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Protein

Transcription elongation factor A protein 2

Gene

TCEA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, elongation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • regulation of DNA-templated transcription, elongation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171703-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein 2
Alternative name(s):
Testis-specific S-II
Transcription elongation factor S-II protein 2
Transcription elongation factor TFIIS.l
Gene namesi
Name:TCEA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11614. TCEA2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: HPA
  • nucleoplasm Source: HPA
  • transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6919.
OpenTargetsiENSG00000171703.
PharmGKBiPA36373.

Polymorphism and mutation databases

BioMutaiTCEA2.
DMDMi28380177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214491 – 299Transcription elongation factor A protein 2Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei60PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15560.
PaxDbiQ15560.
PeptideAtlasiQ15560.
PRIDEiQ15560.

PTM databases

iPTMnetiQ15560.
PhosphoSitePlusiQ15560.

Expressioni

Tissue specificityi

Testis and ovary specific.1 Publication

Gene expression databases

BgeeiENSG00000171703.
CleanExiHS_TCEA2.
ExpressionAtlasiQ15560. baseline and differential.
GenevisibleiQ15560. HS.

Organism-specific databases

HPAiHPA043836.

Interactioni

Subunit structurei

Interacts with the basal transcription factor GTF2B. Interacts with REXO1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-710310,EBI-10173507
ALAS1P131963EBI-710310,EBI-3905054
CCDC136Q96JN2-23EBI-710310,EBI-10171416
CEP44Q9C0F13EBI-710310,EBI-744115
DAB1O755533EBI-710310,EBI-7875264
EXOSC8Q96B263EBI-710310,EBI-371922
FAM9BQ8IZU03EBI-710310,EBI-10175124
GOLGA2Q083793EBI-710310,EBI-618309
GPKOWQ929175EBI-710310,EBI-746309
KIAA1958Q8N8K95EBI-710310,EBI-10181113
KRT40Q6A1623EBI-710310,EBI-10171697
KRTAP10-7P604093EBI-710310,EBI-10172290
KRTAP5-9P263713EBI-710310,EBI-3958099
LZTS2Q9BRK43EBI-710310,EBI-741037
MAGEA11P433642EBI-710310,EBI-739552
MARK3P274482EBI-710310,EBI-707595
MEOX2A4D1275EBI-710310,EBI-10172134
MID2Q9UJV3-23EBI-710310,EBI-10172526
MKRN3Q130643EBI-710310,EBI-2340269
TAX1BP1Q86VP13EBI-710310,EBI-529518
TCF4P158843EBI-710310,EBI-533224
TFCP2Q128003EBI-710310,EBI-717422
THAP1Q9NVV95EBI-710310,EBI-741515
TNIP1Q150256EBI-710310,EBI-357849
TRAF2Q129336EBI-710310,EBI-355744
TRIM27P143735EBI-710310,EBI-719493
TRIM54Q9BYV25EBI-710310,EBI-2130429
TSGA10Q9BZW73EBI-710310,EBI-744794

Protein-protein interaction databases

BioGridi112781. 60 interactors.
IntActiQ15560. 106 interactors.
STRINGi9606.ENSP00000343515.

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi139 – 151Combined sources13
Helixi155 – 159Combined sources5
Helixi163 – 178Combined sources16
Turni181 – 183Combined sources3
Helixi184 – 197Combined sources14
Beta strandi199 – 202Combined sources4
Helixi203 – 209Combined sources7
Helixi215 – 220Combined sources6
Helixi223 – 227Combined sources5
Turni229 – 233Combined sources5
Beta strandi235 – 237Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LW4NMR-A130-239[»]
ProteinModelPortaliQ15560.
SMRiQ15560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 83TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini138 – 254TFIIS centralPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the TFS-II family.Curated
Contains 1 TFIIS central domain.PROSITE-ProRule annotation
Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation
Contains 1 TFIIS-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 297TFIIS-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1105. Eukaryota.
COG1594. LUCA.
GeneTreeiENSGT00390000017794.
HOGENOMiHOG000195015.
HOVERGENiHBG055022.
InParanoidiQ15560.
KOiK03145.
OMAiSMPMTLD.
OrthoDBiEOG091G10EJ.
PhylomeDBiQ15560.
TreeFamiTF314970.

