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Protein

Monocyte to macrophage differentiation factor

Gene

MMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.By similarity

GO - Molecular functioni

  • protein kinase activity Source: CACAO
  • receptor activity Source: ProtInc

GO - Biological processi

  • cytolysis Source: InterPro
  • positive regulation of neuron differentiation Source: CACAO
  • positive regulation of protein kinase activity Source: CACAO
  • regulation of protein localization Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Protein family/group databases

TCDBi1.C.113.2.1. 1.c.113 the hly iii (hly iii) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocyte to macrophage differentiation factor
Alternative name(s):
Progestin and adipoQ receptor family member 11
Progestin and adipoQ receptor family member XI
Gene namesi
Name:MMD
Synonyms:PAQR11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7153. MMD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence analysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Topological domaini50 – 6112LumenalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 10119CytoplasmicSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Topological domaini123 – 1242LumenalSequence analysis
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Topological domaini146 – 1516CytoplasmicSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 1742LumenalSequence analysis
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 1983CytoplasmicSequence analysis
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Topological domaini220 – 23819LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: CACAO
  • integral component of plasma membrane Source: ProtInc
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB-SubCell
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30863.

Polymorphism and mutation databases

BioMutaiMMD.
DMDMi62512174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Monocyte to macrophage differentiation factorPRO_0000218854Add
BLAST

Proteomic databases

PaxDbiQ15546.
PRIDEiQ15546.

PTM databases

iPTMnetiQ15546.
PhosphoSiteiQ15546.

Expressioni

Tissue specificityi

Exhibits relatively ubiquitous expression with preferential expression in mature (in vitro differentiated) macrophages.1 Publication

Gene expression databases

BgeeiQ15546.
CleanExiHS_MMD.
ExpressionAtlasiQ15546. baseline and differential.
GenevisibleiQ15546. HS.

Interactioni

Protein-protein interaction databases

BioGridi117077. 1 interaction.
STRINGi9606.ENSP00000262065.

Structurei

3D structure databases

ProteinModelPortaliQ15546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4243. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00390000001574.
HOGENOMiHOG000039440.
HOVERGENiHBG053507.
InParanoidiQ15546.
KOiK11064.
OMAiIFHVWEK.
OrthoDBiEOG7SJD5B.
PhylomeDBiQ15546.
TreeFamiTF313370.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
IPR005744. Hy-lIII.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01065. hlyIII. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKNRFQRF MNHRAPANGR YKPTCYEHAA NCYTHAFLIV PAIVGSALLH
60 70 80 90 100
RLSDDCWEKI TAWIYGMGLC ALFIVSTVFH IVSWKKSHLR TVEHCFHMCD
110 120 130 140 150
RMVIYFFIAA SYAPWLNLRE LGPLASHMRW FIWLMAAGGT IYVFLYHEKY
160 170 180 190 200
KVVELFFYLT MGFSPALVVT SMNNTDGLQE LACGGLIYCL GVVFFKSDGI
210 220 230
IPFAHAIWHL FVATAAAVHY YAIWKYLYRS PTDFMRHL
Length:238
Mass (Da):27,667
Last modified:April 12, 2005 - v2
Checksum:i0B7328C85911F184
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751V → A in CAA59752 (PubMed:7503749).Curated
Sequence conflicti92 – 921V → A in CAA59752 (PubMed:7503749).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85750 mRNA. Translation: CAA59752.1.
AY424289 mRNA. Translation: AAR08377.1.
CR541893 mRNA. Translation: CAG46691.1.
AK312760 mRNA. Translation: BAG35626.1.
CH471109 Genomic DNA. Translation: EAW94541.1.
CH471109 Genomic DNA. Translation: EAW94542.1.
BC026324 mRNA. Translation: AAH26324.1.
CCDSiCCDS11586.1.
PIRiJC4503.
RefSeqiNP_036461.2. NM_012329.2.
UniGeneiHs.463483.
Hs.656753.

Genome annotation databases

EnsembliENST00000262065; ENSP00000262065; ENSG00000108960.
GeneIDi23531.
KEGGihsa:23531.
UCSCiuc002iui.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85750 mRNA. Translation: CAA59752.1.
AY424289 mRNA. Translation: AAR08377.1.
CR541893 mRNA. Translation: CAG46691.1.
AK312760 mRNA. Translation: BAG35626.1.
CH471109 Genomic DNA. Translation: EAW94541.1.
CH471109 Genomic DNA. Translation: EAW94542.1.
BC026324 mRNA. Translation: AAH26324.1.
CCDSiCCDS11586.1.
PIRiJC4503.
RefSeqiNP_036461.2. NM_012329.2.
UniGeneiHs.463483.
Hs.656753.

3D structure databases

ProteinModelPortaliQ15546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117077. 1 interaction.
STRINGi9606.ENSP00000262065.

Protein family/group databases

TCDBi1.C.113.2.1. 1.c.113 the hly iii (hly iii) family.

PTM databases

iPTMnetiQ15546.
PhosphoSiteiQ15546.

Polymorphism and mutation databases

BioMutaiMMD.
DMDMi62512174.

Proteomic databases

PaxDbiQ15546.
PRIDEiQ15546.

Protocols and materials databases

DNASUi23531.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262065; ENSP00000262065; ENSG00000108960.
GeneIDi23531.
KEGGihsa:23531.
UCSCiuc002iui.4. human.

Organism-specific databases

CTDi23531.
GeneCardsiMMD.
HGNCiHGNC:7153. MMD.
MIMi604467. gene.
neXtProtiNX_Q15546.
PharmGKBiPA30863.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4243. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00390000001574.
HOGENOMiHOG000039440.
HOVERGENiHBG053507.
InParanoidiQ15546.
KOiK11064.
OMAiIFHVWEK.
OrthoDBiEOG7SJD5B.
PhylomeDBiQ15546.
TreeFamiTF313370.

Miscellaneous databases

GenomeRNAii23531.
PROiQ15546.
SOURCEiSearch...

Gene expression databases

BgeeiQ15546.
CleanExiHS_MMD.
ExpressionAtlasiQ15546. baseline and differential.
GenevisibleiQ15546. HS.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
IPR005744. Hy-lIII.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01065. hlyIII. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains."
    Rehli M., Krause S.W., Schwarzfischer L., Kreutz M., Andreesen R.
    Biochem. Biophys. Res. Commun. 217:661-667(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Blood.
  2. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPAQRB_HUMAN
AccessioniPrimary (citable) accession number: Q15546
Secondary accession number(s): B2R6X9, D3DTY6, Q8TAN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 12, 2005
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.