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Protein

Transcription initiation factor TFIID subunit 11

Gene

TAF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

GO - Molecular functioni

  • protein heterodimerization activity Source: InterPro
  • protein N-terminus binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB
  • vitamin D receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SIGNORiQ15544

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 11
Alternative name(s):
TFIID subunit p30-beta
Transcription initiation factor TFIID 28 kDa subunit
Short name:
TAF(II)28
Short name:
TAFII-28
Short name:
TAFII28
Gene namesi
Name:TAF11
Synonyms:TAF2I
ORF Names:PRO2134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000064995.16
HGNCiHGNC:11544 TAF11
MIMi600772 gene
neXtProtiNX_Q15544

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064995
PharmGKBiPA36319

Polymorphism and mutation databases

BioMutaiTAF11
DMDMi3024707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189021 – 211Transcription initiation factor TFIID subunit 11Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15544
MaxQBiQ15544
PaxDbiQ15544
PeptideAtlasiQ15544
PRIDEiQ15544

PTM databases

iPTMnetiQ15544
PhosphoSitePlusiQ15544

Expressioni

Gene expression databases

BgeeiENSG00000064995
CleanExiHS_TAF11
GenevisibleiQ15544 HS

Organism-specific databases

HPAiHPA029326
HPA049127

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF13 both in vitro and intracellularly; also interacts directly with TBP.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein heterodimerization activity Source: InterPro
  • protein N-terminus binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB
  • vitamin D receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112745, 48 interactors
CORUMiQ15544
DIPiDIP-495N
IntActiQ15544, 17 interactors
STRINGi9606.ENSP00000354633

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi115 – 126Combined sources12
Helixi131 – 142Combined sources12
Helixi148 – 175Combined sources28
Helixi184 – 196Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BH8X-ray3.00B113-201[»]
1BH9X-ray2.60B113-201[»]
ProteinModelPortaliQ15544
SMRiQ15544
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15544

Family & Domainsi

Domaini

TBP and TAFII18 bind to distinct domains of TAFII28.

Sequence similaritiesi

Belongs to the TAF11 family.Curated

Phylogenomic databases

eggNOGiKOG3219 Eukaryota
COG5251 LUCA
GeneTreeiENSGT00390000013228
HOGENOMiHOG000006355
HOVERGENiHBG079228
InParanoidiQ15544
KOiK03135
OMAiMDDAHES
OrthoDBiEOG091G0Y7H
PhylomeDBiQ15544
TreeFamiTF315132

Family and domain databases

CDDicd08048 TAF11, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR006809 TAFII28
PANTHERiPTHR13218 PTHR13218, 1 hit
PfamiView protein in Pfam
PF04719 TAFII28, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15544-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDAHESPSD KGGETGESDE TAAVPGDPGA TDTDGIPEET DGDADVDLKE
60 70 80 90 100
AAAEEGELES QDVSDLTTVE REDSSLLNPA AKKLKIDTKE KKEKKQKVDE
110 120 130 140 150
DEIQKMQILV SSFSEEQLNR YEMYRRSAFP KAAIKRLIQS ITGTSVSQNV
160 170 180 190 200
VIAMSGISKV FVGEVVEEAL DVCEKWGEMP PLQPKHMREA VRRLKSKGQI
210
PNSKHKKIIF F
Length:211
Mass (Da):23,307
Last modified:November 1, 1996 - v1
Checksum:i77C7BDC667D19A8F
GO
Isoform 2 (identifier: Q15544-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-211: LIQSITGTSV...NSKHKKIIFF → HWMCVRSGEKCHHYNPNI

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,142
Checksum:i73B2AE01BABD971B
GO

Sequence cautioni

The sequence AAF22038 differs from that shown. Reason: Frameshift at position 208.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01633368T → R1 PublicationCorresponds to variant dbSNP:rs15922Ensembl.1
Natural variantiVAR_052261155S → F. Corresponds to variant dbSNP:rs11537996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044936137 – 211LIQSI…KIIFF → HWMCVRSGEKCHHYNPNI in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83928 mRNA Translation: CAA58780.1
D63705 mRNA Translation: BAA23620.1
AK302226 mRNA Translation: BAG63580.1
AK313475 mRNA Translation: BAG36260.1
CR542068 mRNA Translation: CAG46865.1
BT019404 mRNA Translation: AAV38211.1
BT019405 mRNA Translation: AAV38212.1
AY217767 Genomic DNA Translation: AAO25652.1
AL033520 Genomic DNA No translation available.
BC021972 mRNA Translation: AAH21972.1
AF118094 mRNA Translation: AAF22038.1 Sequence problems.
CCDSiCCDS4797.1 [Q15544-1]
CCDS59014.1 [Q15544-2]
PIRiJC4540
RefSeqiNP_001257417.1, NM_001270488.1 [Q15544-2]
NP_005634.1, NM_005643.3 [Q15544-1]
UniGeneiHs.112444

Genome annotation databases

EnsembliENST00000361288; ENSP00000354633; ENSG00000064995 [Q15544-1]
ENST00000420584; ENSP00000408121; ENSG00000064995 [Q15544-2]
GeneIDi6882
KEGGihsa:6882
UCSCiuc003ojw.3 human [Q15544-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAF11_HUMAN
AccessioniPrimary (citable) accession number: Q15544
Secondary accession number(s): B2R8R3, B4DY18, Q9UHS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health