ; ENSG00000171703 . [Q15560-1 ]
    ENST00000361317 ; ENSP00000354552 ; ENSG00000171703 . [Q15560-2 ]
    GeneIDi 6919.
    KEGGi hsa:6919.
    UCSCi uc021wgp.1. human. [Q15560-1 ]

    Organism-specific databases

    CTDi 6919.
    GeneCardsi GC20P062681.
    H-InvDB HIX0174737.
    HGNCi HGNC:11614. TCEA2.
    HPAi HPA043836.
    MIMi 604784. gene.
    neXtProti NX_Q15560.
    PharmGKBi PA36373.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1594.
    HOGENOMi HOG000195015.
    HOVERGENi HBG055022.
    KOi K03145.
    OMAi GADCEHI.
    OrthoDBi EOG7GQXWQ.
    PhylomeDBi Q15560.
    TreeFami TF314970.

    Miscellaneous databases

    GeneWikii TCEA2.
    GenomeRNAii 6919.
    NextBioi 27067.
    PROi Q15560.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15560.
    Bgeei Q15560.
    CleanExi HS_TCEA2.
    Genevestigatori Q15560.

    Family and domain databases

    Gene3Di 1.10.472.30. 1 hit.
    1.20.930.10. 1 hit.
    InterProi IPR016492. TF_IIS-rel.
    IPR003617. TFIIS/CRSP70_N_sub.
    IPR003618. TFIIS_cen_dom.
    IPR017923. TFIIS_N.
    IPR017890. TFS2M.
    IPR006289. TFSII.
    IPR001222. Znf_TFIIS.
    [Graphical view ]
    Pfami PF08711. Med26. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006704. TF_IIS. 1 hit.
    SMARTi SM00510. TFS2M. 1 hit.
    SM00509. TFS2N. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46942. SSF46942. 1 hit.
    SSF47676. SSF47676. 1 hit.
    TIGRFAMsi TIGR01385. TFSII. 1 hit.
    PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
    PS51319. TFIIS_N. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II."
      Umehara T., Kida S., Yamamoto T., Horikoshi M.
      Gene 167:297-302(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH GTF2B.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    5. "Genomic characterization of a testis-specific TFIIS (TCEA2) gene."
      Weaver Z.A., Kane C.M.
      Genomics 46:516-519(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
      Tissue: Brain.
    6. "RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage."
      Sijbrandi R., Fiedler U., Timmers H.T.M.
      Nucleic Acids Res. 30:2290-2298(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain."
      Tamura K., Miyata K., Sugahara K., Onishi S., Shuin T., Aso T.
      Biochem. Biophys. Res. Commun. 309:189-195(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH REXO1.
    8. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
      Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
      Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-58.
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTCEA2_HUMAN
    AccessioniPrimary (citable) accession number: Q15560
    Secondary accession number(s): B3KNM1, Q8TD37, Q8TD38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3