Family and domain databases

Gene3Di1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProiIPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
PIRSFiPIRSF006704. TF_IIS. 1 hit.
SMARTiSM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view]
SUPFAMiSSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsiTIGR01385. TFSII. 1 hit.
PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG
60 70 80 90 100
MSVNALRKQS SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS
110 120 130 140 150
RDASEAPDPS RKRPELPRAP STPRITTFPP VPVTCDAVRN KCREMLTAAL
160 170 180 190 200
QTDHDHVAIG ADCERLSAQI EECIFRDVGN TDMKYKNRVR SRISNLKDAK
210 220 230 240 250
NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR
260 270 280 290
TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC
Length:299
Mass (Da):33,601
Last modified:November 1, 1996 - v1
Checksum:iFF0EAE8EDC7BCBE9
GO
Isoform 2 (identifier: Q15560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,569
Checksum:iB0023436A8268207
GO

Sequence cautioni

The sequence CAD11900 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAD11901 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → T in BAG51383 (PubMed:14702039).Curated1
Sequence conflicti164E → V in BAG51383 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0473451 – 27Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50495 mRNA. Translation: BAA09089.1.
AK027824 mRNA. Translation: BAG51383.1.
AL590548 Genomic DNA. Translation: CAD11900.1. Sequence problems.
AL590548 Genomic DNA. Translation: CAD11901.1. Sequence problems.
BC018896 mRNA. Translation: AAH18896.1.
U86749 Genomic DNA. Translation: AAC39553.1.
CCDSiCCDS13553.1. [Q15560-1]
CCDS13554.1. [Q15560-2]
PIRiJC4577.
RefSeqiNP_003186.1. NM_003195.4. [Q15560-1]
NP_942016.1. NM_198723.1. [Q15560-2]
XP_016883525.1. XM_017028036.1. [Q15560-2]
XP_016883526.1. XM_017028037.1. [Q15560-2]
UniGeneiHs.505004.
Hs.736326.

Genome annotation databases

EnsembliENST00000343484; ENSP00000343515; ENSG00000171703. [Q15560-1]
ENST00000361317; ENSP00000354552; ENSG00000171703. [Q15560-2]
GeneIDi6919.
KEGGihsa:6919.
UCSCiuc061yqt.1. human. [Q15560-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50495 mRNA. Translation: BAA09089.1.
AK027824 mRNA. Translation: BAG51383.1.
AL590548 Genomic DNA. Translation: CAD11900.1. Sequence problems.
AL590548 Genomic DNA. Translation: CAD11901.1. Sequence problems.
BC018896 mRNA. Translation: AAH18896.1.
U86749 Genomic DNA. Translation: AAC39553.1.
CCDSiCCDS13553.1. [Q15560-1]
CCDS13554.1. [Q15560-2]
PIRiJC4577.
RefSeqiNP_003186.1. NM_003195.4. [Q15560-1]
NP_942016.1. NM_198723.1. [Q15560-2]
XP_016883525.1. XM_017028036.1. [Q15560-2]
XP_016883526.1. XM_017028037.1. [Q15560-2]
UniGeneiHs.505004.
Hs.736326.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LW4NMR-A130-239[»]
ProteinModelPortaliQ15560.
SMRiQ15560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112781. 60 interactors.
IntActiQ15560. 106 interactors.
STRINGi9606.ENSP00000343515.

PTM databases

iPTMnetiQ15560.
PhosphoSitePlusiQ15560.

Polymorphism and mutation databases

BioMutaiTCEA2.
DMDMi28380177.

Proteomic databases

EPDiQ15560.
PaxDbiQ15560.
PeptideAtlasiQ15560.
PRIDEiQ15560.

Protocols and materials databases

DNASUi6919.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343484; ENSP00000343515; ENSG00000171703. [Q15560-1]
ENST00000361317; ENSP00000354552; ENSG00000171703. [Q15560-2]
GeneIDi6919.
KEGGihsa:6919.
UCSCiuc061yqt.1. human. [Q15560-1]

Organism-specific databases

CTDi6919.
DisGeNETi6919.
GeneCardsiTCEA2.
H-InvDBHIX0174737.
HGNCiHGNC:11614. TCEA2.
HPAiHPA043836.
MIMi604784. gene.
neXtProtiNX_Q15560.
OpenTargetsiENSG00000171703.
PharmGKBiPA36373.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1105. Eukaryota.
COG1594. LUCA.
GeneTreeiENSGT00390000017794.
HOGENOMiHOG000195015.
HOVERGENiHBG055022.
InParanoidiQ15560.
KOiK03145.
OMAiSMPMTLD.
OrthoDBiEOG091G10EJ.
PhylomeDBiQ15560.
TreeFamiTF314970.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171703-MONOMER.

Miscellaneous databases

GeneWikiiTCEA2.
GenomeRNAii6919.
PROiQ15560.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171703.
CleanExiHS_TCEA2.
ExpressionAtlasiQ15560. baseline and differential.
GenevisibleiQ15560. HS.

Family and domain databases

Gene3Di1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProiIPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
PIRSFiPIRSF006704. TF_IIS. 1 hit.
SMARTiSM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view]
SUPFAMiSSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsiTIGR01385. TFSII. 1 hit.
PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCEA2_HUMAN
AccessioniPrimary (citable) accession number: Q15560
Secondary accession number(s): B3KNM1, Q8TD37, Q8TD38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.